JPS56104876A - Thiazolidine derivative - Google Patents

Thiazolidine derivative

Info

Publication number
JPS56104876A
JPS56104876A JP755880A JP755880A JPS56104876A JP S56104876 A JPS56104876 A JP S56104876A JP 755880 A JP755880 A JP 755880A JP 755880 A JP755880 A JP 755880A JP S56104876 A JPS56104876 A JP S56104876A
Authority
JP
Japan
Prior art keywords
formula
diabetic
compound
thiazolidine
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP755880A
Other languages
Japanese (ja)
Inventor
Yutaka Kawamatsu
Yujiro Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SENJIYU SEIYAKU KK
Senju Pharmaceutical Co Ltd
Takeda Pharmaceutical Co Ltd
Original Assignee
SENJIYU SEIYAKU KK
Senju Pharmaceutical Co Ltd
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SENJIYU SEIYAKU KK, Senju Pharmaceutical Co Ltd, Takeda Chemical Industries Ltd filed Critical SENJIYU SEIYAKU KK
Priority to JP755880A priority Critical patent/JPS56104876A/en
Priority to AU66100/81A priority patent/AU6610081A/en
Priority to PH25117A priority patent/PH15937A/en
Priority to US06/227,786 priority patent/US4387101A/en
Priority to AR284033A priority patent/AR228144A1/en
Priority to GR63938A priority patent/GR72992B/el
Priority to PT72390A priority patent/PT72390B/en
Priority to DK30781A priority patent/DK30781A/en
Priority to EP81300308A priority patent/EP0033617A3/en
Publication of JPS56104876A publication Critical patent/JPS56104876A/en
Priority to ES508490A priority patent/ES8301951A1/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:Thiazolidine derivatives of formula I (R is phenyl bearing 2 substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxyl and lower acyloxy or bearing methylenedioxy on adjacent positions; R1 is H, lower alkyl).
EXAMPLE: 5-(3,4-Diethoxyphenyl)thiazolidine-2,4-dione.
USE: They are applied to specific chronic diseases caused by diabetes, for example, diabetic cataract, diabetic neuropathy or diabetic retinitis.
PREPARATION: The reaction between a compound of formula II (X is halogen; Z is nitrile, carboxyl, alkoxycarbonyl) and thiourea is conducted in a solvent such as methanol at 100W130°C and the product of formula III (Y is O, imino) is hydrolyzed to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP755880A 1980-01-24 1980-01-24 Thiazolidine derivative Pending JPS56104876A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP755880A JPS56104876A (en) 1980-01-24 1980-01-24 Thiazolidine derivative
AU66100/81A AU6610081A (en) 1980-01-24 1981-01-09 Thiazolidine derivatives
PH25117A PH15937A (en) 1980-01-24 1981-01-21 Thiazolidine derivatives and their pharmaceutical compositions
US06/227,786 US4387101A (en) 1980-01-24 1981-01-21 Thiazolidine derivatives and their use
GR63938A GR72992B (en) 1980-01-24 1981-01-22
AR284033A AR228144A1 (en) 1980-01-24 1981-01-22 PROCEDURE FOR OBTAINING DERIVATIVES OF 5-PHENYL-TRIAZOLIDINE-2,4-DIONA AND ITS SALTS
PT72390A PT72390B (en) 1980-01-24 1981-01-23 Thiazol dine derivatives and their production and use
DK30781A DK30781A (en) 1980-01-24 1981-01-23 PROCEDURE FOR THE PREPARATION OF TRIAZOLIDE INGREDIATES
EP81300308A EP0033617A3 (en) 1980-01-24 1981-01-23 Thiazolidine derivatives and their production and medicinal compositions containing them
ES508490A ES8301951A1 (en) 1980-01-24 1981-12-31 Thiazolidine derivatives and their production and medicinal compositions containing them.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP755880A JPS56104876A (en) 1980-01-24 1980-01-24 Thiazolidine derivative

Publications (1)

Publication Number Publication Date
JPS56104876A true JPS56104876A (en) 1981-08-20

Family

ID=11669128

Family Applications (1)

Application Number Title Priority Date Filing Date
JP755880A Pending JPS56104876A (en) 1980-01-24 1980-01-24 Thiazolidine derivative

Country Status (1)

Country Link
JP (1) JPS56104876A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59137474A (en) * 1983-01-17 1984-08-07 ファイザ−・インコ−ポレ−テッド 5-(2-alkoxyphenyl)thiazolidindiones inhibiting aldose reductase
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
US4855298A (en) * 1986-11-21 1989-08-08 Tanabe Seiyaku Co., Ltd. 6-Halo-1,2,3,4-tetrahydroquinazoline-4-spiro-4-imidazolidine-2,2'5'-triones useful for the treatment and prophylaxis of diabetic complications

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59137474A (en) * 1983-01-17 1984-08-07 ファイザ−・インコ−ポレ−テッド 5-(2-alkoxyphenyl)thiazolidindiones inhibiting aldose reductase
JPH0329073B2 (en) * 1983-01-17 1991-04-23 Pfizer
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
US4855298A (en) * 1986-11-21 1989-08-08 Tanabe Seiyaku Co., Ltd. 6-Halo-1,2,3,4-tetrahydroquinazoline-4-spiro-4-imidazolidine-2,2'5'-triones useful for the treatment and prophylaxis of diabetic complications

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