JPS56122349A - 25-hydroxy-26,26,26-trifluoro-27-norvitamin d3, its hydroxylprotected derivative, and their preparation - Google Patents

25-hydroxy-26,26,26-trifluoro-27-norvitamin d3, its hydroxylprotected derivative, and their preparation

Info

Publication number
JPS56122349A
JPS56122349A JP2519680A JP2519680A JPS56122349A JP S56122349 A JPS56122349 A JP S56122349A JP 2519680 A JP2519680 A JP 2519680A JP 2519680 A JP2519680 A JP 2519680A JP S56122349 A JPS56122349 A JP S56122349A
Authority
JP
Japan
Prior art keywords
compound
formula
protected derivative
norvitamin
trifluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2519680A
Other languages
Japanese (ja)
Other versions
JPS6228953B2 (en
Inventor
Yoshiro Kobayashi
Takeo Taguchi
Nobuo Ikegawa
Masuo Morizaki
Junichi Oshida
Toru Takeshita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP2519680A priority Critical patent/JPS56122349A/en
Publication of JPS56122349A publication Critical patent/JPS56122349A/en
Publication of JPS6228953B2 publication Critical patent/JPS6228953B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R1 and R2 are H or OH-protecting groups) or its OH-protected derivative.
EXAMPLE: 25-Hydroxy-26,26,26-trifluoro-27-norvitamin D3.
USE: Drug having bone resorption activity or calcium absorption activity through the intestinal canals of mammals, similar to known vitamin D3 compounds.
PROCESS: The compound of formula III or its OH-protected derivative can be prepared by irradiating UV-light (200W360nm, pref. 260W310nm) to the compound of formula II or its OH-protected derivative, pref. in an inert organic solvent such as hexane, at -20W+120°C. Isomerization of the compound of the formula III with thermal energy, followed by optional removal of the OH-protecting group, gives the compound of formula I or its OH-protected derivative.
COPYRIGHT: (C)1981,JPO&Japio
JP2519680A 1980-03-03 1980-03-03 25-hydroxy-26,26,26-trifluoro-27-norvitamin d3, its hydroxylprotected derivative, and their preparation Granted JPS56122349A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2519680A JPS56122349A (en) 1980-03-03 1980-03-03 25-hydroxy-26,26,26-trifluoro-27-norvitamin d3, its hydroxylprotected derivative, and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2519680A JPS56122349A (en) 1980-03-03 1980-03-03 25-hydroxy-26,26,26-trifluoro-27-norvitamin d3, its hydroxylprotected derivative, and their preparation

Publications (2)

Publication Number Publication Date
JPS56122349A true JPS56122349A (en) 1981-09-25
JPS6228953B2 JPS6228953B2 (en) 1987-06-23

Family

ID=12159199

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2519680A Granted JPS56122349A (en) 1980-03-03 1980-03-03 25-hydroxy-26,26,26-trifluoro-27-norvitamin d3, its hydroxylprotected derivative, and their preparation

Country Status (1)

Country Link
JP (1) JPS56122349A (en)

Also Published As

Publication number Publication date
JPS6228953B2 (en) 1987-06-23

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