JP7460795B2 - 頭皮活性物質堆積を増強するための方法 - Google Patents
頭皮活性物質堆積を増強するための方法 Download PDFInfo
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- JP7460795B2 JP7460795B2 JP2022562006A JP2022562006A JP7460795B2 JP 7460795 B2 JP7460795 B2 JP 7460795B2 JP 2022562006 A JP2022562006 A JP 2022562006A JP 2022562006 A JP2022562006 A JP 2022562006A JP 7460795 B2 JP7460795 B2 JP 7460795B2
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- personal care
- care composition
- cationic
- polymer
- sodium
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- 229920006317 cationic polymer Polymers 0.000 claims description 70
- 229920006318 anionic polymer Polymers 0.000 claims description 41
- 239000004094 surface-active agent Substances 0.000 claims description 39
- 238000004519 manufacturing process Methods 0.000 claims description 38
- 239000011734 sodium Substances 0.000 claims description 38
- 229910052708 sodium Inorganic materials 0.000 claims description 38
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 37
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 32
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- 239000011701 zinc Substances 0.000 claims description 19
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 17
- 229910052725 zinc Inorganic materials 0.000 claims description 17
- 125000000129 anionic group Chemical group 0.000 claims description 15
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- NJSSICCENMLTKO-HRCBOCMUSA-N [(1r,2s,4r,5r)-3-hydroxy-4-(4-methylphenyl)sulfonyloxy-6,8-dioxabicyclo[3.2.1]octan-2-yl] 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)O[C@H]1C(O)[C@@H](OS(=O)(=O)C=2C=CC(C)=CC=2)[C@@H]2OC[C@H]1O2 NJSSICCENMLTKO-HRCBOCMUSA-N 0.000 claims description 6
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- 239000002888 zwitterionic surfactant Substances 0.000 claims description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 5
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- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 claims description 5
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- 239000011593 sulfur Substances 0.000 claims description 5
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- 239000005730 Azoxystrobin Substances 0.000 claims description 3
- 229920000691 Poly[bis(2-chloroethyl) ether-alt-1,3-bis[3-(dimethylamino)propyl]urea] Polymers 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 125000005250 alkyl acrylate group Chemical group 0.000 claims description 3
- WFDXOXNFNRHQEC-GHRIWEEISA-N azoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1OC1=CC(OC=2C(=CC=CC=2)C#N)=NC=N1 WFDXOXNFNRHQEC-GHRIWEEISA-N 0.000 claims description 3
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- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 3
- UZNHKBFIBYXPDV-UHFFFAOYSA-N trimethyl-[3-(2-methylprop-2-enoylamino)propyl]azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)NCCC[N+](C)(C)C UZNHKBFIBYXPDV-UHFFFAOYSA-N 0.000 claims description 3
- 229920005552 sodium lignosulfonate Polymers 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 description 101
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- 235000019698 starch Nutrition 0.000 description 28
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 description 27
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- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 22
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- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 17
- 229920003118 cationic copolymer Polymers 0.000 description 16
- 239000000047 product Substances 0.000 description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 15
- 239000002253 acid Chemical class 0.000 description 15
- 229930182830 galactose Natural products 0.000 description 15
- 239000004368 Modified starch Substances 0.000 description 14
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 14
- 150000002148 esters Chemical class 0.000 description 13
- 150000003839 salts Chemical class 0.000 description 13
- 150000001298 alcohols Chemical class 0.000 description 12
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 12
- 239000003995 emulsifying agent Substances 0.000 description 12
- 238000009472 formulation Methods 0.000 description 12
- 159000000001 potassium salts Chemical class 0.000 description 12
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 10
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 8
- 150000007513 acids Chemical class 0.000 description 8
- 150000008051 alkyl sulfates Chemical class 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 239000008365 aqueous carrier Substances 0.000 description 8
- 239000002585 base Substances 0.000 description 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 8
- YBBJKCMMCRQZMA-UHFFFAOYSA-N pyrithione Chemical class ON1C=CC=CC1=S YBBJKCMMCRQZMA-UHFFFAOYSA-N 0.000 description 8
- 239000006254 rheological additive Substances 0.000 description 8
- 238000006467 substitution reaction Methods 0.000 description 8
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 7
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 description 7
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 description 7
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- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 6
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- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 6
- 125000003545 alkoxy group Chemical group 0.000 description 6
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- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 6
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- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 239000012905 visible particle Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 239000003878 whitfield ointment Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- MQWLIFWNJWLDCI-UHFFFAOYSA-L zinc;carbonate;hydrate Chemical compound O.[Zn+2].[O-]C([O-])=O MQWLIFWNJWLDCI-UHFFFAOYSA-L 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
- A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
- A61K2800/5424—Polymers characterized by specific structures/properties characterized by the charge anionic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
- A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
- A61K2800/5426—Polymers characterized by specific structures/properties characterized by the charge cationic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/58—Metal complex; Coordination compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Description
本発明は、微粒子頭皮活性物質であり得、更に抗フケ活性物質であり得る、頭皮活性物質を含み得る。更に、粒子状頭皮活性物質は、粒子状抗フケ活性物質であり得、この群には、ピリジンチオン塩、炭酸亜鉛、硫化セレン、粒子状硫黄、アゾキシストロビンなどのストロビルリン、及びそれらの混合物が含まれ得る。頭皮活性物質微粒子/抗フケ微粒子は、ピリジンチオン塩であり得る。このような抗フケ微粒子は、組成物の構成成分と物理的及び化学的に適合している必要があり、過度に製品の安定性、審美性又は性能を過度に損なわないものである必要がある。
パーソナルケア組成物は、組成物に洗浄性能を提供する約10重量%超の界面活性剤系を含み得、組成物に洗浄性能を提供する約12重量%超の界面活性剤系であり得る。界面活性剤系は、アニオン性界面活性剤、並びに/又はアニオン性界面活性剤の組み合わせ、並びに/又はアニオン性界面活性剤と両性、双性イオン性、非イオン性及びこれらの混合物からなる群から選択される共界面活性剤との組み合わせを含む。洗浄性界面活性剤の様々な例及び説明が、米国特許第8,440,605号、米国特許出願公開第2009/155383号、及び米国特許出願公開第2009/0221463号に記載されており、これらの全体が参照により本明細書に組み込まれる。
a)R1O(CH2CHR3O)ySO3M、
b)CH3(CH2)zCHR2CH2O(CH2CHR3O)ySO3M、及び
c)これらの混合物
[式中、R1は、CH3(CH2)10を表し、R2は、H、又はz及びR2における炭素原子の合計が8となるように1~4個の炭素原子を含む炭化水素基を表し、R3は、H又はCH3であり、yは0~7であり、yがゼロ(0)でないときyの平均値は約1であり、Mは、一価又は二価の正電荷カチオンである]からなる群から選択されるアニオン性界面活性剤を含んでよい。
本発明の組成物は、アニオン性ポリマーを更に含有し得る。アニオン性ポリマーは、頭皮活性物質の懸濁を改善すること、頭皮活性物質の堆積を改善すること、及び/又はパーソナルケア製剤の安定性を改善することを考慮して、約0.0005%~約0.5%、約0.002%~約0.30%、約0.01%~約0.2%の組成物の重量レベルで使用することができる。
本発明の組成物は、抗フケ活性物質粒子の表面上のアニオン性ポリマーと強く結合するように、3~10meq/グラム、4~8meq/グラム、5~7meq/グラムの電荷密度を有する、高電荷密度カチオン性ポリマーを含む。カチオン性ポリマーは、天然又は合成であり得、単一のモノマーから重合されるか、又はコポリマーとして合成され得る。カチオン性ポリマーは、ポリクオタニウム-6、すなわち、Solvayによって商品名Mirapol 100で、及びLubrizolによって商品名Merquat 100で製造された、6.2meq/gの電荷密度を有する、ジアリルジメチルアンモニウムクロリドのホモポリマーであり得る。他の好適なカチオン性ポリマーとしては、ポリクオタニウム-2(Solvay、商品名Mirapol A-15、6.6meq/g)、ポリクオタニウム-16(BASF、商品名Luviquat FC-905、6.1meq/g)、ポリクオタニウム-17(Solvay、商品名Mirapol AD-1、4.4meq/g)、ポリクオタニウム-22(Lubrizol、商品名Merquat 280(5.0meq/g)及びMerquat 295(6.1meq/g))、ポリクオタニウム-42(Buckman Labs、商品名Busan 1507、7.8meq/g)、及びポリMAPTAC(メタクリルアミドプロピルトリメチルアンモニウムクロリドのポリマー、Solvay、商品名Polycare 133、4.5meq/g)が挙げられる。
ヘアケア組成物はまた、活性物質堆積とは独立したコンディショニングを達成するために、低電荷密度ポリマーを含み得る。これらのカチオン性ポリマーは、(a)カチオン性グアーポリマー、(b)カチオン性非グアーガラクトマンナンポリマー、(c)カチオン性タピオカポリマー、(d)アクリルアミドモノマーとカチオン性モノマーとのカチオン性コポリマー、及び/又は(e)洗浄性界面活性剤と組み合わせた際にリオトロピック液晶を形成してもしなくてもよい、合成非架橋カチオン性ポリマー、(f)カチオン性セルロースポリマー、のうちの少なくとも1つを含み得る。更に、カチオン性ポリマーは、カチオン性ポリマーの混合物であってもよい。
(i)次式AMのアクリルアミドモノマー:
(ii)次式CMに適合するカチオン性モノマー:
ヘアケア組成物は、
i)1つ以上のカチオン性モノマー単位、及び任意に、
ii)負電荷を有する1つ以上のモノマー単位、及び/又は
iii)非イオン性モノマー、から形成される合成ポリマーであり得る。
ここで、コポリマーのその後の電荷は正電荷である。これらの3種のモノマーの比は「m」、「p」及び「q」で表され、「m」は、カチオン性モノマーの数であり、「p」は、負電荷を有するモノマーの数であり、「q」は、非イオン性モノマーの数である。
Yは、C1~C22アルキル、アルコキシ、アルキリデン、アルキル、又はアリールオキシであり、
Ψは、C1~C22アルキル、アルキルオキシ、アルキルアリール又はアルキルアリールオキシであり.
Zは、C1~C22アルキル、アルキルオキシ、アリール又はアリールオキシであり、
R1は、H、C1~C4の直鎖又は分枝鎖アルキルであり、
sは、0又は1であり、nは、0又は≧31であり、
T及びR7は、C1~C22アルキルであり、
X-は、ハロゲン、ヒドロキシド、アルコキシド、サルフェート又はアルキルサルフェートである。
パーソナルケア組成物は、水性担体を含む。したがって、パーソナルケア組成物の配合物は、注入可能な液状形態とすることができる(周囲条件下)。そのため、このような組成物は、典型的に、水性担体を含むが、これは、約20重量%~約95重量%、又は約60重量%~約85重量%のレベルで存在する。この水性キャリアは、水、又は水と有機溶媒との混和性混合物を含んでもよく、一態様では、特に他の構成成分の微量成分として組成物中に偶発的に組み込まれる場合を除き、最小限の有機溶媒を有するか、又は有意な濃度の有機溶媒を有していない水を含んでもよい。
パーソナルケア組成物がゲルマトリックスを含まない場合、乳化剤を使用することができ、材料をパーソナルケア組成物中に添加する前に予備乳化することができる。各コンディショニング活性物質についての乳化剤の選択は、乳化剤の親水性-親油性-バランス値(HLB値)が指針となる。好適なHLB値の範囲は、6~16であり、8~14のHLB値である。10超のHLBを有する乳化剤は、水溶性である。低いHLBを有する乳化剤は、脂溶性である。好適なHLB値を得るために、2つ以上の乳化剤の混合物を使用してもよい。好適な乳化剤としては、非イオン性、カチオン性、アニオン性及び両性の乳化剤が挙げられる。
上記のパーソナルケア組成物はまた、より良好な感触、使用時の特性、及び組成物の懸濁安定性のために組成物のレオロジー特徴を調節する、1種以上のレオロジー変性剤/増粘剤を含有してもよい。例えば、組成物が保管及び輸送中に均質のままであるように、及び使用中に身体の他の領域、衣類又は家具に滴るという望ましくない状態が生じないように、レオロジー特性が調節される。任意の好適なレオロジー変性剤を使用することができる。更に、リーブオントリートメントは、約0.01%~約3%のレオロジー変性剤、代替として、約0.1%~約1%のレオロジー変性剤を含んでもよい。
上記のパーソナルケア組成物はまた、1つ以上のpH調整物質を含んでもよい。パーソナルケア組成物は、25℃で約2~約10の範囲のpHを有し得る。パーソナルケア組成物は、約2~約6、あるいは約3.5~約5、あるいは約5.25~約7の範囲のpHを有し得る。
本明細書に記載のパーソナルケア組成物は、任意選択で、ヘアケア又はパーソナルケア製品で使用することが知られている1つ以上の追加成分を含んでいてもよいが、ただし、追加成分が、本明細書に記載の必須成分と物理的及び化学的に適合するか、又は製品の安定性、審美性、若しくは性能を過度に損なわない場合に限る。このような追加成分は、最も典型的には、CTFA Cosmetic Ingredient Handbook,Second Edition,The Cosmetic,Toiletries,and Fragrance Association,Inc.1988,1992などの参考文献に記載されているものである。このような追加成分の個々の濃度は、パーソナルケア組成物の約0.001重量%~約10重量%の範囲であり得る。
パーソナルケア組成物は、1種以上のコンディショニング剤を含んでもよい。コンディショニング剤としては、毛髪に特定のコンディショニング効果を与えるために使用される物質が挙げられる。本発明のパーソナルケア組成物に有用なコンディショニング剤は、典型的に、乳化液体粒子を形成する非水溶性の水分散性非揮発性液体を含む。パーソナルケア組成物において使用するのに好適なコンディショニング剤は、一般に、シリコーン、有機コンディショニングオイル若しくはこれらの組み合わせを特徴とするコンディショニング剤、又は他の方法で水性界面活性剤マトリックス中に液体分散粒子を形成するコンディショニング剤である。
本発明の組成物は、1種以上のシリコーンコンディショニング剤を含有していてもよい。シリコーンの例としては、ジメチコン、ジメチコノール、環状シリコーン、メチルフェニルポリシロキサン、及びアミノ基、四級アンモニウム塩の基、脂肪族基、アルコール基、カルボン酸基、エーテル基、エポキシ基、糖又は多糖基、フッ素変性アルキル基、アルコキシ基、又はこのような基の組み合わせなどの様々な官能基を有する変性シリコーンが挙げられる。このようなシリコーンは、水性(又は非水性)製品キャリア中で可溶性であっても不溶性であってもよい。不溶性液体シリコーンの場合、ポリマーは、液滴サイズが約10nm~約30マイクロメートルの乳化形態であり得る。
本発明の組成物のコンディショニング剤はまた、単独で、又は上記のシリコーンなどの他のコンディショニング剤との組み合わせのいずれかで、油又はワックスなどの少なくとも1つの有機コンディショニング物質を含んでいてもよい。有機物質は、非ポリマー、オリゴマー又はポリマーであり得る。これは、油又はワックスの形態であってよく、配合物にそのまま添加してもよいし、予備乳化した形態で添加してもよい。有機コンディショニング材料のいくつかの非限定例としては、i)炭化水素油、ii)ポリオレフィン、iii)脂肪族エステル、iv)フッ素化コンディショニング化合物、v)脂肪族アルコール、vi)アルキルグルコシド及びアルキルグルコシド誘導体、vii)四級アンモニウム化合物、viii)CTFA名称がPEG-20 200、PEG-400、PEG-600、PEG-1000、PEG-2M、PEG-7M、PEG-14M、PEG-45Mであるもの、及びこれらの混合物などの、最大約2,000,000の分子量を有するポリエチレングリコール及びポリプロピレングリコール、が挙げられるが、これらに限定されない。
パーソナルケア組成物は、1種以上の追加の有益剤を更に含んでもよい。有益剤は、フケ防止剤、抗真菌剤、痒み止め剤、抗菌剤、抗細菌剤、保湿剤、抗酸化剤、ビタミン、脂溶性ビタミン、香料、美白剤、酵素、感覚剤、誘引剤、染料、顔料、漂白剤、及びこれらの混合物からなる群から選択される物質を含む。
活性物質、アニオン性ポリマー及びカチオン性ポリマーの混合
活性物質とアニオン性ポリマーとの組み合わせは、攪拌槽、又はホモジナイザ、ロータステータミル、若しくはスタティックミキサなどのインラインデバイスなどの任意の好適な混合容器中で実施することができる。混合を容易にするために組成物の粘度を許容可能なレベルに低減するために、この工程eに適切な量の水又は他の液体担体を含めることができる。堆積効率を最大化するために、本発明は、カチオン性ポリマーを添加する前に、活性物質及びアニオン性ポリマーの全てを一緒にブレンドし得る。完了している間、このカップリング反応ステップは、パーソナルケア製品中の大きな凝集物の存在に起因する増加した不安定性及び消費者の反対に起因するパーソナルケア組成物には不適切な大きな凝集体の形成を回避するのに十分な混合強度及び溶媒希釈を含み得る。
本発明は、狭い粒子サイズ分布又はかなり広い分布を生成し得る。特に、分布が広い場合、粒子サイズの重要な尺度は最大粒子サイズであり、可視粒子からの消費者の苦情を回避し、物理的不安定性を回避する。Zeiss Axioscop 2.0などのNomarski光学系を備えた通常の顕微鏡法での光顕微鏡検査は、この最大粒子サイズを決定するために使用され得る。約10マイクロリットルの最終パーソナルケア組成物をガラススライドに移し、次いでガラスカバースリップの下に広げる。40倍の倍率で10個の200um×200umの画像を、調製された試料から無作為に取得する。Zeiss corporationのZen Coreソフトウェアを使用して、10個の画像の各々における最大粒子のサイズを決定する。これらの10個の無作為な画像から見られる最大サイズを、最大粒子サイズとして報告した。観察された粒子が画像面積の半分を超える場合、最大粒子サイズは「>100um」として報告され、更なる定量化は実施されない。大部分の用途では、作製方法は、10個の無作為な40倍の顕微鏡画像で、100um以上の粒子が見つからない場合に、作製法が成功したとしてみなされる。
頭皮へのインビボでの頭皮活性物質堆積は、適用後、直ちに又は遅延した時点でのいずれかの濯ぎの後、頭皮活性物質含有組成物で頭皮を処理した後、薬剤の溶媒抽出によって決定することができる。エタノール又は酢酸エチルなどの活性物質抽出のための適切な溶媒は、溶解度考慮事項、実験室安全性、及び他の実用的な考慮事項に基づいて、目的の活性物質に対して選択することができる。抽出溶媒中の薬剤濃度を、HPLCで測定される。定量化は、標準曲線を基準にして行われる。HPLCにより検出された濃度は、体積で乗算された濃度を使用することにより収集された量にグラム単位で変換される。次に、HPLCによって測定された薬剤の体積当たりの質量の濃度は、測定されたHPLC濃度に抽出溶媒の体積を乗じ、抽出された頭皮の面積で割ることによって、面積当たりの質量の堆積量に換算される。
以下の実施例は、本明細書に記載されている本発明の非限定例を例示する。例示的なパーソナルケア組成物は、従来の配合及び混合技術によって、更に上記のようにカチオン性ポリマーと活性物質との組み合わせによって調製することができる。本明細書における全ての部、百分率(%)、及び比は、別途指定されない限り、重量基準である。いくつかの構成成分は、供給元から希釈溶液として供給され得る。明記されている量は、別途指定されない限り、活性物質の重量%を表す。
「混合比率」は、総組成物中の活性物質ストリームのカチオン性ポリマーストリームに対する重量比率を特定する。
「混合流量」は、活性物質ストリーム流量とカチオン性ポリマーストリーム流量との合計であり、分当たりのキログラムである。
「混合成功」は、Nomarski顕微鏡及び40倍対物レンズを使用してZeiss Axioscopeの下で観察した場合、最終的なシャンプー中に100ミクロンを超える粒子が見られない場合に生じる。
表3の実施例は、本発明の更なる知識を提供する。実施例17及び18を比較すると、カップリング反応におけるカチオン性ポリマーのより低い濃度が、望ましくない大きな凝集体の形成を回避するのを支持することができるのがわかる。実施例17と19を比較すると、インペラと比較してロータステータミルのより高い混合強度もまた、大規模での過度に大きな粒子を排除するのを支持することがわかる。実施例23及び25の比較は、より小規模な機器を使用した同様の結論を提供する。実施例24は、静的ミキサなどの他の高剪断装置がロータステータミルの代わりに効果的に使用できることを示している。実施例20及び21は、適切に選択された高い混合強度機器を使用する場合に、流量及びポリマー濃度の範囲にわたって成功が達成され得ることを示している。
段落A パーソナルケア組成物を製造する方法であって、
a)粒子状頭皮活性物質をアニオン性ポリマーと組み合わせて、混合物(a)を形成する工程と、
b)混合物(a)を3~10meq/グラムの電荷密度を有するカチオン性ポリマーと組み合わせて、混合物(b)を形成する工程と、
c)混合物(b)をパーソナルケア組成物ベースと組み合わせる工程と、を含む、方法。
段落B カチオン性ポリマーが、ポリクオタニウム-6、ジアリルジメチルアンモニウムクロリドのホモポリマー、ポリクオタニウム-2、ポリクオタニウム-16、ポリクオタニウム-17、ポリクオタニウム-22、ポリクオタニウム-42、ポリMAPTAC、メタクリルアミドプロピルトリメチルアンモニウムクロリドのポリマー、及びそれらの混合物からなる群から選択される、段落Aに記載のパーソナルケア組成物を製造する方法。
段落C 粒子状頭皮活性物質が、亜鉛ピリチオン、硫黄、硫化セレン、アゾキシストロビン、及びそれらの混合物からなる群から選択される、段落A又はBに記載のパーソナルケア組成物を製造する方法。
段落D 工程bにおける混合物(a)のカチオン性ポリマーに対する流量比率が、約1:1~約50:1である、段落A~Cに記載のパーソナルケア組成物を製造する方法。
段落E アニオン性ポリマーの粒子状頭皮活性物質に対する比率が、約1:1~約1:100である、段落A~Dに記載のパーソナルケア組成物を製造する方法。
段落F アニオン性ポリマーの粒子状頭皮活性物質に対する比率が、約1:5~約1:50である、段落A~Eに記載のパーソナルケア組成物を製造する方法。
段落G アニオン性ポリマーのカチオン性ポリマーに対する比率が、約1000:1~約1:35である、段落A~Fに記載のパーソナルケア組成物を製造する方法。
段落H 粒子状頭皮活性物質が、パーソナルケア組成物中に約0.25%~約4%のレベルで存在する、段落A~Gに記載のパーソナルケア組成物を製造する方法。
段落I アニオン性ポリマーのカチオン性ポリマーに対する比率が、約10:1~約1:10である、段落A~Hに記載のパーソナルケア組成物を製造する方法。
段落J 粒子状頭皮活性物質が、約1μg/cm2を超える堆積を提供する、段落A~Iに記載のパーソナルケア組成物を製造する方法。
段落K 粒子状頭皮活性物質の粒子サイズが、100ミクロン未満である、段落A~Jに記載のパーソナルケア組成物を製造する方法。
段落L パーソナルケア組成物が、シャンプーである、段落A~Kに記載のパーソナルケア組成物を製造する方法。
段落M パーソナルケア組成物が、界面活性剤を含む、段落A~Lに記載のパーソナルケア組成物を製造する方法。
段落N パーソナルケア組成物が、アニオン性、両性、非イオン性、若しくは双性イオン性界面活性剤、又はそれらの混合物を含む、段落A~Mに記載のパーソナルケア組成物を製造する方法。
段落O パーソナルケア組成物が、コンディショニング剤を更に含む、段落A~Nに記載のパーソナルケア組成物を製造する方法。
段落P コンディショニング剤が、シリコーンである、段落A~Oに記載のパーソナルケア組成物を製造する方法。
段落Q 約0.5%~約7%の香料を更に含む、段落A~Pに記載のパーソナルケア組成物を製造する方法。
段落R ロータステータミルが、工程bで使用される、段落A~Qに記載のパーソナルケア組成物を製造する方法。
段落S 粒子状頭皮活性物質の、カチオン性ポリマーと組み合わせたアニオン性ポリマーの総ポリマー比率に対する比率が、約5:1~約100:1である、段落A~Rに記載のパーソナルケア組成物を製造する方法。
Claims (17)
- パーソナルケア組成物を製造する方法であって、
a)亜鉛ピジオン、硫黄、硫化セレン、アゾキシストロビン及びこれらの混合物から選択される粒子状頭皮活性物質をアニオン性ポリマーと組み合わせて、混合物(a)を形成する工程と、
b)前記混合物(a)を3~10meq/グラムの電荷密度を有するカチオン性ポリマーと組み合わせて、混合物(b)を形成する工程と、
c)混合物(b)をパーソナルケア組成物ベースと組み合わせる工程と、を含み、
混合物(a)の、工程bの組み合わせる工程における前記カチオン性ポリマーに対する流量比率が、1:1~50:1である、方法。 - 前記アニオン性ポリマーが、ポリナフタレンスルホン酸ナトリウム、リグノスルホン酸ナトリウム、カルボキシメチルセルロースナトリウム、疎水変性無水マレイン酸コポリマーのナトリウム塩、ポリアクリル酸ナトリウム、ポリメタクリル酸ナトリウム、ポリアクリル酸アンモニウム、ポリメタクリル酸アンモニウム、疎水変性架橋アニオン性ポリマー、アクリレート/C10-30アルキルアクリレートクロスポリマー、及びそれらの混合物からなる群から選択される、請求項1に記載のパーソナルケア組成物を製造する方法。
- 前記カチオン性ポリマーが、ポリクオタニウム-6、ジアリルジメチルアンモニウムクロリドのホモポリマー、ポリクオタニウム-2、ポリクオタニウム-16、ポリクオタニウム-17、ポリクオタニウム-22、ポリクオタニウム-42、メタクリルアミドプロピルトリメチルアンモニウムクロリドのポリマー(ポリMAPTAC)、及びそれらの混合物からなる群から選択される、請求項1又は2に記載のパーソナルケア組成物を製造する方法。
- 前記アニオン性ポリマーの粒子状頭皮活性物質に対する比率が、1:1~1:100である、請求項1~3のいずれか一項に記載のパーソナルケア組成物を製造する方法。
- 前記アニオン性ポリマーの粒子状頭皮活性物質に対する比率が、1:5~1:50である、請求項1~4のいずれか一項に記載のパーソナルケア組成物を製造する方法。
- 前記アニオン性ポリマーのカチオン性ポリマーに対する比率が、1000:1~1:35である、請求項1~5のいずれか一項に記載のパーソナルケア組成物を製造する方法。
- 前記アニオン性ポリマーのカチオン性ポリマーに対する比率が、10:1~1:10である、請求項1~6のいずれか一項に記載のパーソナルケア組成物を製造する方法。
- 前記粒子状頭皮活性物質が、前記パーソナルケア組成物中に0.25%~4%のレベルで存在する、請求項1~7のいずれか一項に記載のパーソナルケア組成物を製造する方法。
- 前記粒子状頭皮活性物質が、1μg/cm2を超える堆積を提供する、請求項1~8のいずれか一項に記載のパーソナルケア組成物を製造する方法。
- 前記粒子状頭皮活性物質の粒子サイズが、100ミクロン未満である、請求項1~9のいずれか一項に記載のパーソナルケア組成物を製造する方法。
- 前記パーソナルケア組成物が、シャンプーである、請求項1~10のいずれか一項に記載のパーソナルケア組成物を製造する方法。
- 前記パーソナルケア組成物が、界面活性剤を含む、請求項1~11のいずれか一項に記載のパーソナルケア組成物を製造する方法。
- 前記パーソナルケア組成物が、アニオン性、両性、非イオン性、若しくは双性イオン性界面活性剤、又はそれらの混合物を含む、請求項12に記載のパーソナルケア組成物を製造する方法。
- 前記パーソナルケア組成物が、コンディショニング剤を更に含む、請求項1~13のいずれか一項に記載のパーソナルケア組成物を製造する方法。
- 前記コンディショニング剤が、シリコーンである、請求項14に記載のパーソナルケア組成物を製造する方法。
- ロータステータミルが、工程bで使用される、請求項1~15のいずれか一項に記載のパーソナルケア組成物を製造する方法。
- 粒子状頭皮活性物質の、カチオン性ポリマーと組み合わせたアニオン性ポリマーの総ポリマー比率に対する比率が、5:1~100:1である、請求項1~16のいずれか一項に記載のパーソナルケア組成物を製造する方法。
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