JPH07503478A - 新規なインドリノン誘導体,その製造及びこのものを含む製薬学的組成物 - Google Patents
新規なインドリノン誘導体,その製造及びこのものを含む製薬学的組成物Info
- Publication number
- JPH07503478A JPH07503478A JP5513824A JP51382493A JPH07503478A JP H07503478 A JPH07503478 A JP H07503478A JP 5513824 A JP5513824 A JP 5513824A JP 51382493 A JP51382493 A JP 51382493A JP H07503478 A JPH07503478 A JP H07503478A
- Authority
- JP
- Japan
- Prior art keywords
- formulas
- formula
- tables
- product
- racemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (9)
- 1.ラセミ形またはそのエナンチオマの状態の式▲数式、化学式、表等がありま す▼ の新規なイソインドリノン誘導体並びにその塩。
- 2.ラセミ形の式 ▲数式、化学式、表等があります▼ の生成物の水和を酸の存在下にて水性有機媒質中で行うことを特徴とする、ラセ ミ形の請求の範囲第1項記載の生成物の製造方法。
- 3.請求の範囲第1項記載のラセミ生成物の成分の分離をセルローストリフェニ ルカルバメートで被覆したシリカのカリム上での高速液体クロマトグラフィーに より行うことを特徴とする、請求範囲第1項記載の生成物のエナンチオマの製造 方法。
- 4.式 ▲数式、化学式、表等があります▼ のラセミ生成物の成分を修飾されたパークルタイプの相上での高速液体クロマト グラフィーにより分離することを特徴とする、請求の範囲第1項記載の生成物の エナンチオマーの製造方法。
- 5.修飾されたパークルタイプの相が構造式▲数式、化学式、表等があります▼ 式中、同一もしくは相異なることができるR及び同一もしくは相異なることがで きるR1は炭素原子1〜10個を含むアルキル基を表わし、G1は電子吸収性基 を表わし、そしてnは3乃至13間の整数を表わす、 により定義されることを特徴とする、請求の範囲第4項記載の方法。
- 6.修飾されたバークルタイプの相が構造式▲数式、化学式、表等があります▼ 式中、Rの1つは炭素原子7〜10個を含むアルキル基を表わし、他の2つは炭 素原子1または2個を含むアルキル基を表わし、R1は同一であり、かつメチル またはエチル基を表わし、G1は随時1個またはそれ以上のニトロ基で置換され ていてもよいベンゾイル基を表わし、そしてnは10に等しい、 により定義されることを特徴とする、請求の範囲第4項記載の方法。
- 7.修飾されたパークル相が構造式 ▲数式、化学式、表等があります▼ により定義されることを特徴とする、請求の範囲第4項記載の方法。
- 8.請求の範囲第5、6または7項のいずれかの記載により定義される修飾され たパータルタイプの相。
- 9.1つまたはそれ以上の不活性または治療上活性の、製薬学的に許容し得る補 助剤または希釈剤と組合せて少なくとも1つのラセミ形またはそのエナンチオマ ーの状態の請求の範囲第1項記載の生成物を含むことを特徴とする、製薬学的組 成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR92/01382 | 1992-02-07 | ||
FR9201382A FR2687154B1 (fr) | 1992-02-07 | 1992-02-07 | Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent. |
PCT/FR1993/000113 WO1993016074A1 (fr) | 1992-02-07 | 1993-02-04 | Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002150221A Division JP3507918B2 (ja) | 1992-02-07 | 2002-05-24 | イソインドリノン誘導体のラセミ生成物を構成するエナンチオマーの分離に用いる修飾されたパークルタイプの相 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH07503478A true JPH07503478A (ja) | 1995-04-13 |
JP3342012B2 JP3342012B2 (ja) | 2002-11-05 |
Family
ID=9426427
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51382493A Expired - Lifetime JP3342012B2 (ja) | 1992-02-07 | 1993-02-04 | 新規なインドリノン誘導体,その製造及びこのものを含む製薬学的組成物 |
JP2002150221A Expired - Lifetime JP3507918B2 (ja) | 1992-02-07 | 2002-05-24 | イソインドリノン誘導体のラセミ生成物を構成するエナンチオマーの分離に用いる修飾されたパークルタイプの相 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002150221A Expired - Lifetime JP3507918B2 (ja) | 1992-02-07 | 2002-05-24 | イソインドリノン誘導体のラセミ生成物を構成するエナンチオマーの分離に用いる修飾されたパークルタイプの相 |
Country Status (11)
Country | Link |
---|---|
US (3) | US5494915A (ja) |
EP (1) | EP0625153B1 (ja) |
JP (2) | JP3342012B2 (ja) |
AT (1) | ATE127465T1 (ja) |
CA (1) | CA2127374C (ja) |
DE (1) | DE69300453T2 (ja) |
DK (1) | DK0625153T3 (ja) |
ES (1) | ES2076838T3 (ja) |
FR (1) | FR2687154B1 (ja) |
GR (1) | GR3017348T3 (ja) |
WO (1) | WO1993016074A1 (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2695389B1 (fr) * | 1992-09-08 | 1994-11-04 | Rhone Poulenc Rorer Sa | Nouveau dérivé de l'isoindolinone, sa préparation et les compositions pharmaceutiques qui le contiennent. |
US5624508A (en) * | 1995-05-02 | 1997-04-29 | Flomenblit; Josef | Manufacture of a two-way shape memory alloy and device |
UA71586C2 (en) | 1998-12-04 | 2004-12-15 | Smithkline Beecham Corp | A vitronectin receptor antagonist |
US6855721B1 (en) | 2000-07-28 | 2005-02-15 | Indevus Pharmaceuticals, Inc. | Methods and compositions for alleviating stuttering |
AU783516B2 (en) * | 2001-04-30 | 2005-11-03 | Warner-Lambert Company | Methods, kits and compositions for using pyrrole derivatives |
AU2003212585B2 (en) | 2002-03-29 | 2009-02-26 | Endo Pharmaceuticals Solutions Inc. | Methods of preparation of the 2-(7-chloro-1,8-naphthyridine-2YL)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone |
WO2005105061A2 (en) * | 2004-04-14 | 2005-11-10 | Indevus Pharmaceuticals, Inc. | Transdermal patch |
EP2104322A1 (en) * | 2008-03-18 | 2009-09-23 | BlueTown ApS | Communication system for voice-over internet protocol using license-free frequencies |
JP2014506603A (ja) | 2011-02-25 | 2014-03-17 | コンサート ファーマシューティカルズ インコーポレイテッド | 2−アミノ−ナフチリジン誘導体 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58202043A (ja) * | 1982-05-19 | 1983-11-25 | Sumitomo Chem Co Ltd | グラフトしたクロマトグラフ充填剤およびそれを用いる鏡像体混合物の分析法 |
CA1204720A (en) * | 1982-09-30 | 1986-05-20 | Hajimu Kitahara | Packing materials for chromatographic use and a method for analysis of an enantiomer mixture using the same |
US5312924A (en) * | 1983-12-30 | 1994-05-17 | Dr. Karl Thomae Gmbh | Phenylacetic acid benzylamides |
JPS6169773A (ja) * | 1984-09-14 | 1986-04-10 | Takeda Chem Ind Ltd | イソインドリノン誘導体 |
US4966985A (en) * | 1985-12-27 | 1990-10-30 | Daicel Chemical Industries, Ltd. | Optically active carboalkylated amino alcohols and their utilization in optical resolution |
FR2607503B1 (fr) * | 1986-12-02 | 1989-02-24 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
JPS6420445A (en) * | 1987-07-15 | 1989-01-24 | Sumitomo Chemical Co | Chromatograph packing agent and analysis of enantiomer using said agent |
JP2841546B2 (ja) * | 1989-09-25 | 1998-12-24 | 東ソー株式会社 | 液体クロマトグラフィー用充填剤 |
US5080795A (en) * | 1990-05-23 | 1992-01-14 | Research Corporation Technologies, Inc. | Supported chiral liquid membrane for the separation of enantiomers |
DE69102508T2 (de) * | 1990-07-24 | 1995-01-19 | Shimadzu Corp | Stationäre Phase für die enantiomere Resolution in der Flüssigkeitschromatographie. |
US5254258A (en) * | 1991-09-17 | 1993-10-19 | Research Corporation Technologies, Inc. | Chiral selector useful for separation of enantiomers of β-amino alcohol compounds |
US5256293A (en) * | 1991-09-20 | 1993-10-26 | Research Corporation Technologies, Inc. | Separation of enantiomers of non-steroidal anti-inflammatory drugs and chiral selector therefor |
US5338529A (en) * | 1992-04-27 | 1994-08-16 | Research Corporation Technologies, Inc. | Recognition and separation of carbon clusters |
US5290440A (en) * | 1992-06-23 | 1994-03-01 | Research Corporation Technologies, Inc. | High performance chiral selector |
-
1992
- 1992-02-07 FR FR9201382A patent/FR2687154B1/fr not_active Expired - Lifetime
-
1993
- 1993-02-04 JP JP51382493A patent/JP3342012B2/ja not_active Expired - Lifetime
- 1993-02-04 EP EP93904153A patent/EP0625153B1/fr not_active Expired - Lifetime
- 1993-02-04 DE DE69300453T patent/DE69300453T2/de not_active Expired - Lifetime
- 1993-02-04 ES ES93904153T patent/ES2076838T3/es not_active Expired - Lifetime
- 1993-02-04 DK DK93904153.9T patent/DK0625153T3/da active
- 1993-02-04 WO PCT/FR1993/000113 patent/WO1993016074A1/fr active IP Right Grant
- 1993-02-04 CA CA002127374A patent/CA2127374C/fr not_active Expired - Lifetime
- 1993-02-04 AT AT93904153T patent/ATE127465T1/de active
-
1994
- 1994-08-05 US US08/286,294 patent/US5494915A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/476,749 patent/US5599936A/en not_active Expired - Lifetime
- 1995-09-13 GR GR950401005T patent/GR3017348T3/el unknown
-
1996
- 1996-09-11 US US08/712,282 patent/US5676831A/en not_active Expired - Fee Related
-
2002
- 2002-05-24 JP JP2002150221A patent/JP3507918B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2127374C (fr) | 2004-12-07 |
ES2076838T3 (es) | 1995-11-01 |
US5599936A (en) | 1997-02-04 |
DK0625153T3 (da) | 1995-10-16 |
DE69300453D1 (de) | 1995-10-12 |
ATE127465T1 (de) | 1995-09-15 |
FR2687154B1 (fr) | 1995-05-12 |
EP0625153A1 (fr) | 1994-11-23 |
JP2003048894A (ja) | 2003-02-21 |
EP0625153B1 (fr) | 1995-09-06 |
US5676831A (en) | 1997-10-14 |
FR2687154A1 (fr) | 1993-08-13 |
GR3017348T3 (en) | 1995-12-31 |
WO1993016074A1 (fr) | 1993-08-19 |
JP3342012B2 (ja) | 2002-11-05 |
JP3507918B2 (ja) | 2004-03-15 |
CA2127374A1 (fr) | 1993-08-19 |
US5494915A (en) | 1996-02-27 |
DE69300453T2 (de) | 1996-03-07 |
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