JPS6452765A - Thiazolidine derivative - Google Patents
Thiazolidine derivativeInfo
- Publication number
- JPS6452765A JPS6452765A JP20950087A JP20950087A JPS6452765A JP S6452765 A JPS6452765 A JP S6452765A JP 20950087 A JP20950087 A JP 20950087A JP 20950087 A JP20950087 A JP 20950087A JP S6452765 A JPS6452765 A JP S6452765A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound expressed
- alkyl
- lower alkyl
- alkenylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound expressed by formula I [R1 is H, 1-15C alkyl which may have a substituent group (COOH or lower alkoxycarbonyl) or amino which may have acyl; R2 is H or lower alkyl; X is S or O; R3 is formula II-V; R4 is H, lower alkyl or aralkyl; R5-R8 are H, OH, halogen, lower alkyl, lower alkoxy, CN, CF3 or NH2; A is lower alkylene or lower alkenylene, provided that A is >=2C lower alkylene or >=3C lower alkenylene when X is S; R5 and R8 are H; R1 is H, C4H5 or CH2COOH] and salts thereof. EXAMPLE:5-( 3-Carboxymethoxy-4-methoxybenzylidene )-4-oxo-2-thioxothiazolidi ne-3-acetic acid. USE:An aldose reductase inhibitor and hypoglycemic agent useful for preventing and treating diabetic complications. PREPARATION:A compound expressed by formula VI is reacted with a compound expressed by formula VII to afford the aimed compound expressed by formula I.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62209500A JP2558473B2 (en) | 1987-08-24 | 1987-08-24 | Thiazolidine derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62209500A JP2558473B2 (en) | 1987-08-24 | 1987-08-24 | Thiazolidine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6452765A true JPS6452765A (en) | 1989-02-28 |
| JP2558473B2 JP2558473B2 (en) | 1996-11-27 |
Family
ID=16573835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62209500A Expired - Lifetime JP2558473B2 (en) | 1987-08-24 | 1987-08-24 | Thiazolidine derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2558473B2 (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU701068B2 (en) * | 1995-08-28 | 1999-01-21 | American Home Products Corporation | Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents |
| US5889025A (en) * | 1996-05-06 | 1999-03-30 | Reddy's Research Foundation | Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5985884A (en) * | 1996-07-01 | 1999-11-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| USRE39266E1 (en) | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
-
1987
- 1987-08-24 JP JP62209500A patent/JP2558473B2/en not_active Expired - Lifetime
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU701068B2 (en) * | 1995-08-28 | 1999-01-21 | American Home Products Corporation | Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents |
| US5889025A (en) * | 1996-05-06 | 1999-03-30 | Reddy's Research Foundation | Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5985884A (en) * | 1996-07-01 | 1999-11-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6310069B1 (en) | 1996-07-01 | 2001-10-30 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| US6573268B1 (en) | 1996-07-01 | 2003-06-03 | Dr. Reddy's Laboratories Ltd. | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6780992B2 (en) | 1996-07-01 | 2004-08-24 | Dr. Reddy's Laboratories Ltd. | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| USRE39266E1 (en) | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2558473B2 (en) | 1996-11-27 |
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