JPS5522655A - Preparation of 1alpha,24(r),25-trihydroxycholecalciferol - Google Patents

Preparation of 1alpha,24(r),25-trihydroxycholecalciferol

Info

Publication number
JPS5522655A
JPS5522655A JP15918278A JP15918278A JPS5522655A JP S5522655 A JPS5522655 A JP S5522655A JP 15918278 A JP15918278 A JP 15918278A JP 15918278 A JP15918278 A JP 15918278A JP S5522655 A JPS5522655 A JP S5522655A
Authority
JP
Japan
Prior art keywords
compound
acyl
trihydroxycholecalciferol
eliminating
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15918278A
Other languages
Japanese (ja)
Other versions
JPS5846507B2 (en
Inventor
Yoshinori Kato
Toru Takeshita
Tsunemasa Yoshida
Yoshio Ishimoto
Nobuo Ikegawa
Masuo Morizaki
Naoyuki Koizumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP53159182A priority Critical patent/JPS5846507B2/en
Publication of JPS5522655A publication Critical patent/JPS5522655A/en
Publication of JPS5846507B2 publication Critical patent/JPS5846507B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound which is a vitamin D3 derivative having blood Ca level increasing activity, economically, in high yield, by eliminating the hydroxy-protecting group of 1α,24(R),25-trihydroxycholecalciferol derivative.
CONSTITUTION: The objective compound II is prepared by eliminating the OH- protecting groups of the compound I (R1 is acyl; R2 is acyl, trimethylsilyl, H). When the groups are acyl, the elimination can be carried out by decomposing the compound I in an alkaline methanol solvent at -10W+50°C. The starting compound I can be prepared by (1) irradiating a compound III with UV radiation (pref. 260W310nm in wave length) in an inert organic solvent such as hexane, in Ar or N2 atmosphere free of O2, at -20W+80°C, and (2) heating and isomerizing the product.
COPYRIGHT: (C)1980,JPO&Japio
JP53159182A 1978-12-26 1978-12-26 Method for producing 1α,24(R),25↓-trihydroxycholecalciferol Expired JPS5846507B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP53159182A JPS5846507B2 (en) 1978-12-26 1978-12-26 Method for producing 1α,24(R),25↓-trihydroxycholecalciferol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53159182A JPS5846507B2 (en) 1978-12-26 1978-12-26 Method for producing 1α,24(R),25↓-trihydroxycholecalciferol

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP3107575A Division JPS51108047A (en) 1975-03-17 1975-03-17 1 arufua * 24 * r * *255 torihidorokishikorekarushifuerooruno seizoho

Publications (2)

Publication Number Publication Date
JPS5522655A true JPS5522655A (en) 1980-02-18
JPS5846507B2 JPS5846507B2 (en) 1983-10-17

Family

ID=15688091

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53159182A Expired JPS5846507B2 (en) 1978-12-26 1978-12-26 Method for producing 1α,24(R),25↓-trihydroxycholecalciferol

Country Status (1)

Country Link
JP (1) JPS5846507B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043645A1 (en) * 1998-02-24 1999-09-02 Chugai Seiyaku Kabushiki Kaisha 24-hydroxyvitamin d derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043645A1 (en) * 1998-02-24 1999-09-02 Chugai Seiyaku Kabushiki Kaisha 24-hydroxyvitamin d derivatives

Also Published As

Publication number Publication date
JPS5846507B2 (en) 1983-10-17

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