JP7088918B2 - 眼薬徐放性製剤およびその利用 - Google Patents
眼薬徐放性製剤およびその利用 Download PDFInfo
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- JP7088918B2 JP7088918B2 JP2019516703A JP2019516703A JP7088918B2 JP 7088918 B2 JP7088918 B2 JP 7088918B2 JP 2019516703 A JP2019516703 A JP 2019516703A JP 2019516703 A JP2019516703 A JP 2019516703A JP 7088918 B2 JP7088918 B2 JP 7088918B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00772—Apparatus for restoration of tear ducts
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
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- A—HUMAN NECESSITIES
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K31/60—Salicylic acid; Derivatives thereof
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Surgery (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nanotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2022093373A JP7324342B2 (ja) | 2016-09-30 | 2022-06-09 | 眼薬徐放性製剤およびその利用 |
JP2023122928A JP2023133438A (ja) | 2016-09-30 | 2023-07-28 | 眼薬徐放性製剤およびその利用 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662402938P | 2016-09-30 | 2016-09-30 | |
US62/402,938 | 2016-09-30 | ||
PCT/US2017/054654 WO2018064648A1 (fr) | 2016-09-30 | 2017-09-30 | Formulation ophtalmique à libération pharmacologique prolongée et ses utilisations |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022093373A Division JP7324342B2 (ja) | 2016-09-30 | 2022-06-09 | 眼薬徐放性製剤およびその利用 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019534872A JP2019534872A (ja) | 2019-12-05 |
JP7088918B2 true JP7088918B2 (ja) | 2022-06-21 |
Family
ID=61763607
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019516703A Active JP7088918B2 (ja) | 2016-09-30 | 2017-09-30 | 眼薬徐放性製剤およびその利用 |
JP2022093373A Active JP7324342B2 (ja) | 2016-09-30 | 2022-06-09 | 眼薬徐放性製剤およびその利用 |
JP2023122928A Pending JP2023133438A (ja) | 2016-09-30 | 2023-07-28 | 眼薬徐放性製剤およびその利用 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022093373A Active JP7324342B2 (ja) | 2016-09-30 | 2022-06-09 | 眼薬徐放性製剤およびその利用 |
JP2023122928A Pending JP2023133438A (ja) | 2016-09-30 | 2023-07-28 | 眼薬徐放性製剤およびその利用 |
Country Status (10)
Country | Link |
---|---|
US (2) | US11324693B2 (fr) |
EP (2) | EP3518897B1 (fr) |
JP (3) | JP7088918B2 (fr) |
KR (1) | KR20190061047A (fr) |
CN (1) | CN110475543B (fr) |
CA (1) | CA3038115A1 (fr) |
DK (1) | DK3518897T3 (fr) |
ES (1) | ES2907847T3 (fr) |
IL (1) | IL265677A (fr) |
WO (1) | WO2018064648A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3518897T3 (da) * | 2016-09-30 | 2022-03-07 | Mati Therapeutics Inc | Depotformulering af optalmisk lægemiddel og anvendelser deraf |
AU2020302924A1 (en) | 2019-06-27 | 2022-02-17 | Layerbio, Inc. | Ocular device delivery methods and systems |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2006500328A (ja) | 2002-07-15 | 2006-01-05 | アルコン,インコーポレイテッド | 眼内使用のための非ポリマー親油性薬学的インプラント組成物 |
US20090196905A1 (en) | 2008-02-06 | 2009-08-06 | Spada Lon T | Stabilization of mitochondrial membranes in ocular diseases and conditions |
JP2010513555A (ja) | 2006-12-19 | 2010-04-30 | アラーガン、インコーポレイテッド | 眼内使用のための環状脂質インプラントの製造法 |
JP2012515628A (ja) | 2009-01-23 | 2012-07-12 | キュー エル ティー インク. | 1つまたは複数の薬剤の徐放性送達 |
JP2013518049A (ja) | 2010-01-22 | 2013-05-20 | アラーガン、インコーポレイテッド | 治療薬持続放出型腔内インプラント |
WO2016037169A1 (fr) | 2014-09-06 | 2016-03-10 | Integral Biosystems Llc | Méthodes et compositions biocompatibles pour obtenir une libération prolongée de médicament dans l'œil |
Family Cites Families (35)
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EP0179583A1 (fr) * | 1984-10-04 | 1986-04-30 | Merck & Co. Inc. | Système pour augmenter la vitesse de dissolution dans l'eau et la solubilité de médicaments peu solubles |
US5273530A (en) | 1990-11-14 | 1993-12-28 | The University Of Rochester | Intraretinal delivery and withdrawal instruments |
JP4194114B2 (ja) * | 1994-02-23 | 2008-12-10 | ビーエム リサーチ エイ/エス | 制御放出組成物 |
US5632773A (en) * | 1994-05-03 | 1997-05-27 | Allergan, Inc. | Biostable corneal implants |
GB9412273D0 (en) * | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
AUPP279698A0 (en) * | 1998-04-03 | 1998-04-30 | Sunscape Developments Limited | Sustained release formulation |
WO2001049352A2 (fr) | 2000-01-03 | 2001-07-12 | Johns Hopkins University | Dispositif et procede destines a une pose manuelle de catheter dans une veine retinienne |
US6954933B2 (en) | 2000-10-30 | 2005-10-11 | Microsoft Corporation | Method and apparatus for providing and integrating high-performance message queues in a user interface environment |
AU2004215898A1 (en) | 2003-02-26 | 2004-09-10 | Medivas, Llc | Bioactive stents and methods for use thereof |
US7662864B2 (en) | 2003-06-04 | 2010-02-16 | Rutgers, The State University Of New Jersey | Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent |
US20050129731A1 (en) | 2003-11-03 | 2005-06-16 | Roland Horres | Biocompatible, biostable coating of medical surfaces |
US20080231987A1 (en) | 2004-01-19 | 2008-09-25 | Koninklijke Philips Electronic, N.V. | Disk Cartridge Having Centering Means |
US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
US8529927B2 (en) | 2004-04-30 | 2013-09-10 | Allergan, Inc. | Alpha-2 agonist polymeric drug delivery systems |
EP1765454B1 (fr) | 2004-07-02 | 2016-04-13 | Mati Therapeutics Inc. | DISPOSITIF DE MISE EN PLACE D'UN MOYEN DE TRAITEMENT POUR l'OEIL |
AU2005271700B2 (en) | 2004-07-12 | 2010-11-11 | Allergan, Inc. | Opthalmic compositions and methods for treating ophthalmic conditions |
EP1787643A1 (fr) * | 2004-09-09 | 2007-05-23 | Jimenez Bayardo, Arturo | Implants et microspheres de liberation prolongee de medicaments a usage ophtalmique et methodes de preparation |
WO2006031658A2 (fr) * | 2004-09-10 | 2006-03-23 | Allergan, Inc. | Inserts therapeutiques pour canal lacrymal et methodes connexes |
US8313763B2 (en) * | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
CN101069004A (zh) | 2005-04-04 | 2007-11-07 | 京商株式会社 | 多缸两冲程星形内燃机 |
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US8039010B2 (en) * | 2006-11-03 | 2011-10-18 | Allergan, Inc. | Sustained release intraocular drug delivery systems comprising a water soluble therapeutic agent and a release modifier |
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US10603274B2 (en) * | 2016-09-30 | 2020-03-31 | Mati Therapeutics Inc. | Ophthalmic drug sustained release formulation and uses thereof |
DK3518897T3 (da) * | 2016-09-30 | 2022-03-07 | Mati Therapeutics Inc | Depotformulering af optalmisk lægemiddel og anvendelser deraf |
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2017
- 2017-09-30 DK DK17857601.3T patent/DK3518897T3/da active
- 2017-09-30 ES ES17857601T patent/ES2907847T3/es active Active
- 2017-09-30 CN CN201780071539.8A patent/CN110475543B/zh active Active
- 2017-09-30 EP EP17857601.3A patent/EP3518897B1/fr active Active
- 2017-09-30 WO PCT/US2017/054654 patent/WO2018064648A1/fr unknown
- 2017-09-30 EP EP22152097.6A patent/EP4046609A1/fr active Pending
- 2017-09-30 JP JP2019516703A patent/JP7088918B2/ja active Active
- 2017-09-30 KR KR1020197012390A patent/KR20190061047A/ko not_active Application Discontinuation
- 2017-09-30 CA CA3038115A patent/CA3038115A1/fr active Pending
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2019
- 2019-03-27 IL IL265677A patent/IL265677A/en unknown
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2020
- 2020-03-30 US US16/833,883 patent/US11324693B2/en active Active
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2022
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CN110475543B (zh) | 2023-07-25 |
EP3518897A1 (fr) | 2019-08-07 |
DK3518897T3 (da) | 2022-03-07 |
US11957784B2 (en) | 2024-04-16 |
CN110475543A (zh) | 2019-11-19 |
ES2907847T3 (es) | 2022-04-26 |
EP4046609A1 (fr) | 2022-08-24 |
KR20190061047A (ko) | 2019-06-04 |
US20200222317A1 (en) | 2020-07-16 |
US20230091568A1 (en) | 2023-03-23 |
JP2023133438A (ja) | 2023-09-22 |
CA3038115A1 (fr) | 2018-04-05 |
US11324693B2 (en) | 2022-05-10 |
JP2022125050A (ja) | 2022-08-26 |
WO2018064648A1 (fr) | 2018-04-05 |
JP2019534872A (ja) | 2019-12-05 |
IL265677A (en) | 2019-05-30 |
JP7324342B2 (ja) | 2023-08-09 |
EP3518897B1 (fr) | 2022-02-09 |
EP3518897A4 (fr) | 2020-05-27 |
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