JP6974922B2 - 可溶性フィルムを有するバリアパッチ及び皮膚の外観を改善する方法 - Google Patents
可溶性フィルムを有するバリアパッチ及び皮膚の外観を改善する方法 Download PDFInfo
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
- A61F13/025—Adhesive bandages or dressings characterised by the skin-adhering layer having a special distribution arrangement of the adhesive
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Description
水溶性フィルムゾーンであって、
ポリエチレンオキシド及びこれらの組み合わせからなる群から選択されるポリマーを含む水溶性フィルム形成ポリマー、並びに
有効量の皮膚活性剤を含む化粧品組成物を含む、水溶性フィルムゾーンと、
バリアパッチであって、
第1の表面及び第2の表面を有する裏材層、並びに
上面及び下面を有する感圧接着剤ゾーンであって、感圧接着剤の下面が、裏材層の第1の表面と接触している、感圧接着剤ゾーンを含む、バリアパッチと、を含み、
可溶性フィルムゾーンが、裏材層の第1の表面、接着剤ゾーンの上面、又はその両方と接触し、可溶性フィルムゾーン又は製品が、第1の可視状態から第2の可視状態に変化することができ、好ましくは、バリアパッチが透明であり、好ましくは、水溶性フィルムゾーンが、水中油型又は油中水型エマルションを更に含み、かつ、約10〜約100の初期不透明度を有し、好ましくは、水溶性フィルム形成ポリマーが、エマルションを超える、水溶性フィルムゾーンの重量に基づくレベルで使用され、それにより好ましくは水溶性フィルムゾーンが、約35%〜45%のエマルション、及び約51%〜約70%の水溶性フィルム形成ポリマーを含み得る、多層美容ケア製品を提供する。
水溶性フィルムゾーンであって、
a.有効量の皮膚活性剤を含む化粧品組成物、
b.ポリエチレンオキシド及びこれらの組み合わせからなる群から選択されるポリマーを含む水溶性フィルム形成ポリマー、
c.可溶性フィルムゾーンの約2重量%〜約80重量%の可塑剤、を含む、水溶性フィルムゾーンと、
バリアパッチであって、
第1の表面及び第2の表面、及び約1g/m2/24時間〜約500g/m2/24時間のWVTRを有する裏材層、並びに
上面及び下面を有する感圧接着剤ゾーンであって、感圧接着剤の下面が、裏材層の第1の表面と接触している、感圧接着剤ゾーンを含む、バリアパッチと、を含み、
可溶性フィルムゾーンが、裏材層の第1の表面、接着剤ゾーンの上面、又はその両方のいずれかと接触し、接着剤ゾーン又は裏材層が、有効量の皮膚活性剤を実質的に含まず、可溶性フィルムゾーン又は製品が、不透明度試験方法に従って、約2.5〜約50の不透明度変化指数を有する、第1の可視状態から第2の可視状態に変化することができる、多層美容ケア製品を提供する。
水溶性フィルムゾーンであって、
メチルセルロース、ヒドロキシプロピルメチルセルロース、ヒドロキシプロピルセルロース、及びこれらの組み合わせからなる群から選択されるポリマーを含む水溶性フィルム形成ポリマー、並びに
水中油型又は油中水型エマルション、及び
有効量の皮膚活性剤を含む、化粧品組成物、
任意選択的に、可溶性フィルムゾーンの約2重量%〜約80重量%の可塑剤、を含み、
好ましくは、水溶性フィルムゾーンが、約10〜約100の初期不透明度を有する、水溶性フィルムゾーンと、
バリアパッチであって、
第1の表面及び第2の表面を有する裏材層、並びに
上面及び下面を有する感圧接着剤ゾーンであって、感圧接着剤の下面が、裏材層の第1の表面と接触している、感圧接着剤ゾーンを含む、バリアパッチと、を含み、
可溶性フィルムゾーンが、裏材層の第1の表面、接着剤ゾーンの上面、又はその両方と接触し、可溶性フィルムゾーン又は製品が、任意選択的に不透明度試験方法に従って、約2.5〜約50の不透明度変化指数を有する、第1の可視状態から第2の可視状態に変化することができ、好ましくは、接着剤ゾーン又は裏材層が、有効量の皮膚活性剤を実質的に含まない、多層美容ケア製品を提供する。
水溶性フィルムゾーンは、水溶性フィルム形成ポリマーと、有効量の皮膚活性剤を含む化粧品組成物と、を含む。水溶性フィルム形成ポリマーは、本明細書の不透明度試験方法に従った約2.5〜約50の不透明度変化指数によって定義される溶解度も有する、好ましくは水溶性フィルムの群から選択される水溶性フィルムを形成する。本明細書で使用するとき、「水溶性フィルム」とは、本明細書の溶解方法に従って溶解するフィルムを意味する。この特色のおかげで、製品は、本明細書で提供されるように、低WVTRを有する低い通気性を有する裏材層によって、可溶性フィルムが皮膚を遮蔽するときなど、可溶性フィルムゾーンの不透明度の変化を通じてユーザーにシグナルを提供する。
a.)可溶性フィルムゾーンの重量に基づいて、約40重量%〜約70重量%、好ましくは、約53重量%〜約70重量%の水溶性フィルム形成ポリマーと、
b.)可溶性フィルムゾーンの重量に基づいて約30重量%〜約60重量%の、油中水型又は水中油型エマルション、及び有効量の皮膚活性剤、及び任意選択的に安全かつ有効な量の可塑剤、を含む化粧品組成物と、を含み得る。
本明細書の水溶性フィルムゾーンはまた、1つ以上の可塑剤を含むことができる。例えば、可溶性フィルムゾーン又は水溶性フィルム形成ポリマーの重量に基づいて、約2重量%〜約80%、又は約2重量%〜約60重量%、又は約10重量%〜約50重量%、又は約20重量%〜約45重量%のレベルで可塑剤を添加することが有益であり得る。可塑剤は、例えば、グリセロール、エチレングリコール、ジエチレングリコール、ヘキシレングリコール、トリエチレングリコール、プロピレングリコール、ポリエチレングリコール、ポリプロピルグリコール、クエン酸アルキル、ソルビトール、ペンタエリスリトール、グルカミン、N−メチルグルカミン、クメンスルホン酸ナトリウム、及びこれらの混合物であってもよい。一態様では、可塑剤は、グリセロールである。他の可塑剤としては、植物油、ポリソルビトール、ポリエチレンオキシド、ジメチコン、鉱物油、パラフィン、C1〜C3アルコール、ジメチルスルホキシド、N,N−ジメチルアセトアミド、スクロース、コーンシロップ、フルクトース、ジオクチル−ナトリウム−スルホ−サクシネート、トリエチルシトレート、トリブチルシトレート、1,2−プロピレングリコール、グリセロールのモノアセテート、ジアセテート又はトリアセテート、天然ガム、シトレート、及びこれらの混合物が挙げられ得る。
本明細書の水溶性フィルムゾーン又は水溶性フィルム形成ポリマーはまた、1つ以上の任意選択的な成分を含み得る。任意選択的な成分としては、増量剤、充填剤、希釈剤、界面活性剤、安定化剤、乳化剤、増粘剤、防腐剤、結合剤、着色剤、顔料、可溶化剤、湿潤剤、水溶性不活性充填剤、緩衝剤、透過性向上剤、及び組み合わせが挙げられる。増粘剤としては、アラビアガム、カラギーナン、カラヤガム、トラガカントガム、キャロブガム、クインスシード又はマルメロガム、カゼイン、デキストリン、ゼラチン、ペクチン酸ナトリウム、アルギン酸ナトリウム、メチルセルロース、CMC、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ポリビニルアルコール、PVM、PVP、ポリアクリル酸ナトリウム、カルボキシビニルポリマー、ローカストビーンガム、グアーガム、タマリンドガム、セルロースジアルキルジメチルアンモニウムサルフェート、キサンタンガム、ケイ酸アルミニウムマグネシウム、ベントナイト、ヘクトライト、AIMgシリケート又はビーガム(beagum)、ラポナイト、及びケイ酸無水物が挙げられ得る。
製品1の例示的な態様を、図1、図2A、図2B、図3、及び図4に示す。図1、図2A、及び図2Bは、感圧接着剤3及び裏材層4を有するバリアパッチ2を含む製品1を示す。図2Aは、2A−2Aに沿って取られた図1の断面図である。図1は、製品1の長手方向軸に対してオフセットした一連の平行なストライプを作り出す複数の可溶性フィルムゾーン6を示す。したがって、製品1は、感圧接着剤3の上面16に適用される可溶性フィルムゾーン6のストライプの代替的な列を有する。
一態様では、バリアパッチは、第1の表面及び第2の表面を有する裏材層と、約1g/m2/24時間〜約500g/m2/24時間のWVTRと、上面及び下面を有する感圧接着剤ゾーンと、を含み得、感圧接着剤は、裏材層の第1の表面と接触し得る。
(i)第1の表面を有する非発泡性ポリマーフィルムを含む第1の非発泡性層と、
(ii)45%〜80%、好ましくは50%〜75%、より好ましくは55%〜73%の平均ボイド体積率、10マイクロメートル〜250マイクロメートル、好ましくは40マイクロメートル〜160マイクロメートルの厚さを有する発泡性ポリマーフィルムを含む第2の発泡性層と、を含む、裏材を含む。
このバリアパッチは、裏材層及び感圧接着剤ゾーンを含み得る。典型的には、感圧接着剤ゾーンは、長期的な皮膚接触に好適であり得、裏材層及び/又は存在する添加剤と物理的かつ化学的に適合可能であろう感圧接着剤(PSA)を含む。好適な接着剤材料の例としては、アクリル酸エステル及びメタクリル酸エステルのホモポリマー又はコポリマー、ブチルゴム系システム、シリコーン、ウレタン、ビニルエステル及びアミド、オレフィンコポリマー材料、天然又は合成ゴム、ホットメルト接着剤(例えば、米国特許第5,387,450号参照);ポリエチレン;ポリシロキサン;ポリイソブチレン;ポリアクリレート;ポリアクリルアミド;ポリウレタン;可塑化エチレン−ビニルアセテートコポリマー;並びにポリイソブテン、ポリブタジエン、ポリスチレン−イソプレンコポリマー、ポリスチレン−ブタジエンコポリマー、及びネオプレン(ポリクロロプレン)などの粘着性ゴム、並びにこれらの組み合わせが挙げられるが、これらに限定されない。
一態様では、バリアパッチ又は製品の全体的な合計厚さは、20マイクロメートル〜500マイクロメートル、好ましくは50マイクロメートル〜200マイクロメートル、より好ましくは70〜180マイクロメートル、更により好ましくは75〜150マイクロメートル、及びこれらの組み合わせである。
感圧接着剤ゾーン及び水溶性フィルムゾーンは、連続又は不連続なパターンを含むように、連続的又は不連続的であってもよい。一態様では、接着剤ゾーン及び可溶性フィルムゾーンは、両方とも連続的であってもよい。いくつかの態様では、接着剤ゾーン及び可溶性フィルムゾーンの一部分は連続的であり、別の部分は不連続であってもよい。可溶性フィルムゾーン及び接着剤ゾーンを不連続なパターンで裏材層に適用することによって、製品及び接着剤ゾーンの皮膚に面する表面の一部分が皮膚に露出して保持されて、感圧接着剤を介して皮膚への十分な接着を可能にする。一態様では、可溶性フィルムゾーンは、接着剤ゾーン若しくは製品の皮膚に面する表面積の約1%〜約99%、又は接着剤ゾーン若しくは製品の皮膚に面する表面積の約10%〜約90%、及び/又は約20%〜約80%を覆うように、接着剤ゾーンに適用されるべきである。
製品は、ヒトの顔若しくはその一部、脚、手、腕、足、又はヒトの胴体であり得る皮膚の所望の標的区域になじむように適応したサイズ及び形状を有し得る。それらは一般に、外観が平坦である。
一態様によれば、裏材層又はバリアパッチは、約1g/m2/24時間〜約500g/m2/24時間のWTVR値を有し、別の態様では、約1g/m2/24時間〜約250g/m2/24時間、及び/又は約1g/m2/24時間〜約180g/m2/24時間、及び/又は約2mg2/24時間〜約150g/m2/24時間、及び/又は約2〜約20g/m2/24時間のWVTRを有する。用語WTVRは、「水蒸気透過率」、すなわち、ある特定の期間中に単位面積当たりに通過することができる蒸気の量を表す。
本明細書の製品は、製品の感圧接着剤又は可溶性フィルムゾーンの消費者に面する側面に取り外し可能に取り付けられた保護剥離層を、任意選択的に更に含み得る。剥離層は、感圧接着剤ゾーン及び/又は可溶性フィルムゾーンに、環境からの保護、及びユーザーによって適用される前の保護を提供する。
一態様では、水溶性フィルムゾーンは、有効量の皮膚活性剤及び水溶性フィルム形成ポリマーを含む、化粧品組成物を含む。組成物はまた、皮膚科学的に許容可能な担体を含み得る。
一態様では、製品は、皮膚の標的区域に送達される有効量の皮膚活性剤を提供する。別の態様では、製品は、約0.5mg/cm2〜約3mg/cm2、及び/又は約1mg/cm2〜約2mg/cm2の化粧品組成物を皮膚の標的区域に提供する。一態様では、及び理論に束縛されるものではないが、適切な量の化粧品組成物の使用は、化粧品組成物と感圧接着剤との相互作用を最小限に抑えるであろう。本発明の組成物は、スキンケア製品の使用に特徴的な特定のスキンケア効果を提供する皮膚活性剤を含み得る。スキンケア効果は、皮膚の外観又はメークアップに関係する効果を含み得る。皮膚活性剤は、短期的(即時かつ短時間持続する)効果、又は長期的(長期かつ、より長時間持続する)効果を提供し得る。
不透明度及び不透明度変化指数
不透明度は、材料が、背景にあるものを不明瞭にする能力の尺度である。本明細書で使用するとき、不透明度変化指数は、製品又は水溶性フィルムゾーン又は可溶性フィルム試料(水溶性フィルム形成ポリマーから作製された)が、本明細書の溶解度試験方法に供されるときの不透明度の変化を測定する。不透明度変化指数は、
不透明度変化指数=初期不透明度/24時間不透明度である。
1.25マイクロメートル〜100マイクロメートルの厚さを有する試料を、3インチ×3インチに切断する。
2.製品がまだ組み立てられていない場合、可溶性フィルムをMylarの一片に直接適用し、平らにする。可能な場合、水溶性フィルムのしわを回避する。裏材層、接着剤、及び可溶性フィルムを含む多層製品を使用する場合、製品がしわにならないように注意しながら、Mylarの一片に製品を適用する。あるいは、裏材層、接着剤、及び可溶性フィルムを含む多層製品を使用する場合、裏材層及び接着剤を製品から除去し、残りの可溶性フィルム試料(可溶性フィルムに残留接着剤が存在してもしなくてもよい)を、試料がしわにならないように注意しながら、Mylarの一片に適用することも許容可能である。スコッチテープを使用して、テープを試料と1/4インチ重ねて、試料を4つ全ての側面でマイラーに取り付ける。
3.ステップ2のように試料を調製し、以下のステップ6に従って試料の不透明度を測定する。これは、初期不透明度である。次いで、飽和塩化カリウム溶液を収容している85%RHの容器にそれらを入れる。試料を、試料のMylar側が容器の開放湿潤空気から遠ざけて、可溶性フィルムが容器の開放湿潤空気に向かって面するように配置するべきである。好適な容器は、浄化されたポリプロピレン製の、8〜12クオートの容量、気密性シリコーン封止部を備え、4つの固定クランプで基部に取り付けられる蓋を有する、Container Storeからの気密性のSmart Locks Keep Box容器である。
4.試料をこの容器内に24時間静置する。
5.24時間後、試料を含む容器をHunter Labscan XEへと運び、不透明度を測定する。
6.不透明度測定。容器から1回に1つの試料を取り出し、容器を再度閉じ、可能な限り迅速に約1〜2分以内に不透明度を実行する。
i.不透明度は、0°の照明/45°の検出、円形の光学的形状、Hunter Color Flex EZ分光光度計、又は同等の、HunterLab Headquarters(Reston VA)などのコンピュータインターフェースを有する分光光度計を使用して測定する。
ii.試料の色に対する通常の実験室温度及び湿気範囲の影響は無視できるため、不透明度を決定する前に試料を調整する必要はない。
iii.機器の較正及び測定は、白黒の標準較正プレートを使用して行う。いかなる試験を開始する前にも、製造業者の指示に従い、機器と共に供給される黒色及び白色の標準タイルを使用して、分光光度計を較正する。色差式をXYZに、視野を10°に、及び照明をD65に設定する。この機器を、製造業者の手順に従って、0.7インチポートサイズ及び0.5インチ視野域を使用して標準化する。較正後、ソフトウェアはY不透明度手順に設定され、これは測定中に白又黒のいずれかの較正タイルで試料を覆うようにオペレータを促す。試料を測定ポートに被せて置く。試料は、ポートに向けられた可溶性フィルム表面に対応する表面がポートプレートに対して平坦になるように、ポートを完全に覆うべきである。次いで、試料を、白色の標準プレートで覆う。表示を読み取り、次いで白色のタイルを取り出し、試験を動かさずに黒色の標準タイルに置き換える。第2の表示を読み取る。
iv.不透明度の値は、フィルムの黒い裏材での反射率を、同じ材料の白い裏材で得られた反射率で除することによって決定される。これは、不透明度が以下のように計算される、コントラスト比法と呼ばれる。
不透明度=(Y値(黒色裏材)/Y値(白色裏材))×100
v.5つの同一の製品又はフィルムからの試料を分析し、これらの不透明度の結果を記録する。試料の平均不透明度を計算し、報告する。
7.全ての試料で行われるまでステップ6を繰り返す。
8.全ての試料について不透明度変化指数を計算し、結果を記録する。
不透明度変化指数=初期不透明度/24時間不透明度である。
本明細書の可溶性フィルム又は製品の不透明度変化指数は、約2.5〜約50、又は約3〜約40、又は約5〜約20である。
バリアパッチ又は裏材層のWVTRは、ASTM F1249 13に従って、37℃及び35%RHに従って測定する。試料は、ASTM F1249を使用して、MOCON Permatran−W 3/33水蒸気透過性機器で分析してもよい。より高いWVTRを有する試料(例えば、およそ300g/m2/24時間〜500g/m2/24時間)では、ASTM E−96に従って、乾燥剤を試験カップ内に入れ、35%のカップの外部周辺RHで、試料を分析してもよい。バリアパッチの試料を調製し、試料は感圧接着剤を含まない。
以下のとおり坪量を計算する。試料調製:TAPPI条件(50%RH、23℃)で100時間、試料を平衡化した。JDC 1インチストリップカッターを使用して、試料を25.4mm幅のストリップに切断する。ゲージブロックを使用して、試料を長さ80mmに切断する。4つの位置で分析天秤を使用して、各試料を秤量する。質量を面積=25.4mm×80mm=2032mm=0.002032メートルで、天秤上で測定した試料質量/面積として、坪量を計算する。坪量は、グラム/メートル2の単位で報告する。
厚さ測定は、典型的には既知の圧力(0.1psi)でパッドキャリパ及びゲージセンサを使用する、ASTM D5729を使用して実行してもよい。www.WorldofTest.comから入手可能なQualitest Thickness Tester、モデルCHY−C2を使用してもよい。
水溶性フィルムを、21℃(+/−1.5℃)及び相対湿度50%(相対湿度+1〜1.5%)で24時間劣化させる。水溶性フィルム試料の3つの試験片を、3.8cm×3.2cmのサイズに切断する。各試料片を別個の35mmスライド台に固定する。500mLの蒸留水で好適なビーカーを充填し、20℃の一定温度を維持する。水のカラムの高さにマークを付ける。磁気撹拌器の上にビーカーを置き、ビーカーに磁気撹拌棒を加え、撹拌器のスイッチを入れ、水カラムの高さのおよそ5分の1の渦が出現するまで撹拌速度を調整する。渦の深さをマークする。スライド台紙の長い端が水表面に平行であるように、スライド搭載ホルダーのワニ口クランプに35mmスライド台紙を固定する。水に浸けたときに、クランプの末端部が水の表面の0.6cm下になるように、ホルダーの深さ調節器を設定すべきである。フィルム表面が水流に垂直になるように、スライド台の短い方の側面の一方はビーカーの側部に隣接するべきであり、他方は撹拌棒の中心の真上に配置するべきである。1回の動作で、固定されたスライド及びクランプを水中に下ろし、タイマーを起動させる。全ての目に見えるフィルムがスライド台から剥離したら、未溶解のフィルムの断片に関して溶液を引き続きモニターしながら、スライドを水から持ち上げる。各試料について、各試料の全てのフィルム断片が肉眼でもはや見えず、溶液が透明になったときの時間を記録する。3つの試料の時間値を平均し、平均時間が15分以下である場合、試料は水溶性フィルムであるとする。
以下の配合及び手順を使用する。
代替的なポリマー溶液を使用してもよく、以下のように調製する。535.8gのエタノールをビーカーに入れ、オーバーヘッドミキサーを用いて300RPMで撹拌する。次いで、0.2gのフェノキシエタノール撹拌を添加する。分散したら、200gの200k PEO、(Dowから入手可能な約200,000の分子量を有する、Polyox WSR N−80)を添加し、15分間300RPMで撹拌して分散させる。分散したら、264gの蒸留水を添加し、100RPMで2時間撹拌する。次いで、ポリマー溶液対エマルションの混合物の比60:40で、ポリマー溶液をエマルションと混合する。次いで、Gardo Draw Downテーブル及び#44 Draw Downバーを使用して、フィルムを転写シート上にキャストする。
代替的なポリマー溶液を使用してもよく、以下のように調製する。799.8gの蒸留水をビーカーに入れ、300RPMでオーバーヘッドミキサーから撹拌しながら95Cに加熱する。95Cになったら、0.2gのフェノキシエタノールを添加し、分散するまで撹拌する。次に、300RPMで撹拌しながら、Methocel E5LV粉末を添加する。全てのMethocel E5LVを添加したら、熱を除去し、混合物が60Cになるまで300RPMで撹拌する。60Cになったら、撹拌を150RPMに下げ、ビーカーを氷浴に入れ、完全に水和されるまで、通常は一晩撹拌する。次いで、ポリマー溶液対エマルションの混合物の比60:40で、ポリマー溶液をエマルションと混合する。次いで、Gardo Draw Downテーブル及び#44 Draw Downバーを使用して、フィルムを転写シート上にキャストする。この水溶性フィルムゾーンの不透明度変化指数は、以下のように約5.74である。
2015年11月19日出願の米国仮特許出願第62/257,341号の試料3に従った裏材層が、提供される。具体的には、試料3は、発泡性コア層及び非発泡性外層を有する3層フィルムである。全ての層はEVAで作製される。外側層は、各々およそ20μmの厚さを有し、コア発泡性層はおよそ130μmの厚さを有する。裏材層の合計厚さは、およそ170μmである。坪量は約99gsmであり、WVTRは82g/m2/24時間である。裏材層は、第1の表面を有する。
Claims (11)
- 皮膚に皮膚活性剤を適用するための多層美容ケア製品であって、前記製品は、
複数の不連続な水溶性フィルムゾーンであって、
ポリエチレンオキシドを含む水溶性フィルム形成ポリマー、並びに
有効量の皮膚活性剤を含む化粧品組成物を含む、水溶性フィルムゾーンと、
バリアパッチであって、
第1の表面及び第2の表面を有する裏材層、並びに
上面及び下面を有する感圧接着剤ゾーンであって、前記感圧接着剤の前記下面が、前記裏材層の前記第1の表面と接触している、感圧接着剤ゾーンを含む、バリアパッチと、を含み、
前記感圧接着剤が、アクリル酸エステル及びメタクリル酸エステルのホモポリマー又はコポリマー、ブチルゴム系システム、シリコーン、ウレタン、ビニルエステル及びアミド、オレフィンコポリマー材料、並びにこれらの組み合わせからなる群から選択され、
前記複数の不連続な水溶性フィルムゾーンは、前記感圧接着剤ゾーンにより空間的に離間されており、
前記水溶性フィルムゾーンが、前記裏材層の前記第1の表面、前記接着剤ゾーンの前記上面、又はその両方と接触し、前記水溶性フィルムゾーン又は製品が、2.5〜50の不透明度変化指数を有する、第1の不透明度を有する第1の可視状態から第2の不透明度を有する第2の可視状態に変化することができ、第2の不透明度は第1の不透明度よりも小さく、第1の不透明度、第2の不透明度、および不透明度変化指数は、本明細書に記載の不透明度試験方法に従って測定され、
不透明度変化指数は、
不透明度変化指数=初期不透明度/24時間不透明度
の式で求められる、多層美容ケア製品。 - 前記裏材層が、1g/m2/24時間〜500g/m2/24時間のWVTRを有する、請求項1に記載の製品。
- 前記水溶性フィルム形成ポリマーが、500〜10,000,000の分子量を有するポリエチレンオキシドからなる群から選択される、請求項1又は2に記載の製品。
- 前記接着剤ゾーン、裏材層、又はバリアパッチが、有効量の皮膚活性剤を含まない、請求項1〜3のいずれか一項に記載の製品。
- 前記水溶性フィルムゾーンが、前記水溶性フィルムゾーンの2重量%〜80重量%の可塑剤を更に含み、前記可塑剤が、グリセロール、エチレングリコール、ジエチレングリコール、プロピレングリコール、ソルビトール、ペンタエリスリトール、グルカミン、N−メチルグルカミン、クメンスルホン酸ナトリウム、及びこれらの組み合わせからなる群から選択される、請求項1〜4のいずれか一項に記載の製品。
- 前記水溶性フィルムゾーンが、最上面及び底面を更に含み、前記水溶性フィルムゾーンの前記最上面及び前記接着剤ゾーンの前記上面が、同一平面上又は同一線上にある、請求項1〜5のいずれか一項に記載の製品。
- 前記水溶性フィルムゾーンが、2マイクロメートル〜200マイクロメートルの合計厚さを有し、前記バリアパッチ又は製品が、20マイクロメートル〜500マイクロメートルの合計厚さを有する、請求項1〜6のいずれか一項に記載の製品。
- 前記製品、バリアパッチ、又は裏材層が、繊維状吸収性材料、超吸収性材料、不織布材料、綿、レーヨン、アクリル、ポリプロピレン繊維、及びポリエステル繊維を含まない、請求項1〜7のいずれか一項に記載の製品。
- 前記バリアパッチ又は裏材層が透明である、請求項1〜8のいずれか一項に記載の製品。
- 前記水溶性フィルムゾーンが、水中油型又は油中水型エマルションを更に含み、かつ、約10〜約100の初期不透明度を有し、初期不透明度は、本明細書に記載の不透明度試験方法に従って測定され、前記水溶性フィルム形成ポリマーが、前記エマルションを超える、前記水溶性フィルムゾーンの重量に基づくレベルで使用され、それにより前記水溶性フィルムゾーンが、約35%〜45%の前記エマルション、及び約51%〜約70%の前記水溶性フィルム形成ポリマーを含み得る、請求項1〜9のいずれか一項に記載の製品。
- 前記皮膚活性剤が、ナイアシンアミド、グリセリン、トコフェロールアセテート、D−パンテノールおよびそれらの組み合わせからなる群から選択される、請求項1〜9のいずれか一項に記載の製品。
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Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016065008A1 (en) | 2014-10-21 | 2016-04-28 | The Procter & Gamble Company | Method of improving skin appearance |
US10576023B2 (en) | 2015-10-22 | 2020-03-03 | The Procter & Gamble Company | Barrier patch of a foamed film and methods of improving skin appearance |
EP3365067B1 (en) | 2015-10-22 | 2019-11-20 | The Procter and Gamble Company | Barrier patch of a foamed film and methods of improving skin appearance |
US10857076B2 (en) | 2017-01-09 | 2020-12-08 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
CN110167642B (zh) | 2017-01-09 | 2022-06-07 | 宝洁公司 | 具有可溶性膜的阻隔贴片和改善皮肤外观的方法 |
US10751265B2 (en) | 2017-01-09 | 2020-08-25 | The Procter & Gamble | Barrier patch with soluble film and methods of improving skin appearance |
EP3641952B1 (en) | 2017-06-22 | 2023-08-02 | The Procter & Gamble Company | Beauty care films including a water-soluble layer and a vapor-deposited coating |
EP3768249B1 (en) * | 2018-03-19 | 2024-04-17 | The Procter & Gamble Company | Method of making a barrier patch with soluble film |
JP7148646B2 (ja) * | 2018-06-29 | 2022-10-05 | ザ プロクター アンド ギャンブル カンパニー | 二相製品 |
US20210130752A1 (en) * | 2019-11-05 | 2021-05-06 | The Procter & Gamble Company | Substrates having water-soluble polymer zones comprising a freshening active and consumer products comprising the same |
CN115607725A (zh) * | 2021-12-31 | 2023-01-17 | 上海炫鑫医药科技有限公司 | 一种强抗菌性的医用敷料及其制备方法 |
Family Cites Families (162)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3155034A (en) | 1961-11-01 | 1964-11-03 | Rineglas Inc | Silk screen printing press |
US3482300A (en) | 1966-10-31 | 1969-12-09 | Screen Printing Systems Inc | Printing screen and method of making same |
US3696741A (en) | 1969-12-03 | 1972-10-10 | George W Reinke | Foraminous printing screen |
US3759799A (en) | 1971-08-10 | 1973-09-18 | Screen Printing Systems | Method of making a metal printing screen |
US3759800A (en) | 1971-09-27 | 1973-09-18 | Screen Printing Systems | Seamless rotary printing screen and method of making same |
JPS5052044U (ja) | 1973-09-08 | 1975-05-20 | ||
US4341209A (en) | 1981-01-12 | 1982-07-27 | The Kendall Company | Adhesive bandage with foam backing |
US4472328A (en) | 1981-06-09 | 1984-09-18 | Mitsubishi Chemical Industries, Ltd. | Process for producing porous film or sheet |
US4377616A (en) | 1981-12-30 | 1983-03-22 | Mobil Oil Corporation | Lustrous satin appearing, opaque film compositions and method of preparing same |
JPS6033021U (ja) | 1983-08-12 | 1985-03-06 | 大道 七海男 | パツケ−ジ |
DE3423293C2 (de) | 1984-06-23 | 1995-08-24 | Lohmann Therapie Syst Lts | Selbstklebendes Pflaster |
DE3423328A1 (de) | 1984-06-23 | 1986-01-02 | Beiersdorf Ag, 2000 Hamburg | Selbstklebendes pflaster |
US4725439A (en) | 1984-06-29 | 1988-02-16 | Alza Corporation | Transdermal drug delivery device |
US4773408A (en) | 1985-01-04 | 1988-09-27 | E. R. Squibb & Sons, Inc. | Wound dressing |
US4649186A (en) | 1985-07-01 | 1987-03-10 | Eastman Kodak Company | Process for preparing copolymers of ethylene and vinyl acetate |
US4578297A (en) | 1985-07-11 | 1986-03-25 | Mobil Oil Corporation | Polymer film/polymer foam laminate and heat-resistant container fabricated therefrom |
US4743249A (en) | 1986-02-14 | 1988-05-10 | Ciba-Geigy Corp. | Dermal and transdermal patches having a discontinuous pattern adhesive layer |
GB8604117D0 (en) | 1986-02-19 | 1986-03-26 | Mclauchlan R A | Light tube protector |
DE3634016A1 (de) | 1986-04-17 | 1987-10-29 | Lohmann Gmbh & Co Kg | Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung |
US4781294A (en) | 1986-10-08 | 1988-11-01 | Warner-Lambert Company | Tear oriented package |
DK157899C (da) | 1987-12-15 | 1990-09-03 | Coloplast As | Hudpladeprodukt |
GB8818114D0 (en) | 1988-07-29 | 1988-09-01 | Johnson & Johnson | Haemostatic wound dressing material |
ATE142557T1 (de) | 1989-05-11 | 1996-09-15 | Landec Corp | Von der temperatur aktivierte bindemitteleinheiten |
US5262165A (en) | 1992-02-04 | 1993-11-16 | Schering Corporation | Transdermal nitroglycerin patch with penetration enhancers |
JPH0645227B2 (ja) | 1989-09-25 | 1994-06-15 | チッソ株式会社 | 不透明で真珠様光沢を有する積層延伸成形物及びその製造方法 |
US5455043A (en) | 1990-06-13 | 1995-10-03 | Fischel-Ghodsian; Fariba | Device for controlled release of vaporous medications through nasal route |
GB9105977D0 (en) | 1991-03-21 | 1991-05-08 | Smith & Nephew | Percutaneous anaesthesia |
US5123900A (en) | 1991-08-16 | 1992-06-23 | Bertek, Inc. | Moisture permeable double disk |
EP0612232B1 (en) | 1991-11-06 | 1999-05-06 | Bioderm, Inc. | Occlusive wound dressing and applicator |
JPH0679002A (ja) | 1993-12-14 | 1994-03-22 | Hisamitsu Pharmaceut Co Inc | 経皮投与用パッチシステム |
ES2099974T3 (es) | 1992-09-25 | 1997-06-01 | Minnesota Mining & Mfg | Tratamiento de la piel con propiedades de mejora de la adherencia. |
DE4308649C2 (de) | 1993-03-18 | 1995-11-16 | Lohmann Gmbh & Co Kg | Medizinisches Pflastermaterial sowie Verfahren zu seiner Herstellung und dessen Verwendung |
US5503844A (en) | 1993-05-18 | 1996-04-02 | Mli Acquisition Corp. Ii | Foam laminate transdermal patch |
US5670557A (en) * | 1994-01-28 | 1997-09-23 | Minnesota Mining And Manufacturing Company | Polymerized microemulsion pressure sensitive adhesive compositions and methods of preparing and using same |
US5476664A (en) | 1994-04-15 | 1995-12-19 | Leonard Bloom | Treatment of warts using anthralins and occlusion |
JPH10508856A (ja) | 1994-11-15 | 1998-09-02 | オスモティクス コーポレーション | スキンケア組成物及びその適用方法 |
US5968533A (en) | 1994-11-15 | 1999-10-19 | Porter; Steven S. | Skin care compositions and methods |
US5559165A (en) | 1995-08-08 | 1996-09-24 | National Starch And Chemical Investment Holding Corporation | Hot melt adhesives for bonding to sensitive areas of the human body |
US5571096A (en) | 1995-09-19 | 1996-11-05 | The Procter & Gamble Company | Absorbent article having breathable side panels |
JP2935343B2 (ja) | 1996-03-04 | 1999-08-16 | 花王株式会社 | シート状パック |
JPH09295929A (ja) | 1996-05-02 | 1997-11-18 | 宰賢 ▲べ▼ | 皮膚皺除去用皮膚粘着型化粧料及びその製造方法 |
GR1002807B (el) | 1996-06-20 | 1997-11-13 | Lavipharm A.E. | Συστημα για την τοπικη θεραπεια της ακμης και μεθοδος παραγωγης του |
US6338855B1 (en) | 1996-10-25 | 2002-01-15 | The Procter & Gamble Company | Cleansing articles for skin and/or hair which also deposit skin care actives |
US5972359A (en) | 1997-05-23 | 1999-10-26 | The Procter & Gamble Company | Skin care compositions and method of improving skin appearance |
US6180133B1 (en) | 1997-11-25 | 2001-01-30 | Watson Pharmaceuticals, Inc. | Antioxidant composition for topical/transdermal prevention and treatment of wrinkles |
US5958447A (en) | 1998-03-17 | 1999-09-28 | Plc Holding, L.L.C. | Adhesive matrix type transdermal patch and method of manufacturing same |
US5965154A (en) | 1998-03-17 | 1999-10-12 | Plc Holding, L.L.C. | Adhesive matrix type transdermal patch and method of manufacturing same |
US6325565B1 (en) | 1998-06-30 | 2001-12-04 | The Procter & Gamble Company | Anti-perspirant/deodorant applicator |
DE19830649C2 (de) | 1998-07-09 | 2003-04-10 | Lohmann Therapie Syst Lts | Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe |
US6221369B1 (en) | 1998-09-03 | 2001-04-24 | Dan B. Pool | Human skin care product and method |
US6596298B2 (en) * | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
FR2784581B1 (fr) | 1998-10-20 | 2002-12-13 | Oreal | Patch, ensemble constitue d'un patch et d'un recipient, et procede |
US6162458A (en) | 1998-11-17 | 2000-12-19 | Nagaoka & Co., Ltd. | Patch for beautification |
AU1825200A (en) | 1998-11-24 | 2000-06-13 | Johnson & Johnson Consumer Companies, Inc. | Coating useful as a dispenser of an active ingredient on dressings and bandages |
US6183770B1 (en) | 1999-04-15 | 2001-02-06 | Acutek International | Carrier patch for the delivery of agents to the skin |
US7063859B1 (en) | 1999-04-28 | 2006-06-20 | Noven Pharmaceuticals, Inc. | Barrier film lined backing layer composition and method for topical administration of active agents |
US6277401B1 (en) | 1999-05-07 | 2001-08-21 | U.S. Dermatologics, Inc. | Drug delivery device |
FI112587B (fi) | 1999-06-04 | 2003-12-31 | Eriksson Capital Ab | Kestomakkaran polymeerisuoli, menetelmä kestomakkaran valmistamiseksi ja polymeerisuolen käyttö kestomakkaroiden valmistuksessa |
USD440315S1 (en) | 1999-06-18 | 2001-04-10 | The Procter & Gamble Company | Eye wrinkle treatment pad |
AU5782700A (en) | 1999-07-06 | 2001-01-22 | Procter & Gamble Company, The | Sheet-like devices |
WO2001001816A1 (en) | 1999-07-06 | 2001-01-11 | Procter & Gamble Company | Cosmetic or dermapharmaceutical patch |
US6495229B1 (en) | 1999-09-17 | 2002-12-17 | Avery Dennison Corporation | Pattern coated adhesive article |
US6926960B1 (en) | 1999-11-05 | 2005-08-09 | Kao Corporation | Adhesive cleaning sheet |
US6168028B1 (en) | 1999-11-19 | 2001-01-02 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Packaged skin product |
US20030072724A1 (en) | 1999-12-16 | 2003-04-17 | Maibach Howard I. | Topical pharmaceutical composition to treat hyperpigmentation of the skin |
US6673363B2 (en) | 1999-12-16 | 2004-01-06 | Dermatrends, Inc. | Transdermal and topical administration of local anesthetic agents using basic enhancers |
US20020022052A1 (en) | 2000-04-06 | 2002-02-21 | Dransfield Charles William | Transdermal delivery system |
US20020077266A1 (en) | 2000-04-08 | 2002-06-20 | Gabriel Flor Gutierrez | Portable stain removal product |
BR0017212A (pt) | 2000-04-12 | 2003-01-07 | Procter & Gamble | Dispositivo pré-formado; método de produção do dispositivo; e método de transferência de pelo menos um agente de benefìcio cosmético à pele, cabelos ou unhas |
US7658942B2 (en) | 2000-04-12 | 2010-02-09 | The Procter & Gamble Company | Cosmetic devices |
US20020022040A1 (en) * | 2000-07-10 | 2002-02-21 | The Proctor & Gamble Company | Methods of enhancing delivery of oil-soluble skin care actives |
JP2002076432A (ja) | 2000-08-30 | 2002-03-15 | Stanley Electric Co Ltd | 端面発光型半導体装置、その製造方法及び光空間伝送装置 |
DE10056010A1 (de) | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Pflaster mit hautpflegenden Substanzen |
US6448303B1 (en) | 2000-12-29 | 2002-09-10 | National Starch And Chemical Investment Holding Corporation | Hot melt adhesives for dermal application |
US6495158B1 (en) | 2001-01-19 | 2002-12-17 | Lec Tec Corporation | Acne patch |
US20050013784A1 (en) | 2001-02-08 | 2005-01-20 | The Procter & Gamble Company | Mask composition |
JP2002249422A (ja) | 2001-02-23 | 2002-09-06 | Fumio Kamiyama | スキンケア用貼付剤 |
US20020187181A1 (en) * | 2001-05-14 | 2002-12-12 | 3M Innovative Properties Company | System for delivering cosmetics and pharmaceuticals |
US20030082219A1 (en) | 2001-10-01 | 2003-05-01 | The Procter & Gamble Company | Skin care compositions comprising low concentrations of skin treatment agents |
US7666337B2 (en) * | 2002-04-11 | 2010-02-23 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
KR100588286B1 (ko) | 2001-12-11 | 2006-06-12 | 더 프록터 앤드 갬블 캄파니 | 예비 성형체를 제조하기 위한 방법 |
USD484985S1 (en) | 2001-12-28 | 2004-01-06 | Hisamitsu Pharmaceutical Co., Inc. | Sheet for cooling human body |
US20030152610A1 (en) | 2002-01-28 | 2003-08-14 | David Rolf | Cosmetic patch |
US20030167556A1 (en) | 2002-03-05 | 2003-09-11 | Consumers Choice Systems, Inc. | Methods and devices for transdermal delivery of anti-aging compounds for treatment and prevention of facial or neck skin aging |
US20030175328A1 (en) | 2002-03-06 | 2003-09-18 | Adi Shefer | Patch for the controlled delivery of cosmetic, dermatological, and pharmaceutical active ingredients into the skin |
US20030175333A1 (en) | 2002-03-06 | 2003-09-18 | Adi Shefer | Invisible patch for the controlled delivery of cosmetic, dermatological, and pharmaceutical active ingredients onto the skin |
US20030180347A1 (en) | 2002-03-19 | 2003-09-25 | W.F. Young, Incorporated | Patch for the delivery of topical agents |
DE10212864B4 (de) | 2002-03-22 | 2005-12-22 | Beiersdorf Ag | Polymermatrizes umfassend ein Mischsystem zur Löslichkeitsvermittlung von pharmazeutischen Wirkstoffen, Verfahren zu deren Herstellung und deren Verwendung |
US6706775B2 (en) | 2002-04-02 | 2004-03-16 | H. H. Brown Shoe Technologies, Inc. | Polyurethane foam products with controlled release of agents and additives |
JP2004051516A (ja) | 2002-07-18 | 2004-02-19 | Kanebo Ltd | シート状パック |
EP1523297A1 (en) | 2002-07-19 | 2005-04-20 | The Procter & Gamble Company | Mask composition containing emulsified liquid composition |
US20040101494A1 (en) * | 2002-11-26 | 2004-05-27 | Scott Douglas Craig | Chewable solid unit dosage forms and methods for delivery of active agents into occlusal surfaces of teeth |
US20040115137A1 (en) * | 2002-12-17 | 2004-06-17 | Verrall Andrew P. | Water-soluble film for oral administration |
US20040116018A1 (en) | 2002-12-17 | 2004-06-17 | Kimberly-Clark Worldwide, Inc. | Method of making fibers, nonwoven fabrics, porous films and foams that include skin treatment additives |
US7887842B2 (en) | 2003-02-07 | 2011-02-15 | Teikoku Pharma Usa, Inc. | Methods of administering a dermatological agent to a subject |
WO2004077990A1 (en) | 2003-03-07 | 2004-09-16 | Aerotech Australia Pty Ltd | A device for treating skin tissue |
US7479132B2 (en) | 2003-03-10 | 2009-01-20 | Tokuyama Corporation | Patch material for ionic medicine administration |
AU2004319243B2 (en) * | 2003-05-28 | 2010-06-03 | Aquestive Therapeutics, Inc. | Polyethylene oxide-based films and drug delivery systems made therefrom |
AU2004247102A1 (en) | 2003-06-11 | 2004-12-23 | The Procter & Gamble Company | Preparation-at-use device comprising pre-formed hydrogel product |
CN100413913C (zh) | 2003-07-07 | 2008-08-27 | 陶氏环球技术公司 | 薄泡沫聚乙烯片材 |
US7758878B2 (en) | 2003-10-10 | 2010-07-20 | Access Business Group International Llc | Cosmetic treatment system and methods |
US7470397B2 (en) * | 2003-10-24 | 2008-12-30 | Adhesives Research, Inc. | Disintegratable films for diagnostic devices |
US20070292491A1 (en) | 2003-11-28 | 2007-12-20 | Grazyna Hansen | Adhesive Patch |
US20060177487A1 (en) | 2005-02-07 | 2006-08-10 | Christine Martz | Moisture and lotion retainer |
DE102004009903A1 (de) | 2004-02-26 | 2005-09-22 | Grünenthal GmbH | Pflaster mit reduzierter Hautirritation |
US9205062B2 (en) | 2004-03-09 | 2015-12-08 | Mylan Pharmaceuticals, Inc. | Transdermal systems containing multilayer adhesive matrices to modify drug delivery |
US20050266059A1 (en) | 2004-05-26 | 2005-12-01 | Poss Valerie S | Heel moisturizing patch |
JP2006021789A (ja) | 2004-07-07 | 2006-01-26 | Kao Corp | 容器起立機能付き箱 |
USD519239S1 (en) | 2004-11-01 | 2006-04-18 | Ayako Katagiri | Cosmetic device |
EP1806152B1 (en) | 2004-11-10 | 2012-08-01 | Hisamitsu Pharmaceutical Co., Inc. | Drug for external use and adhesive patch |
US20060104931A1 (en) | 2004-11-12 | 2006-05-18 | Takeshi Fukutome | Cosmetic treatment article comprising substrate and gel composition |
JP4758434B2 (ja) | 2004-11-12 | 2011-08-31 | ザ プロクター アンド ギャンブル カンパニー | 下層形状に適合可能なトリートメント物品 |
JP2008520735A (ja) | 2004-11-22 | 2008-06-19 | ニュー‐ティーン カンパニー,インク. | 局所用皮膚パッチ |
US20060188558A1 (en) | 2005-02-18 | 2006-08-24 | Mylan Technologies, Inc. | Transdermal systems having control delivery system |
US20070020220A1 (en) | 2005-04-27 | 2007-01-25 | Procter & Gamble | Personal care compositions |
US20070060855A1 (en) | 2005-07-28 | 2007-03-15 | Hollister Incorporated | Pressure-sensitive adhesive compositions and self-adhering wound dressings comprising same |
KR100663163B1 (ko) | 2005-10-24 | 2007-01-02 | (주)아모레퍼시픽 | 비스테로이드성 소염진통제를 함유하는 경피 투여 제제 |
CN101641079A (zh) * | 2006-03-13 | 2010-02-03 | 宝洁公司 | 组合施加能量和局部用组合物以调节哺乳动物皮肤状况 |
US20070259029A1 (en) | 2006-05-08 | 2007-11-08 | Mcentire Edward Enns | Water-dispersible patch containing an active agent for dermal delivery |
DE102006026578B4 (de) | 2006-06-08 | 2009-01-08 | Lts Lohmann Therapie-Systeme Ag | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
KR101179900B1 (ko) * | 2006-07-14 | 2012-09-06 | 더 프록터 앤드 갬블 캄파니 | 집중 케어와 총체적 트리트먼트를 동시에 전달할 수 있는 트리트먼트 용품 |
JP4943960B2 (ja) | 2006-07-19 | 2012-05-30 | 三菱樹脂株式会社 | 積層シート状物 |
KR20080014461A (ko) | 2006-08-11 | 2008-02-14 | 쓰리엠 이노베이티브 프로퍼티즈 캄파니 | 경피투여형 화장료 패치 |
US20080057090A1 (en) * | 2006-09-01 | 2008-03-06 | Mcentire Edward Enns | Wrinkle masking film composition for skin |
DE102006047229A1 (de) | 2006-10-04 | 2008-04-10 | Henkel Kgaa | Wasch- oder Reinigungsmittelabgabesystem |
DE102006058649B4 (de) | 2006-12-11 | 2011-01-20 | Beiersdorf Ag | Ultraschallpflaster und dessen Verwendung zur Hautfaltenreduktion |
US20080200591A1 (en) | 2007-02-15 | 2008-08-21 | Isao Noda | Melt Processable Reactive Pellets Capable of Forming Ester Condensates and Process for Forming Melt Processable Reactive Pellets |
ITMI20070798A1 (it) | 2007-04-18 | 2008-10-19 | Biofarmitalia Spa | Dispositivo per distendere le rughe della pelle umana |
KR100871282B1 (ko) | 2007-06-22 | 2008-11-28 | 김정현 | 안면 주름개선용 미용패드 |
US20090010998A1 (en) * | 2007-07-03 | 2009-01-08 | Marchitto Kevin S | Drug-delivery patch comprising a dissolvable layer and uses thereof |
WO2009055048A1 (en) | 2007-10-24 | 2009-04-30 | Bio Med Sciences, Inc. | Wrinkle reducing skin patch, process of manufacture and useful articles thereof |
US8974814B2 (en) | 2007-11-12 | 2015-03-10 | California Institute Of Technology | Layered drug delivery polymer monofilament fibers |
WO2009155326A1 (en) | 2008-06-20 | 2009-12-23 | The Procter & Gamble Company | Foamed film package |
US20100239619A1 (en) | 2009-03-20 | 2010-09-23 | Marni Markell Hurwitz | Semi-permanent color for application to the skin and applicators therefor |
EP2316436A1 (en) | 2009-10-30 | 2011-05-04 | Johnson & Johnson GmbH | Tape, in particular adhesive tape, for the treatment of skin disorders comprising a film , in particular dissolvable film, containing at least one enzyme |
EP2316438A1 (en) | 2009-10-30 | 2011-05-04 | Johnson & Johnson GmbH | Tape , in particular adhesive tape, for the treatment of skin disorders comprising at least one hyperkeratosis inhibitor and/or at least one keratinolytic agent |
BR112012020661A2 (pt) | 2010-02-17 | 2016-07-26 | Procter & Gamble | artigo para cuidados pessoais flexível |
JP2011178693A (ja) | 2010-02-26 | 2011-09-15 | Kose Corp | 美容方法 |
US20110300198A1 (en) | 2010-06-03 | 2011-12-08 | Amos Nussinovitch | Hydrocolloid - essential oil patches |
EP2654708A4 (en) * | 2010-12-22 | 2015-08-05 | Avon Prod Inc | COSMETIC FILMS |
US20120308619A1 (en) | 2011-06-03 | 2012-12-06 | Tousley Catherine L B | Cosmetic anti-wrinkle patch |
EP2559425A1 (en) | 2011-08-17 | 2013-02-20 | The Procter & Gamble Company | Depilatory method and kit |
EP2561856B1 (en) | 2011-08-24 | 2017-10-25 | The Procter and Gamble Company | Method and kit for depilation |
CN103826595B (zh) * | 2011-09-14 | 2016-11-09 | 高露洁-棕榄公司 | 增白牙贴 |
WO2013153678A1 (en) | 2012-04-11 | 2013-10-17 | L'oreal | Self-standing cosmetic sheet |
DE102012108705B4 (de) | 2012-09-17 | 2020-01-09 | Mondi Ag | Kunststofffolie |
US20140083878A1 (en) * | 2012-09-21 | 2014-03-27 | Mylan Inc. | Transdermal drug delivery device |
EP2922515B1 (en) | 2012-11-21 | 2016-09-28 | Coloplast A/S | Adhesive dressing and method of producing the same |
EP2937066B1 (en) | 2012-12-19 | 2018-04-25 | Nichiban Co. Ltd. | Facial patch |
AR095259A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria |
US20140376835A1 (en) | 2013-06-24 | 2014-12-25 | The Procter & Gamble Company | Foamed Film Packaging |
US20140377512A1 (en) | 2013-06-24 | 2014-12-25 | The Procter & Gamble Company | Printed Foamed Film Packaging |
WO2015161481A1 (en) | 2014-04-24 | 2015-10-29 | The Procter & Gamble Company | Bag made from a foamed film laminate |
WO2016065008A1 (en) | 2014-10-21 | 2016-04-28 | The Procter & Gamble Company | Method of improving skin appearance |
US10576023B2 (en) | 2015-10-22 | 2020-03-03 | The Procter & Gamble Company | Barrier patch of a foamed film and methods of improving skin appearance |
EP3365067B1 (en) | 2015-10-22 | 2019-11-20 | The Procter and Gamble Company | Barrier patch of a foamed film and methods of improving skin appearance |
CN108135787B (zh) | 2015-10-22 | 2022-05-17 | 宝洁公司 | 发泡膜的阻隔贴片以及改善皮肤外观的方法 |
US10857076B2 (en) | 2017-01-09 | 2020-12-08 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
CN110167642B (zh) | 2017-01-09 | 2022-06-07 | 宝洁公司 | 具有可溶性膜的阻隔贴片和改善皮肤外观的方法 |
US10751265B2 (en) * | 2017-01-09 | 2020-08-25 | The Procter & Gamble | Barrier patch with soluble film and methods of improving skin appearance |
EP3641952B1 (en) | 2017-06-22 | 2023-08-02 | The Procter & Gamble Company | Beauty care films including a water-soluble layer and a vapor-deposited coating |
EP3768249B1 (en) | 2018-03-19 | 2024-04-17 | The Procter & Gamble Company | Method of making a barrier patch with soluble film |
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2018
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US20180200158A1 (en) | 2018-07-19 |
CN110049803B (zh) | 2022-06-07 |
WO2018129496A1 (en) | 2018-07-12 |
US10806681B2 (en) | 2020-10-20 |
US10799431B2 (en) | 2020-10-13 |
EP3565641B1 (en) | 2021-06-23 |
US20180193230A1 (en) | 2018-07-12 |
CN110167642B (zh) | 2022-06-07 |
EP3565641A1 (en) | 2019-11-13 |
WO2018129495A1 (en) | 2018-07-12 |
CN110167642A (zh) | 2019-08-23 |
EP3565642A1 (en) | 2019-11-13 |
CN110049803A (zh) | 2019-07-23 |
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