JP6772060B2 - 寛骨臼インプラント位置合わせデバイスおよび方法 - Google Patents
寛骨臼インプラント位置合わせデバイスおよび方法 Download PDFInfo
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4609—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of acetabular cups
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/34—Acetabular cups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
- A61B17/17—Guides or aligning means for drills, mills, pins or wires
- A61B17/1739—Guides or aligning means for drills, mills, pins or wires specially adapted for particular parts of the body
- A61B17/1742—Guides or aligning means for drills, mills, pins or wires specially adapted for particular parts of the body for the hip
- A61B17/1746—Guides or aligning means for drills, mills, pins or wires specially adapted for particular parts of the body for the hip for the acetabulum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/36—Femoral heads ; Femoral endoprostheses
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4684—Trial or dummy prostheses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2825—Femur
- A61F2002/2828—Femoral head
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30604—Special structural features of bone or joint prostheses not otherwise provided for modular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30604—Special structural features of bone or joint prostheses not otherwise provided for modular
- A61F2002/30616—Sets comprising a plurality of prosthetic parts of different sizes or orientations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30617—Visible markings for adjusting, locating or measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2002/4687—Mechanical guides for implantation instruments
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- Orthopedic Medicine & Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
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- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
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Description
本出願は、2013年4月26日に出願された米国特許仮出願第61/816,415号、2013年5月1日に出願された米国特許仮出願第61/818,269号、および2014年2月26日に出願された米国特許仮出願第61/944,932号に基づく利益を主張するものである。これらの各仮出願は、ここに参照によりその全体が本明細書に組み込まれる。
5 円弧
10 左股関節
20 寛骨臼
30 大腿骨
40 脛骨
41 脛骨軸
100 ブローチ
110 トライアル骨頸
120 CSFHAC
200 マーキング
300 CSFHAC
310 ドリルガイド
320 アーム
330 ドリル穴
400 CSFHAC
410 ドリルガイド
420 アーム
445 伏角
470 固定具
500 CSFHAC
530 目印
600 リーマ
700 軸
Claims (21)
- 患者の寛骨臼内に植え込まれる寛骨臼構成要素の位置決めを行うためのトライアル医用器械であって、
患者の寛骨臼内に嵌るように構成された第1の部分であって、前記寛骨臼内に前記寛骨臼構成要素を配置するための位置を示すために前記寛骨臼内で移動されるように構成された寛骨臼接合部を備える第1の部分と、
前記第1の部分から延在する第2の部分であって、患者の大腿骨と所定の関係で前記トライアル医用器械を位置合わせするために前記大腿骨に結合するように構成された大腿骨接合部と、前記大腿骨接合部と前記第1の部分との間に結合される本体であって、前記大腿骨接合部と固定関係において前記第1の部分を配向するように構成された本体と、を備える第2の部分と、
を備え、
前記第1の部分は、大腿骨インプラント構成要素が結合される大腿骨が、前記寛骨臼構成要素が植え込まれる寛骨臼に対して、前記大腿骨の可動域の限界付近の位置をとる場合に、前記寛骨臼構成要素に結合された前記大腿骨インプラント構成要素によって形成される形状を模倣する方向へと前記第2の部分が前記第1の部分から延在するように、前記寛骨臼内で移動されるように構成されている、トライアル医用器械。 - 前記寛骨臼に対面するように構成された前記第1の部分の表面にエッチング加工された目印をさらに含み、前記目印は、前記寛骨臼に対する位置合わせのために基準を与えるように構成されている、請求項1に記載のトライアル医用器械。
- 前記目印は、平行な線、または数文字、またはアルファベット文字を含む、請求項2に記載のトライアル医用器械。
- 前記寛骨臼に対する前記第1の部分の望ましい位置をマーキングするために、軌道に沿って前記寛骨臼の中または付近に固定具を送るように構成された固定具ガイドを備える、請求項1から3のいずれか一項に記載のトライアル医用器械。
- 前記固定具ガイドは、前記寛骨臼の中心により画定される軸からオフセットされた角度で前記固定具を送るように構成されている、請求項4に記載のトライアル医用器械。
- 寛骨臼構成要素を位置合わせしかつ植え込むためのシステムであって、
大腿骨と所定の関係で請求項1〜5のいずれか一項に記載のトライアル医用器械を位置合わせするための手段と、
寛骨臼内に前記寛骨臼構成要素を配置するための誘導を与えるために、前記寛骨臼内の前記トライアル医用器械の位置を示唆するための手段と、
前記位置合わせするための手段と固定関係にて示唆するための手段を配向するための手段であって、前記固定関係は、大腿骨構成要素に結合されるように構成された大腿骨が、前記大腿骨の可動域の限界付近の前記寛骨臼に対する位置をとる場合には、前記寛骨臼構成要素と前記大腿骨構成要素との間の関係と実質的に同一である、手段と、
を備える、システム。 - 前記寛骨臼に対して示唆するための手段を位置合わせするための基準を与えるための手段をさらに備える、請求項6に記載のシステム。
- 前記寛骨臼に対する前記寛骨臼構成要素の望ましい位置をマーキングするために、軌道に沿って前記寛骨臼の中または付近に固定具を送るための手段をさらに備える、請求項7に記載のシステム。
- 前記送るための手段は、前記寛骨臼の中心により画定される軸に対してある角度で前記固定具を送るための手段をさらに備える、請求項8に記載のシステム。
- 前記システムが、前記大腿骨に前記トライアル医用器械を結合するための手段をさらに備える、請求項9に記載のシステム。
- 前記システムが、前記大腿骨に前記トライアル医用器械を結合するための手段に前記トライアル医用器械を結合するための手段をさらに備える、請求項10に記載のシステム。
- 寛骨臼に対する大腿骨の位置に基づき寛骨臼構成要素を位置合わせするための医用器械であって、
前記大腿骨と所定の関係で前記医用器械を位置合わせするために前記大腿骨に結合するように構成された大腿骨接合部と、
前記寛骨臼内に前記寛骨臼構成要素を配置するための位置を示すために前記寛骨臼内で移動されるように構成された寛骨臼接合部と、
前記大腿骨接合部と前記寛骨臼接合部との間に結合される本体であって、前記大腿骨接合部と固定関係において前記寛骨臼接合部を配向する本体と、
を備え、
前記大腿骨接合部に対する前記寛骨臼接合部の前記固定関係は、大腿骨構成要素に結合されるように構成された前記大腿骨が、前記大腿骨の可動域の限界付近の前記寛骨臼に対する位置をとる場合には、前記寛骨臼構成要素と前記大腿骨構成要素との間の関係と実質的に同一である、医用器械。 - 前記大腿骨接合部は、前記大腿骨の髄内管に結合するために髄内構成要素を備える、請求項12に記載の医用器械。
- 前記寛骨臼接合部は、少なくとも部分的に球状である、請求項12に記載の医用器械。
- 前記寛骨臼接合部は、半球状である、請求項14に記載の医用器械。
- 前記寛骨臼接合部は、寛骨臼構成要素を受けるために前記寛骨臼をマーキングするための基準を与える目印を備える、または前記寛骨臼接合部は、前記寛骨臼に対する前記寛骨臼接合部のサイズおよび配向を判定するために基準を与える目印を備える、請求項12に記載の医用器械。
- 前記寛骨臼接合部は、リーマ加工された寛骨臼内でまたはリーマ加工されない寛骨臼内で移動されるように構成される、請求項12に記載の医用器械。
- 前記大腿骨接合部、前記寛骨臼接合部、および前記本体は、単体ピースである、
または、前記寛骨臼接合部および前記本体は、単体ピースであり、かつ前記大腿骨接合部は、前記本体に取外し可能に固定されるように構成される、
または、前記大腿骨接合部および前記本体は、単体ピースであり、かつ前記寛骨臼接合部は、前記本体に取外し可能に固定されるように構成される、請求項12に記載の医用器械。 - 前記医用器械に結合された前記大腿骨が、前記所定の位置において前記大腿骨の可動域の前記限界付近の前記寛骨臼に対する位置をとる場合に、前記寛骨臼内における前記寛骨臼構成要素の位置は、望ましい位置となり、
前記寛骨臼構成要素の望ましい位置は、前記寛骨臼構成要素の縁の面が前記寛骨臼の外周部と実質的に平行になる場合の位置である、請求項12に記載の医用器械。 - 前記大腿骨が、前記大腿骨の可動域の前記限界付近の寛骨臼に対する位置をとる場合に、前記大腿骨は、15〜30度の範囲内で前捻方向に前記大腿骨を回転させることによってほぼ中立の位置から回転位置へと移動されている、請求項12に記載の医用器械。
- 前記医用器械は、骨に対する寛骨臼構成要素の相対位置を確立および維持するために、軌道に沿って前記骨の中に骨固定具を送るように構成された固定具ガイドを備える、請求項12に記載の医用器械。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361816415P | 2013-04-26 | 2013-04-26 | |
US61/816,415 | 2013-04-26 | ||
US201361818269P | 2013-05-01 | 2013-05-01 | |
US61/818,269 | 2013-05-01 | ||
US201461944932P | 2014-02-26 | 2014-02-26 | |
US61/944,932 | 2014-02-26 | ||
PCT/US2014/035535 WO2014176548A1 (en) | 2013-04-26 | 2014-04-25 | Acetabular implantalignment devices and methods |
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Application Number | Title | Priority Date | Filing Date |
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JP2019202427A Division JP7128793B2 (ja) | 2013-04-26 | 2019-11-07 | 寛骨臼インプラント位置合わせデバイスおよび方法 |
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JP2016516540A JP2016516540A (ja) | 2016-06-09 |
JP2016516540A5 JP2016516540A5 (ja) | 2020-09-24 |
JP6772060B2 true JP6772060B2 (ja) | 2020-10-21 |
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EP3253336A1 (en) * | 2015-02-02 | 2017-12-13 | Orthosoft, Inc. | Mechanically guided impactor for hip arthroplasty |
RU173036U1 (ru) * | 2016-11-17 | 2017-08-07 | федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) | Устройство-измеритель для интраоперационной коррекции офсета и длины бедренной кости |
GB201705920D0 (en) * | 2017-04-12 | 2017-05-24 | Depuy Ireland Ultd Co | Apparatus and method for hip surgery |
GB201705918D0 (en) * | 2017-04-12 | 2017-05-24 | Depuy Ireland Ultd Co | Orientation guide |
AU2018265160B2 (en) | 2017-05-10 | 2023-11-16 | Mako Surgical Corp. | Robotic spine surgery system and methods |
US11033341B2 (en) | 2017-05-10 | 2021-06-15 | Mako Surgical Corp. | Robotic spine surgery system and methods |
WO2018213749A1 (en) * | 2017-05-18 | 2018-11-22 | Smith & Nephew, Inc. | Systems and methods for determining the position and orientation of an implant for joint replacement surgery |
WO2019038203A1 (en) * | 2017-08-21 | 2019-02-28 | Depuy Ireland Unlimited Company | GUIDE, PARTS KIT AND GUIDE ASSEMBLY FOR HIP SURGERY |
KR20200115518A (ko) | 2018-01-26 | 2020-10-07 | 마코 서지컬 코포레이션 | 수술 로봇에 의해 가이드된 보철물에 충격을 가하기 위한 엔드 이펙터, 시스템 및 방법 |
CN108095803A (zh) * | 2018-03-21 | 2018-06-01 | 芜湖锐进医疗设备有限公司 | 带有指示功能的医用手钻 |
US11857423B2 (en) | 2021-11-16 | 2024-01-02 | Arthrology Consulting, Llc | Off-center liner for acetabular cup |
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US5879401A (en) | 1996-05-17 | 1999-03-09 | Johnson & Johnson Professional, Inc. | Acetabular trial |
NO994445D0 (no) | 1999-09-13 | 1999-09-13 | Bjoern Franc Iversen | FremgangsmÕte samt verktöy for kontroll av innbyrdes vinkel mellom delene i hofteleddsprotese |
US6673114B2 (en) * | 2000-05-03 | 2004-01-06 | Smith & Nephew, Inc. | Multi modular trialing system and instrumentation |
US20050065617A1 (en) | 2003-09-05 | 2005-03-24 | Moctezuma De La Barrera Jose Luis | System and method of performing ball and socket joint arthroscopy |
GB0420346D0 (en) * | 2004-09-13 | 2004-10-13 | Finsbury Dev Ltd | Tool |
DE202005014270U1 (de) | 2005-09-09 | 2007-01-11 | Waldemar Link Gmbh & Co. Kg | Einsetzinstrument für eine Endoprothese mit einem in einem Markraum einzusetzenden Prothesenschaft |
CN101370437A (zh) | 2005-11-18 | 2009-02-18 | 罗伯特·利耶 | 手术对准导向件 |
CA2717233C (en) | 2008-02-25 | 2019-04-23 | Smith & Nephew, Inc. | Method and system of mapping femoral head for acetabular prosthesis alignment |
GB0803625D0 (en) | 2008-02-28 | 2008-04-02 | Depuy Int Ltd | Acetabular alignment guide |
GB0803723D0 (en) | 2008-02-29 | 2008-04-09 | Depuy Int Ltd | An instrument for use in a joint replacement procedure |
AT507521B1 (de) | 2008-10-23 | 2012-07-15 | Implantech Medizintechnik Ges M B H | Manipuliersystem zur auswahl |
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EP2988702A1 (en) | 2016-03-02 |
AU2014256877B2 (en) | 2019-02-14 |
RU2015150086A (ru) | 2017-06-02 |
US11173045B2 (en) | 2021-11-16 |
EP2988702B1 (en) | 2021-12-22 |
JP2016516540A (ja) | 2016-06-09 |
WO2014176548A1 (en) | 2014-10-30 |
CN105307599A (zh) | 2016-02-03 |
US10463506B2 (en) | 2019-11-05 |
CA2910168A1 (en) | 2014-10-30 |
JP7128793B2 (ja) | 2022-08-31 |
US20160081819A1 (en) | 2016-03-24 |
AU2014256877A1 (en) | 2015-11-05 |
CN105307599B (zh) | 2018-05-18 |
BR112015026709A2 (pt) | 2017-07-25 |
BR112015026709A8 (pt) | 2019-12-24 |
JP2020036926A (ja) | 2020-03-12 |
US20200008957A1 (en) | 2020-01-09 |
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