JPH07502255A - 抗ウイルス化合物類 - Google Patents
抗ウイルス化合物類Info
- Publication number
- JPH07502255A JPH07502255A JP4504396A JP50439692A JPH07502255A JP H07502255 A JPH07502255 A JP H07502255A JP 4504396 A JP4504396 A JP 4504396A JP 50439692 A JP50439692 A JP 50439692A JP H07502255 A JPH07502255 A JP H07502255A
- Authority
- JP
- Japan
- Prior art keywords
- formulas
- tables
- mathematical
- chemical
- chemical formulas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Description
Claims (5)
- 1.式 ▲数式、化学式、表等があります▼ 〔xは0又は1であり、 P1はQ又はBてあり、Bは ▲数式、化学式、表等があります▼ てあり、ただしBがp−ヒドロキシベンジル又はp−アルコキシベンジル以外で あることを条件とし、aは0又は1、2又は3であり、 bは0又は1であり、 cは0又は1、2、3、4又は5であり、dは1又は2であり、 eは0、1又は2てあり、 Qは▲数式、化学式、表等があります▼であり、P2はC1−6アルキル、シク ロベンチル、シクロヘキシル、ヒドロキシC1−6アルキレン又は▲数式、化学 式、表等があります▼であり、ここでTはH又はC(O)R4であり、Rは−C H2CHO、ヒドロキシC1−6アルキレン、C1−8アルコキシC1−6アル キレン、C1−6アルキル、フェニル、▲数式、化学式、表等があります▼又は Qであり、R1はベンジルオキシ、C1−8アルコキシ、C1−8アルキル、フ ェニル、ベンジル、フェネチル、フルオレニルメチレノキシ、2−インキノリニ ル、PDL、▲数式、化学式、表等があります▼、NHS02R4、H(R4) (ベンジル)、及びN(R4)(PDL)であり、ただしPDLは−(CH2) ■−2−、3−、又は4−ビリジル又はp−W−置換ベンジロキシであり、ここ でWはニトロ、OHアミノ、C1−6アルコキシ、又はヒドロキシC1−6アル キレン、又はハロゲノであり、 R3はC1−6アレニル、C1−6アルコキシ、C1−6アルコキシC1−6ア ルキレン、ヒドロキシC1−6アルキレン、C1−6アルキル、H又はOHであ り、 R4はH、C1−6アルキル、フェニル、又はベンジルであり、 R5はH、C1−6アルキル、OH、C1−6アルコキシ、▲数式、化学式、表 等があります▼ であり、ここでVはOR4又は ヒドロキシC1−6アルキレン、CH2Si(CH3)2(R3)、−(CH2 )d−O、PDL、−N−(CH2)2−O−⊂H2−OH2、▲数式、化学式 、表等があります▼、▲数式、化学式、表等があります▼、−(C1−6アルキ レン)−〇R4又は−CH(Y)(Z)であって、ここでYはヒドロキシC1− 6アルキレン、C1−6アルキル、又は(CH2)■−C6H4−(V)■であ り、ZはCHO、C02R4、CO2NHR4又は(CH2)■−OR4であり 、R6はR5に対し定義された通りであるが、但しR6はR5がHのときH以外 であり、そしてR5とR6はそれらが結合している窒素原子とともに以下の式の 複素環部分も形成し、 ▲数式、化学式、表等があります▼(a)、▲数式、化学式、表等があります( b)、▲数式、化学式、表等があります▼(c)▲数式、化学式、表等がありま す▼(d)▲数式、化学式、表等があります▼(e)▲数式、化学式、表等があ ります▼(f)又は▲数式、化学式、表等があります▼(g)、▲数式、化学式 、表等があります▼(h)、又は▲数式、化学式、表等があります▼(i)R7 はCH20R4又はC(O)NHR4であり、R8は(H,OH)又は=Oであ る〕の化合物及びその水和物、アイソスタ一類及び製藁上受け入れられる塩。
- 2.xが1である請求項1に記載の化合物。
- 3.P1がBである請求項1に記載の化合物。
- 4.P1がQである請求項1に記載の化合物。
- 5.xが1であり、R1がベンジルオキシ、▲数式、化学式、表等があります▼ (3−ビリジル)エチル、イソキノリル、4−アルコキシベンジルオキシ又はモ ルホリルであり、P2はイソプロピル、シクロベンチル、2−(4,4−ジフル オロ)ビロリジル、2−ヒドロキシ−2−プロピル、t−ブチルであり、P1は ビベロニル、4−(ベンジルオキシ)ベンジル、3−(ベンジルオキシ)ベンジ ル、(4−ベンジルオキシ−3−メトキシ)ベンジルであり、R5がHであると きはR6はベンジル、ビベロニル、−CH2−ビリジル、4−(ベンジルオキシ )ベンジル、モルホリノ、テトラヒドロイソキノリル、4−(3−ヒドロキシプ ロピル)ベンジル、2−(3−ヒドロキシプロピル)ベンジル、 ▲数式、化学式、表等があります▼(a)、▲数式、化学式、表等があります( b)、▲数式、化学式、表等があります▼(c)▲数式、化学式、表等がありま す▼(d)▲数式、化学式、表等があります▼(e)▲数式、化学式、表等があ ります▼(f)又は▲数式、化学式、表等があります▼(g)、▲数式、化学式 、表等があります▼(h)、▲数式、化学式、表等があります▼(i)又はR7 はCH20R4又はC(O)NHR4であり、R8は(H,OH)又は=Oであ る]の化合物、そのハイドレート、アイソスク一類及び製薬上受け入れられる塩 を製造する方法において、 式 ▲数式、化学式、表等があります▼ [式中R1、P2、P1、R5及びR6は上に定義の通りである]の化合物を使 用し、その化合物を酸化し、そして任意付加的に生じる酸化された化合物を製薬 上受け入れられるその塩に変換することもありうることからなる方法。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91400005 | 1991-01-02 | ||
EP91400005.4 | 1991-01-02 | ||
PCT/US1991/009741 WO1992012123A1 (en) | 1991-01-02 | 1991-12-20 | Anti-viral compounds |
US08/788,098 US5716973A (en) | 1991-01-02 | 1997-01-23 | Anti-viral compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH07502255A true JPH07502255A (ja) | 1995-03-09 |
JP3198416B2 JP3198416B2 (ja) | 2001-08-13 |
Family
ID=26129945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50439692A Expired - Lifetime JP3198416B2 (ja) | 1991-01-02 | 1991-12-20 | 抗ウイルス化合物類 |
Country Status (19)
Country | Link |
---|---|
US (1) | US5716973A (ja) |
EP (1) | EP0565631B1 (ja) |
JP (1) | JP3198416B2 (ja) |
AT (1) | ATE143025T1 (ja) |
AU (1) | AU649766B2 (ja) |
CA (1) | CA2098020C (ja) |
DE (1) | DE69122266T2 (ja) |
DK (1) | DK0565631T3 (ja) |
ES (1) | ES2094344T3 (ja) |
FI (1) | FI106466B (ja) |
GR (1) | GR3021988T3 (ja) |
HU (1) | HU210647B (ja) |
IE (1) | IE75381B1 (ja) |
IL (1) | IL100477A (ja) |
NO (1) | NO180334C (ja) |
NZ (1) | NZ241099A (ja) |
PT (1) | PT99961B (ja) |
WO (1) | WO1992012123A1 (ja) |
ZA (1) | ZA9110141B (ja) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5888992A (en) * | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
DE69333270T2 (de) | 1992-03-11 | 2004-08-05 | Narhex Ltd. | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
US6071895A (en) * | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
WO1993018006A1 (en) * | 1992-03-11 | 1993-09-16 | Narhex Limited | Amine derivatives of oxo- and hydroxy-substitued hydrocarbons |
US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
US5939430A (en) * | 1993-02-22 | 1999-08-17 | Merrell Pharmaceuticals Inc. | Combinations of retroviral inhibitors |
GB9303518D0 (en) * | 1993-02-22 | 1993-04-07 | Merrell Dow Pharma | Combinations of retroviral inhibitors |
AU680009B2 (en) * | 1993-07-08 | 1997-07-17 | Aventisub Ii Inc. | Difluoro statone analogs |
JPH09502437A (ja) * | 1993-09-09 | 1997-03-11 | メレルファーマスーティカルズ インコーポレイテッド | ジフルオロスタトン抗ウイルス類似体 |
IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
US5977074A (en) * | 1993-10-01 | 1999-11-02 | Merrell Pharmaceuticals, Inc. | Inhibitors of β-amyloid protein production |
DE69426574T2 (de) * | 1994-02-04 | 2001-08-09 | Merrell Pharma Inc | Makrocyclische difluorostatonderivate als antivirale mittel |
NZ288836A (en) * | 1994-07-15 | 1998-01-26 | Merrell Pharma Inc | Difluorostatone derivatives; used as antiviral agents |
US6114380A (en) * | 1995-12-18 | 2000-09-05 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
CN100344616C (zh) | 2001-06-12 | 2007-10-24 | 维尔斯达医疗公司 | 用于治疗代谢失调的化合物 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1171103A (en) * | 1966-03-24 | 1969-11-19 | Gas Council | Hydrogenation of Hydrocarbons. |
CH672792A5 (ja) * | 1985-02-19 | 1989-12-29 | Sandoz Ag | |
US5066643A (en) * | 1985-02-19 | 1991-11-19 | Sandoz Ltd. | Fluorine and chlorine statine or statone containing peptides and method of use |
EP0218688B1 (en) * | 1985-04-19 | 1990-09-12 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
GB8619182D0 (en) * | 1986-08-06 | 1986-09-17 | Sandoz Ltd | Peptides & derivatives |
NZ223148A (en) * | 1987-01-16 | 1989-10-27 | Merrell Dow Pharma | Peptide derivatives having peptidase inhibition activity |
FR2614533A1 (fr) * | 1987-04-23 | 1988-11-04 | Sandoz Sa | Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments |
GB2212158A (en) * | 1987-12-15 | 1989-07-19 | Sandoz Ltd | Trialkylsilymethyl-substituted peptides; renin inhibitors |
IL90872A0 (en) * | 1988-07-08 | 1990-02-09 | Smithkline Beckman Corp | Retroviral protease binding peptides |
HUT58764A (en) * | 1988-07-08 | 1992-03-30 | Smithkline Beckman Corp | Process for producing peptides, pharmaceutical compositions containing them and amino-acid intermediates |
CA2010531A1 (en) * | 1989-03-06 | 1990-09-06 | Werner Neidhart | Amino acid derivatives |
US5151438A (en) * | 1989-05-23 | 1992-09-29 | Abbott Laboratories | Retroviral protease inhibiting compounds |
KR100220876B1 (ko) * | 1991-01-02 | 1999-10-01 | 슈테펜엘.네스비트 | 항 바이러스 화합물 |
CZ229594A3 (en) * | 1992-03-25 | 1995-04-12 | Pfizer | Peptides, process of their preparation, their use and pharmaceutical compositions based thereon |
ATE199545T1 (de) * | 1992-05-21 | 2001-03-15 | Monsanto Co | Inhibitoren retroviraler proteasen |
-
1991
- 1991-12-20 NZ NZ241099A patent/NZ241099A/xx unknown
- 1991-12-20 DK DK92904336.2T patent/DK0565631T3/da active
- 1991-12-20 AU AU91790/91A patent/AU649766B2/en not_active Ceased
- 1991-12-20 JP JP50439692A patent/JP3198416B2/ja not_active Expired - Lifetime
- 1991-12-20 WO PCT/US1991/009741 patent/WO1992012123A1/en active IP Right Grant
- 1991-12-20 CA CA002098020A patent/CA2098020C/en not_active Expired - Fee Related
- 1991-12-20 HU HU9301918A patent/HU210647B/hu not_active IP Right Cessation
- 1991-12-20 DE DE69122266T patent/DE69122266T2/de not_active Expired - Lifetime
- 1991-12-20 EP EP92904336A patent/EP0565631B1/en not_active Expired - Lifetime
- 1991-12-20 AT AT92904336T patent/ATE143025T1/de not_active IP Right Cessation
- 1991-12-20 ES ES92904336T patent/ES2094344T3/es not_active Expired - Lifetime
- 1991-12-23 ZA ZA9110141A patent/ZA9110141B/xx unknown
- 1991-12-23 IL IL10047791A patent/IL100477A/en not_active IP Right Cessation
- 1991-12-31 IE IE458091A patent/IE75381B1/en not_active IP Right Cessation
- 1991-12-31 PT PT99961A patent/PT99961B/pt not_active IP Right Cessation
-
1993
- 1993-06-29 NO NO932377A patent/NO180334C/no not_active IP Right Cessation
- 1993-06-29 FI FI932997A patent/FI106466B/fi active
-
1996
- 1996-12-11 GR GR960403424T patent/GR3021988T3/el unknown
-
1997
- 1997-01-23 US US08/788,098 patent/US5716973A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1992012123A1 (en) | 1992-07-23 |
PT99961B (pt) | 1999-06-30 |
HU9301918D0 (en) | 1993-12-28 |
PT99961A (pt) | 1993-01-29 |
NZ241099A (en) | 1994-08-26 |
IE75381B1 (en) | 1997-09-10 |
NO932377D0 (no) | 1993-06-29 |
NO932377L (no) | 1993-06-29 |
DE69122266T2 (de) | 1997-03-27 |
HU210647B (en) | 1995-06-28 |
DE69122266D1 (de) | 1996-10-24 |
HUT65739A (en) | 1994-07-28 |
IE914580A1 (en) | 1992-07-15 |
NO180334C (no) | 1997-04-02 |
US5716973A (en) | 1998-02-10 |
CA2098020C (en) | 2003-10-21 |
ATE143025T1 (de) | 1996-10-15 |
EP0565631B1 (en) | 1996-09-18 |
EP0565631A1 (en) | 1993-10-20 |
ES2094344T3 (es) | 1997-01-16 |
FI932997A0 (fi) | 1993-06-29 |
IL100477A (en) | 1996-07-23 |
JP3198416B2 (ja) | 2001-08-13 |
NO180334B (no) | 1996-12-23 |
FI932997A (fi) | 1993-06-29 |
AU649766B2 (en) | 1994-06-02 |
DK0565631T3 (da) | 1996-10-07 |
AU9179091A (en) | 1992-08-17 |
GR3021988T3 (en) | 1997-03-31 |
CA2098020A1 (en) | 1992-07-03 |
ZA9110141B (en) | 1992-10-28 |
FI106466B (fi) | 2001-02-15 |
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