JPS565462A - Piperazinylalkoxyindanes and their acid addition salt - Google Patents

Piperazinylalkoxyindanes and their acid addition salt

Info

Publication number
JPS565462A
JPS565462A JP8050579A JP8050579A JPS565462A JP S565462 A JPS565462 A JP S565462A JP 8050579 A JP8050579 A JP 8050579A JP 8050579 A JP8050579 A JP 8050579A JP S565462 A JPS565462 A JP S565462A
Authority
JP
Japan
Prior art keywords
formula
acid addition
addition salt
piperazinylalkoxyindanes
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8050579A
Other languages
Japanese (ja)
Other versions
JPS6237627B2 (en
Inventor
Ryoji Kikumoto
Akihiro Tobe
Jiichi Fukami
Mitsuo Egawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP8050579A priority Critical patent/JPS565462A/en
Priority to US06/157,341 priority patent/US4339580A/en
Priority to DE8080103462T priority patent/DE3060445D1/en
Priority to EP80103462A priority patent/EP0021368B1/en
Publication of JPS565462A publication Critical patent/JPS565462A/en
Publication of JPS6237627B2 publication Critical patent/JPS6237627B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:The titled compound shown by the formula I (n is 3 or 4; R is phenyl or pyridyl which may be substituted by a group selected from halogen, CF3, alkoxy, and alkylcarbonyl) and its acid addition salt.
EXAMPLE: 5-[3-(4-Phenyl-1-piperazinyl)propoxy]indane.
USE: A sedative having antianxiety action. Daily dose is usually 0.5W50mg/kg of the body. To be administered once or more times.
PROCESS: A halogenoalkoxyindane shown by the formula II ( X is halogen) is reacted with a piperazine shown by the formula III preferably in an inert solvent usually at room temperatures to 150°C for 10minW20hr to give a compound shown by the formula I. A base is preferably added as a reaction promotor.
COPYRIGHT: (C)1981,JPO&Japio
JP8050579A 1979-06-26 1979-06-26 Piperazinylalkoxyindanes and their acid addition salt Granted JPS565462A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP8050579A JPS565462A (en) 1979-06-26 1979-06-26 Piperazinylalkoxyindanes and their acid addition salt
US06/157,341 US4339580A (en) 1979-06-26 1980-06-09 Piperazinylalkoxyindanes and acid addition salts thereof
DE8080103462T DE3060445D1 (en) 1979-06-26 1980-06-20 Piperazinylalkoxyindanes and acid addition salts thereof
EP80103462A EP0021368B1 (en) 1979-06-26 1980-06-20 Piperazinylalkoxyindanes and acid addition salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8050579A JPS565462A (en) 1979-06-26 1979-06-26 Piperazinylalkoxyindanes and their acid addition salt

Publications (2)

Publication Number Publication Date
JPS565462A true JPS565462A (en) 1981-01-20
JPS6237627B2 JPS6237627B2 (en) 1987-08-13

Family

ID=13720161

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8050579A Granted JPS565462A (en) 1979-06-26 1979-06-26 Piperazinylalkoxyindanes and their acid addition salt

Country Status (1)

Country Link
JP (1) JPS565462A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS582343A (en) * 1981-06-30 1983-01-07 Osaka Soda Co Ltd Vulcanizable rubber composition having excellent resistance to nitrogen oxide
JPS582344A (en) * 1981-06-30 1983-01-07 Osaka Soda Co Ltd Vulcanizable rubber composition having excellent resistance to nitrogen oxide
JPH01193221A (en) * 1988-01-29 1989-08-03 Mitsubishi Kasei Corp Anxiolytic
US5219855A (en) * 1988-01-29 1993-06-15 Mitsubishi Kasei Corporation Anxiolytic drug

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS582343A (en) * 1981-06-30 1983-01-07 Osaka Soda Co Ltd Vulcanizable rubber composition having excellent resistance to nitrogen oxide
JPS582344A (en) * 1981-06-30 1983-01-07 Osaka Soda Co Ltd Vulcanizable rubber composition having excellent resistance to nitrogen oxide
JPS6129617B2 (en) * 1981-06-30 1986-07-08 Osaka Soda Co Ltd
JPS6225180B2 (en) * 1981-06-30 1987-06-02 Osaka Soda Co Ltd
JPH01193221A (en) * 1988-01-29 1989-08-03 Mitsubishi Kasei Corp Anxiolytic
EP0355169A1 (en) * 1988-01-29 1990-02-28 Mitsubishi Chemical Corporation Use of piperazine derivatives in the manufacture of a medicament for treating anxiety
US5219855A (en) * 1988-01-29 1993-06-15 Mitsubishi Kasei Corporation Anxiolytic drug

Also Published As

Publication number Publication date
JPS6237627B2 (en) 1987-08-13

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