JPH0141316B2 - - Google Patents

Info

Publication number: JPH0141316B2
Authority: JP; Japan
Prior art keywords: acid; amino; glycine; bacterial cells; glutamyl
Prior art date: 1982-02-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP57016699A

Other languages

English (en)

Japanese (ja)

Other versions

JPS58134997A (ja

Inventor

Hidehiko Kumagai

Tatsurokuro Tochikura

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ajinomoto Co Inc

Original Assignee

Ajinomoto Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-02-04

Filing date

1982-02-04

Publication date

1989-09-05

1982-02-04 Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc

1982-02-04 Priority to JP57016699A priority Critical patent/JPS58134997A/ja

1983-08-11 Publication of JPS58134997A publication Critical patent/JPS58134997A/ja

1989-09-05 Publication of JPH0141316B2 publication Critical patent/JPH0141316B2/ja

Status Granted legal-status Critical Current

Links

JCMUOFQHZLPHQP-BQBZGAKWSA-N ophthalmic acid Chemical compound OC(=O)CNC(=O)[C@H](CC)NC(=O)CC[C@H](N)C(O)=O JCMUOFQHZLPHQP-BQBZGAKWSA-N 0.000 claims description 16
108010036164 Glutathione synthase Proteins 0.000 claims description 11
102100034294 Glutathione synthetase Human genes 0.000 claims description 11
239000007864 aqueous solution Substances 0.000 claims description 5
238000004519 manufacturing process Methods 0.000 claims description 5
FTKCTBKQLUYKAC-ZBHICJROSA-N (6s)-2,6-diamino-5-oxononanedioic acid Chemical compound OC(=O)C(N)CCC(=O)[C@@H](N)CCC(O)=O FTKCTBKQLUYKAC-ZBHICJROSA-N 0.000 claims description 3
210000004027 cell Anatomy 0.000 description 16
230000001580 bacterial effect Effects 0.000 description 14
JCMUOFQHZLPHQP-UHFFFAOYSA-N L-L-Ophthalmic acid Natural products OC(=O)CNC(=O)C(CC)NC(=O)CCC(N)C(O)=O JCMUOFQHZLPHQP-UHFFFAOYSA-N 0.000 description 13
108010088490 ophthalmic acid Proteins 0.000 description 13
HVVLQPOCRDLFGA-UHFFFAOYSA-N ophthalmic acid Natural products CCC(NC(=O)C(N)CCC(=O)O)C(=O)NCC(=O)O HVVLQPOCRDLFGA-UHFFFAOYSA-N 0.000 description 13
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 12
239000000243 solution Substances 0.000 description 12
102000004190 Enzymes Human genes 0.000 description 9
108090000790 Enzymes Proteins 0.000 description 9
239000004471 Glycine Substances 0.000 description 7
229940088598 enzyme Drugs 0.000 description 6
238000000034 method Methods 0.000 description 6
239000000284 extract Substances 0.000 description 5
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 4
229910052921 ammonium sulfate Inorganic materials 0.000 description 4
235000011130 ammonium sulphate Nutrition 0.000 description 4
238000005119 centrifugation Methods 0.000 description 4
230000000694 effects Effects 0.000 description 4
238000005194 fractionation Methods 0.000 description 4
239000000203 mixture Substances 0.000 description 4
239000008363 phosphate buffer Substances 0.000 description 4
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
230000000813 microbial effect Effects 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
239000000047 product Substances 0.000 description 3
241000588986 Alcaligenes Species 0.000 description 2
241000222120 Candida <Saccharomycetales> Species 0.000 description 2
241000196324 Embryophyta Species 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 2
108090000364 Ligases Proteins 0.000 description 2
102000003960 Ligases Human genes 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
241000254275 Mucoa Species 0.000 description 2
241000228143 Penicillium Species 0.000 description 2
239000001888 Peptone Substances 0.000 description 2
108010080698 Peptones Proteins 0.000 description 2
241000235648 Pichia Species 0.000 description 2
102000007327 Protamines Human genes 0.000 description 2
108010007568 Protamines Proteins 0.000 description 2
241000588770 Proteus mirabilis Species 0.000 description 2
241000235527 Rhizopus Species 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
241000187747 Streptomyces Species 0.000 description 2
JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
229940024606 amino acid Drugs 0.000 description 2
235000001014 amino acid Nutrition 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
238000004440 column chromatography Methods 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
239000008103 glucose Substances 0.000 description 2
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
210000004185 liver Anatomy 0.000 description 2
229910001629 magnesium chloride Inorganic materials 0.000 description 2
238000005259 measurement Methods 0.000 description 2
235000019319 peptone Nutrition 0.000 description 2
239000011347 resin Substances 0.000 description 2
229920005989 resin Polymers 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
235000019157 thiamine Nutrition 0.000 description 2
KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 2
229960003495 thiamine Drugs 0.000 description 2
239000011721 thiamine Substances 0.000 description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
241000186361 Actinobacteria <class> Species 0.000 description 1
241000589158 Agrobacterium Species 0.000 description 1
241000589155 Agrobacterium tumefaciens Species 0.000 description 1
241000186063 Arthrobacter Species 0.000 description 1
241000228212 Aspergillus Species 0.000 description 1
240000006439 Aspergillus oryzae Species 0.000 description 1
235000002247 Aspergillus oryzae Nutrition 0.000 description 1
241000193830 Bacillus <bacterium> Species 0.000 description 1
244000063299 Bacillus subtilis Species 0.000 description 1
235000014469 Bacillus subtilis Nutrition 0.000 description 1
241000722885 Brettanomyces Species 0.000 description 1
241000193764 Brevibacillus brevis Species 0.000 description 1
241000186146 Brevibacterium Species 0.000 description 1
YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
241000272201 Columbiformes Species 0.000 description 1
241000186216 Corynebacterium Species 0.000 description 1
241000186145 Corynebacterium ammoniagenes Species 0.000 description 1
GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
241000178951 Endomyces Species 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
108010024636 Glutathione Proteins 0.000 description 1
239000007836 KH2PO4 Substances 0.000 description 1
241000588915 Klebsiella aerogenes Species 0.000 description 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
229930064664 L-arginine Natural products 0.000 description 1
235000014852 L-arginine Nutrition 0.000 description 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
239000004395 L-leucine Substances 0.000 description 1
235000019454 L-leucine Nutrition 0.000 description 1
229930182821 L-proline Natural products 0.000 description 1
241000192041 Micrococcus Species 0.000 description 1
102000016943 Muramidase Human genes 0.000 description 1
108010014251 Muramidase Proteins 0.000 description 1
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
241000221960 Neurospora Species 0.000 description 1
241000588912 Pantoea agglomerans Species 0.000 description 1
244000046052 Phaseolus vulgaris Species 0.000 description 1
235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
241000203720 Pimelobacter simplex Species 0.000 description 1
101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
241000588769 Proteus <enterobacteria> Species 0.000 description 1
241000588767 Proteus vulgaris Species 0.000 description 1
241000589516 Pseudomonas Species 0.000 description 1
241000589517 Pseudomonas aeruginosa Species 0.000 description 1
241000158504 Rhodococcus hoagii Species 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
241000191940 Staphylococcus Species 0.000 description 1
241000191967 Staphylococcus aureus Species 0.000 description 1
239000004473 Threonine Substances 0.000 description 1
241000209140 Triticum Species 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical compound CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
YEESUBCSWGVPCE-UHFFFAOYSA-N azanylidyneoxidanium iron(2+) pentacyanide Chemical compound [Fe++].[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+] YEESUBCSWGVPCE-UHFFFAOYSA-N 0.000 description 1
210000005252 bulbus oculi Anatomy 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
229960002303 citric acid monohydrate Drugs 0.000 description 1
238000004737 colorimetric analysis Methods 0.000 description 1
239000013078 crystal Substances 0.000 description 1
239000012531 culture fluid Substances 0.000 description 1
229940079919 digestives enzyme preparation Drugs 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940092559 enterobacter aerogenes Drugs 0.000 description 1
210000001508 eye Anatomy 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000012634 fragment Substances 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
235000013922 glutamic acid Nutrition 0.000 description 1
229960003180 glutathione Drugs 0.000 description 1
229960002885 histidine Drugs 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
238000002955 isolation Methods 0.000 description 1
229960003136 leucine Drugs 0.000 description 1
238000004811 liquid chromatography Methods 0.000 description 1
229960000274 lysozyme Drugs 0.000 description 1
235000010335 lysozyme Nutrition 0.000 description 1
239000004325 lysozyme Substances 0.000 description 1
238000009629 microbiological culture Methods 0.000 description 1
244000005700 microbiome Species 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
229960002460 nitroprusside Drugs 0.000 description 1
102000039446 nucleic acids Human genes 0.000 description 1
108020004707 nucleic acids Proteins 0.000 description 1
150000007523 nucleic acids Chemical class 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
229960002429 proline Drugs 0.000 description 1
229940048914 protamine Drugs 0.000 description 1
229950008679 protamine sulfate Drugs 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
229940007042 proteus vulgaris Drugs 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000011002 quantification Methods 0.000 description 1
239000002994 raw material Substances 0.000 description 1
238000011160 research Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
HPQYKCJIWQFJMS-UHFFFAOYSA-L tetrathionate(2-) Chemical compound [O-]S(=O)(=O)SSS([O-])(=O)=O HPQYKCJIWQFJMS-UHFFFAOYSA-L 0.000 description 1
238000010257 thawing Methods 0.000 description 1
229960002898 threonine Drugs 0.000 description 1
238000011282 treatment Methods 0.000 description 1
238000002525 ultrasonication Methods 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Classifications

- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

JP57016699A 1982-02-04 1982-02-04 γ−グルタミル−α−アミノ−ｎ−ブチリル−グリシンの製造法 Granted JPS58134997A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP57016699A JPS58134997A (ja)	1982-02-04	1982-02-04	γ−グルタミル−α−アミノ−ｎ−ブチリル−グリシンの製造法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP57016699A JPS58134997A (ja)	1982-02-04	1982-02-04	γ−グルタミル−α−アミノ−ｎ−ブチリル−グリシンの製造法

Publications (2)

Publication Number	Publication Date
JPS58134997A JPS58134997A (ja)	1983-08-11
JPH0141316B2 true JPH0141316B2 (es)	1989-09-05

Family

ID=11923532

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP57016699A Granted JPS58134997A (ja)	1982-02-04	1982-02-04	γ−グルタミル−α−アミノ−ｎ−ブチリル−グリシンの製造法

Country Status (1)

Country	Link
JP (1)	JPS58134997A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007055388A2 (en) *	2005-11-09	2007-05-18	Ajinomoto Co., Inc.	Calcium receptor activator

1982
- 1982-02-04 JP JP57016699A patent/JPS58134997A/ja active Granted

Also Published As

Publication number	Publication date
JPS58134997A (ja)	1983-08-11

Publication	Publication Date	Title
Asthana et al.	2003	Microbial L-asparaginase: A potent antitumour enzyme
D'Cunha et al.	1996	Purification of phenylalanine ammonia lyase from Rhodotorula glutinis
DE69922301T2 (de)	2005-12-01	D-aminoacylasen aus Pilzen und Verfahren zur Herstellung von D-Aminosäuren
Volcani et al.	1957	A new species (Flavobacterium polyglutamicum) which hydrolyzes the γ-L-glutamyl bond in polypeptides
Warangkar et al.	2009	Screening, enrichment and media optimization for L-asparaginase production
Tsuchiya et al.	2003	Purification and characterization of glutamate decarboxylase from Aspergillus oryzae
JPH0141316B2 (es)	1989-09-05
JP3976941B2 (ja)	2007-09-19	ビタミンｂ６の酵素的製造
US4904593A (en)	1990-02-27	Novel microorganism, a novel esterase and method for preparing the same
JP2640958B2 (ja)	1997-08-13	ヒドロキサム酸加水分解酵素
JPH0141315B2 (es)	1989-09-05
US4207395A (en)	1980-06-10	Process for deacylating N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carboxylic acids
Toyama et al.	1973	Occurrence of taurine-pyruvate aminotransferase in bacterial extract
JP3093039B2 (ja)	2000-10-03	新規エステル分解酵素ａおよびその製造方法
US3345269A (en)	1967-10-03	Process for the production of proteolytic enzymes
JPS5854797B2 (ja)	1983-12-06	γ−Ｌ−グルタミル−４−ヒドロキシアニリドの製造法
JPH0144316B2 (es)	1989-09-27
JPS6210158B2 (es)	1987-03-04
JP3685814B2 (ja)	2005-08-24	アミノペプチダーゼおよびその生産方法
JPS6251600B2 (es)	1987-10-30
JP2597849B2 (ja)	1997-04-09	リゾチーム阻害物質
JP2873936B2 (ja)	1999-03-24	低温活性プロテアーゼ及びその製法
JPS6319158B2 (es)	1988-04-21
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