BE872990A - Trans-4a-aryl-octahydro-1h-2-pyrindines et leur utilisation therapeutique - Google Patents

Trans-4a-aryl-octahydro-1h-2-pyrindines et leur utilisation therapeutique

Info

Publication number
BE872990A
BE872990A BE1009211A BE1009211A BE872990A BE 872990 A BE872990 A BE 872990A BE 1009211 A BE1009211 A BE 1009211A BE 1009211 A BE1009211 A BE 1009211A BE 872990 A BE872990 A BE 872990A
Authority
BE
Belgium
Prior art keywords
pyrindins
octahydro
trans
aryl
therapeutic use
Prior art date
Application number
BE1009211A
Other languages
English (en)
French (fr)
Inventor
D M Zimmerman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BE872990A publication Critical patent/BE872990A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BE1009211A 1977-12-27 1978-12-22 Trans-4a-aryl-octahydro-1h-2-pyrindines et leur utilisation therapeutique BE872990A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86489977A 1977-12-27 1977-12-27

Publications (1)

Publication Number Publication Date
BE872990A true BE872990A (fr) 1979-06-22

Family

ID=25344312

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1009211A BE872990A (fr) 1977-12-27 1978-12-22 Trans-4a-aryl-octahydro-1h-2-pyrindines et leur utilisation therapeutique

Country Status (24)

Country Link
EP (1) EP0002937A1 (xx)
JP (1) JPS5498770A (xx)
AR (1) AR221352A1 (xx)
AU (1) AU4286678A (xx)
BE (1) BE872990A (xx)
BG (1) BG30927A3 (xx)
CA (1) CA1105026A (xx)
CS (1) CS203940B2 (xx)
DD (1) DD141156A5 (xx)
DK (1) DK577078A (xx)
ES (1) ES476385A1 (xx)
FI (1) FI783992A (xx)
FR (1) FR2413370A1 (xx)
GB (1) GB2010806A (xx)
GR (1) GR70349B (xx)
IL (1) IL56268A0 (xx)
IT (1) IT1101682B (xx)
LU (1) LU80719A1 (xx)
NZ (1) NZ189230A (xx)
PL (1) PL117572B1 (xx)
PT (1) PT68934A (xx)
RO (1) RO75805A (xx)
SU (1) SU841586A3 (xx)
ZA (1) ZA787156B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4415736A (en) * 1981-12-28 1983-11-15 E. I. Du Pont De Nemours & Co. Certain tetrahydropyridine intermediates
US4537963A (en) * 1981-12-28 1985-08-27 E. I. Du Pont De Nemours And Company Intermediates for octahydrobenzofuro[3,2-E]isoquinolines
US4579952A (en) * 1981-12-28 1986-04-01 E. I. Du Pont De Nemours And Company Intermediates for octahydrobenzofuro[3,2-e]isoquinolines
FR2617481B1 (fr) * 1987-07-03 1989-11-10 Roussel Uclaf Nouveaux derives de la tetrahydropyridine, leur procede de preparation et les intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US8598164B2 (en) 2010-05-06 2013-12-03 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
SI2670752T1 (sl) 2011-02-02 2016-10-28 Vertex Pharmaceuticals Incorporated Pirolopirazin-spirociklični piperidin amidi kot modulatorji ionskih kanalčkov
EP2675812B1 (en) 2011-02-18 2017-08-30 Vertex Pharmaceuticals Incorporated Chroman - spirocyclic piperidine amides as modulators of ion channels
AU2012229187B2 (en) 2011-03-14 2016-11-10 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
KR102306951B1 (ko) * 2013-07-10 2021-10-01 버텍스 파마슈티칼스 인코포레이티드 이온 채널의 조절제로서의 융합된 피페리딘 아미드

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1024149A (en) * 1972-07-20 1978-01-10 E.I. Du Pont De Nemours And Company 4.alpha.-ARYL-TRANS-DECAHYDROISOQUINOLINES
AT330179B (de) * 1972-07-20 1976-06-25 Du Pont Verfahren zur herstellung von neuen 4a-aryl- transdecahydroisochinolinderivaten sowie deren optischen isomeren
PT67194B (en) * 1976-11-02 1979-03-23 Lilly Co Eli Process for preparing 4a-aryl-octahydro-1h-2-pyrindines

Also Published As

Publication number Publication date
ZA787156B (en) 1980-08-27
JPS5498770A (en) 1979-08-03
NZ189230A (en) 1981-05-15
ES476385A1 (es) 1979-11-16
PL211919A1 (pl) 1979-09-10
DD141156A5 (de) 1980-04-16
FI783992A (fi) 1979-06-28
FR2413370A1 (fr) 1979-07-27
IL56268A0 (en) 1979-03-12
RO75805A (ro) 1981-02-28
CA1105026A (en) 1981-07-14
IT7831268A0 (it) 1978-12-22
LU80719A1 (fr) 1979-04-13
CS203940B2 (en) 1981-03-31
BG30927A3 (en) 1981-09-15
AR221352A1 (es) 1981-01-30
IT1101682B (it) 1985-10-07
PL117572B1 (en) 1981-08-31
GB2010806A (en) 1979-07-04
DK577078A (da) 1979-06-28
PT68934A (en) 1979-01-01
EP0002937A1 (en) 1979-07-11
SU841586A3 (ru) 1981-06-23
AU4286678A (en) 1979-07-05
GR70349B (xx) 1982-09-23

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