JPS5519250A - Cephalosporin analog, or its salts, their preparation, and preventive and remedy for microbism - Google Patents

Cephalosporin analog, or its salts, their preparation, and preventive and remedy for microbism

Info

Publication number: JPS5519250A
Authority: JP; Japan
Prior art keywords: formula; group; preventive; salts; lower alkyl
Prior art date: 1978-06-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP7092679A

Other languages

English (en)

Other versions

JPS647075B2 (ja

Inventor

Shinji Hashimoto

Keiji Henmi

Matsuhiko Araya

Shuichi Takeno

Daijiro Hagiwara

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fujisawa Pharmaceutical Co Ltd

Original Assignee

Fujisawa Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-06-06

Filing date

1979-06-05

Publication date

1980-02-09

1979-06-05 Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd

1980-02-09 Publication of JPS5519250A publication Critical patent/JPS5519250A/ja

1989-02-07 Publication of JPS647075B2 publication Critical patent/JPS647075B2/ja

Status Granted legal-status Critical Current

Links

150000003839 salts Chemical class 0.000 title abstract 3
229930186147 Cephalosporin Natural products 0.000 title abstract 2
229940124587 cephalosporin Drugs 0.000 title abstract 2
150000001780 cephalosporins Chemical class 0.000 title abstract 2
230000003449 preventive effect Effects 0.000 title abstract 2
-1 (protected) carboxy group Chemical group 0.000 abstract 2
SPEUIVXLLWOEMJ-UHFFFAOYSA-N 1,1-dimethoxyethane Chemical compound COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
208000024386 fungal infectious disease Diseases 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

JP7092679A 1978-06-06 1979-06-05 Cephalosporin analog, or its salts, their preparation, and preventive and remedy for microbism Granted JPS5519250A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7826421		1978-06-06

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
JP61216879A Division JPS6270354A (ja)	1978-06-06	1986-09-12	置換−２−オキソアゼチジン化合物

Publications (2)

Publication Number	Publication Date
JPS5519250A true JPS5519250A (en)	1980-02-09
JPS647075B2 JPS647075B2 (ja)	1989-02-07

Family

ID=10497874

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
JP7092679A Granted JPS5519250A (en)	1978-06-06	1979-06-05	Cephalosporin analog, or its salts, their preparation, and preventive and remedy for microbism
JP61216879A Granted JPS6270354A (ja)	1978-06-06	1986-09-12	置換−２−オキソアゼチジン化合物

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
JP61216879A Granted JPS6270354A (ja)	1978-06-06	1986-09-12	置換−２−オキソアゼチジン化合物

Country Status (7)

Country	Link
US (2)	US4264597A (ja)
JP (2)	JPS5519250A (ja)
CH (1)	CH644866A5 (ja)
DE (1)	DE2922590A1 (ja)
FR (1)	FR2428042A1 (ja)
IT (1)	IT1121273B (ja)
NL (1)	NL7904456A (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR208283A1 (es) *	1973-03-15	1976-12-20	Fujisawa Pharmaceutical Co	Un procedimiento para la preparacion de derivados de acido 2-alquil-2-o 3-fefem-4-carboxilico
CA1136132A (en) *	1975-02-17	1982-11-23	Teruji Tsuji	Cyclization to form cephem ring and intermediates therefor
US4364865A (en) *	1975-12-08	1982-12-21	Ciba-Geigy Corporation	Bicyclic unsaturated thia-aza compounds and 4-acylthio azetidinone intermediates
US4370326A (en) *	1977-09-13	1983-01-25	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds and composition
US4264597A (en) *	1978-06-06	1981-04-28	Masashi Hashimoto	Cephalosporin analogues and processes for the preparation thereof
US4407755A (en) *	1979-11-07	1983-10-04	Bristol-Myers Company	6-Amino penam derivatives
US4374982A (en) *	1979-11-07	1983-02-22	Bristol-Myers Company	Cepham compounds
JPS5857360A (ja) *	1981-10-01	1983-04-05	Ajinomoto Co Inc	アゼチジノン誘導体
US4609730A (en) *	1982-11-22	1986-09-02	Fujisawa Pharmaceutical Co., Ltd.	7-[substituted imino-2-(2-aminothiazol-4-yl)-acetamido]-3(2,2-dihalovinyl or ethynyl)-3-cephem-4-carboxylic acid (syn isomers), having antimicrobial activities
US4533497A (en) *	1982-12-27	1985-08-06	Eli Lilly And Company	N-ethylidene azetidinones
US4652651A (en) *	1983-05-31	1987-03-24	Hoffmann-La Roche Inc.	Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
EA028342B1 (ru)	2011-09-09	2017-11-30	Мерк Шарп И Доум Корп.	Способы лечения пневмонии
US8809314B1 (en)	2012-09-07	2014-08-19	Cubist Pharmacueticals, Inc.	Cephalosporin compound
US8476425B1 (en)	2012-09-27	2013-07-02	Cubist Pharmaceuticals, Inc.	Tazobactam arginine compositions
US9872906B2 (en)	2013-03-15	2018-01-23	Merck Sharp & Dohme Corp.	Ceftolozane antibiotic compositions
US20140274994A1 (en)	2013-03-15	2014-09-18	Cubist Pharmaceuticals, Inc.	Stabilizing ceftolozane
US20140274996A1 (en)	2013-03-15	2014-09-18	Cubist Pharmaceuticals, Inc.	Tazobactam and ceftolozane antibiotic compositions
EP3043797B1 (en)	2013-09-09	2020-04-08	Merck Sharp & Dohme Corp.	Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en)	2013-09-27	2015-04-02	Calixa Therapeutics, Inc.	Solid forms of ceftolozane

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1935970A1 (de) *	1968-07-23	1970-01-29	Ciba Geigy	Oxyessigsaeureverbindungen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4014872A (en) *	1974-01-03	1977-03-29	Glaxo Laboratories Limited	Substituted 3-hydroxy- or 3-oxo-cephams
US4070477A (en) *	1975-12-08	1978-01-24	Ciba-Geigy Corporation	2-Penem compounds
JPS5858355B2 (ja) *	1976-01-01	1983-12-24	塩野義製薬株式会社	オキソチアゾリノアゼチジニルハロブテン酸類
US4089956A (en) *	1976-09-08	1978-05-16	Smithkline Corporation	7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
US4264597A (en) *	1978-06-06	1981-04-28	Masashi Hashimoto	Cephalosporin analogues and processes for the preparation thereof

1979
- 1979-05-30 US US06/043,706 patent/US4264597A/en not_active Expired - Lifetime
- 1979-06-02 DE DE19792922590 patent/DE2922590A1/de not_active Withdrawn
- 1979-06-05 JP JP7092679A patent/JPS5519250A/ja active Granted
- 1979-06-05 FR FR7914342A patent/FR2428042A1/fr active Granted
- 1979-06-06 IT IT23326/79A patent/IT1121273B/it active
- 1979-06-06 NL NL7904456A patent/NL7904456A/xx not_active Application Discontinuation
- 1979-06-06 CH CH527279A patent/CH644866A5/de not_active IP Right Cessation
1980
- 1980-10-14 US US06/196,830 patent/US4342760A/en not_active Expired - Lifetime
1986
- 1986-09-12 JP JP61216879A patent/JPS6270354A/ja active Granted

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1935970A1 (de) *	1968-07-23	1970-01-29	Ciba Geigy	Oxyessigsaeureverbindungen

Also Published As

Publication number	Publication date
JPS6270354A (ja)	1987-03-31
FR2428042A1 (fr)	1980-01-04
JPS645022B2 (ja)	1989-01-27
FR2428042B1 (ja)	1983-05-20
US4264597A (en)	1981-04-28
IT7923326A0 (it)	1979-06-06
NL7904456A (nl)	1979-12-10
JPS647075B2 (ja)	1989-02-07
DE2922590A1 (de)	1979-12-20
IT1121273B (it)	1986-04-02
US4342760A (en)	1982-08-03
CH644866A5 (de)	1984-08-31

Publication	Publication Date	Title
JPS5519250A (en)	1980-02-09	Cephalosporin analog, or its salts, their preparation, and preventive and remedy for microbism
IE802347L (en)	1981-05-19	7-acylamino-3-vinylcephalosporanic acid derivatives
JPS55105689A (en)	1980-08-13	Novel cephem and cepham compounds, their preparation and preventive and remedy for microbism
JPS5777689A (en)	1982-05-15	Novel cephen compound, or its salt, its preparation, and preventive it as active ingredient
JPS56125392A (en)	1981-10-01	Cepham and cephem compound and preparation thereof
JPS5543011A (en)	1980-03-26	7-halothiazolylalkoxyiminoacetamido-3-cephem compound
JPS5553282A (en)	1980-04-18	Dibenzothiepin derivative and its preparation
EP0088385A3 (en)	1984-12-05	7-acylamino-3-cephem-4-carboxylic acid derivatives, processes for the preparation of the same and pharmaceutical composition comprising the same
ES8400488A1 (es)	1983-11-01	Un procedimiento para la preparacion de la sustancia f.r.-48756 acido 1-(6-amino-9-h-purin-9-il)-1,3-didedoxo-3-(o-metil l-tirosilamino)-b-d-ribofuranuronico.
JPS56103168A (en)	1981-08-18	Thiazole derivative, its preparation, and antihistaminic agent containing the same
JPS5795984A (en)	1982-06-15	Pyridinecarboxamide derivative and its preparation
JPS57169478A (en)	1982-10-19	Piperazine derivative
JPS57131758A (en)	1982-08-14	1-sulfo-2-oxoazetidine derivative, its preparation and use
JPS57165382A (en)	1982-10-12	Fluoro-pgi2 compound and its preparation
JPS54106491A (en)	1979-08-21	Cephalosporin analog or its salt, their preparation, and prophylactics and remedies for microbisms consisting mainly of them
JPS57134452A (en)	1982-08-19	N-acyl acidic amino acid diamide, its preparation, and antiulcer agent containing the same
JPS54157583A (en)	1979-12-12	Dibenzothiepin derivative and its preparation
JPS56142282A (en)	1981-11-06	Penem-3-carboxylic acid derivative and its preparation
JPS56104883A (en)	1981-08-20	Novel pyridinecarboxamide derivative and its preparation
ES8302719A1 (es)	1982-12-01	Un procedimiento para preparar compuestos de cefem
JPS55145669A (en)	1980-11-13	8,10-diazaprostanoic acid derivative and its preparation
JPS57109742A (en)	1982-07-08	Butanediol derivative and its preparation
JPS57145883A (en)	1982-09-09	Novel cephem compound or its salt, its preparation, preventive and remedy for microbism comprising it as active ingredient
JPS55145667A (en)	1980-11-13	Tetrahydroisoquinoline derivative and its preparation
JPS57169458A (en)	1982-10-19	Preparation of indole derivative