JP6100427B2 - 血液と接触する表面を被覆するに際して非イオン性エステルを使用する医療器具・装置 - Google Patents
血液と接触する表面を被覆するに際して非イオン性エステルを使用する医療器具・装置 Download PDFInfo
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- JP6100427B2 JP6100427B2 JP2016122710A JP2016122710A JP6100427B2 JP 6100427 B2 JP6100427 B2 JP 6100427B2 JP 2016122710 A JP2016122710 A JP 2016122710A JP 2016122710 A JP2016122710 A JP 2016122710A JP 6100427 B2 JP6100427 B2 JP 6100427B2
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- 238000000576 coating method Methods 0.000 title claims description 51
- 210000004369 blood Anatomy 0.000 title claims description 47
- 239000008280 blood Substances 0.000 title claims description 47
- 239000011248 coating agent Substances 0.000 title claims description 39
- 150000002148 esters Chemical class 0.000 title claims description 26
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 19
- 229930195729 fatty acid Natural products 0.000 claims description 19
- 239000000194 fatty acid Substances 0.000 claims description 19
- 150000004665 fatty acids Chemical class 0.000 claims description 18
- -1 polypropylene Polymers 0.000 claims description 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 229920006395 saturated elastomer Polymers 0.000 claims description 8
- 229920005862 polyol Polymers 0.000 claims description 6
- 229920003023 plastic Polymers 0.000 claims description 5
- 239000004033 plastic Substances 0.000 claims description 5
- 229920001296 polysiloxane Polymers 0.000 claims description 4
- 229920002943 EPDM rubber Polymers 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 239000002473 artificial blood Substances 0.000 claims description 3
- 210000004204 blood vessel Anatomy 0.000 claims description 3
- 210000003734 kidney Anatomy 0.000 claims description 3
- 210000004072 lung Anatomy 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000004417 polycarbonate Substances 0.000 claims description 3
- 229920000515 polycarbonate Polymers 0.000 claims description 3
- 150000003077 polyols Chemical class 0.000 claims description 3
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 239000011116 polymethylpentene Substances 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 239000004814 polyurethane Substances 0.000 claims description 2
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- 125000002015 acyclic group Chemical group 0.000 claims 1
- 150000004671 saturated fatty acids Chemical class 0.000 claims 1
- 235000003441 saturated fatty acids Nutrition 0.000 claims 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 1
- 239000008389 polyethoxylated castor oil Substances 0.000 description 10
- 229920001983 poloxamer Polymers 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 101800003265 Beta-thromboglobulin Proteins 0.000 description 6
- 102000007329 beta-Thromboglobulin Human genes 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 230000004913 activation Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 3
- KIHBGTRZFAVZRV-UHFFFAOYSA-N 2-Hydroxyoctadecanoic acid Natural products CCCCCCCCCCCCCCCCC(O)C(O)=O KIHBGTRZFAVZRV-UHFFFAOYSA-N 0.000 description 3
- 238000004873 anchoring Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000024203 complement activation Effects 0.000 description 3
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 3
- 229940066675 ricinoleate Drugs 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 230000002785 anti-thrombosis Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 230000002612 cardiopulmonary effect Effects 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 2
- 229920001993 poloxamer 188 Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 108010034753 Complement Membrane Attack Complex Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 206010053159 Organ failure Diseases 0.000 description 1
- 229920002675 Polyoxyl Polymers 0.000 description 1
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 description 1
- RKZXQQPEDGMHBJ-LIGJGSPWSA-N [(2s,3r,4r,5r)-2,3,4,5,6-pentakis[[(z)-octadec-9-enoyl]oxy]hexyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC RKZXQQPEDGMHBJ-LIGJGSPWSA-N 0.000 description 1
- 125000005396 acrylic acid ester group Chemical group 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 230000004154 complement system Effects 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 229920000306 polymethylpentene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/04—Use of organic materials, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0076—Chemical modification of the substrate
- A61L33/0082—Chemical modification of the substrate by reacting with an organic compound other than heparin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31507—Of polycarbonate
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31551—Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
- Y10T428/31565—Next to polyester [polyethylene terephthalate, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31652—Of asbestos
- Y10T428/31663—As siloxane, silicone or silane
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31786—Of polyester [e.g., alkyd, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31786—Of polyester [e.g., alkyd, etc.]
- Y10T428/31797—Next to addition polymer from unsaturated monomers
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials For Medical Uses (AREA)
- External Artificial Organs (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Description
nは1から4までの整数であり、
a−fは、同一または異なる整数であって、数a−fの合計は0と200の間である;
nは1から4までの整数であり、
a−fは、同一または異なる整数であって、数a−fの合計は0と200の間である;
a−dは、同一であっても異なっていてもよい整数であり、数a−dの合計は0と200との間である;
Claims (4)
- 血液を輸送するために設けられた導管を含む医療器具・装置であって、前記導管は血液と接触するように意図された少なくとも一つの表面を有し、前記導管の前記少なくとも一つの表面はコーティングを含み、前記コーティングは非環式C3−C6(OH)3-6ポリオールおよび少なくとも3個のC12−C26脂肪酸から形成された非イオン性エステルを含み、前記非イオン性エステルは、さらに少なくとも1個の親水性基を有し、前記非イオン性エステルは前記表面を血液適合性にするように前記少なくとも3個のC 12 −C 26 脂肪酸によって前記導管の前記表面に固着されており、それにより前記コーティングの組成は血流に露出された場合に洗い流されることに抵抗するように前記少なくとも一つの表面に接着することができ、前記非イオン性エステルは前記コーティングを前記表面に直接接着させ、前記非イオン性エステルは以下の式:
(式中、R 1 、R 2 およびR 3 は、各々の場合に、同一または異なる、飽和または不飽和の脂肪酸であって、適切な場所には少なくとも1個のヒドロキシル基を有するC 12- C 26 脂肪酸であり、
nは1から4までの整数であり、
a、bおよびcは、同一であっても異なっていてもよい整数であり、数a、bおよびcの合計は0と200の間である);および
(式中、R 4 、R 5 およびR 6 は、各々の場合に、同一または異なる、飽和または不飽和のC 12- C 26 脂肪酸であって、基R 4 、R 5 およびR 6 のうち少なくとも1つは少なくとも1個のヒドロキシル基を有するC 12- C 26 脂肪酸であり、
mは1から4までの整数であり、
d、eおよびfは、同一であっても異なっていてもよい整数であり、数d、eおよびfの合計は0と200の間である)
から選ばれる式を有することを特徴とする医療器具・装置。 - 前記導管の前記表面がプラスチック表面であり、前記コーティングが前記導管の前記表面で乾燥させられるように前記導管が設けられている請求項1に記載の医療器具・装置。
- 前記導管の前記表面が、ポリプロピレン(PP)、ポリカ−ボネート(PC)、ポリメチルペンテン(PMP)、ポリウレタン(PU)、ポリエチレン(PE)、ポリエステル、シリコーン、ポリ塩化ビニル(PVC)、アクリロニトリルブタジエンスチレン(ABS)およびエチレンプロピレンジエンモノマー(EPDM)の材料のうち少なくとも1つからなることを特徴とする請求項1に記載の医療器具・装置。
- 前記医療器具・装置が、人工心肺装置、人工肺、カテーテル、人工心臓、人工腎、ガス交換膜および人工血管用の使い捨て器具からなる群から選ばれることを特徴とする請求項1に記載の医療器具・装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE200510040211 DE102005040211B4 (de) | 2005-08-16 | 2005-08-16 | Verwendung von nichtionischen Estern in einer Beschichtung für mit Blut in Kontakt kommende Oberflächen und medizinische Vorrichtung |
DE102005040211.9 | 2005-08-16 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015046146A Division JP6104968B2 (ja) | 2005-08-16 | 2015-03-09 | 血液と接触する表面を被覆するに際して非イオン性エステルを使用する医療器具・装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016195778A JP2016195778A (ja) | 2016-11-24 |
JP6100427B2 true JP6100427B2 (ja) | 2017-03-22 |
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Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008526411A Active JP5743173B2 (ja) | 2005-08-16 | 2006-08-09 | 血液と接触する表面を被覆するに際して非イオン性エステル類を使用する医療器具・装置 |
JP2015046146A Active JP6104968B2 (ja) | 2005-08-16 | 2015-03-09 | 血液と接触する表面を被覆するに際して非イオン性エステルを使用する医療器具・装置 |
JP2016122710A Active JP6100427B2 (ja) | 2005-08-16 | 2016-06-21 | 血液と接触する表面を被覆するに際して非イオン性エステルを使用する医療器具・装置 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008526411A Active JP5743173B2 (ja) | 2005-08-16 | 2006-08-09 | 血液と接触する表面を被覆するに際して非イオン性エステル類を使用する医療器具・装置 |
JP2015046146A Active JP6104968B2 (ja) | 2005-08-16 | 2015-03-09 | 血液と接触する表面を被覆するに際して非イオン性エステルを使用する医療器具・装置 |
Country Status (8)
Country | Link |
---|---|
US (2) | US8187622B2 (ja) |
EP (1) | EP1915183B1 (ja) |
JP (3) | JP5743173B2 (ja) |
KR (1) | KR100990926B1 (ja) |
CN (1) | CN101242863B (ja) |
DE (1) | DE102005040211B4 (ja) |
HK (1) | HK1110810A1 (ja) |
WO (1) | WO2007019994A1 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005040211B4 (de) * | 2005-08-16 | 2010-02-11 | Maquet Cardiopulmonary Ag | Verwendung von nichtionischen Estern in einer Beschichtung für mit Blut in Kontakt kommende Oberflächen und medizinische Vorrichtung |
DE102008027133A1 (de) | 2008-05-30 | 2009-12-03 | Ls Medcap Gmbh | Vollsynthetisches Albumin-Analogon |
DE102009032119A1 (de) * | 2009-06-26 | 2010-12-30 | Koslar, Björn H. | Gefäßprothese |
US20110065798A1 (en) * | 2009-09-17 | 2011-03-17 | Becton, Dickinson And Company | Anti-infective lubricant for medical devices and methods for preparing the same |
KR101899059B1 (ko) | 2017-04-07 | 2018-09-17 | (주)파이버프로 | 평면 광도파로 및 광 모듈 |
WO2023106256A1 (ja) | 2021-12-06 | 2023-06-15 | 学校法人順天堂 | 改変型アデノ随伴ウイルスベクター |
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GB8428109D0 (en) * | 1984-11-07 | 1984-12-12 | Biocompatibles Ltd | Biocompatible surfaces |
WO1989002282A1 (en) * | 1987-09-21 | 1989-03-23 | Terumo Kabushiki Kaisha | Medical instrument and production thereof |
FR2620624B1 (fr) * | 1987-09-23 | 1993-08-20 | Irap | Article en materiau polymere, modifie en surface pour presenter une hemocompatibilite amelioree et une thrombogeneicite diminuee, et son procede d'obtention |
US5032666A (en) * | 1989-06-19 | 1991-07-16 | Becton, Dickinson And Company | Amine rich fluorinated polyurethaneureas and their use in a method to immobilize an antithrombogenic agent on a device surface |
US5195969A (en) * | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
DE69220871T2 (de) * | 1991-10-03 | 1997-11-20 | Bayer Ag | Vorrichtung und Verfahren zur Auftrennung und Analyse von Vollblut |
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CZ267796A3 (cs) * | 1996-09-12 | 1998-04-15 | Galena A.S. | Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů |
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DE50305580D1 (de) * | 2002-05-09 | 2006-12-14 | Hemoteq Gmbh | Verbindungen und verfahren zur hemokompatiblen beschichtung von oberflächen |
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Publication number | Publication date |
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DE102005040211B4 (de) | 2010-02-11 |
JP2009504286A (ja) | 2009-02-05 |
DE102005040211A1 (de) | 2007-04-05 |
EP1915183A1 (de) | 2008-04-30 |
US8187622B2 (en) | 2012-05-29 |
WO2007019994A1 (de) | 2007-02-22 |
JP6104968B2 (ja) | 2017-03-29 |
US9226999B2 (en) | 2016-01-05 |
KR100990926B1 (ko) | 2010-11-01 |
US20120238771A1 (en) | 2012-09-20 |
JP2015110064A (ja) | 2015-06-18 |
US20080131583A1 (en) | 2008-06-05 |
EP1915183B1 (de) | 2013-11-27 |
JP2016195778A (ja) | 2016-11-24 |
CN101242863B (zh) | 2012-11-28 |
CN101242863A (zh) | 2008-08-13 |
KR20080032185A (ko) | 2008-04-14 |
JP5743173B2 (ja) | 2015-07-01 |
HK1110810A1 (en) | 2008-07-25 |
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