JPS565462A - Piperazinylalkoxyindanes and their acid addition salt - Google Patents
Piperazinylalkoxyindanes and their acid addition saltInfo
- Publication number
- JPS565462A JPS565462A JP8050579A JP8050579A JPS565462A JP S565462 A JPS565462 A JP S565462A JP 8050579 A JP8050579 A JP 8050579A JP 8050579 A JP8050579 A JP 8050579A JP S565462 A JPS565462 A JP S565462A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- acid addition
- addition salt
- piperazinylalkoxyindanes
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:The titled compound shown by the formula I (n is 3 or 4; R is phenyl or pyridyl which may be substituted by a group selected from halogen, CF3, alkoxy, and alkylcarbonyl) and its acid addition salt.
EXAMPLE: 5-[3-(4-Phenyl-1-piperazinyl)propoxy]indane.
USE: A sedative having antianxiety action. Daily dose is usually 0.5W50mg/kg of the body. To be administered once or more times.
PROCESS: A halogenoalkoxyindane shown by the formula II ( X is halogen) is reacted with a piperazine shown by the formula III preferably in an inert solvent usually at room temperatures to 150°C for 10minW20hr to give a compound shown by the formula I. A base is preferably added as a reaction promotor.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8050579A JPS565462A (en) | 1979-06-26 | 1979-06-26 | Piperazinylalkoxyindanes and their acid addition salt |
US06/157,341 US4339580A (en) | 1979-06-26 | 1980-06-09 | Piperazinylalkoxyindanes and acid addition salts thereof |
DE8080103462T DE3060445D1 (en) | 1979-06-26 | 1980-06-20 | Piperazinylalkoxyindanes and acid addition salts thereof |
EP80103462A EP0021368B1 (en) | 1979-06-26 | 1980-06-20 | Piperazinylalkoxyindanes and acid addition salts thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8050579A JPS565462A (en) | 1979-06-26 | 1979-06-26 | Piperazinylalkoxyindanes and their acid addition salt |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS565462A true JPS565462A (en) | 1981-01-20 |
JPS6237627B2 JPS6237627B2 (en) | 1987-08-13 |
Family
ID=13720161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8050579A Granted JPS565462A (en) | 1979-06-26 | 1979-06-26 | Piperazinylalkoxyindanes and their acid addition salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS565462A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS582343A (en) * | 1981-06-30 | 1983-01-07 | Osaka Soda Co Ltd | Vulcanizable rubber composition having excellent resistance to nitrogen oxide |
JPS582344A (en) * | 1981-06-30 | 1983-01-07 | Osaka Soda Co Ltd | Vulcanizable rubber composition having excellent resistance to nitrogen oxide |
JPH01193221A (en) * | 1988-01-29 | 1989-08-03 | Mitsubishi Kasei Corp | Anxiolytic |
US5219855A (en) * | 1988-01-29 | 1993-06-15 | Mitsubishi Kasei Corporation | Anxiolytic drug |
-
1979
- 1979-06-26 JP JP8050579A patent/JPS565462A/en active Granted
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS582343A (en) * | 1981-06-30 | 1983-01-07 | Osaka Soda Co Ltd | Vulcanizable rubber composition having excellent resistance to nitrogen oxide |
JPS582344A (en) * | 1981-06-30 | 1983-01-07 | Osaka Soda Co Ltd | Vulcanizable rubber composition having excellent resistance to nitrogen oxide |
JPS6129617B2 (en) * | 1981-06-30 | 1986-07-08 | Osaka Soda Co Ltd | |
JPS6225180B2 (en) * | 1981-06-30 | 1987-06-02 | Osaka Soda Co Ltd | |
JPH01193221A (en) * | 1988-01-29 | 1989-08-03 | Mitsubishi Kasei Corp | Anxiolytic |
EP0355169A1 (en) * | 1988-01-29 | 1990-02-28 | Mitsubishi Chemical Corporation | Use of piperazine derivatives in the manufacture of a medicament for treating anxiety |
US5219855A (en) * | 1988-01-29 | 1993-06-15 | Mitsubishi Kasei Corporation | Anxiolytic drug |
Also Published As
Publication number | Publication date |
---|---|
JPS6237627B2 (en) | 1987-08-13 |
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