JP6792082B2 - 測定用チップ、測定装置、および測定方法 - Google Patents
測定用チップ、測定装置、および測定方法 Download PDFInfo
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- JP6792082B2 JP6792082B2 JP2019539134A JP2019539134A JP6792082B2 JP 6792082 B2 JP6792082 B2 JP 6792082B2 JP 2019539134 A JP2019539134 A JP 2019539134A JP 2019539134 A JP2019539134 A JP 2019539134A JP 6792082 B2 JP6792082 B2 JP 6792082B2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/272—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N2021/4173—Phase distribution
- G01N2021/418—Frequency/phase diagrams
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7776—Index
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- Urology & Nephrology (AREA)
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- Investigating Or Analysing Materials By Optical Means (AREA)
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Description
10…光源
11…導入部
13…伝搬部
15…測定装置
17…導出部
30…受光部
31…測定部
32…制御部
101…伝搬層
102…リガンド
105…基材
107…中間層
109…伝搬層
201…アナライト
Claims (17)
- 光が伝搬する伝搬層と、
前記伝搬層に前記光を導入する導入部と、
前記伝搬層から前記光を導出する導出部と、
被検出物質に反応する反応物質が形成された前記伝搬層の表面において、前記光の伝搬方向に所定の長さに亘って、前記反応物質の含有量が前記伝搬方向に直交する垂直方向で単調に変化する領域を含む反応部と、
を備えた測定用チップ。 - 請求項1に記載の測定用チップであって、
前記反応部の領域は、前記光の伝搬方向に所定の長さに亘って、前記反応物質の含有量が前記垂直方向で連続的に変化する領域を含む
ことを特徴とする測定用チップ。 - 請求項1または請求項2に記載の測定用チップであって、
前記反応部の領域は、前記光の伝搬方向に所定の長さに亘って、前記反応物質の含有量が前記垂直方向で線形に変化する領域を含む
ことを特徴とする測定用チップ。 - 請求項1乃至請求項3のいずれかに記載の測定用チップであって、
前記反応物質の含有量は、前記光の伝搬方向における単位長さあたりの前記反応物質の含有密度に前記所定の長さを乗じたものである
ことを特徴とする測定用チップ。 - 請求項4に記載の測定用チップであって、
前記反応物質の含有密度が一定であって、かつ、前記所定の長さが前記垂直方向で単調に変化する
ことを特徴とする測定用チップ。 - 請求項4または請求項5に記載の測定用チップであって、
前記反応物質の含有密度が一定であって、かつ、前記所定の長さが前記垂直方向で連続的に変化する
ことを特徴とする測定用チップ。 - 請求項4乃至請求項6のいずれかに記載の測定用チップであって、
前記反応物質の含有密度が一定であって、かつ、前記所定の長さが前記垂直方向で線形に変化する
ことを特徴とする測定用チップ。 - 請求項4に記載の測定用チップであって、
前記所定の長さが前記垂直方向で一定であり、かつ、前記反応物質の含有密度が前記垂直方向で単調に変化する
ことを特徴とする測定用チップ。 - 請求項1乃至請求項8のいずれかに記載の測定用チップであって、
前記反応部は、前記被検出物質と前記反応物質との反応による前記伝搬層の周辺における屈折率の変化により、前記光の位相分布を変化させる
ことを特徴とする測定用チップ。 - 請求項1乃至請求項9のいずれかに記載の測定用チップであって、
前記反応部は、前記伝搬層を挟む両表面に形成されていることを特徴とする測定用チップ。 - 請求項1乃至請求項10のいずれかに記載の測定用チップであって、
前記光は、ガウスビームであることを特徴とする測定用チップ。 - 請求項1乃至請求項11のいずれかに記載の測定用チップが配置される測定装置であって、
前記測定用チップの前記導入部に前記光を導く光源と、
前記導出部から導出された光を受光する受光部と、
前記受光部で受光される光のパターンを分析する制御部と、
を備えた測定装置。 - 請求項12に記載の測定装置であって、
前記制御部は、前記光のパターンの変化を分析する分析処理を行うことを特徴とする測定装置。 - 請求項12または請求項13に記載の測定装置であって、
前記制御部は、前記光の進行方向の変化を分析する分析処理を行うことを特徴とする測定装置。 - 伝搬層に光を導入し、
被検出物質に反応する反応物質が形成された前記伝搬層の表面において、前記光の伝搬方向に所定の長さに亘って、前記反応物質の含有量を前記伝搬方向に直交する垂直方向で単調に変化させ、
前記伝搬層から前記光を導出する、
測定方法。 - 請求項15に記載の測定方法であって、
前記反応物質の含有量は、前記光の伝搬方向における単位長さあたりの前記反応物質の含有密度に前記所定の長さを乗じたものであることを特徴とする測定方法。 - 請求項15または請求項16に記載の測定方法であって、
前記反応による前記光のパターンの変化を分析する、
測定方法。
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US (2) | US11543347B2 (ja) |
EP (1) | EP3677901A4 (ja) |
JP (2) | JP6792082B2 (ja) |
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WO2023079110A2 (en) * | 2021-11-04 | 2023-05-11 | Vysens B.V. | Method for concentration and avidity detection of antibodies against infectious diseases measured with evanescent field based biosensors using a continuous gradient of ligand densities |
JP2024076618A (ja) * | 2022-11-25 | 2024-06-06 | 古野電気株式会社 | 測定用チップ、測定装置、および測定方法 |
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US5030420A (en) * | 1982-12-23 | 1991-07-09 | University Of Virginia Alumni Patents Foundation | Apparatus for oxygen determination |
US5866430A (en) * | 1996-06-13 | 1999-02-02 | Grow; Ann E. | Raman optrode processes and devices for detection of chemicals and microorganisms |
DE59703919D1 (de) * | 1996-08-16 | 2001-08-02 | Zeptosens Ag Witterswil | Optische detektionsvorrichtung |
EP0884581A1 (en) * | 1997-06-13 | 1998-12-16 | Hoechst Aktiengesellschaft | Optical sensor for detecting chemical substances dissolved or dispersed in water |
EP1190236A1 (de) * | 1999-06-05 | 2002-03-27 | Zeptosens AG | Sensorplatform und verfahren zur multianalytbestimmung |
EP1327135B1 (de) * | 2000-09-04 | 2010-02-24 | Bayer Technology Services GmbH | System und verfahren zur multianalytbestimmung |
GB0206008D0 (en) * | 2002-03-14 | 2002-04-24 | Farfield Sensors Ltd | Optical interferometer |
JP2004069397A (ja) * | 2002-08-02 | 2004-03-04 | Nec Corp | 分析チップおよび分析装置 |
JP2005009944A (ja) * | 2003-06-18 | 2005-01-13 | Hitachi Ltd | 化学物質検出装置 |
US20050070027A1 (en) * | 2003-09-30 | 2005-03-31 | Jacques Gollier | Double resonance interrogation of grating-coupled waveguides |
JP2007171027A (ja) * | 2005-12-22 | 2007-07-05 | Toshiba Corp | 光学検査方法およびこれに用いる光学検査装置 |
EP2137514B1 (de) * | 2007-03-13 | 2018-06-20 | Creoptix AG | Integriert-optischer sensor |
WO2009131535A1 (en) * | 2008-04-23 | 2009-10-29 | Oesterlund Lars | Optical sensor unit for evanescence wave spectroscopy |
EP2707715A1 (en) * | 2011-05-11 | 2014-03-19 | Ssens B.V. | Method for determining intrinsic binding parameters of an analyte to a ligand, a method for selecting an analyte from a group of analyts, the selected ligand or analyte, and sensor |
US20150204723A1 (en) * | 2011-05-20 | 2015-07-23 | Beihang University | Optical phase device, method and system |
JP5648613B2 (ja) * | 2011-09-12 | 2015-01-07 | コニカミノルタ株式会社 | 表面プラズモン励起増強蛍光分光法用センサチップおよびそれを用いた測定方法 |
FR2987129B1 (fr) * | 2012-02-21 | 2014-03-14 | Commissariat Energie Atomique | Capteurs de nez ou de langue electronique |
CN107709974B (zh) * | 2015-07-07 | 2020-09-29 | 古野电气株式会社 | 测定用芯片、测定装置及测定方法 |
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Publication number | Publication date |
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US20230097717A1 (en) | 2023-03-30 |
JP2021015130A (ja) | 2021-02-12 |
WO2019044418A1 (ja) | 2019-03-07 |
CN118329872A (zh) | 2024-07-12 |
US11543347B2 (en) | 2023-01-03 |
US20200240911A1 (en) | 2020-07-30 |
JPWO2019044418A1 (ja) | 2020-10-08 |
JP6946537B2 (ja) | 2021-10-06 |
CN111033234A (zh) | 2020-04-17 |
EP3677901A4 (en) | 2021-05-12 |
CN111033234B (zh) | 2024-04-26 |
EP3677901A1 (en) | 2020-07-08 |
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