JP7301080B2 - Mriによる導電率測定値に基づいて頭部上の電極位置を最適化したttfield治療 - Google Patents
Mriによる導電率測定値に基づいて頭部上の電極位置を最適化したttfield治療 Download PDFInfo
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Description
本出願は、米国仮特許出願第62/247,314号(2015年10月28日出願)および第62/294,372号(2016年2月12日出願)の利益を主張し、それら各々の全体を参照により本明細書に援用する。
正確な計算ファントムの作成は、好ましくは、計算ファントム内の各地点における電気的性質(例えば、導電率、抵抗率)を正確にマッピングすることを伴う。計算ファントムを作成する1つの従来的な方法は、頭部を個別の等方性の電気的性質を備えた異なる組織タイプにセグメント化することを伴う。この方法を使用してモデルを構築する際、各組織タイプの電気的性質がモデルへと正確にマッピングされるように、3D空間における各組織タイプの境界を正確に特定することが重要である。
アレイレイアウトの最適化は、患者の脳の患部領域(腫瘍)内の電場を最適化するアレイレイアウトを見つけることを意味する。この最適化は、以下の4つのステップを実施することによって実現されてもよい。(S21)現実的な頭部モデル内における治療の標的とされる体積(標的体積)を特定するステップ、(S22)変換器アレイを自動的に配置し、現実的な頭部モデルにおいて境界条件を設定するステップ、(S23)アレイが現実的な頭部モデルに配置され、境界条件が適用されると、現実的な頭部モデル内で展開する電場を計算するステップ、ならびに、(S24)最適化アルゴリズムを稼働して、標的体積内の最適な電場分布をもたらすレイアウトを見つけるステップ。これら4つのステップを実現するための詳細な例を以下に提供する。
a. 変換器アレイの中央点がモデル頭部上に配置される位置を規定する。位置は、ユーザが、またはステップS24で考察した電場最適化アルゴリズムのステップの1つとして規定することができる。
b. ステップ(a)からの入力を、ディスクの幾何学形状に関する知識、およびディスクを整列して配列する方法の知識と併せて使用して、モデル内の変換器アレイにおける全てのディスクの中心の近似位置を計算する。
c. ディスクが配置される位置における、現実的なモデルの表面の配向を計算する。計算は、指定のディスク中心からディスク半径1つ分の距離以内にある、計算ファントムの皮膚上の全ての地点を見出すことによって実施される。これらの地点の座標が行列の列状に配列され、特異値分解が行列に対して実施される。そこで、モデルの皮膚に対する法線は、見出される最小固有値に対応する固有ベクトルである。
d. 変換器アレイの各ディスクに関して、ディスクと患者の身体との間の良好な接触を担保するのに要する、医療用ゲルの厚さを計算する。これは、皮膚表面の法線に対して平行にその高さが配向された円筒のパラメータを見出すことによって行われる。円筒は、ディスクの半径に等しい半径を有して規定され、その高さは、法線を見つけるのに使用される皮膚上の点を越えて所定の量(所定の定数)延在するように設定される。これによって、ファントム表面から少なくとも所定の量が延在する円筒がもたらされる。
e. モデル上に、(d)で説明した円筒を作成する。
f. 二値論理演算(例えば、頭部を円筒から減算する)を通して、患者の現実的なモデル内へと突出する円筒の領域をモデルから除去する。結果として得られる「切頭円筒」は、変換器アレイと関連付けられた医療用ゲルを表す。
g. 「切頭円筒」の外側に、変換器アレイのセラミックディスクを表すディスクを配置する。
概念の証明は、皮質組織の異方性導電率値を組み込んだ、前に展開した現実的なヒトの頭部モデルに対する修正に基づくものであった。このモデルは健康な被験者から生じたものなので、腫瘍を仮想病変によって表さなければならなかった。ファントムは、TTFields印加後の電場分布を計算するのに既に使用されている。
22 単純化した等方性モデル、頭部の左右(LR)アレイ
23 単純化した異方性モデル、頭部の左右(LR)アレイ
24 現実的な等方性モデル、前後(AP)部分のアレイ
25 単純化した等方性モデル、前後(AP)部分のアレイ
26 単純化した異方性モデル、前後(AP)部分のアレイ
31 原型モデル
32 simple1モデル
33 simple2モデル
40 頭皮
42 変換器アレイ
44 変換器アレイ
51 SHM1
52 SHM2
54 頭骨
55 CSF
56 灰白質
58 白質
62 凸包
64 脳室
66 腫瘍
71 RHM等方性モデル
72 SHM2等方性モデル
73 RHM異方性モデル
74 SHM2異方性モデル
75 SHM4異方性モデル
Claims (8)
- プロセッサが哺乳類の頭部のモデルを作成する方法であって、前記頭部が、脳組織、CSF、頭骨、および頭皮を含み、前記方法が、
導電率テンソルの3Dセットを使用して、前記脳組織に対応する前記頭部の領域をモデル化するステップと、
一定の導電率を有する少なくとも1つのシェルを使用して、前記CSF、前記頭骨、および前記頭皮をモデル化するステップと、
前記脳組織内の標的組織の場所を特定するステップと、
前記標的組織の前記特定された場所と、導電率テンソルの前記3Dセットと、前記少なくとも1つのシェルの導電率とに基づいて、前記標的組織において治療仕様を最適化する複数の電極の位置を計算することによって、前記複数の電極の位置を決定するステップとを含み、
前記モデル化するステップは、前記脳組織を異なるタイプの脳組織にセグメント化せずに実現され、
前記各ステップは、前記プロセッサによって実行される、方法。 - 前記導電率テンソルの3DセットがMRIを使用して取得される、請求項1に記載の方法。
- 前記導電率テンソルの3Dセットが拡散テンソル画像法データセットから導き出される、請求項2に記載の方法。
- 前記CSF、前記頭骨、および前記頭皮をモデル化する前記ステップが、
前記脳組織の外側に前記脳組織と接触して配設される、第1のシェルとして前記CSFをモデル化するステップであって、前記第1のシェルが第1の一定の導電率を有する、ステップと、
前記CSFの外側に前記CSFと接触して配設される、第2の一定の導電率を有する第2のシェルとして前記頭骨をモデル化するステップであって、前記第2のシェルが第2の一定の導電率を有する、ステップと、
前記頭骨の外側に前記頭骨と接触して配設される、第3のシェルとして前記頭皮をモデル化するステップであって、前記第3のシェルが第3の一定の導電率を有する、ステップとを含む、請求項1に記載の方法。 - 前記CSF、前記頭骨、および前記頭皮をモデル化する前記ステップが、
前記脳組織の外側に前記脳組織と接触して配設される、単一のシェルとして、前記CSF、前記頭骨、および前記頭皮を総合してモデル化するステップであって、前記単一のシェルが一定の導電率を有する、ステップを含む、請求項1に記載の方法。 - 導電率テンソルの3Dセットを使用して領域をモデル化する前記ステップが、異方性比率に基づいて各体積要素の組織タイプを分類するステップを含む、請求項1に記載の方法。
- 導電率テンソルの3Dセットを使用して領域をモデル化する前記ステップが、平均導電率に基づいて各体積要素の組織タイプを分類するステップを含む、請求項1に記載の方法。
- 導電率テンソルの3Dセットを使用して領域をモデル化する前記ステップが、導電率テンソルの固有値の幾何平均を特定の等方性基準値に対して整合させるステップを含む、請求項1に記載の方法。
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US62/294,372 | 2016-02-12 | ||
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JP2021176654A Active JP7383679B2 (ja) | 2015-10-28 | 2021-10-28 | Mriによる導電率測定値に基づいて頭部上の電極位置を最適化したttfield治療 |
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JP2021176654A Active JP7383679B2 (ja) | 2015-10-28 | 2021-10-28 | Mriによる導電率測定値に基づいて頭部上の電極位置を最適化したttfield治療 |
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Families Citing this family (117)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9851426B2 (en) * | 2012-05-04 | 2017-12-26 | The Regents Of The University Of Michigan | Error analysis and correction of MRI ADC measurements for gradient nonlinearity |
US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
US10943350B2 (en) * | 2015-02-25 | 2021-03-09 | London Health Science Center Research Inc. | Automated segmentation of histological sections for vasculature quantification |
US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
US10441776B2 (en) | 2016-06-30 | 2019-10-15 | Novocure Gmbh | Arrays for longitudinal delivery of TTFields to a body |
US11446487B2 (en) | 2016-09-23 | 2022-09-20 | Beth Israel Deaconess Medical Center, Inc. | System and methods for cancer treatment using alternating electric fields |
JP7184774B2 (ja) | 2016-12-13 | 2022-12-06 | ノボキュア ゲーエムベーハー | 変形可能テンプレートを使用して最適化された電極位置を有するttフィールドを用いて患者を治療する |
US11573221B2 (en) | 2017-01-19 | 2023-02-07 | Novocure Gmbh | System for viewing cell cultures under a microscope whilst applying TTFields |
CA3056694C (en) * | 2017-05-18 | 2022-01-18 | Brainlab Ag | Determining a clinical target volume |
KR101950815B1 (ko) * | 2017-08-25 | 2019-02-21 | 뉴로핏 주식회사 | 패치 가이드 방법 및 프로그램 |
US11986319B2 (en) | 2017-08-25 | 2024-05-21 | NEUROPHET Inc. | Patch guide method and program |
KR101995900B1 (ko) * | 2017-09-11 | 2019-07-04 | 뉴로핏 주식회사 | 3차원 뇌지도 생성 방법 및 프로그램 |
US11723579B2 (en) | 2017-09-19 | 2023-08-15 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
EP3731749A4 (en) | 2017-12-31 | 2022-07-27 | Neuroenhancement Lab, LLC | NEURO-ACTIVATION SYSTEM AND METHOD FOR ENHANCING EMOTIONAL RESPONSE |
US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
CN112566665A (zh) | 2018-04-09 | 2021-03-26 | 莫舍·吉拉迪 | 用TTFields和Aurora激酶抑制剂*** |
CA3096429C (en) | 2018-04-10 | 2023-10-17 | Zeev Bomzon | Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times |
US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
WO2020009306A1 (ko) * | 2018-07-03 | 2020-01-09 | 고려대학교 산학협력단 | 최적화 알고리즘을 이용한 전기장 암치료장치 및 방법 |
CN114082099A (zh) | 2018-07-03 | 2022-02-25 | 埃德温·阊 | 使用交变电场提高细胞膜通透性 |
KR102104961B1 (ko) | 2018-07-03 | 2020-04-27 | 고려대학교산학협력단 | 최적화 알고리즘을 이용한 전기장 암치료장치 |
US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
CN112469465A (zh) | 2018-07-10 | 2021-03-09 | 诺沃库勒有限责任公司 | 使用交变电场抑制病毒感染 |
WO2020018662A1 (en) | 2018-07-17 | 2020-01-23 | Dignity Health | Systems and methods for treatment of cancer using alternating electric field generation |
JP7267393B2 (ja) | 2018-07-18 | 2023-05-01 | ノボキュア ゲーエムベーハー | 腫瘍治療場(tt場)の線量を定量化するための電力損失密度および関連する処置の使用 |
KR102651496B1 (ko) | 2018-08-23 | 2024-03-25 | 카스텐 하게만 | 뇌-혈액 장벽 투과성을 향상시키기 위한 교번 전기장의 이용 |
US11623085B2 (en) * | 2018-08-29 | 2023-04-11 | Regents Of The University Of Minnesota | Devices and methods for treatment of tumors using electromagnetic signal |
US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
CN112770806A (zh) | 2018-09-07 | 2021-05-07 | 诺沃库勒有限责任公司 | 使用交变电场治疗自身免疫性疾病以减少t细胞的增殖 |
US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
CN113382683A (zh) | 2018-09-14 | 2021-09-10 | 纽罗因恒思蒙特实验有限责任公司 | 改善睡眠的***和方法 |
CN112822981A (zh) | 2018-10-09 | 2021-05-18 | 皇家飞利浦有限公司 | 自动eeg传感器配准 |
WO2020079554A1 (en) | 2018-10-15 | 2020-04-23 | Zeev Bomzon | Generating tumor treating fields (ttfields) with high uniformity throughout the brain |
US11369790B2 (en) | 2018-10-25 | 2022-06-28 | Novocure Gmbh | Delivering alternating electric fields (e.g., TTFields) to a subject's spinal anatomy |
PL3922301T3 (pl) | 2018-11-19 | 2024-06-10 | Novocure Gmbh | Szyki do dostarczania zmiennych pól elektrycznych do leczenia nowotworów (ttfields) z selektywnie adresowalnymi pod-elementami |
MX2021002625A (es) | 2018-11-29 | 2021-05-12 | Novocure Gmbh | Arreglos de transductores de mayor flexibilidad para suministrar campos tt (campos de tratamiento de tumores). |
US11141585B2 (en) * | 2018-12-28 | 2021-10-12 | Palo Alto Research Center Incorporated | Non-invasive neural interface |
JP7246486B2 (ja) | 2019-01-08 | 2023-03-27 | ノボキュア ゲーエムベーハー | 腫瘍治療電場(ttfields)を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価 |
CN109864733A (zh) * | 2019-01-16 | 2019-06-11 | 漫迪医疗仪器(上海)有限公司 | 心脑异常的检测方法、***、介质及设备 |
KR102185662B1 (ko) * | 2019-01-31 | 2020-12-02 | 뉴로핏 주식회사 | 10-20 시스템 기반의 위치 정보 제공 방법 |
US11554262B2 (en) | 2019-02-26 | 2023-01-17 | Novocure Gmbh | Determining a frequency for TTFields treatment based on an electrical characteristic of targeted cancer cells |
EP3917423A1 (en) | 2019-02-27 | 2021-12-08 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
US11911610B2 (en) | 2019-03-29 | 2024-02-27 | Novocure Gmbh | Methods for restoring sensitivity to TTFields in TTFields-resistant cancer cells with PTGER3 inhibitors |
EP3924039B1 (en) | 2019-04-17 | 2023-11-22 | Novocure GmbH | Uploading data from an isolated system without compromising isolation |
EP4378519A1 (en) | 2019-04-22 | 2024-06-05 | Boston Scientific Scimed, Inc. | Electrical stimulation devices for cancer treatment |
JP7410176B2 (ja) | 2019-04-22 | 2024-01-09 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 癌を治療するために電気刺激を与えるためのシステム |
WO2020219521A1 (en) | 2019-04-23 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation with thermal treatment or thermal monitoring |
US11607542B2 (en) | 2019-04-23 | 2023-03-21 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
EP4356955A3 (en) | 2019-04-23 | 2024-07-17 | Boston Scientific Scimed, Inc. | Electrodes for electrical stimulation to treat cancer |
US11620789B2 (en) * | 2019-05-03 | 2023-04-04 | Novocure Gmbh | Methods, systems, and apparatuses for managing transducer array placement |
EP3972684A4 (en) * | 2019-05-20 | 2023-07-05 | Neuroelectrics USA Corporation | SYSTEMS AND METHODS FOR TREATMENT OF TUMORS BY TARGETED NEUROSTIMULATION |
CN110119586B (zh) * | 2019-05-21 | 2023-02-28 | 中煤科工集团西安研究院有限公司 | 轴向电导率各向异性瞬变电磁三分量三维fdtd正演方法 |
US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
KR20210003333A (ko) * | 2019-07-01 | 2021-01-12 | 고려대학교 산학협력단 | 피부에 인가되는 분산 전류를 이용한 전기장 기반 암 치료장치 |
US11654279B2 (en) | 2019-07-31 | 2023-05-23 | Novocure Gmbh | Applying tumor treating fields (TTFields) via electrodes embedded into skull implants |
US11890467B2 (en) | 2019-08-30 | 2024-02-06 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the neck |
WO2021069966A1 (en) * | 2019-10-07 | 2021-04-15 | Novocure Gmbh | Methods, systems, and apparatuses for guiding transducer array placement |
WO2021071871A1 (en) * | 2019-10-09 | 2021-04-15 | Trustees Of Boston University | Electrography system employing layered electrodes for improved spatial resolution |
US11534601B2 (en) | 2019-11-08 | 2022-12-27 | Novocure Gmbh | Perforated hydrogel configurations and methods of production and use thereof |
WO2021111186A1 (en) | 2019-12-02 | 2021-06-10 | Novocure Gmbh | Methods and apparatuses for optimizing transducer array placement |
WO2021136964A1 (en) | 2019-12-31 | 2021-07-08 | Novocure Gmbh | Methods, systems, and apparatuses for associating dielectric properties with a patient model |
JP2023508586A (ja) | 2019-12-31 | 2023-03-02 | ノボキュア ゲーエムベーハー | 電界分布の高速近似のための方法、システム、および装置 |
WO2021136965A2 (en) | 2019-12-31 | 2021-07-08 | Novocure Gmbh | Methods, systems, and apparatuses for image segmentation |
US20210196967A1 (en) | 2019-12-31 | 2021-07-01 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
CA3163315A1 (en) | 2019-12-31 | 2021-07-08 | Novocure Gmbh | High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels |
ES2950234T3 (es) | 2019-12-31 | 2023-10-06 | Novocure Gmbh | Matrices para administrar campos de tratamiento de tumores (camposTT) con elementos de electrodos y sensores de temperatura accesibles individualmente |
US20230147250A1 (en) | 2019-12-31 | 2023-05-11 | Novocure Gmbh | Methods, systems, and apparatuses for combined tumor treating fields and mental health therapy |
TW202140096A (zh) | 2020-01-22 | 2021-11-01 | 瑞士商諾沃庫勒有限責任公司 | 含有兩個導電性膠體組成物之組件及其製造和使用方法 |
EP4110455B1 (en) | 2020-02-24 | 2024-05-22 | Boston Scientific Scimed, Inc. | Systems for treatment of pancreatic cancer |
US20210299439A1 (en) * | 2020-03-31 | 2021-09-30 | Novocure Gmb | Methods, systems, and apparatuses for guiding transducer placements for tumor treating fields |
CN111420271A (zh) * | 2020-04-02 | 2020-07-17 | 河北普尼医疗科技有限公司 | 一种基于头部肿瘤治疗的电极贴片定位方法 |
TW202200232A (zh) | 2020-05-06 | 2022-01-01 | 瑞士商諾沃庫勒有限責任公司 | 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法 |
KR102464313B1 (ko) | 2020-05-18 | 2022-11-08 | 주식회사 필드큐어 | 전기장 암 치료 시스템을 위한 품질 보증 장치 및 방법 |
WO2021257967A1 (en) | 2020-06-19 | 2021-12-23 | The Methodist Hospital Dba Houston Methodist Hospital | Method and apparatus for oncomagnetic treatment |
US11818943B2 (en) | 2020-06-25 | 2023-11-14 | Novocure Gmbh | Fabricating organic light emitting diodes (OLEDs) using tubulin |
KR102490645B1 (ko) | 2020-07-16 | 2023-01-25 | 고려대학교 산학협력단 | 흡수에너지 기반 전기장 암치료 계획 시스템 및 방법 |
KR102385708B1 (ko) * | 2020-07-20 | 2022-04-13 | 경희대학교 산학협력단 | 알츠하이머병 진단을 위한 인공지능 기반의 전도도 영상 복원 장치 및 방법 |
KR102458768B1 (ko) * | 2020-09-29 | 2022-10-26 | 고려대학교 산학협력단 | 체내 온도 제어 및 흡수에너지 기반 종양치료 전기장 최적화 방법 및 시스템, 및 이를 포함하는 전기장 시스템 구동 방법 및 시스템 |
US20220096853A1 (en) * | 2020-09-30 | 2022-03-31 | Novocure Gmbh | Methods and systems for transducer array placement and skin surface condition avoidance |
US20220096829A1 (en) * | 2020-09-30 | 2022-03-31 | Novocure Gmbh | Method and apparatus for delivering tumor treating fields to a torso, and method for determining locations for transducers to deliver tumor treating fields |
TWI805954B (zh) * | 2020-10-16 | 2023-06-21 | 瑞士商諾沃庫勒有限責任公司 | 經由嵌入顱骨植入物中之電極來應用腫瘤治療電場(TTFields) |
TWI827889B (zh) * | 2020-10-16 | 2024-01-01 | 瑞士商諾沃庫勒有限責任公司 | 用於管理傳感器陣列佈置的方法和設備以及相關的非暫態的電腦可讀取的媒體 |
US20220148171A1 (en) * | 2020-11-06 | 2022-05-12 | Novocure Gmbh | Methods and apparatuses for determining transducer locations to generate tumor treating fields |
WO2022137019A1 (en) | 2020-12-21 | 2022-06-30 | Novocure Gmbh | Optimization of composite electrode |
US11869151B2 (en) | 2021-01-26 | 2024-01-09 | Beth Israel Deaconess Medical Center | Systems and methods for finite element analysis of tumor treating fields |
WO2022190043A2 (en) | 2021-03-12 | 2022-09-15 | Novocure Gmbh | Electrode array and methods of production and use thereof |
WO2022195542A2 (en) | 2021-03-18 | 2022-09-22 | Novocure Gmbh | Constructing a 3d phantom with liquid hydrogel |
IL305564A (en) * | 2021-03-31 | 2023-10-01 | Novocure Gmbh | Impedance tomography using field system electrodes treat the tumor |
US20240165419A1 (en) * | 2021-04-04 | 2024-05-23 | Dignity Health | Systems and methods for machine-learning guided treatment planning and monitoring of electric field therapy implants |
CN113101517B (zh) * | 2021-04-15 | 2022-02-01 | 中国医学科学院北京协和医院 | 植入式电极装置及其制备方法 |
CN113096765A (zh) * | 2021-04-16 | 2021-07-09 | 湖南安泰康成生物科技有限公司 | 一种用于靶向目标范围电场强度计算的有限元建模方法及装置 |
JP2024524745A (ja) | 2021-07-21 | 2024-07-05 | ノボキュア ゲーエムベーハー | 腫瘍治療フィールドを発生させる伝導性パッド、ならびに、その生産および使用の方法 |
WO2023042080A1 (en) | 2021-09-14 | 2023-03-23 | Novocure Gmbh | Temperature independent method and system for applying ttfields |
US20230102915A1 (en) | 2021-09-30 | 2023-03-30 | Novocure Gmbh | Method and system for applying tumor treating fields interfacing with hair follicles |
WO2023084340A1 (en) * | 2021-11-12 | 2023-05-19 | Novocure Gmbh | Adjusting tumor treating fields simulation and treatment using molecular imaging |
WO2023095111A1 (en) | 2021-11-29 | 2023-06-01 | Novocure Gmbh | Methods of reducing ciliogenesis with alternating electric fields |
US20230173265A1 (en) | 2021-12-10 | 2023-06-08 | Novocure Gmbh | Garment providing a biasing force on a transducer array |
WO2023168033A1 (en) * | 2022-03-03 | 2023-09-07 | Medtronic, Inc. | Electric field therapy via implantable electrodes |
US20230398367A1 (en) | 2022-06-13 | 2023-12-14 | Novocure Gmbh | Systems and methods for increasing intestinal absorption of therapeutic agents |
WO2023248139A1 (en) | 2022-06-20 | 2023-12-28 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields and vegf inhibitors |
US20230407282A1 (en) | 2022-06-21 | 2023-12-21 | Novocure Gmbh | Systems and methods for treating conditions and diseases using alternating electric fields and crispr-cas system |
US20240001133A1 (en) * | 2022-06-30 | 2024-01-04 | Novocure Gmbh | Tumor treating field transducers with protective border, and apparatuses and methods for active detection of improper transducer configuration |
US20240081939A1 (en) | 2022-09-08 | 2024-03-14 | Novocure Gmbh | Constructing a 3d phantom with a matrix material having conductive particles dispersed therein |
US20240103041A1 (en) | 2022-09-27 | 2024-03-28 | Novocure Gmbh | Ingestible implantable device to measure internal ttfield intensity |
CA3180284A1 (en) | 2022-09-29 | 2024-03-29 | Novocure Gmbh | Transducer array having a temperature sensor isolation layer between a temperature sensor and external environment |
US20240108908A1 (en) | 2022-09-29 | 2024-04-04 | Novocure Gmbh | System and method for maintaining ttfields during battery changes |
WO2024069539A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Single wire temperature measurement solution for a ttfield application system and methods of production and use thereof |
US20240108699A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Compositions, systems, and methods for reducing electrosensation and/or skin irritation |
WO2024069538A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using alternating electric fields and dendritic cells |
WO2024069531A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using alternating electric fields and apoptotic cancer cell vaccination |
US20240173544A1 (en) | 2022-11-30 | 2024-05-30 | Novocure Gmbh | Transducer arrays having alternative array materials |
WO2024127192A1 (en) | 2022-12-13 | 2024-06-20 | Novocure Gmbh | Wireless transducer arrays applying tumor treating fields and systems and methods of use thereof |
CN116542115B (zh) * | 2023-07-06 | 2023-10-20 | 湖南安泰康成生物科技有限公司 | 生物体目标区域电场强度模的确定方法、装置及电子设备 |
CN117933174B (zh) * | 2024-03-22 | 2024-05-31 | 湖南安泰康成生物科技有限公司 | 电极片定制化方法及装置、肿瘤电场治疗仪及存储介质 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060017749A1 (en) | 2004-07-07 | 2006-01-26 | Mcintyre Cameron C | Brain stimulation models, systems, devices, and methods |
JP2006513739A (ja) | 2002-10-02 | 2006-04-27 | スタンデン・リミテッド | 腫瘍等を治療するための装置ならびに腫瘍の治療のための装置を備えた製品 |
JP2007517571A (ja) | 2004-01-14 | 2007-07-05 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | リアルタイムの磁場マッピングを用いる磁気共鳴撮像方法及び装置 |
US20120265261A1 (en) | 2009-04-13 | 2012-10-18 | Marom Bikson | Neurocranial Electrostimulation Models, Systems, Devices, and Methods |
WO2014025353A1 (en) | 2012-08-09 | 2014-02-13 | Northeastern University | Electric field encephalography: electric field based brain signal detection and monitoring |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5568816A (en) | 1990-09-07 | 1996-10-29 | Sam Technology, Inc. | EEG deblurring method and system for improved spatial detail |
JPH09173315A (ja) * | 1995-12-26 | 1997-07-08 | Hitachi Medical Corp | 磁気共鳴イメージング方法 |
US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
US7565206B2 (en) | 2000-02-17 | 2009-07-21 | Standen Ltd. | Treating a tumor or the like with electric fields at different orientations |
WO2001060994A1 (en) | 2000-02-17 | 2001-08-23 | Palti Yoram Prof | Method and apparatus for destroying dividing cells |
US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
US8447395B2 (en) | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
CA2556934C (en) * | 2004-02-20 | 2018-05-22 | James F. Dempsey | System for delivering conformal radiation therapy while simultaneously imaging soft tissue |
JP4750784B2 (ja) | 2004-04-23 | 2011-08-17 | ノヴォキュアー・リミテッド | 異なる周波数の電界による腫瘍等の治療 |
US8180601B2 (en) * | 2006-03-09 | 2012-05-15 | The Cleveland Clinic Foundation | Systems and methods for determining volume of activation for deep brain stimulation |
CN102389618B (zh) | 2004-12-07 | 2015-01-28 | 斯坦顿有限公司 | 用于长时间对活体施加电场的电极 |
CN101287519B (zh) | 2005-06-08 | 2014-10-29 | 斯坦顿有限公司 | 利用被导引到身体内的期望位置的电场来治疗癌症的装置 |
CN101578119A (zh) * | 2005-06-16 | 2009-11-11 | 迈克尔·J·拉塞尔 | 引导的经颅电刺激技术 |
US9307925B2 (en) | 2005-06-16 | 2016-04-12 | Aaken Laboratories | Methods and systems for generating electrical property maps of biological structures |
EP3804809B1 (en) | 2005-10-03 | 2023-12-27 | Novocure GmbH | Optimizing characteristics of an electric field to increase the field's effect on proliferating cells |
WO2007103475A2 (en) | 2006-03-07 | 2007-09-13 | Beth Israel Deaconess Medical Center, Inc. | Transcranial magnetic stimulation (tms) methods and apparatus |
US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
ES2629612T3 (es) | 2007-03-06 | 2017-08-11 | Novocure Ltd. | Tratamiento del cáncer usando campos electromagnéticos en combinación con terapia fotodinámica |
EP2183024B1 (en) | 2007-08-14 | 2019-05-15 | Novocure Ltd. | Treating parasites with electric fields |
US8715203B2 (en) | 2007-09-17 | 2014-05-06 | Novocure Limited | Composite electrode |
WO2012052543A1 (en) * | 2010-10-22 | 2012-04-26 | Herlev Hospital | A method for treating a tissue region with an electric field |
US9265557B2 (en) | 2011-01-31 | 2016-02-23 | Medtronic Ablation Frontiers Llc | Multi frequency and multi polarity complex impedance measurements to assess ablation lesions |
US9655669B2 (en) | 2013-05-06 | 2017-05-23 | Novocure Limited | Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment |
US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
CN104123416A (zh) * | 2014-07-21 | 2014-10-29 | 中国医学科学院生物医学工程研究所 | 一种模拟真实人体颅脑电特性分布的有限元仿真模型 |
CN104096316B (zh) * | 2014-07-21 | 2015-11-18 | 中国医学科学院生物医学工程研究所 | 一种用于脑深部经颅磁刺激的h型线圈优化方法 |
CN104063565A (zh) * | 2014-07-21 | 2014-09-24 | 中国医学科学院生物医学工程研究所 | 一种用于深部磁刺激研究的真实人体头部有限元模型 |
US20190117963A1 (en) | 2014-07-25 | 2019-04-25 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
US10441776B2 (en) | 2016-06-30 | 2019-10-15 | Novocure Gmbh | Arrays for longitudinal delivery of TTFields to a body |
CA2972699A1 (en) | 2016-07-10 | 2018-01-10 | Novocure Limited | Synchronizing tumor cells to the g2/m phase using ttfields combined with taxane or other anti-microtubule agents |
DK3500334T3 (da) | 2016-08-18 | 2023-10-09 | Novocure Gmbh | Temperaturmåling i arrays til levering af ttfields |
JP7184774B2 (ja) | 2016-12-13 | 2022-12-06 | ノボキュア ゲーエムベーハー | 変形可能テンプレートを使用して最適化された電極位置を有するttフィールドを用いて患者を治療する |
US11573221B2 (en) | 2017-01-19 | 2023-02-07 | Novocure Gmbh | System for viewing cell cultures under a microscope whilst applying TTFields |
CN112566665A (zh) | 2018-04-09 | 2021-03-26 | 莫舍·吉拉迪 | 用TTFields和Aurora激酶抑制剂*** |
CA3096429C (en) | 2018-04-10 | 2023-10-17 | Zeev Bomzon | Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times |
CN114082099A (zh) | 2018-07-03 | 2022-02-25 | 埃德温·阊 | 使用交变电场提高细胞膜通透性 |
US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
JP7267393B2 (ja) | 2018-07-18 | 2023-05-01 | ノボキュア ゲーエムベーハー | 腫瘍治療場(tt場)の線量を定量化するための電力損失密度および関連する処置の使用 |
KR102651496B1 (ko) | 2018-08-23 | 2024-03-25 | 카스텐 하게만 | 뇌-혈액 장벽 투과성을 향상시키기 위한 교번 전기장의 이용 |
US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
CN112770806A (zh) | 2018-09-07 | 2021-05-07 | 诺沃库勒有限责任公司 | 使用交变电场治疗自身免疫性疾病以减少t细胞的增殖 |
US20200108031A1 (en) | 2018-10-05 | 2020-04-09 | Novocure Gmbh | Treating Tumors Using TTFields Combined with ABT-751 |
EP3870188B1 (en) | 2018-10-23 | 2024-06-19 | The Board of Trustees of the Leland Stanford Junior University | Prevention and treatment of teratoma formation in stem cell-based thereapies using alternating electric fields |
US11369790B2 (en) | 2018-10-25 | 2022-06-28 | Novocure Gmbh | Delivering alternating electric fields (e.g., TTFields) to a subject's spinal anatomy |
US20200146586A1 (en) | 2018-11-14 | 2020-05-14 | Novocure Gmbh | Creating Accurate Computational Head Models of Patients Using Datasets Combining MRI and CT Images |
PL3922301T3 (pl) | 2018-11-19 | 2024-06-10 | Novocure Gmbh | Szyki do dostarczania zmiennych pól elektrycznych do leczenia nowotworów (ttfields) z selektywnie adresowalnymi pod-elementami |
MX2021002625A (es) | 2018-11-29 | 2021-05-12 | Novocure Gmbh | Arreglos de transductores de mayor flexibilidad para suministrar campos tt (campos de tratamiento de tumores). |
JP7246486B2 (ja) | 2019-01-08 | 2023-03-27 | ノボキュア ゲーエムベーハー | 腫瘍治療電場(ttfields)を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価 |
EP3911299A1 (en) | 2019-02-22 | 2021-11-24 | Novocure GmbH | Treating gastric cancer using ttfields combined with xelox or folfox |
US11554262B2 (en) | 2019-02-26 | 2023-01-17 | Novocure Gmbh | Determining a frequency for TTFields treatment based on an electrical characteristic of targeted cancer cells |
EP3917423A1 (en) | 2019-02-27 | 2021-12-08 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
US11911610B2 (en) | 2019-03-29 | 2024-02-27 | Novocure Gmbh | Methods for restoring sensitivity to TTFields in TTFields-resistant cancer cells with PTGER3 inhibitors |
EP3924039B1 (en) | 2019-04-17 | 2023-11-22 | Novocure GmbH | Uploading data from an isolated system without compromising isolation |
-
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006513739A (ja) | 2002-10-02 | 2006-04-27 | スタンデン・リミテッド | 腫瘍等を治療するための装置ならびに腫瘍の治療のための装置を備えた製品 |
JP2007517571A (ja) | 2004-01-14 | 2007-07-05 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | リアルタイムの磁場マッピングを用いる磁気共鳴撮像方法及び装置 |
US20060017749A1 (en) | 2004-07-07 | 2006-01-26 | Mcintyre Cameron C | Brain stimulation models, systems, devices, and methods |
US20120265261A1 (en) | 2009-04-13 | 2012-10-18 | Marom Bikson | Neurocranial Electrostimulation Models, Systems, Devices, and Methods |
WO2014025353A1 (en) | 2012-08-09 | 2014-02-13 | Northeastern University | Electric field encephalography: electric field based brain signal detection and monitoring |
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