JPS5576857A - 24, 24-difluoro-25-hydroxyvitamin d3, its oh-protected derivative, and their preparation - Google Patents

24, 24-difluoro-25-hydroxyvitamin d3, its oh-protected derivative, and their preparation

Info

Publication number
JPS5576857A
JPS5576857A JP14902978A JP14902978A JPS5576857A JP S5576857 A JPS5576857 A JP S5576857A JP 14902978 A JP14902978 A JP 14902978A JP 14902978 A JP14902978 A JP 14902978A JP S5576857 A JPS5576857 A JP S5576857A
Authority
JP
Japan
Prior art keywords
difluoro
pref
protected derivative
hydroxyvitamin
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14902978A
Other languages
Japanese (ja)
Other versions
JPS6148498B2 (en
Inventor
Yoshiro Kobayashi
Takeo Taguchi
Nobuo Ikegawa
Toru Takeshita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP14902978A priority Critical patent/JPS5576857A/en
Publication of JPS5576857A publication Critical patent/JPS5576857A/en
Publication of JPS6148498B2 publication Critical patent/JPS6148498B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R is H or OH-protecting group).
USE: Drug for accelerating absorption through the bones or absorption of calcium through the intestinal canals of mammals.
PROCESS: The compound I is prepared by (1) irradiating 24, 24-difluoro-25-hydroxycholesta-5, 7-diene or its OH-protected derivative II with UV-radiation (wave length: 200W360nm, pref. 260W310nm) in an inert organic solvent such as hexane, at -20W+120°C, pref. -10W+50°C, (2) isomerizing the resulting compound III at 20W120°C, pref. 40W100°C, and if necessary, (3) eliminating the OH-protecting group.
COPYRIGHT: (C)1980,JPO&Japio
JP14902978A 1978-12-04 1978-12-04 24, 24-difluoro-25-hydroxyvitamin d3, its oh-protected derivative, and their preparation Granted JPS5576857A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14902978A JPS5576857A (en) 1978-12-04 1978-12-04 24, 24-difluoro-25-hydroxyvitamin d3, its oh-protected derivative, and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14902978A JPS5576857A (en) 1978-12-04 1978-12-04 24, 24-difluoro-25-hydroxyvitamin d3, its oh-protected derivative, and their preparation

Publications (2)

Publication Number Publication Date
JPS5576857A true JPS5576857A (en) 1980-06-10
JPS6148498B2 JPS6148498B2 (en) 1986-10-24

Family

ID=15466105

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14902978A Granted JPS5576857A (en) 1978-12-04 1978-12-04 24, 24-difluoro-25-hydroxyvitamin d3, its oh-protected derivative, and their preparation

Country Status (1)

Country Link
JP (1) JPS5576857A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868165A (en) * 1985-05-30 1989-09-19 Taisho Pharmaceutical Co., Ltd. 24,24-difluoro-26,27-dimethylvitamin D3 derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868165A (en) * 1985-05-30 1989-09-19 Taisho Pharmaceutical Co., Ltd. 24,24-difluoro-26,27-dimethylvitamin D3 derivatives

Also Published As

Publication number Publication date
JPS6148498B2 (en) 1986-10-24

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