JPS57134452A - N-acyl acidic amino acid diamide, its preparation, and antiulcer agent containing the same - Google Patents
N-acyl acidic amino acid diamide, its preparation, and antiulcer agent containing the sameInfo
- Publication number
- JPS57134452A JPS57134452A JP56019587A JP1958781A JPS57134452A JP S57134452 A JPS57134452 A JP S57134452A JP 56019587 A JP56019587 A JP 56019587A JP 1958781 A JP1958781 A JP 1958781A JP S57134452 A JPS57134452 A JP S57134452A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- amino acid
- acidic amino
- acid diamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:An N-acyl acidic amino acid diamide of formulaI(R1 and R3 are H or lower alkyl; R2 and R4 are lower alkyl; n is 1W3; R5 is OH or aryl, ar-(lower alkyl) or ar-(lower alkenyl) substituted with OH or lower alkoxy).
EXAMPLE: 2-( 2-Methoxybenzamido )-N5, N5-dimethyl-N1, N1-di-n-propylpentane- 1,5-diamide.
USE: Antiulcer agent useful for the remedy of human and animal ulcers. Dose: 10W 500mg/day for adult by oral administration.
PROCESS: The objective compound of formulaIis prepared by reacting the compound of formula II with the compound of formula R5COOH or its reactive derivative at the carboxyl group. The starting compound of formula II can be obtained by protecting the amino group of the compound of formula III, subjecting the compound to the dehydrative condensation with paraformaldehyde to obtain the compound of formula IV, reacting the compound with the amine of formula V or formula VI, and removing the protecting group.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56019587A JPS57134452A (en) | 1981-02-14 | 1981-02-14 | N-acyl acidic amino acid diamide, its preparation, and antiulcer agent containing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56019587A JPS57134452A (en) | 1981-02-14 | 1981-02-14 | N-acyl acidic amino acid diamide, its preparation, and antiulcer agent containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57134452A true JPS57134452A (en) | 1982-08-19 |
JPS6352621B2 JPS6352621B2 (en) | 1988-10-19 |
Family
ID=12003379
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56019587A Granted JPS57134452A (en) | 1981-02-14 | 1981-02-14 | N-acyl acidic amino acid diamide, its preparation, and antiulcer agent containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57134452A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59227847A (en) * | 1983-06-09 | 1984-12-21 | Toyama Chem Co Ltd | N-acyl acidic amino acid diamide, its preparation and antiulcer agent containing the same |
FR2565587A1 (en) * | 1984-06-12 | 1985-12-13 | Toyama Chemical Co Ltd | NOVEL DERIVATIVE OF N-ACYLIC ACIDIC ACID AMINO ACID DIAMIDE, A SALT THEREOF, A PROCESS FOR PRODUCTION THEREOF AND AN ANTI-ULCEROUS AGENT CONTAINING THE SAME |
EP0250148A2 (en) * | 1986-06-16 | 1987-12-23 | Merck & Co. Inc. | Amino acid analogs as CCK-antagonists |
WO1996026194A1 (en) * | 1995-02-21 | 1996-08-29 | Degussa Aktiengesellschaft | Method of producing oxazolidinones, the use thereof and novel oxazolidinones |
JP2009215268A (en) * | 2008-03-12 | 2009-09-24 | Shiseido Co Ltd | Glutamic acid derivative, parakeratosis-suppressing agent, pore shrinking agent, rough skin preventing and ameliorating agent, and composition for external preparation for skin |
-
1981
- 1981-02-14 JP JP56019587A patent/JPS57134452A/en active Granted
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59227847A (en) * | 1983-06-09 | 1984-12-21 | Toyama Chem Co Ltd | N-acyl acidic amino acid diamide, its preparation and antiulcer agent containing the same |
JPH0460983B2 (en) * | 1983-06-09 | 1992-09-29 | Toyama Chemical Co Ltd | |
FR2565587A1 (en) * | 1984-06-12 | 1985-12-13 | Toyama Chemical Co Ltd | NOVEL DERIVATIVE OF N-ACYLIC ACIDIC ACID AMINO ACID DIAMIDE, A SALT THEREOF, A PROCESS FOR PRODUCTION THEREOF AND AN ANTI-ULCEROUS AGENT CONTAINING THE SAME |
EP0250148A2 (en) * | 1986-06-16 | 1987-12-23 | Merck & Co. Inc. | Amino acid analogs as CCK-antagonists |
WO1996026194A1 (en) * | 1995-02-21 | 1996-08-29 | Degussa Aktiengesellschaft | Method of producing oxazolidinones, the use thereof and novel oxazolidinones |
US6051715A (en) * | 1995-02-21 | 2000-04-18 | Degussa-Huls Ag | Method of producing oxazolidinones, the use thereof and novel oxazolidinones |
JP2009215268A (en) * | 2008-03-12 | 2009-09-24 | Shiseido Co Ltd | Glutamic acid derivative, parakeratosis-suppressing agent, pore shrinking agent, rough skin preventing and ameliorating agent, and composition for external preparation for skin |
Also Published As
Publication number | Publication date |
---|---|
JPS6352621B2 (en) | 1988-10-19 |
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