JPH10500406A - 頭痛を低減する方法 - Google Patents
頭痛を低減する方法Info
- Publication number
- JPH10500406A JPH10500406A JP7529042A JP52904295A JPH10500406A JP H10500406 A JPH10500406 A JP H10500406A JP 7529042 A JP7529042 A JP 7529042A JP 52904295 A JP52904295 A JP 52904295A JP H10500406 A JPH10500406 A JP H10500406A
- Authority
- JP
- Japan
- Prior art keywords
- neurotoxin
- presynaptic neurotoxin
- toxin
- presynaptic
- headache
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Yarns And Mechanical Finishing Of Yarns Or Ropes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.1以上の筋肉中へのシナプス前部神経毒のデリバリーにより哺乳動物に医薬 的に安全な形での無脊椎動物のシナプス前部神経毒の治療的有効量を投与するこ とを含む、哺乳動物における頭痛に関連する痛みを軽減する方法。 2.神経毒が顔、頭蓋及び首の1以上の筋肉にデリバリーされる請求の範囲第1 項の方法。 3.シナプス前部神経毒が前頭筋、しゅう筋、鼻根筋及び両側の側頭筋の1以上 にデリバリーされる請求の範囲第2項の方法。 4.シナプス前部神経毒が哺乳動物の背の1以上の筋肉にもデリバリーされる請 求の範囲第2項の方法。 5.シナプス前部神経毒が筋肉中に筋電図注射により投与される請求の範囲第1 項の方法。 6.シナプス前部神経毒が神経筋接合部のエリア中の筋肉中に注射により投与さ れる請求の範囲第1項の方法。 7.シナプス前部神経毒がボツリヌス毒素である請求の範囲第1項の方法。 8.ボツリヌス毒素がボツリヌスA型毒素である請求の範囲第6項の方法。 9.シナプス前部神経毒がタンパク質毒素の生物学的に活性なフラグメントであ る請求の範囲第1項の方法。 10.生物学的に活性なフラグメントが破傷風毒素のIbcフラグメントである請求 の範囲第8項の方法。 11.1以上の筋肉中へのシナプス前部神経毒のデリバリーにより哺乳動物に医薬 的に安全な形での無脊椎動物のシナプス前部神経毒の治療的有効量を投与するこ とを含む、哺乳動物における頭痛の始まり又は存在に関連する症候を軽減する方 法。 12.顔、頭蓋又は首の筋肉外部位へのシナプス前部神経毒のデリバリーにより哺 乳動物に医薬的に安全な形での無脊椎動物のシナプス前部神経毒の治療的有効量 を投与することを含む、哺乳動物における頭痛に関連する痛みを軽減する方法。 13.哺乳動物が経験する頭痛の1以上の標的部位に神経毒がデリバリーされる請 求の範囲第12項の方法。 14.シナプス前部神経毒が顔の前頭、側部及び後頭下部エ リアの1以上にデリバリーされる請求の範囲第13項の方法。 15.シナプス前部神経毒が血管周囲注射により投与される請求の範囲第12項の方 法。 16.シナプス前部神経毒が皮下注射により投与される請求の範囲第12項の方法。 17.シナプス前部神経毒がボツリヌス毒素である請求の範囲第12項の方法。 18.ボツリヌス毒素がボツリヌスA型毒素である請求の範囲第17項の方法。 19.シナプス前部神経毒がタンパク質性毒素の生物学的に活性なフラグメントで ある請求の範囲第12項の方法。 20.生物学的に活性なフラグメントが破傷風毒素のIbcフラグメントである請求 の範囲第19項の方法。 21.顔、頭蓋又は首における筋肉外部位へのシナプス前部神経毒のデリバリーの より哺乳動物に医薬的に安全な形の無脊椎動物のシナプス前部神経毒の治療的有 効量を投与することを含む、哺乳動物における頭痛の始まり又は存在に 関連する症候を軽減する方法。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US343,331 | 1982-01-27 | ||
US24097394A | 1994-05-09 | 1994-05-09 | |
US08/240,973 | 1994-05-09 | ||
US34333194A | 1994-11-21 | 1994-11-21 | |
US08/343,331 | 1994-11-21 | ||
US240,973 | 1994-11-21 | ||
PCT/US1995/005422 WO1995030431A1 (en) | 1994-05-09 | 1995-05-02 | Method for reduction of headache pain |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10500406A true JPH10500406A (ja) | 1998-01-13 |
JP3066079B2 JP3066079B2 (ja) | 2000-07-17 |
Family
ID=26933871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7529042A Expired - Lifetime JP3066079B2 (ja) | 1994-05-09 | 1995-05-02 | 頭痛を低減する方法 |
Country Status (12)
Country | Link |
---|---|
US (1) | US5714468A (ja) |
EP (2) | EP0758900B1 (ja) |
JP (1) | JP3066079B2 (ja) |
AT (2) | ATE215832T1 (ja) |
AU (1) | AU2431995A (ja) |
CA (2) | CA2190011C (ja) |
DE (2) | DE69534150T2 (ja) |
DK (2) | DK0758900T3 (ja) |
ES (2) | ES2238969T3 (ja) |
LU (1) | LU92052I2 (ja) |
PT (2) | PT1086702E (ja) |
WO (1) | WO1995030431A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002114706A (ja) * | 1993-12-28 | 2002-04-16 | Allergan Sales Inc | 頭痛を処置するための医薬組成物 |
JP2006525353A (ja) * | 2003-05-02 | 2006-11-09 | アラーガン、インコーポレイテッド | 副鼻腔頭痛を処置する方法 |
JP2012131826A (ja) * | 2005-02-01 | 2012-07-12 | Allergan Inc | 三叉神経・自律神経性頭痛、片頭痛および血管症状の治療および予防のためのボツリヌス毒素の標的デリバリー |
JP2012140462A (ja) * | 2003-10-29 | 2012-07-26 | Allergan Inc | 神経障害および神経精神障害のボツリヌス毒素処置 |
JP2017160249A (ja) * | 2012-05-23 | 2017-09-14 | バインダー,ウイリアム,ジェイ. | シナプス前部神経毒を用いた片頭痛の治療 |
Families Citing this family (173)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9120306D0 (en) | 1991-09-24 | 1991-11-06 | Graham Herbert K | Method and compositions for the treatment of cerebral palsy |
US8557256B2 (en) | 1993-12-28 | 2013-10-15 | Allergan, Inc. | Treatment for cervical dystonia with the neurotoxic component of a botulinum toxin |
US8187612B2 (en) | 1993-12-28 | 2012-05-29 | Allergan, Inc. | Use of the neurotoxic component of a botulinum toxin for treating a spastic muscle |
US20040126396A1 (en) * | 1993-12-28 | 2004-07-01 | Allergan, Inc. | Botulinum toxin treatment for strabismus |
US6974578B1 (en) * | 1993-12-28 | 2005-12-13 | Allergan, Inc. | Method for treating secretions and glands using botulinum toxin |
US5721215A (en) * | 1996-03-20 | 1998-02-24 | Allergan | Injectable therapy for control of muscle spasms and pain related to muscle spasms |
US6063768A (en) * | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
AU2340299A (en) | 1998-01-26 | 1999-08-09 | University Of Massachusetts | Biologically active hemagglutinin from type a (clostridium botulinum) and methods of use |
US7537773B1 (en) * | 1998-08-25 | 2009-05-26 | Botulinum Toxin Research Associates, Inc. | Chemodenervating pharmaceutical as anti-inflammatory agent |
US6139545A (en) * | 1998-09-09 | 2000-10-31 | Vidaderm | Systems and methods for ablating discrete motor nerve regions |
TW574036B (en) | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
AUPP627498A0 (en) * | 1998-10-02 | 1998-10-22 | University Of Queensland, The | Novel peptides - i |
WO2000062746A1 (en) * | 1999-04-16 | 2000-10-26 | Marvin Schwartz | Method to reduce hair loss and stimulate hair regrowth |
DE19925739A1 (de) | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
US6767544B2 (en) * | 2002-04-01 | 2004-07-27 | Allergan, Inc. | Methods for treating cardiovascular diseases with botulinum toxin |
US6113915A (en) * | 1999-10-12 | 2000-09-05 | Allergan Sales, Inc. | Methods for treating pain |
US6265379B1 (en) * | 1999-10-13 | 2001-07-24 | Allergan Sales, Inc. | Method for treating otic disorders |
US7838008B2 (en) * | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating diverse cancers |
US7838007B2 (en) | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating mammary gland disorders |
US6429189B1 (en) * | 1999-12-10 | 2002-08-06 | Botulinum Toxin Research Associates, Inc. | Cytotoxin (non-neurotoxin) for the treatment of human headache disorders and inflammatory diseases |
US6500436B2 (en) | 2000-01-19 | 2002-12-31 | Allergan, Inc. | Clostridial toxin derivatives and methods for treating pain |
US7138127B1 (en) * | 2000-01-19 | 2006-11-21 | Allergan, Inc. | Clostridial toxin derivatives and methods for treating pain |
US6641820B1 (en) | 2000-01-19 | 2003-11-04 | Allergan, Inc. | Clostridial toxin derivatives and methods to treat pain |
US8632785B2 (en) * | 2000-02-08 | 2014-01-21 | Allergan, Inc. | Clostridial toxin pharmaceutical composition containing a gelatin fragment |
US7780967B2 (en) * | 2000-02-08 | 2010-08-24 | Allergan, Inc. | Reduced toxicity Clostridial toxin pharmaceutical compositions |
US20030118598A1 (en) * | 2000-02-08 | 2003-06-26 | Allergan, Inc. | Clostridial toxin pharmaceutical compositions |
PT1398038E (pt) * | 2000-02-08 | 2007-02-28 | Allergan Inc | Composições farmacêuticas de toxina botulínica |
US20060269575A1 (en) * | 2000-02-08 | 2006-11-30 | Allergan, Inc. | Botulinum toxin pharmaceutical compositions formulated with recombinant albumin |
US6821520B2 (en) * | 2000-02-15 | 2004-11-23 | Allergan, Inc. | Clostridial toxin therapy for Hashimoto's thyroiditis |
US6753315B2 (en) | 2000-02-24 | 2004-06-22 | Brown University Research Foundation | α-bungarotoxin molecules and uses thereof |
US6464986B1 (en) | 2000-04-14 | 2002-10-15 | Allegan Sales, Inc. | Method for treating pain by peripheral administration of a neurotoxin |
US6299893B1 (en) * | 2000-04-17 | 2001-10-09 | Marvin Schwartz | Method to reduce hair loss and stimulate hair regrowth |
US6565870B1 (en) | 2000-04-28 | 2003-05-20 | Allergan, Inc. | Methods for treating bone tumors |
US20040033241A1 (en) * | 2000-06-02 | 2004-02-19 | Allergan, Inc. | Controlled release botulinum toxin system |
US20040170665A1 (en) * | 2000-06-02 | 2004-09-02 | Allergan, Inc. | Intravitreal botulinum toxin implant |
CA2413301A1 (en) * | 2000-06-28 | 2002-01-03 | Ira Sanders | Methods for using tetanus toxin for benificial purposes in animals (mammals) |
US6903187B1 (en) * | 2000-07-21 | 2005-06-07 | Allergan, Inc. | Leucine-based motif and clostridial neurotoxins |
US7491799B2 (en) * | 2000-07-21 | 2009-02-17 | Allergan, Inc. | Modified botulinum neurotoxins |
US7691983B2 (en) * | 2000-07-21 | 2010-04-06 | Allergan, Inc. | Chimera botulinum toxin type E |
US20040219619A1 (en) * | 2000-07-21 | 2004-11-04 | Ester Fernandez-Salas | Methods of identifying compounds that alter toxin persistence and/or protease activity |
US7223577B2 (en) * | 2000-11-17 | 2007-05-29 | Allergan, Inc. | Post-translational modifications and Clostridial neurotoxins |
US20020127247A1 (en) | 2000-11-17 | 2002-09-12 | Allergen Sales, Inc. | Modified clostridial neurotoxins with altered biological persistence |
US7255865B2 (en) | 2000-12-05 | 2007-08-14 | Allergan, Inc. | Methods of administering botulinum toxin |
US20020086036A1 (en) | 2000-12-05 | 2002-07-04 | Allergan Sales, Inc. | Methods for treating hyperhidrosis |
US20020192239A1 (en) * | 2001-01-09 | 2002-12-19 | Borodic Gary E. | Use of botulinum toxin for the treatment of chronic facial pain |
JP4707254B2 (ja) * | 2001-04-24 | 2011-06-22 | クミアイ化学工業株式会社 | 粒状組成物及びその製造方法 |
US7255866B2 (en) | 2001-09-17 | 2007-08-14 | Allergan, Inc. | Botulinum toxin therapy for fibromyalgia |
US6623742B2 (en) | 2001-09-17 | 2003-09-23 | Allergan, Inc. | Methods for treating fibromyalgia |
CA2466697C (en) * | 2001-11-15 | 2013-09-24 | Micro Algae Corporation | Pharmaceutical compositions containing 3,4-propinoperhydropurines and uses thereof for blocking neuronal transmission |
US7022329B2 (en) * | 2002-02-25 | 2006-04-04 | Allergan, Inc. | Method for treating neurogenic inflammation pain with botulinum toxin and substance P components |
US20030224019A1 (en) * | 2002-03-01 | 2003-12-04 | O'brien Christopher | Methods of treating nerve entrapment syndromes |
US7140371B2 (en) * | 2002-03-14 | 2006-11-28 | Allergan, Inc. | Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins |
US6688311B2 (en) | 2002-03-14 | 2004-02-10 | Allergan, Inc. | Method for determining effect of a clostridial toxin upon a muscle |
US6921538B2 (en) * | 2002-05-10 | 2005-07-26 | Allergan, Inc. | Therapeutic treatments for neuropsychiatric disorders |
US7691394B2 (en) * | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
KR20050061541A (ko) * | 2002-10-15 | 2005-06-22 | 알러간, 인코포레이티드 | 보툴리눔 독소 치과 치료 및 시술 |
US20040086532A1 (en) * | 2002-11-05 | 2004-05-06 | Allergan, Inc., | Botulinum toxin formulations for oral administration |
US7238357B2 (en) * | 2002-11-05 | 2007-07-03 | Allergan, Inc. | Methods for treating ulcers and gastroesophageal reflux disease |
US7758872B1 (en) * | 2003-02-07 | 2010-07-20 | Eric Finzi | Method of treating depression |
US20060153876A1 (en) * | 2003-02-24 | 2006-07-13 | Ira Sanders | Cell membrane translocation of regulated snare inhibitors, compositions therefor, and methods for treatment of disease |
US8071550B2 (en) | 2003-03-03 | 2011-12-06 | Allergan, Inc. | Methods for treating uterine disorders |
MXPA05009425A (es) * | 2003-03-06 | 2006-02-10 | Botulinum Toxin Res Ass Inc | Tratamiento del dolor facial cronico y cefalea relacionados con la sinusitis con toxina botulinica. |
WO2004078200A1 (en) * | 2003-03-06 | 2004-09-16 | Botulinum Toxin Research Associates, Inc. | Selection of patients with increased responsiveness to botulinum toxin |
WO2004084839A2 (en) * | 2003-03-24 | 2004-10-07 | Cady Roger K | Method and article for treatment of sensory neuron related disorders through transdermal application of botulinum toxin |
MXPA05010886A (es) * | 2003-04-16 | 2005-11-25 | Allergan Inc | Dispositivo de inyeccion y aspiracion de volumenes controlados. |
US7390496B2 (en) * | 2003-04-25 | 2008-06-24 | Allergan, Inc. | Therapeutic treatments for repetitive hand washing |
US7422753B2 (en) * | 2003-04-25 | 2008-09-09 | Allergan, Inc. | Methods for treating trichotillomania |
US7396535B2 (en) * | 2003-04-25 | 2008-07-08 | Ackerman Alan H | Therapy for obsessive compulsive head banging |
US7393537B2 (en) | 2003-04-25 | 2008-07-01 | Allergan, Inc. | Botulinum toxin for treatment of obsessive compulsive finger biting disorder |
US7393538B2 (en) * | 2003-04-25 | 2008-07-01 | Ackerman Alan H | Clostridial toxin treatment for dermatillomania |
US7220422B2 (en) * | 2003-05-20 | 2007-05-22 | Allergan, Inc. | Methods and compositions for treating eye disorders |
US20040253274A1 (en) * | 2003-06-11 | 2004-12-16 | Allergan, Inc. | Use of a clostridial toxin to reduce appetite |
US20050013850A1 (en) * | 2003-07-15 | 2005-01-20 | Caers Jan K. | Device to assist hyperhydrosis therapy |
WO2006096164A1 (en) | 2005-03-03 | 2006-09-14 | Allergan, Inc. | Media for clostridium bacterium and processes for obtaining a clostridial toxin |
US8617572B2 (en) | 2003-10-29 | 2013-12-31 | Allergan, Inc. | Botulinum toxin treatments of depression |
US7172764B2 (en) * | 2003-11-17 | 2007-02-06 | Allergan, Inc. | Rescue agents for treating botulinum toxin intoxications |
US8871224B2 (en) * | 2003-12-09 | 2014-10-28 | Allergan, Inc. | Botulinum toxin therapy for skin disorders |
US8048423B2 (en) * | 2003-12-09 | 2011-11-01 | Allergan, Inc. | Botulinum toxin therapy for skin disorders |
US20050129677A1 (en) * | 2003-12-10 | 2005-06-16 | Shengwen Li | Lipid rafts and clostridial toxins |
US20050148935A1 (en) * | 2003-12-29 | 2005-07-07 | Rozalina Dimitrova | Botulinum toxin injection guide |
US7270287B2 (en) * | 2004-01-06 | 2007-09-18 | Allergan, Inc. | Botulinum toxin treatment for kinesia |
US6974579B2 (en) * | 2004-01-08 | 2005-12-13 | Allergan, Inc. | Methods for treating vascular disorders |
US9078892B2 (en) | 2004-02-26 | 2015-07-14 | Allergan, Inc. | Methods for treating pain and for treating a medication overuse disorder |
US20050191321A1 (en) * | 2004-02-26 | 2005-09-01 | Allergan, Inc. | Methods for treating headache |
US20100266638A1 (en) | 2004-02-26 | 2010-10-21 | Allergan, Inc. | Headache treatment method |
US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
CA3031270A1 (en) | 2004-03-03 | 2005-12-22 | Revance Therapeutics, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
US20050220821A1 (en) * | 2004-03-31 | 2005-10-06 | Allergan, Inc. | Pressure sore treatment |
US20050220734A1 (en) * | 2004-04-02 | 2005-10-06 | Allergan, Inc. | Therapy for melanin related afflictions |
US20080021051A1 (en) * | 2004-05-07 | 2008-01-24 | Phytotox Limited | Phycotoxins and Uses Thereof |
US8377951B2 (en) * | 2004-05-07 | 2013-02-19 | Phytotox Limited | Transdermal administration of phycotoxins |
US6991789B2 (en) * | 2004-06-29 | 2006-01-31 | Allergas, Inc. | Methods of modulating intracellular degradation rates of toxins |
US7922983B2 (en) * | 2005-07-28 | 2011-04-12 | Kimberly-Clark Worldwide, Inc. | Sterilization wrap with additional strength sheet |
US7811584B2 (en) | 2004-06-30 | 2010-10-12 | Allergan, Inc. | Multivalent clostridial toxins |
JP5685357B2 (ja) | 2004-07-09 | 2015-03-18 | ロバート セービン, | 哺乳類疾病の治療のための組成物および使用法 |
US20070258900A1 (en) * | 2004-07-20 | 2007-11-08 | Joseph Francis | Blood Flow Assessment of Clostridial Toxin Applications |
WO2006130161A2 (en) * | 2004-07-21 | 2006-12-07 | The Cornell Research Foundation, Inc. | Therapeutic compounds derived from spider venom and their method of use |
US20060024794A1 (en) * | 2004-07-30 | 2006-02-02 | Shengwen Li | Novel methods for production of di-chain botulinum toxin |
US20060024331A1 (en) * | 2004-08-02 | 2006-02-02 | Ester Fernandez-Salas | Toxin compounds with enhanced membrane translocation characteristics |
US7429386B2 (en) * | 2004-09-03 | 2008-09-30 | Allergan, Inc. | Stretch mark treatment |
US7179474B2 (en) * | 2004-09-03 | 2007-02-20 | Allergan, Inc. | Methods for treating a buttock deformity |
US20060073208A1 (en) | 2004-10-01 | 2006-04-06 | Allergan, Inc. | Cosmetic neurotoxin compositions and methods |
US7897147B2 (en) * | 2004-10-20 | 2011-03-01 | Allergan, Inc. | Treatment of premenstrual disorders |
US7749515B2 (en) | 2005-02-01 | 2010-07-06 | Allergan, Inc. | Targeted delivery of botulinum toxin to the sphenopalatine ganglion |
AU2012241076B2 (en) * | 2005-02-01 | 2015-05-14 | Allergan, Inc. | Targeted delivery of Botulinum toxin for the treatment and prevention of trigeminal autonomic cephalgias, migraine and vascular conditions |
EP1861112A4 (en) | 2005-03-03 | 2009-07-22 | Revance Therapeutics Inc | COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL DELIVERY OF BOTULINUM TOXINS |
US7731411B2 (en) * | 2005-04-04 | 2010-06-08 | Schlumberger Technology Corporation | Circulating fluid system for powder fluidization and method of performing same |
WO2006122123A2 (en) * | 2005-05-09 | 2006-11-16 | Levin Bruce H | Methods of alleviating disorders and their associated pain |
US7419675B2 (en) * | 2005-05-26 | 2008-09-02 | Allergan, Inc. | Method for treating peritoneal adhesions |
US8105611B2 (en) * | 2005-06-17 | 2012-01-31 | Allergan, Inc. | Treatment of autoimmune disorder with a neurotoxin |
US7910116B2 (en) * | 2005-08-24 | 2011-03-22 | Allergan, Inc. | Use of a botulinum toxin to improve gastric emptying and/or to treat GERD |
DE102005058639A1 (de) * | 2005-12-07 | 2007-07-26 | Armin Maurer | Behandlung von Trichodynie und anschwellender Arteria temporalis superficialis |
US7824694B2 (en) * | 2006-01-12 | 2010-11-02 | Allergan, Inc. | Methods for enhancing therapeutic effects of a neurotoxin |
US20070178121A1 (en) * | 2006-01-27 | 2007-08-02 | Allergan, Inc. | Methods for enhancing skin treatments |
US7794386B2 (en) | 2006-03-15 | 2010-09-14 | Allergan, Inc. | Methods for facilitating weight loss |
US20080021437A1 (en) * | 2006-04-27 | 2008-01-24 | Boyd James P | Enhancement of the efficacy of a clenching reduction device by augmenting with botulinum toxin type A |
US7811586B2 (en) * | 2006-05-02 | 2010-10-12 | Allergan, Inc. | Methods for alleviating testicular pain |
CN101074935B (zh) * | 2006-05-19 | 2011-03-23 | 清华大学 | 探测器阵列及设备 |
US9061025B2 (en) * | 2006-08-31 | 2015-06-23 | Allergan, Inc. | Methods for selecting headache patients responsive to botulinum toxin therapy |
US20080092910A1 (en) * | 2006-10-18 | 2008-04-24 | Allergan, Inc. | Apparatus and method for treating obesity using neurotoxins in conjunction with bariatric procedures |
US20080113051A1 (en) * | 2006-11-13 | 2008-05-15 | Allergan, Inc. | Methods for alleviating tattoo pain |
EP2583687B1 (en) * | 2007-02-15 | 2014-08-27 | Allergan, Inc. | Use of botulinum toxin for treating hyperhydrosis |
CA2703364A1 (en) * | 2007-10-23 | 2009-04-30 | Allergan, Inc. | Methods of treating chronic neurogenic inflammation using modified clostridial toxins |
US8470337B2 (en) * | 2008-03-13 | 2013-06-25 | Allergan, Inc. | Therapeutic treatments using botulinum neurotoxin |
US8617571B2 (en) | 2008-04-03 | 2013-12-31 | Allergan, Inc. | Suture line administration technique using botulinum toxin |
ES2356883B1 (es) * | 2008-07-24 | 2012-02-22 | Bcn Peptides, S.A. | Composición para el tratamiento del dolor y/o la inflamación. |
US20100028385A1 (en) * | 2008-08-04 | 2010-02-04 | Allergan, Inc. | Treatment of excess cerumen secretion |
US9204925B2 (en) | 2008-08-14 | 2015-12-08 | The Cleveland Clinic Foundation | Apparatus and method for treating a neuromuscular defect |
US8512715B2 (en) | 2008-08-14 | 2013-08-20 | The Cleveland Clinic Foundation | Apparatus and method for treating a neuromuscular defect |
CA2745657C (en) | 2008-12-04 | 2022-06-21 | Botulinum Toxin Research Associates, Inc. | Extended length botulinum toxin formulation for human or mammalian use |
CA2774951C (en) | 2009-09-24 | 2014-12-16 | Allergan, Inc. | Method of treating osteoporosis with a neurotoxin |
US8940308B2 (en) | 2010-03-30 | 2015-01-27 | Allergan, Inc. | Methods for treating depression |
EP2627350A1 (en) | 2010-10-14 | 2013-08-21 | Allergan, Inc. | Targeted delivery of targeted exocytosis modulators to the sphenopalatine ganglion for treatment of headache disorders |
US20120195878A1 (en) | 2011-01-28 | 2012-08-02 | Allergan, Inc. | Protocol for the administration of botulinum toxins |
US10111938B2 (en) | 2011-03-30 | 2018-10-30 | Allergan, Inc. | Injection paradigm for administration of botulinum toxins |
US8697090B2 (en) | 2011-05-05 | 2014-04-15 | Allergan, Inc. | Method of treating persistent genital arousal disorder with a neurotoxin |
US9764009B2 (en) | 2011-06-13 | 2017-09-19 | Allergan, Inc. | Treatment of psychological trauma |
US8992941B2 (en) | 2011-07-08 | 2015-03-31 | Allergan, Inc. | Method for treatment of esophageal spasm |
CN103747796A (zh) | 2011-07-08 | 2014-04-23 | 阿勒根公司 | 用于治疗自主神经***病症的方法 |
JP6092205B2 (ja) | 2011-07-14 | 2017-03-08 | アラーガン、インコーポレイテッドAllergan,Incorporated | 性的行為に関連した失禁の治療方法 |
RU2014103543A (ru) | 2011-07-20 | 2015-08-27 | Аллерган, Инк. | Ботулотоксины для применения в способе лечения жировых отложений |
US20130236446A1 (en) | 2012-03-12 | 2013-09-12 | William J. Binder | Treatment of migraine headache with diffusion of toxin in non-muscle related areas of the mouth |
US20150231068A1 (en) | 2012-03-12 | 2015-08-20 | Miotox, Llc | Treatment of Migraine Headaches with Presynaptic Neurotoxin |
ES2424294B1 (es) | 2012-03-22 | 2014-07-21 | Lipotec, S.A. | Exopolisacárido para el tratamiento y/o cuidado de la piel, mucosas, cabello y/o uñas |
US9393291B2 (en) | 2012-04-12 | 2016-07-19 | Botulinum Toxin Research Associates, Inc. | Use of botulinum toxin for the treatment of cerebrovascular disease, renovascular and retinovascular circulatory beds |
EP2649983A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (II) |
WO2013153191A1 (en) | 2012-04-13 | 2013-10-17 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (ii) |
EP2649985A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (III) |
EP2649984A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis |
CN108178801B (zh) | 2012-05-30 | 2022-05-03 | 哈佛大学校长及研究员协会 | 工程化的肉毒神经毒素 |
US20140120077A1 (en) | 2012-10-28 | 2014-05-01 | Revance Therapeutics, Inc. | Compositions and Methods for Safe Treatment of Rhinitis |
EP2919807B1 (en) | 2012-11-16 | 2018-07-11 | Finzi, Eric | Treatment of post-traumatic stress disorder using botulinum toxin a |
KR20150135425A (ko) | 2013-03-22 | 2015-12-02 | 리포텍 에스.에이. | 피부, 점막 및/또는 손톱의 치료 및/또는 관리를 위한 세포외 다당류 |
US10149893B2 (en) | 2013-09-24 | 2018-12-11 | Allergan, Inc. | Methods for modifying progression of osteoarthritis |
US9480731B2 (en) | 2013-12-12 | 2016-11-01 | Medy-Tox, Inc. | Long lasting effect of new botulinum toxin formulations |
US9216210B2 (en) | 2013-12-23 | 2015-12-22 | Dublin City University | Multiprotease therapeutics for chronic pain |
US9901627B2 (en) | 2014-07-18 | 2018-02-27 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
CN115925835A (zh) | 2015-03-26 | 2023-04-07 | 哈佛大学校长及研究员协会 | 工程改造的肉毒杆菌神经毒素 |
MX2018015254A (es) | 2016-06-08 | 2019-08-16 | Childrens Medical Center | Neurotoxinas botulinicas modificadas. |
UA125965C2 (uk) | 2016-07-08 | 2022-07-20 | Чілдренс Медікал Сентр Корпорейшн | Новий ботулінічний нейротоксин та його похідні |
CN110072880A (zh) | 2016-08-24 | 2019-07-30 | 哈佛大学校长及研究员协会 | 工程化肉毒杆菌神经毒素 |
WO2018038301A1 (en) | 2016-08-26 | 2018-03-01 | Hugel Inc. | Stabilized liquid formulation of botulinum toxin and preparation method thereof |
KR20240023684A (ko) | 2016-09-13 | 2024-02-22 | 알레간 인코포레이티드 | 안정화된 비단백질 클로스트리듐 독소 조성물 |
EP3687566A2 (en) | 2017-09-29 | 2020-08-05 | Children's Medical Center Corporation | A neurotoxin-like toxin and uses thereof |
EP3470054B1 (en) | 2017-10-11 | 2023-09-20 | Hugel Inc. | Microstructure formulation techniques for botulinum toxin |
US10792400B2 (en) | 2017-10-12 | 2020-10-06 | Hugel Inc. | Microstructure formulation techniques for botulinum toxin |
US10525111B2 (en) | 2017-10-12 | 2020-01-07 | Hugel, Inc. | Microstructure formulation techniques for botulinum toxin |
EP3825689A3 (en) | 2018-11-29 | 2021-09-15 | Hugel Inc. | A cell-based method for determining an activity of botulinum toxin |
WO2020146333A1 (en) | 2019-01-07 | 2020-07-16 | Azizzadeh Babak | Treatment of stress disorders, including post-traumatic stress disorder, using acetylcholine release inhibiting neurotoxic proteins to reduce stress levels |
EP4022054A4 (en) * | 2019-08-30 | 2023-09-06 | Aeon Biopharma, Inc. | NEUROTOXIN COMPOSITIONS FOR USE IN THE TREATMENT OF HEADACHE |
TW202136518A (zh) | 2019-12-20 | 2021-10-01 | 瑞士商葛德瑪控股公司 | 生產肉毒桿菌毒素的方法 |
WO2021247890A1 (en) * | 2020-06-03 | 2021-12-09 | Miotox, Llc | Zonal and targeted methods and uses for treating a migraine disorder |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9120306D0 (en) * | 1991-09-24 | 1991-11-06 | Graham Herbert K | Method and compositions for the treatment of cerebral palsy |
JP4381477B2 (ja) * | 1993-01-15 | 2009-12-09 | ボツリヌム トキシン リサーチ アソシエイト インコーポレイテッド | 筋膜疼痛症候群の治療方法 |
DE69435270D1 (de) * | 1993-12-28 | 2010-04-01 | Allergan Inc | Verwendung der neurotoxischen Komponente von Botulinum Toxin zur Behandlung spastischer Muskeln |
TW574036B (en) * | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
-
1995
- 1995-05-02 ES ES00204206T patent/ES2238969T3/es not_active Expired - Lifetime
- 1995-05-02 AU AU24319/95A patent/AU2431995A/en not_active Abandoned
- 1995-05-02 DK DK95918353T patent/DK0758900T3/da active
- 1995-05-02 EP EP95918353A patent/EP0758900B1/en not_active Expired - Lifetime
- 1995-05-02 DK DK00204206T patent/DK1086702T3/da active
- 1995-05-02 WO PCT/US1995/005422 patent/WO1995030431A1/en active IP Right Grant
- 1995-05-02 PT PT00204206T patent/PT1086702E/pt unknown
- 1995-05-02 CA CA002190011A patent/CA2190011C/en not_active Expired - Lifetime
- 1995-05-02 ES ES95918353T patent/ES2174945T3/es not_active Expired - Lifetime
- 1995-05-02 AT AT95918353T patent/ATE215832T1/de active
- 1995-05-02 JP JP7529042A patent/JP3066079B2/ja not_active Expired - Lifetime
- 1995-05-02 DE DE69534150T patent/DE69534150T2/de not_active Expired - Lifetime
- 1995-05-02 DE DE69526340T patent/DE69526340T2/de not_active Expired - Lifetime
- 1995-05-02 EP EP00204206A patent/EP1086702B1/en not_active Expired - Lifetime
- 1995-05-02 PT PT95918353T patent/PT758900E/pt unknown
- 1995-05-02 AT AT00204206T patent/ATE292977T1/de active
- 1995-05-02 CA CA002312047A patent/CA2312047A1/en not_active Withdrawn
-
1996
- 1996-01-19 US US08/588,654 patent/US5714468A/en not_active Expired - Lifetime
-
2012
- 2012-08-03 LU LU92052C patent/LU92052I2/fr unknown
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002114706A (ja) * | 1993-12-28 | 2002-04-16 | Allergan Sales Inc | 頭痛を処置するための医薬組成物 |
JP2006525353A (ja) * | 2003-05-02 | 2006-11-09 | アラーガン、インコーポレイテッド | 副鼻腔頭痛を処置する方法 |
JP2011137042A (ja) * | 2003-05-02 | 2011-07-14 | Allergan Inc | 副鼻腔頭痛を処置する方法 |
JP4814086B2 (ja) * | 2003-05-02 | 2011-11-09 | アラーガン、インコーポレイテッド | 副鼻腔頭痛を処置する方法 |
JP2012140462A (ja) * | 2003-10-29 | 2012-07-26 | Allergan Inc | 神経障害および神経精神障害のボツリヌス毒素処置 |
JP2012131826A (ja) * | 2005-02-01 | 2012-07-12 | Allergan Inc | 三叉神経・自律神経性頭痛、片頭痛および血管症状の治療および予防のためのボツリヌス毒素の標的デリバリー |
JP2017160249A (ja) * | 2012-05-23 | 2017-09-14 | バインダー,ウイリアム,ジェイ. | シナプス前部神経毒を用いた片頭痛の治療 |
Also Published As
Publication number | Publication date |
---|---|
PT1086702E (pt) | 2005-08-31 |
DK1086702T3 (da) | 2005-05-23 |
JP3066079B2 (ja) | 2000-07-17 |
PT758900E (pt) | 2002-09-30 |
CA2190011A1 (en) | 1995-11-16 |
DE69534150D1 (de) | 2005-05-19 |
DE69534150T2 (de) | 2006-02-16 |
EP0758900A1 (en) | 1997-02-26 |
ATE215832T1 (de) | 2002-04-15 |
ES2174945T3 (es) | 2002-11-16 |
DK0758900T3 (da) | 2002-07-29 |
US5714468A (en) | 1998-02-03 |
DE69526340T2 (de) | 2002-11-14 |
AU2431995A (en) | 1995-11-29 |
EP1086702A2 (en) | 2001-03-28 |
EP0758900A4 (en) | 1997-05-21 |
WO1995030431A1 (en) | 1995-11-16 |
ATE292977T1 (de) | 2005-04-15 |
EP1086702B1 (en) | 2005-04-13 |
LU92052I2 (fr) | 2013-04-03 |
EP0758900B1 (en) | 2002-04-10 |
ES2238969T3 (es) | 2005-09-16 |
CA2190011C (en) | 2000-09-26 |
EP1086702A3 (en) | 2001-04-04 |
CA2312047A1 (en) | 1995-11-16 |
DE69526340D1 (de) | 2002-05-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP3066079B2 (ja) | 頭痛を低減する方法 | |
US5670484A (en) | Method for treatment of skin lesions associated with cutaneous cell-proliferative disorders | |
EP1790352B1 (en) | Use of botulinum toxin for the manufacture of a medicament for reducing low back pain | |
KR101095725B1 (ko) | 신경학적 및 신경정신학적 장애의 보툴리눔 독소 처치 | |
JP5594962B2 (ja) | 神経毒による自己免疫疾患の治療 | |
TWI323663B (en) | Use of botulinum toxin for the manufacture of medicament for treating sinus headache | |
EP1846018B1 (en) | Targeted delivery of botulinum toxin for the treatment and prevention of trigeminal autonomic cephalgias, migraine and vascular conditions | |
US8187612B2 (en) | Use of the neurotoxic component of a botulinum toxin for treating a spastic muscle | |
KR20220003061A (ko) | 보툴리눔 톡신 a형 복합체, 이의 제형 및 이의 사용 방법 | |
EP0845267B1 (en) | Neurotoxins for treating cutaneous disorders in mammals | |
JP3124244B2 (ja) | 皮膚細胞増殖疾患に関連した皮膚病変の処置方法 | |
CA2190564C (en) | Method for treatment of skin lesions associated with cutaneous cell-proliferative disorders | |
CA3238234A1 (en) | Botulinum neurotoxin composition | |
CA2300766C (en) | Neurotoxic component of botulinum toxin for treating cervical dystonia |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090512 Year of fee payment: 9 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100512 Year of fee payment: 10 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110512 Year of fee payment: 11 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120512 Year of fee payment: 12 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120512 Year of fee payment: 12 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130512 Year of fee payment: 13 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140512 Year of fee payment: 14 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |