JPH11510837A - 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル - Google Patents
薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲルInfo
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
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- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S525/941—Polymer mixture containing block copolymer is mixed or reacted with chemical treating agent
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.少なくとも4つの共有結合したポリマーのブロックおよび少なくとも2つの 架橋可能な基を含むマクロマーであって、 a)少なくとも1つのブロックが親水性であり、ここで、各親水性のブロック が少なくとも1グラム/リットルの水に対する溶解性を個々に有し;そして b)少なくとも2つのブロックが疎水性であり、 ここで、該架橋可能な基が架橋されている場合、該マクロマーがゲル化され得 、そして ここで、ブロックの1つが熱応答性のブロックであり、 該架橋可能な基が、エポキシド、イソシアネート、イソチオシアネート、アル デヒド、アミン、スルホン酸、カルボン酸、およびエチレン性不飽和基からなる 群から独立的に選択され、そして 該架橋可能な基は、生理学的条件下で分解可能である少なくとも1つの分解可 能な結合により分離される、マクロマー。 2.前記親水性のブロックが同一であるかまたは異なり、そしてポリ(エチレン グリコール)、ポリ(エチレンオキシド)、ポリ(ビニルアルコール)、ポリ( ビニルピロリドン)、ポリ(エチルオキサゾリン)、多糖、およびアミノ酸ポリ マーからなる群から選択される、請求項1に記載のマクロマー。 3.前記疎水性のブロックが同一であるかまたは異なり、そしてポリプロピレン オキシド、ポリブチレンオキシド、疎水性混合ポリ(アルキレンオキシド)、ポ リヒドロキシ酸、ポリラクトン、ポリアミノ酸、ポリ無水物、ポリオルトエステ ル、ポリホスファゼン、およびポリホスフェートからなる群から選択される、請 求項1に記載のマクロマー。 4.前記架橋可能な基がエポキシド、イソシアネート、イソチオシアネート、ア ルデヒド、アミン、スルホン酸、およびカルボン酸からなる群から選択される、 請求項1に記載のマクロマー。 5.前記架橋可能な基がエチレン性不飽和基を含む、請求項1に記載のマクロマ ー。 6.前記マクロマーに共有結合した少なくとも1つのイオン的に電荷を帯びた部 分をさらに含む、請求項1に記載のマクロマー。 7.少なくとも2つの化学的に異なる疎水性のブロックを含む、請求項1に記載 のマクロマー。 8.少なくとも1つの疎水性ブロックが、任意の架橋可能な基から少なくとも1 つの親水性ブロックだけ分離されている、請求項1に記載のマクロマー。 9.各疎水性ブロックが、任意の他の疎水性ブロックから1つの親水性ブロック だけ分離されている、請求項1に記載のマクロマー。 10.前記マクロマーが、該マクロマーの水溶液中で少なくとも2重量%の濃度 において熱可逆的ゲル化し得、そしてここで該ゲル化の温度が約0℃と約65℃と の間である、請求項1に記載のマクロマー。 11.請求項1に記載のマクロマーおよび治療薬剤を含む、組成物。 12.請求項1に記載のマクロマーおよび非共有結合的に該マクロマーと会合し た疎水性物質を含む、組成物。 13.前記疎水性物質が炭水化物、脂質、脂肪酸、およびステロールからなる群 から選択される、請求項12に記載の組成物。 14.請求項1に記載のマクロマーおよび薬学的に受容可能なキャリアを含む組 成物。 15.前記キャリアが非経口投与に適切である、請求項14に記載の組成物。 16.前記マクロマーがゲル化している、請求項14に記載の組成物。 17.前記マクロマー上の架橋可能な基が共有結合的に架橋されている、請求項 14に記載の組成物。 18.治療薬剤をさらに含む、請求項17に記載の組成物。 19.前記治療薬剤が粒子、プロドラッグ結合体、およびリポソームからなる群 から選択される形態で提供される、請求項18に記載の組成物。 20.前記ゲルが生物学的組織の表面への適用に適切な形態である、請求項17 に記載の組成物。 21.医学的デバイスをさらに含み、前記ゲルが該医学的デバイスの表面上で形 成される、請求項17に記載の組成物。 22.前記ゲルが対向する表面の間で形成され、そして該表面を互いに接着させ る、請求項17に記載の組成物。 23.前記マクロマーの水溶液を、インビボで組織に適用する工程を含む医学的 状態を処置するための方法における、請求項1に記載のマクロマーの使用。 24.前記水溶液が溶解または懸濁された治療薬剤をさらに含む、請求項23に 記載の使用。 25.前記医学的状態が皮膚の火傷または擦過傷である、請求項23に記載の使 用。 26.前記医学的状態が外科手術の介入から生じる創傷である、請求項23に記 載の使用。 27.前記外科手術が血管形成術である、請求項26に記載の使用。 28.前記外科手術がトロカールのカニューレを通して行われる、請求項26に 記載の使用。 29.生物学的に活性な物質の送達の速度を制御するための方法であって、以下 の工程: a)活性な物質を、少なくとも4つの共有結合したポリマーのブロックおよび 少なくとも2つの架橋可能な基を含むマクロマーの溶液と混合する工程であって 、ここで i)少なくとも1つのブロックが親水性であり、ここで各親水性のブロックが 少なくとも1グラム/リットルの水に対する可溶性を個々に有し;そして ii)少なくとも2つのブロックが疎水性であり、 ここで、該マクロマーが該架橋可能な基が架橋される場合に、ゲル化され得、 そしてここで該ブロックの1つが熱応答性のブロックであり、 該架橋可能な基が、エポキシド、イソシアネート、イソチオシアネート、アル デヒド、アミン、スルホン酸、カルボン酸、およびエチレン性不飽和基からなる 群から独立的に選択され、そして 該架橋可能な基が、生理学的条件下で分解し得る少なくとも1つの分解可能な 結合により分離される、工程、 b)該マクロマーを架橋してゲルを形成する工程;および c)該ゲルの浸透性を変化させて該物質の制御された送達をもたらす工程、 を含む、方法。 30.前記架橋可能なゲルが、イオン濃度の変化またはpHの変化に応答して浸透 性を変化させる、請求項29に記載の方法。 31.少なくとも1つの疎水性のブロックが水溶液中で凝集して、疎水性のドメ インを形成する、請求項29に記載の方法。 32.前記ドメインの疎水性が、前記ブロックの疎水性を選択することにより制 御される、請求項31に記載の方法。 33.前記ドメインの疎水性が、前記ゲル形成マクロマー溶液に疎水性の物質を 添加することにより制御される、請求項31に記載の方法。 34.前記活性な物質が粒子、プロドラッグ結合体、およびリポソームからなる 群から選択される形態である、請求項29に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US172395P | 1995-07-28 | 1995-07-28 | |
US60/001,723 | 1995-07-28 | ||
PCT/US1996/012285 WO1997005185A2 (en) | 1995-07-28 | 1996-07-26 | Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents |
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JP2005293028A Division JP2006097031A (ja) | 1995-07-28 | 2005-10-05 | 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル |
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JPH11510837A true JPH11510837A (ja) | 1999-09-21 |
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JP9507762A Withdrawn JPH11510837A (ja) | 1995-07-28 | 1996-07-26 | 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル |
JP2005293028A Withdrawn JP2006097031A (ja) | 1995-07-28 | 2005-10-05 | 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル |
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EP (1) | EP0842209B1 (ja) |
JP (2) | JPH11510837A (ja) |
AT (1) | ATE342295T1 (ja) |
CA (1) | CA2228118A1 (ja) |
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WO (1) | WO1997005185A2 (ja) |
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DE69329594T2 (de) | 1992-02-28 | 2001-05-31 | Univ Texas | Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung |
US5573934A (en) * | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
KR940003548U (ko) | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
ATE173171T1 (de) | 1993-03-23 | 1998-11-15 | Focal Inc | Gerät und methode für den lokalen auftrag von polymermaterial auf gewebe |
TW272976B (ja) | 1993-08-06 | 1996-03-21 | Ciba Geigy Ag | |
US5525657A (en) | 1994-10-11 | 1996-06-11 | Basf Corporation | Latex composition employing specifically defined ethylene oxide/propylene oxide block copolymer surfactant and hydrophobic defoaming agent |
CA2228118A1 (en) * | 1995-07-28 | 1997-02-13 | Focal, Inc. | Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatments agents |
US5702717A (en) | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
WO2004075568A2 (en) | 2003-02-19 | 2004-09-02 | Fujitsu Limited | Method and apparatus for packet scheduling |
-
1996
- 1996-07-26 CA CA002228118A patent/CA2228118A1/en not_active Abandoned
- 1996-07-26 EP EP96926138A patent/EP0842209B1/en not_active Expired - Lifetime
- 1996-07-26 AT AT96926138T patent/ATE342295T1/de not_active IP Right Cessation
- 1996-07-26 US US08/692,914 patent/US6201065B1/en not_active Expired - Lifetime
- 1996-07-26 DE DE69636626T patent/DE69636626T2/de not_active Expired - Lifetime
- 1996-07-26 JP JP9507762A patent/JPH11510837A/ja not_active Withdrawn
- 1996-07-26 WO PCT/US1996/012285 patent/WO1997005185A2/en active IP Right Grant
-
2000
- 2000-11-09 US US09/710,416 patent/US6410645B1/en not_active Expired - Lifetime
-
2002
- 2002-04-02 US US10/114,722 patent/US6639014B2/en not_active Expired - Lifetime
-
2003
- 2003-08-27 US US10/650,163 patent/US6923986B2/en not_active Expired - Fee Related
-
2005
- 2005-06-22 US US11/158,565 patent/US7250177B2/en not_active Expired - Fee Related
- 2005-10-05 JP JP2005293028A patent/JP2006097031A/ja not_active Withdrawn
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JP2001514931A (ja) * | 1997-08-18 | 2001-09-18 | ボストン サイエンティフィック リミテッド | 移植可能なプロテーゼ用の生体溶解吸収性組成物 |
JP2003527172A (ja) * | 2000-03-13 | 2003-09-16 | バイオキュア・インコーポレーテッド | 組織増量及び被覆用組成物 |
JP2005534732A (ja) * | 2002-06-14 | 2005-11-17 | ポリメーレクスペール エス アー | 熱感応性ポリマー及びそのポリマーから得られた熱可逆性ゲル |
JP2006504451A (ja) * | 2002-08-22 | 2006-02-09 | フレセニウス メディカル ケア ドイチェランド ゲーエムベーハー | ポリマー支持体表面にハイドロゲル形成ポリマーを固定化するための方法 |
JP2010500917A (ja) * | 2006-06-15 | 2010-01-14 | マイクロベンション, インコーポレイテッド | 膨張性ポリマーで構成される塞栓形成デバイス |
JP2013236948A (ja) * | 2006-06-15 | 2013-11-28 | Microvention Inc | 膨張性ポリマーで構成される塞栓形成デバイス |
JP2008106269A (ja) * | 2006-09-29 | 2008-05-08 | Nof Corp | 生分解性ポリオキシアルキレン誘導体の製造方法 |
JP2011507637A (ja) * | 2007-12-21 | 2011-03-10 | マイクロベンション, インコーポレイテッド | 生物医学的使用のためのハイドロゲルフィラメント |
JP2009261931A (ja) * | 2008-04-23 | 2009-11-12 | Tyco Healthcare Group Lp | 生体吸収性外科用組成物 |
JP2016509610A (ja) * | 2012-12-17 | 2016-03-31 | シーカー,マティアス | 鎖延長されたポロキサマー、生物材料を含むそれから形成された熱可逆性ハイドロゲルおよびその医学的適用 |
WO2016143647A1 (ja) * | 2015-03-10 | 2016-09-15 | 国立大学法人 東京大学 | ゲル前駆体クラスターを用いた低濃度ゲルの製造方法、及び当該製造方法により得られるゲル |
JPWO2016143647A1 (ja) * | 2015-03-10 | 2017-12-21 | 国立大学法人 東京大学 | ゲル前駆体クラスターを用いた低濃度ゲルの製造方法、及び当該製造方法により得られるゲル |
US10550225B2 (en) | 2015-03-10 | 2020-02-04 | The University Of Tokyo | Process for producing low-concentration gel using gel-precursor clusters, and gel obtained by said production process |
WO2020027016A1 (ja) * | 2018-07-31 | 2020-02-06 | 国立大学法人 東京大学 | スポンジ様の多孔体構造を有する高分子ゲル |
JPWO2020027016A1 (ja) * | 2018-07-31 | 2021-08-10 | 国立大学法人 東京大学 | スポンジ様の多孔体構造を有する高分子ゲル |
Also Published As
Publication number | Publication date |
---|---|
DE69636626D1 (de) | 2006-11-23 |
WO1997005185A3 (en) | 1997-03-13 |
DE69636626T2 (de) | 2007-08-30 |
US6201065B1 (en) | 2001-03-13 |
US6639014B2 (en) | 2003-10-28 |
US20040072961A1 (en) | 2004-04-15 |
ATE342295T1 (de) | 2006-11-15 |
US20020151650A1 (en) | 2002-10-17 |
MX9801706A (es) | 1998-05-31 |
EP0842209B1 (en) | 2006-10-11 |
US7250177B2 (en) | 2007-07-31 |
CA2228118A1 (en) | 1997-02-13 |
US20050238722A1 (en) | 2005-10-27 |
WO1997005185A2 (en) | 1997-02-13 |
US6923986B2 (en) | 2005-08-02 |
JP2006097031A (ja) | 2006-04-13 |
US6410645B1 (en) | 2002-06-25 |
EP0842209A2 (en) | 1998-05-20 |
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