JPS5498770A - 4aaarylloctahydroo1hh22pyrindines - Google Patents

4aaarylloctahydroo1hh22pyrindines

Info

Publication number
JPS5498770A
JPS5498770A JP16448778A JP16448778A JPS5498770A JP S5498770 A JPS5498770 A JP S5498770A JP 16448778 A JP16448778 A JP 16448778A JP 16448778 A JP16448778 A JP 16448778A JP S5498770 A JPS5498770 A JP S5498770A
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16448778A
Other languages
English (en)
Inventor
Emu Tsuinmaaman Denisu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS5498770A publication Critical patent/JPS5498770A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
JP16448778A 1977-12-27 1978-12-25 4aaarylloctahydroo1hh22pyrindines Pending JPS5498770A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86489977A 1977-12-27 1977-12-27

Publications (1)

Publication Number Publication Date
JPS5498770A true JPS5498770A (en) 1979-08-03

Family

ID=25344312

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16448778A Pending JPS5498770A (en) 1977-12-27 1978-12-25 4aaarylloctahydroo1hh22pyrindines

Country Status (24)

Country Link
EP (1) EP0002937A1 (ja)
JP (1) JPS5498770A (ja)
AR (1) AR221352A1 (ja)
AU (1) AU4286678A (ja)
BE (1) BE872990A (ja)
BG (1) BG30927A3 (ja)
CA (1) CA1105026A (ja)
CS (1) CS203940B2 (ja)
DD (1) DD141156A5 (ja)
DK (1) DK577078A (ja)
ES (1) ES476385A1 (ja)
FI (1) FI783992A (ja)
FR (1) FR2413370A1 (ja)
GB (1) GB2010806A (ja)
GR (1) GR70349B (ja)
IL (1) IL56268A0 (ja)
IT (1) IT1101682B (ja)
LU (1) LU80719A1 (ja)
NZ (1) NZ189230A (ja)
PL (1) PL117572B1 (ja)
PT (1) PT68934A (ja)
RO (1) RO75805A (ja)
SU (1) SU841586A3 (ja)
ZA (1) ZA787156B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016526571A (ja) * 2013-07-10 2016-09-05 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ イオンチャネルのモジュレーターとしての縮合ピペリジンアミド

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4579952A (en) * 1981-12-28 1986-04-01 E. I. Du Pont De Nemours And Company Intermediates for octahydrobenzofuro[3,2-e]isoquinolines
US4415736A (en) * 1981-12-28 1983-11-15 E. I. Du Pont De Nemours & Co. Certain tetrahydropyridine intermediates
US4537963A (en) * 1981-12-28 1985-08-27 E. I. Du Pont De Nemours And Company Intermediates for octahydrobenzofuro[3,2-E]isoquinolines
FR2617481B1 (fr) * 1987-07-03 1989-11-10 Roussel Uclaf Nouveaux derives de la tetrahydropyridine, leur procede de preparation et les intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US8598164B2 (en) 2010-05-06 2013-12-03 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
EP2670752B1 (en) 2011-02-02 2016-03-16 Vertex Pharmaceuticals Incorporated Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
EP2675812B1 (en) 2011-02-18 2017-08-30 Vertex Pharmaceuticals Incorporated Chroman - spirocyclic piperidine amides as modulators of ion channels
CN103517910B (zh) 2011-03-14 2016-12-14 沃泰克斯药物股份有限公司 作为离子通道调节剂的吗啉-螺环哌啶酰胺

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA734895B (en) * 1972-07-20 1974-06-26 Du Pont Analgesigs and/or narcotic antagonists
DE2351599A1 (de) * 1972-07-20 1974-01-31 Du Pont 4a-aryl-trans-decahydrochinoline und verfahren zu ihrer herstellung
PT67194B (en) * 1976-11-02 1979-03-23 Lilly Co Eli Process for preparing 4a-aryl-octahydro-1h-2-pyrindines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016526571A (ja) * 2013-07-10 2016-09-05 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ イオンチャネルのモジュレーターとしての縮合ピペリジンアミド

Also Published As

Publication number Publication date
ZA787156B (en) 1980-08-27
SU841586A3 (ru) 1981-06-23
NZ189230A (en) 1981-05-15
BE872990A (fr) 1979-06-22
DK577078A (da) 1979-06-28
ES476385A1 (es) 1979-11-16
DD141156A5 (de) 1980-04-16
LU80719A1 (fr) 1979-04-13
CA1105026A (en) 1981-07-14
FI783992A (fi) 1979-06-28
BG30927A3 (en) 1981-09-15
PL117572B1 (en) 1981-08-31
PL211919A1 (pl) 1979-09-10
IL56268A0 (en) 1979-03-12
IT1101682B (it) 1985-10-07
PT68934A (en) 1979-01-01
AR221352A1 (es) 1981-01-30
RO75805A (ro) 1981-02-28
FR2413370A1 (fr) 1979-07-27
GR70349B (ja) 1982-09-23
AU4286678A (en) 1979-07-05
EP0002937A1 (en) 1979-07-11
IT7831268A0 (it) 1978-12-22
GB2010806A (en) 1979-07-04
CS203940B2 (en) 1981-03-31

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