JPH09505888A - 化学発光アッセイ用金属キレート含有組成物 - Google Patents
化学発光アッセイ用金属キレート含有組成物Info
- Publication number
- JPH09505888A JPH09505888A JP7515126A JP51512695A JPH09505888A JP H09505888 A JPH09505888 A JP H09505888A JP 7515126 A JP7515126 A JP 7515126A JP 51512695 A JP51512695 A JP 51512695A JP H09505888 A JPH09505888 A JP H09505888A
- Authority
- JP
- Japan
- Prior art keywords
- group
- photosensitizer
- compound
- composition
- analyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/586—Liposomes, microcapsules or cells
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/13—Tracers or tags
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.(a)ユーロピウム、テルビウム、ジスプロシウム、サマリウム、オスミ ウム、およびルテニウムからなる群から選択される金属を、少なくとも六配位結 合状態で含んでなる金属キレートと、(b)一方のアリール基が他方に対して電 子供与するものである2つのアリール基で置換された二重結合、酸素原子、およ び、酸素、硫黄、および窒素からなる群から選択される原子、である構造部分、 とを有する化合物: を含んでなる組成物。 2.該化合物が、構造部分: 式中、XはO、SまたはNであり、Nの結合価は水素またはC、O、N、S、お よびPからなる群から選択される原子からなる有機基で満たされており、Arお よびAr'は、独立してアリールであるが、ArまたはAr'の一つがもう一方に対 して電子供与するものである、 を有する、請求の範囲第1項記載の組成物。 3.請求の範囲第1項記載の組成物を中に組み込んでいるラテックス粒子物質 を含んでなる組成物。 4.Arが、5員および6員の芳香環およびヘテロ芳香環からなる群から選択 され、好ましくは二重結合に結合している炭素に対してメタまたはパラであるフ ェニルの位置で、電子供与基により置換されたフェニルであり、Ar'は、好まし くはフェニルである、請求の範囲第1項記載の組成物。 5.(a)(1)分析物を含有する疑いのある媒質、(2)酸素をその励起状 態で活性化して一重項状態にする能力のある光増感剤、ただし、該光増感剤は特 異 的結合対(sbp)構成員と結合しているものである、および(3)該粒子物質 が自身にsbp構成員を結合しているものである請求の範囲第3項記載の組成物 、との組み合わせを提供し、 (b)該組み合わせを光で処理して該光増感剤を励起させ、そして、 (c)該組み合わせを、そこから放出される発光量、ただし、その発光量 は該媒質中の分析物の量と相関するものである、について試験すること、 を含んでなる、該分析物の測定法。 6.パッケージした組み合わせ物中に: (a)請求の範囲第3項記載の組成物、および、 (b)該組成物中にはなく、かつ酸素をその励起状態で活性化して一重項 状態にする能力のある光増感剤、 を含んでなる、キット。 7.該化合物が: 式中、X'はSまたはNR'、ただし、R'は、アルキル、好ましくは低級アルキ ル、最も好ましくはメチルであるか、またはアリール、好ましくはフェニルであ り、DおよびD'は、独立してアルキルおよびアルキルラジカルからなる群から 選択され、例えばメチルである、 である、請求の範囲第1項記載の組成物。 8.(a)ユーロピウム、テルビウム、ジスプロシウム、サマリウム、オスミ ウム、およびルテニウムから成る群から選択される金属を、少なくとも六配位結 合状態で含む金属キレート、および、 (b)請求の範囲第7項記載の化合物、 を含んでなる組成物。 9.式: 式中、X'はSまたはNR'であり、R'はアルキルまたはアリール、好ましくは メチルまたはフェニルであり、DおよびD'は独立してアルキルおよびアルキル ラジカルからなる群から選択される、 で示される化合物。 10.(a)ユーロピウム、テルビウム、ジスプロシウム、サマリウム、オスミ ウム、およびルテニウムからなる群から選択される金属を、少なくとも六配位結 合状態で含んでなる金属キレート、および、 (b)請求の範囲第9項記載の化合物、 を含んでなる組成物。 11.式: 式中、X"はO、SまたはNR"、ただし、R"は、アルキル、好ましくはメチル であるか、またはアリール、好ましくはフェニルであり、nは1ないし4、好ま しくは2であり、ArおよびAr'は、独立してアリールであるが、ArまたはAr' の一つがもう一方に対して電子供与するものであり、さらに、Yは水素、または C、O、N、S、およびPからなる群から選択される原子からなる有機基であり 、mは0ないし2である、 で示される化合物を中に組み込んでいるラテックスを含んでなる、組成物。 12.Arが、5員および6員の芳香環およびヘテロ芳香環からなる群から選択 され、好ましくは二重結合に結合している炭素に対してメタまたはパラであるフ ェニルの位置で、電子供与基により置換されたフェニルであり、Ar'は、好まし くはフェニルである、請求の範囲第11項記載の組成物。 13.金属がユーロピウム、テルビウム、ジスプロシウム、サマリウム、オスミ ウム、およびルテニウムからなる群から選択され、少なくとも六配位結合状態で ある、金属キレートを含んでなる、請求の範囲第11項記載の組成物。 14.式: 式中、X'はSまたはNR'、ただし、R'は、アルキル、好ましくはメチルであ るか、またはアリール、好ましくはフェニルであり、DおよびD'は、独立して アルキルおよびアルキルラジカルからなる群から選択される、 で示される化合物を中に組み込んでいるラテックスを含んでなる、組成物。 15.(a)(1)分析物を含有する疑いのある媒質、(2)その励起状態で、 酸素を一重項状態へと活性化する能力のある光増感剤、ただし、該光増感剤は特 異的結合対(sbp)構成員と結合(アソシエート)しているものである、およ び(3)化学発光化合物を含んでなる懸濁可能なラテックス粒子物質、ただし、 該 粒子物質は、自身にsbp構成員を結合しているものであり、該化学発光化合物 は、式: 式中、X"はO、SまたはNR"、ただし、R"は、アルキル、好ましくはメチル であるか、またはアリール、好ましくはフェニルであり、nは1ないし4、好ま しくは2であり、ArおよびAr'は、独立してアリールであるが、ArまたはAr' の一つがもう一方に対して電子供与するものであり、さらに、Yは水素、または C、O、N、S、およびPからなる群から選択される原子からなる有機基であり 、mは0ないし2である、 を有するものである、 の組み合わせを提供し、 (b)該組み合わせを光で処理して該光増感剤を励起させ、そして、 (c)該組み合わせを、そこから放出される発光量、ただし、その発光量 は該媒質中の分析物の量と相関するものである、について試験すること、 を含んでなる、分析物の測定法。 16.光増感剤が第2の懸濁可能な粒子物質中に組み込まれている、請求の範囲 第15項記載の方法。 17.Arが、5員および6員の芳香環およびヘテロ芳香環からなる群から選択 され、好ましくは二重結合に結合している炭素に対してメタまたはパラであるフ ェニルの位置で、電子供与基により置換されたフェニルであり、Ar'は、好まし くはフェニルである、請求の範囲第15項記載の方法。 18.光増感剤が、励起状態で、分子酸素を一重項状態へと活性化する能力のあ る染料である、請求の範囲第15項記載の方法。 19.染料が、メチレンブルー、ローズベンガル、ポルフィリン類、およびフタ ロシアニン類からなる群から選択される、請求の範囲第18項記載の方法。 20.sbp構成員が、独立して、受容体類、リガンド類、およびポリヌクレオ チド類からなる群から選択される、請求の範囲第15項記載の方法。 21.分析物が、薬剤類、タンパク質類、核酸類、および微生物類からなる群か ら選択される、請求の範囲第15項記載の方法。 22.方法が均一系イムノアッセイである、請求の範囲第15項記載の方法。 23.組み合わせ物を照射により処理して、該光増感剤を励起させる、請求の範 囲第15項記載の方法。 24.組み合わせ物に波長450−950nmの光を照射する、請求の範囲第15 項記載の方法。 25.光増感剤と結合しているsbp構成員が、アビジンまたは抗体であり、該 化学発光化合物のsbp構成員が、アビジンまたは抗体である、請求の範囲第1 5項記載の方法。 26.粒子物質が、ユーロピウム、テルビウム、ジスプロシウム、サマリウム、 オスミウム、およびルテニウムから成る群から選択される金属を含む金属キレー トを含んでなる、請求の範囲第15項記載の方法。 27.(a)(1)分析物を含有する疑いのある媒質、(2)その励起状態で、 酸素を一重項状態へと活性化する能力のある光増感剤、ただし、該光増感剤は特 異的結合対(sbp)構成員と結合(アソシエート)しているものである、およ び(3)化学発光化合物を含んでなる懸濁可能なラテックス粒子物質、ただし、 該粒子物質は、自身にsbp構成員を結合しているものであり、該化学発光化合 物は、式: 式中、X'はSまたはNR'、ただし、R'は、アルキル、好ましくはメチルであ るか、またはアリール、好ましくはフェニルであり、DおよびD'は、独立して アルキルおよびアルキルラジカルからなる群から選択される、 を有するものである、 の組み合わせを提供し、 (b)該組み合わせを光で処理して該光増感剤を励起させ、そして、 (c)該組み合わせを、そこから放出される発光量、ただし、その発光量 は該媒質中の分析物の量と相関するものである、について試験すること、 を含んでなる、分析物の測定法。 28.粒子物質が、ユーロピウム、テルビウム、ジスプロシウム、サマリウム、 オスミウム、およびルテニウムから成る群から選択される金属を少なくとも六配 位結合状態で含む金属キレートを含んでなる、請求の範囲第27項記載の方法。 29.パッケージした組み合わせ物中に:(1)式: 式中、X"はO、SまたはNR"、ただし、R"は、アルキルまたはアリールであ り、nは1ないし4であり、ArおよびAr'は、独立してアリールであるが、Ar またはAr'の一つがもう一方に対して電子供与するものであり、さらに、Yは水 素、またはC、O、N、S、およびPからなる群から選択される原子からなる有 機基であり、mは0ないし2である、 で示される、化学発光化合物を含む懸濁可能なラテックス粒子を含んでなる組成 物、ただし、該粒子は自身に特異的結合対(sbp)構成員を結合しているもの である、および(2)その励起状態で、酸素をその一重項状態へと活性化する能 力のある光増感剤、を含んでなるキット。 30.該光増感剤を含む第2の懸濁可能な粒子、ただし該第2の懸濁可能な粒子 は自身にsbp構成員を結合しているものである、を含む組成物を含んでなる、 請求の範囲第29項記載のキット。 31.粒子物質が、ユーロピウム、テルビウム、ジスプロシウム、サマリウム、 オスミウム、およびルテニウムから成る群から選択される金属を含む金属キレー トを含んでなる、請求の範囲第29項記載のキット。
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PCT/US1994/013193 WO1995014928A1 (en) | 1993-11-22 | 1994-11-21 | Metal chelate containing compositions for use in chemiluminescent assays |
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JP3426241B2 (ja) | 2003-07-14 |
US7229842B2 (en) | 2007-06-12 |
US20040121490A1 (en) | 2004-06-24 |
US6916667B2 (en) | 2005-07-12 |
US6692975B2 (en) | 2004-02-17 |
US5811311A (en) | 1998-09-22 |
ATE239917T1 (de) | 2003-05-15 |
US5780646A (en) | 1998-07-14 |
DE69432640D1 (de) | 2003-06-12 |
DE69432640T2 (de) | 2004-03-25 |
EP0730738A1 (en) | 1996-09-11 |
US20020058280A1 (en) | 2002-05-16 |
CA2177143C (en) | 2007-09-18 |
US5578498A (en) | 1996-11-26 |
EP0730738B1 (en) | 2003-05-07 |
US6340599B1 (en) | 2002-01-22 |
US6180354B1 (en) | 2001-01-30 |
CA2177143A1 (en) | 1995-06-01 |
WO1995014928A1 (en) | 1995-06-01 |
EP1091211A1 (en) | 2001-04-11 |
US5536834A (en) | 1996-07-16 |
US20050214875A1 (en) | 2005-09-29 |
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