JPS56104876A - Thiazolidine derivative - Google Patents
Thiazolidine derivativeInfo
- Publication number
- JPS56104876A JPS56104876A JP755880A JP755880A JPS56104876A JP S56104876 A JPS56104876 A JP S56104876A JP 755880 A JP755880 A JP 755880A JP 755880 A JP755880 A JP 755880A JP S56104876 A JPS56104876 A JP S56104876A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- diabetic
- compound
- thiazolidine
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:Thiazolidine derivatives of formula I (R is phenyl bearing 2 substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxyl and lower acyloxy or bearing methylenedioxy on adjacent positions; R1 is H, lower alkyl).
EXAMPLE: 5-(3,4-Diethoxyphenyl)thiazolidine-2,4-dione.
USE: They are applied to specific chronic diseases caused by diabetes, for example, diabetic cataract, diabetic neuropathy or diabetic retinitis.
PREPARATION: The reaction between a compound of formula II (X is halogen; Z is nitrile, carboxyl, alkoxycarbonyl) and thiourea is conducted in a solvent such as methanol at 100W130°C and the product of formula III (Y is O, imino) is hydrolyzed to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP755880A JPS56104876A (en) | 1980-01-24 | 1980-01-24 | Thiazolidine derivative |
AU66100/81A AU6610081A (en) | 1980-01-24 | 1981-01-09 | Thiazolidine derivatives |
PH25117A PH15937A (en) | 1980-01-24 | 1981-01-21 | Thiazolidine derivatives and their pharmaceutical compositions |
US06/227,786 US4387101A (en) | 1980-01-24 | 1981-01-21 | Thiazolidine derivatives and their use |
GR63938A GR72992B (en) | 1980-01-24 | 1981-01-22 | |
AR284033A AR228144A1 (en) | 1980-01-24 | 1981-01-22 | PROCEDURE FOR OBTAINING DERIVATIVES OF 5-PHENYL-TRIAZOLIDINE-2,4-DIONA AND ITS SALTS |
PT72390A PT72390B (en) | 1980-01-24 | 1981-01-23 | Thiazol dine derivatives and their production and use |
DK30781A DK30781A (en) | 1980-01-24 | 1981-01-23 | PROCEDURE FOR THE PREPARATION OF TRIAZOLIDE INGREDIATES |
EP81300308A EP0033617A3 (en) | 1980-01-24 | 1981-01-23 | Thiazolidine derivatives and their production and medicinal compositions containing them |
ES508490A ES8301951A1 (en) | 1980-01-24 | 1981-12-31 | Thiazolidine derivatives and their production and medicinal compositions containing them. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP755880A JPS56104876A (en) | 1980-01-24 | 1980-01-24 | Thiazolidine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56104876A true JPS56104876A (en) | 1981-08-20 |
Family
ID=11669128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP755880A Pending JPS56104876A (en) | 1980-01-24 | 1980-01-24 | Thiazolidine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56104876A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59137474A (en) * | 1983-01-17 | 1984-08-07 | ファイザ−・インコ−ポレ−テッド | 5-(2-alkoxyphenyl)thiazolidindiones inhibiting aldose reductase |
US4762839A (en) * | 1985-06-06 | 1988-08-09 | Tanabe Seiyaku Co., Ltd. | Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications |
US4855298A (en) * | 1986-11-21 | 1989-08-08 | Tanabe Seiyaku Co., Ltd. | 6-Halo-1,2,3,4-tetrahydroquinazoline-4-spiro-4-imidazolidine-2,2'5'-triones useful for the treatment and prophylaxis of diabetic complications |
-
1980
- 1980-01-24 JP JP755880A patent/JPS56104876A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59137474A (en) * | 1983-01-17 | 1984-08-07 | ファイザ−・インコ−ポレ−テッド | 5-(2-alkoxyphenyl)thiazolidindiones inhibiting aldose reductase |
JPH0329073B2 (en) * | 1983-01-17 | 1991-04-23 | Pfizer | |
US4762839A (en) * | 1985-06-06 | 1988-08-09 | Tanabe Seiyaku Co., Ltd. | Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications |
US4855298A (en) * | 1986-11-21 | 1989-08-08 | Tanabe Seiyaku Co., Ltd. | 6-Halo-1,2,3,4-tetrahydroquinazoline-4-spiro-4-imidazolidine-2,2'5'-triones useful for the treatment and prophylaxis of diabetic complications |
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