JPH04159218A - Gelatin capsule composition - Google Patents
Gelatin capsule compositionInfo
- Publication number
- JPH04159218A JPH04159218A JP2284979A JP28497990A JPH04159218A JP H04159218 A JPH04159218 A JP H04159218A JP 2284979 A JP2284979 A JP 2284979A JP 28497990 A JP28497990 A JP 28497990A JP H04159218 A JPH04159218 A JP H04159218A
- Authority
- JP
- Japan
- Prior art keywords
- gelatin
- capsules
- capsule
- capsule composition
- value
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007903 gelatin capsule Substances 0.000 title claims abstract description 14
- 239000000203 mixture Substances 0.000 title claims abstract description 11
- 108010010803 Gelatin Proteins 0.000 claims abstract description 22
- 229920000159 gelatin Polymers 0.000 claims abstract description 21
- 239000008273 gelatin Substances 0.000 claims abstract description 21
- 235000019322 gelatine Nutrition 0.000 claims abstract description 21
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 21
- 239000003906 humectant Substances 0.000 claims abstract description 6
- 239000002775 capsule Substances 0.000 abstract description 31
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract description 21
- 239000003814 drug Substances 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 5
- 239000002537 cosmetic Substances 0.000 abstract description 4
- 229920001223 polyethylene glycol Polymers 0.000 abstract description 4
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 abstract description 3
- 239000002202 Polyethylene glycol Substances 0.000 abstract description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 abstract description 2
- 238000002156 mixing Methods 0.000 abstract description 2
- 238000004321 preservation Methods 0.000 abstract description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 abstract 1
- 235000019437 butane-1,3-diol Nutrition 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 239000008399 tap water Substances 0.000 description 8
- 235000020679 tap water Nutrition 0.000 description 8
- 235000011187 glycerol Nutrition 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- -1 polyoxyethylene Polymers 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229910000679 solder Inorganic materials 0.000 description 3
- 239000001043 yellow dye Substances 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000007963 capsule composition Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 239000008118 PEG 6000 Substances 0.000 description 1
- 229920002538 Polyethylene Glycol 20000 Polymers 0.000 description 1
- 229920002556 Polyethylene Glycol 300 Polymers 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
Landscapes
- General Preparation And Processing Of Foods (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明はゼラチン１００部に対して、ＩＯＢ値が３．５
以下の保湿剤を１０〜２００部含有することを特徴とす
るゼラチンカプセル組成物に関し、さらに詳しくは高温
に放置しても容器と付着せず、カプセル同士が付着しな
いため安定性に優れ、しかも人体に対して安全なゼラチ
ンカプセル組成物に関するものであり、例えば医薬品、
医薬部外品、化粧品、食料品及び雑貨品等の分野で利用
されるものである。[Detailed Description of the Invention] [Industrial Application Field] The present invention has an IOB value of 3.5 for 100 parts of gelatin.
Regarding a gelatin capsule composition characterized by containing 10 to 200 parts of the following moisturizing agent, more specifically, it does not stick to the container even when left at high temperatures, has excellent stability because the capsules do not stick to each other, and has excellent stability in human body. The present invention relates to gelatin capsule compositions that are safe for pharmaceuticals,
It is used in fields such as quasi-drugs, cosmetics, foodstuffs, and miscellaneous goods.
通常、医薬品、医薬部外品、化粧品、食料品及び雑貨品
の分野では、中味の保存あるいは、使い易さの点で外側
を覆う剤皮として、ゼラチンカプセルが使用されている
。Gelatin capsules are usually used in the fields of pharmaceuticals, quasi-drugs, cosmetics, foodstuffs, and miscellaneous goods to preserve the contents and to cover the outside for ease of use.
これらのゼラチンカプセルの組成は、ゼラチンを主成分
として可塑剤にグリセリン及び水が加えられたもので、
加工、成形及び乾燥したものをゼラチンカプセル剤皮と
して使用されている。The composition of these gelatin capsules is gelatin as the main ingredient, with glycerin and water added to a plasticizer.
The processed, molded and dried product is used as a gelatin capsule shell.
この様なカプセル剤皮を医薬品、医薬部外品、化粧品、
食料品及び雑貨品に利用する場合、中味の保存、保持及
び使い易さは当然の事ながら、長期保存安定生に優れて
いる事が重要なファクターとなってくる。このため、上
記目的で使用されるカプセルは高い安定生、すなわち保
形安定性、容器とカプセルが付着しない事、カプセル同
志が付着とない事及びカプセルの溶解性が悪くならない
事等を合わせ持つ事が要求させる。Such capsule shells can be used for pharmaceuticals, quasi-drugs, cosmetics,
When used in foodstuffs and miscellaneous goods, the important factors are not only the preservation and retention of contents and ease of use, but also excellent long-term storage stability. Therefore, the capsules used for the above purpose must have high stability, that is, shape retention stability, the capsule does not stick to the container, the capsules do not stick to each other, and the solubility of the capsule does not deteriorate. makes demands.
しかしながら、従来のカプセル剤皮には上記の点を充分
に満たすものは知られていなかった。However, no conventional capsule shell has been known that fully satisfies the above points.
例えば、密封したガラス及びプラスチイックス容器にカ
プセルを入れて、高温に放置するとカプセル同志が付着
したり、カプセルと容器が付着して取れなくなってしま
うという問題点があった。For example, if a capsule is placed in a sealed glass or plastic container and left at a high temperature, the capsules may stick to each other or the capsule and the container may stick together and become difficult to remove.
本発明者らは、このような事情に鑑み、上記問題点が解
決出来ないものかと鋭意検討を行った結果、従来このよ
うなカプセル組成物に配合されていなかった保湿剤を含
有すると、高温に放置しても容器と付着しないカプセル
及びカプセル同志が付着しないカプセルが得られること
を見出し、本発明を完成するに至った。In view of these circumstances, the inventors of the present invention have conducted extensive studies to see if the above problems can be solved.As a result, if a moisturizing agent, which has not been conventionally incorporated in such capsule compositions, is contained, the capsule compositions may be exposed to high temperatures. The present inventors have discovered that it is possible to obtain capsules that do not stick to the container even when left standing, and capsules that do not stick to each other, and have completed the present invention.
すなわち、本発明は、ゼラチン１００部に対して、ＩＯ
Ｂ値が３．５以下の保湿剤を１０〜２００部含有するこ
とを特徴とするゼラチンカプセル組成物を提供するもの
である。That is, in the present invention, for 100 parts of gelatin, IO
The present invention provides a gelatin capsule composition containing 10 to 200 parts of a humectant having a B value of 3.5 or less.
以下、本発明の構成について詳述する。Hereinafter, the configuration of the present invention will be explained in detail.
本発明において使用される保湿剤は、ＪＯＢ値が３．５
以下のものである。The moisturizer used in the present invention has a JOB value of 3.5.
These are as follows.
本発明でいうＩ ＯＢ （ｉｎｏｒｇａｎｉｃ ｏｒｇ
ａｎｉｃ ｂａｌａｎｃｅ ）値とは、「化学の領域」
第１１巻、第１Ｏ号、第７１９頁〜第７２５頁、１９５
７年に示されている、藤田による計算方法に従い算出し
た、無機性及び有機性の値の比、すなわち、次式によっ
て表される数値である。IOB (inorganic org) referred to in the present invention
anic balance) value is the ``area of chemistry''
Volume 11, No. 1O, pages 719-725, 195
It is the ratio of the inorganic and organic values calculated according to the calculation method by Fujita shown in 1997, that is, the value expressed by the following formula.
１０Ｂ値＝Σ無機性／Σ有機性
本発明のこれら保湿剤としては、例えばプロピレングリ
コール、ポリエチレングリコール（以下ＰＥＧと略す）
、ジプロピレングリコール、１゜３ブチレングリコール
、多価アルコールのポリオキシエチレン（以下ＰＯＥと
略す）付加重合体、多価アルコールのポリオキシプロピ
レン（以下ＰＯＰと略す）付加重合体、ジグリコールの
ポリオキシエチレン及びポリオキシプロピレン付加重合
体、ポリオキシエチレンポリオキシプロピレン共重合体
で分子内のポリエキシエチレン基の割合が８：２〜２：
８のもの等が挙げられる。より具体的には、ＰＥＧ２０
０、ＰＥＧ３００、ＰＥＧ４００、ＰＥＧ ｌ ５００
、ＰＥＧ４０００、ＰＥＧ６０００、ＰＥＧ２００００
、プロピレングリコール（ＰＯ）２モル、グリセリン（
ＰＯ）３モル、ジグリコール（ＰＯ）１モル（ＰＯ）６
モル等が挙げられる。10B value=ΣInorganic/ΣOrganic These moisturizing agents of the present invention include, for example, propylene glycol and polyethylene glycol (hereinafter abbreviated as PEG).
, dipropylene glycol, 1゜3-butylene glycol, polyoxyethylene (hereinafter abbreviated as POE) addition polymer of polyhydric alcohol, polyoxypropylene (hereinafter abbreviated as POP) addition polymer of polyhydric alcohol, polyoxy of diglycol Ethylene and polyoxypropylene addition polymer, polyoxyethylene polyoxypropylene copolymer with a ratio of polyexyethylene groups in the molecule of 8:2 to 2:
Examples include 8. More specifically, PEG20
0, PEG300, PEG400, PEG l 500
, PEG4000, PEG6000, PEG20000
, 2 moles of propylene glycol (PO), glycerin (
PO) 3 mol, diglycol (PO) 1 mol (PO) 6
Examples include moles and the like.
配合量はいずれもゼラチン１００部に対して１０〜２０
０部である。１０部未満では効果に劣り、ゼラチンの可
塑性がなくなり、収縮性に欠は成型出来なくなる。また
２００部を超えるとゼラチンの粘度が低く成型出来なく
なる。The blending amount is 10 to 20 parts per 100 parts of gelatin.
It is 0 copies. If it is less than 10 parts, the effect will be poor, the gelatin will lose its plasticity, and the gelatin will lack shrinkage and will not be able to be molded. Moreover, if it exceeds 200 parts, the viscosity of the gelatin becomes low and it becomes impossible to mold it.
本発明のゼラチンカプセル組成物には上記した必須成分
の他に、水、グリセリン等地の保湿剤、色素、防腐剤、
紫外線吸収剤等通常ゼラチンカプセルに配合する成分を
効果を損なわない範囲で配合することができる。In addition to the above-mentioned essential ingredients, the gelatin capsule composition of the present invention contains water, a humectant such as glycerin, a pigment, a preservative,
Components that are usually included in gelatin capsules, such as ultraviolet absorbers, can be included within the range that does not impair the effectiveness.
本発明のゼラチンカプセル組成物は、高温に放置しても
容器と付着せず、カプセル同士が付着しないため安定性
に優れ、しかも人体に対して安全なものである。The gelatin capsule composition of the present invention does not stick to the container even when left at high temperatures, and the capsules do not stick to each other, so it has excellent stability and is safe for the human body.
次に、比較例および実施例に基づいて、さらに詳細に説
明する。本発明はこれらの実施例によって限定されるも
のではない。配合量は全て重量％である。Next, a more detailed explanation will be given based on comparative examples and examples. The present invention is not limited to these examples. All compounding amounts are weight %.
比較例、実施例はそれぞれ次のような製造方法にて得た
ものである。Comparative Examples and Examples were obtained using the following manufacturing methods.
〈製造方法〉
（イ）ゼラチンの溶解方法
ジャケット式の釜にゼラチン、保湿剤、水を仕込みジャ
ケットに熱湯を通して釜の温度を７０℃に加熱し、攪拌
しながらゼラチンを溶解した。その後、脱気して、温度
を下げて６０℃に保った。<Manufacturing method> (a) Method for dissolving gelatin Gelatin, a humectant, and water were placed in a jacket-type pot, and boiling water was poured into the jacket to heat the pot to 70° C., and the gelatin was dissolved while stirring. Thereafter, it was degassed and the temperature was lowered and maintained at 60°C.
（ロ）ゼラチンのシート化及びカプセル化溶解したゼラ
チンは、６０℃に保温し、１昼夜放置後、ローラー上で
シート化し、シートは、ロータリー式全自動ソフトカプ
セル成計機の円筒型成型ダイロールに供給し双方向から
の回転により、次つぎに成型され、同時にポンプによっ
て内容液が充填される。内容液が規定量に達すると同時
に成型も完了し、このとき接着に必要な温度は、形状セ
グメントにより、シートに与えられ、ダイロールの圧力
によってカプセルは接着される。ダイロールと充填ポン
プの動きは完全に連動し、内容液のロス、及びカプセル
内への空気の混入は皆無である。また充填ポンプの運転
精度は、充填内容量のバラツキ上３％以内で高収率が実
現出来る（ハ）内容液
内容液の代表としてスクワランを選びカプセル内に包接
した。(b) Formation and encapsulation of gelatin The melted gelatin is kept at 60°C, left for one day and night, and then formed into a sheet on a roller.The sheet is fed to a cylindrical molding die roll of a rotary fully automatic soft capsule forming machine. By rotating in both directions, the mold is molded one after the other, and at the same time, the liquid is filled by a pump. Molding is completed as soon as the content liquid reaches a specified amount. At this time, the temperature necessary for adhesion is applied to the sheet by the shaped segments, and the capsules are adhered by the pressure of the die roll. The movements of the die roll and filling pump are completely linked, and there is no loss of liquid content or air getting into the capsule. In addition, the operating accuracy of the filling pump is such that a high yield can be achieved within 3% due to variations in the filling content (c) Content liquid Squalane was selected as a representative of the content liquid and included in the capsule.
（ニ）カプセルの水分調整
（ロ）で得たカプセルは温度２２℃、湿度３０％の室に
放置し、カプセル皮膜の水分が３〜１２％になるまで乾
燥し、最終のサンプルを得た。(d) Capsule moisture adjustment The capsules obtained in (b) were left in a room at a temperature of 22° C. and a humidity of 30%, and dried until the moisture content of the capsule film became 3 to 12% to obtain a final sample.
比較例１
（１）ゼラチン ４０％（２
）グリセリン ２０％（３）水
道水 ４０％製造方法
（１）〜（３）を順番に釜に仕込み、前期製造方法（イ
）〜（ニ）に従い、カプセル化した。Comparative Example 1 (1) Gelatin 40% (2
) Glycerin 20% (3) Tap water 40% Production methods (1) to (3) were placed in a pot in order, and encapsulated according to the previous production methods (a) to (d).
比較例２
（１）ゼラチン ３０％（２
）グリセリン ３０％（３）水
道水 適 量（４）黄色色
素１号 ０．００１％（５）メチルパラ
ベン ０．１％（６）２−ヒドロキシ
−
４−メトキシベンゾフェノン ０．１％製造方法
（１１〜（６）を順番に釜に仕込み、前記製造方法（イ
）〜（ニ）に従い、カプセル化した。Comparative Example 2 (1) Gelatin 30% (2
) Glycerin 30% (3) Tap water appropriate amount (4) Yellow dye No. 1 0.001% (5) Methylparaben 0.1% (6) 2-Hydroxy-4-methoxybenzophenone 0.1% Manufacturing method (11- (6) were charged into a pot in order and encapsulated according to the manufacturing methods (a) to (d) above.
実施例１
（１）ゼラチン ４０％（２
）ＰＧ ２０％（３）
水道水 ４０％製造方法
（１）〜（３）を順番に釜に仕込み、前記製造方法（イ
）〜（ニ）に従い、カプセル化した。Example 1 (1) Gelatin 40% (2
)PG 20% (3)
Tap water 40% Production methods (1) to (3) were charged in order into a pot, and encapsulated according to the production methods (a) to (d).
実施例２
（１）ゼラチン ４０％（２
）１．３ブチレングリコール ４％（３）水
道水 適 量（４）黄色色
素１号 ０．００１％製造方法
（１）〜（４）を順番に釜に仕込み、前記製造方法（イ
）〜（ニ）に従い、カプセル化した。Example 2 (1) Gelatin 40% (2
) 1.3 Butylene glycol 4% (3) Tap water appropriate amount (4) Yellow dye No. 1 0.001% Production methods (1) to (4) were charged in order to a pot, and the above production methods (a) to ( d) was encapsulated.
実施例３
（１）ゼラチン ２５％（２
）ＤＰＧ ５０％（３
）水道水 適 量（４）黄
色色素１号 ０．００１％（５）メチル
パラベン ０．１％（６）紫外線吸収
剤 ０．１％製造方法
（１）〜（６）を順番に釜に仕込み、前記製造方法（イ
）〜（ニ）に従い、カプセル化した。Example 3 (1) Gelatin 25% (2
) DPG 50% (3
) Appropriate amount of tap water (4) Yellow dye No. 1 0.001% (5) Methyl paraben 0.1% (6) Ultraviolet absorber 0.1% Manufacturing method Place (1) to (6) in order in a pot. It was encapsulated according to the manufacturing methods (a) to (d) above.
実施例４
（１）ゼラチン ４０％（２
ＪＰＥＧ３００ ２０％（３）水
道水 ４０％製造方法
（１）〜（３）を順番に釜に仕込み、前記製造方法（イ
）〜（ニ）に従い、カプセル化した。Example 4 (1) Gelatin 40% (2
JPEG300 20% (3) Tap water 40% Production methods (1) to (3) were charged in order into a pot, and encapsulated according to the production methods (a) to (d).
実施例５
（１）ゼラチン ４０％（２
）グリセリン（ＰＯＰ３モル付加） ２０％（３）水
道水 ４０％製造方法
（１）〜（３）を順番に釜に仕込み、前記製造方法（イ
）〜（ニ）に従い、カプセル化した。Example 5 (1) Gelatin 40% (2
) Glycerin (addition of 3 moles of POP) 20% (3) Tap water 40% Production methods (1) to (3) were charged in order into a pot, and encapsulated according to the production methods (a) to (d).
実施例６
（１）ゼラチン ４０％（２
１ＰＯＥ／ＰＯＰ ： ６／４ ２
０％（３）水道水 ４０％
製造方法
（１）〜（３）を順番に釜に仕込み、前記製造方法（イ
）〜（ニ）に従い、カプセル化した。Example 6 (1) Gelatin 40% (2
1POE/POP: 6/4 2
0% (3) Tap water 40%
Manufacturing methods (1) to (3) were charged in order into a pot, and encapsulated according to the manufacturing methods (a) to (d).
上記の比較例および実施例で得た試料の評価は（１１カ
プセルの形状安定性、（２）カプセルとガラスおよびプ
ラスチイックス容器のと付着、（３）カプセル同志の付
着について以下の評価方法で評価した。The samples obtained in the comparative examples and examples above were evaluated using the following evaluation methods: (11) shape stability of capsules, (2) adhesion of capsules to glass and plastic containers, and (3) adhesion of capsules to each other. did.
結果を表−１に示す。The results are shown in Table-1.
カプセルの形 安定性
試料を０℃、２５℃および４０℃の温度に一カ月間放置
し、カプセルの形状について肉眼で観察した。評点は以
下の評価基準に従い行った。Capsule Shape Stability samples were left at temperatures of 0°C, 25°C and 40°C for one month and the capsule shapes were visually observed. Ratings were made according to the following evaluation criteria.
１：全く変化なし。1: No change at all.
２：はんの僅か変形が見られる。2: Slight deformation of solder is observed.
３：僅か変形が見られる。3: Slight deformation is observed.
４；かなり変形が見られる。4; Significant deformation is observed.
５；形がくずれている。5; The shape is distorted.
カプセルと容器との・
試料を０℃、２５℃および４０℃の温度に一カ月間放置
し、カプセルとガラス容器およびプラスチイックス容器
との付着度合いについて官能で評価した。評点は以下の
評価基準に従い行った。Between the capsule and the container The samples were left at temperatures of 0°C, 25°C and 40°C for one month, and the degree of adhesion between the capsule and the glass container and the plastics container was sensory evaluated. Ratings were made according to the following evaluation criteria.
１：全く付着しない。1: No adhesion at all.
２：はんの僅か付着が見られる。2: Slight adhesion of solder is observed.
３：僅か付着が見られる。3: Slight adhesion is observed.
４：かなり付着が見られる。4: Considerable adhesion is observed.
５：付着してとれない。5: It sticks and cannot be removed.
カプセル６志の・
試料を０℃、２５℃および４０℃の温度に一カ月間放置
し、カプセル同志の付着度合いについてて官能で評価し
た。評点は以下の評価基準に従い行った。Samples of six capsules were left at temperatures of 0°C, 25°C, and 40°C for one month, and the degree of adhesion of the capsules to each other was sensory evaluated. Ratings were made according to the following evaluation criteria.
ｌ：全く付着しない。l: No adhesion at all.
２：はんの僅か付着が見られる。2: Slight adhesion of solder is observed.
３：僅か付着が見られる。3: Slight adhesion is observed.
４：かなり付着が見られる。4: Considerable adhesion is observed.
５：付着してとれない。5: It sticks and cannot be removed.
表−１
表−１から明らかなように本発明のゼラチンカプセル組
成物は、形くずれが少なく、保存する容器と付着しにく
く、またカプセル同志も付着しにくいため長期間、色々
な容器に保存しても容易にカプセルを取り出すことがで
きる。Table 1 As is clear from Table 1, the gelatin capsule composition of the present invention does not easily lose its shape, does not easily stick to the container in which it is stored, and does not easily stick to other capsules, so it can be stored in various containers for a long period of time. Capsules can be easily taken out.
Claims (1)
下の保湿剤を１０〜２００部含有することを特徴とする
ゼラチンカプセル組成物。(1) A gelatin capsule composition containing 10 to 200 parts of a humectant having an IOB value of 3.5 or less per 100 parts of gelatin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2284979A JPH04159218A (en) | 1990-10-23 | 1990-10-23 | Gelatin capsule composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2284979A JPH04159218A (en) | 1990-10-23 | 1990-10-23 | Gelatin capsule composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04159218A true JPH04159218A (en) | 1992-06-02 |
Family
ID=17685562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2284979A Pending JPH04159218A (en) | 1990-10-23 | 1990-10-23 | Gelatin capsule composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH04159218A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5419916A (en) * | 1992-08-27 | 1995-05-30 | Japan Elanco Company, Limited | Gelatin coating composition and hard gelatin capsule |
| KR100388368B1 (en) * | 1994-12-30 | 2003-09-19 | 지보댕-루르 (엥떼르나시오날) 세아 | Method for encapsulating food or flavor particles using hot fish gelatin and capsules prepared therefrom |
-
1990
- 1990-10-23 JP JP2284979A patent/JPH04159218A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5419916A (en) * | 1992-08-27 | 1995-05-30 | Japan Elanco Company, Limited | Gelatin coating composition and hard gelatin capsule |
| KR100388368B1 (en) * | 1994-12-30 | 2003-09-19 | 지보댕-루르 (엥떼르나시오날) 세아 | Method for encapsulating food or flavor particles using hot fish gelatin and capsules prepared therefrom |
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