JP5902096B2 - 歯科治療のための液体噴射装置および方法 - Google Patents
歯科治療のための液体噴射装置および方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
- A61C17/02—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication
- A61C17/024—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication with constant liquid flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C5/00—Filling or capping teeth
- A61C5/40—Implements for surgical treatment of the roots or nerves of the teeth; Nerve needles; Methods or instruments for medication of the roots
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C5/00—Filling or capping teeth
- A61C5/60—Devices specially adapted for pressing or mixing capping or filling materials, e.g. amalgam presses
- A61C5/62—Applicators, e.g. syringes or guns
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
- A61C17/02—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication
- A61C17/028—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication with intermittent liquid flow
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- Oral & Maxillofacial Surgery (AREA)
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Description
本出願は、2009年11月13日出願の米国仮特許出願第61/261,293号(「APPARATUS AND METHODS FOR ROOT CANAL TREATMENTS」)(参照によりその全体が本書に援用され、本明細書の記載の一部としている)の35U.S.C.§119(e)下の利益を主張する。
本明細書は、一般的に歯の治療のための方法および装置に関し、より詳細には、歯から有機物を除去するために液体の噴射を使用する方法および装置に関する。
本明細書は、例えば、歯内処置などの歯科的処置を行うための装置および方法を説明する。説明の装置および方法は、有利には根管の洗浄処置と使用して、例えば、根管系から効果的に有機物および/または無機物を除去し得る。装置および方法は、例えば、虫歯の洗浄処置、歯石および歯垢の除去などの他の歯科治療に使用してもよい。有機材料(または有機物)は、一般に、例えば生きている、炎症性、感染性、疾患性、壊死性、または分解性であるに関わらず、軟組織、歯髄、血管、神経、結合組織、細胞物質(cellular matter)、膿、および微生物などの、健康なまたは病んだ歯または根管系に見られる有機物質を含む。無機物は、根管系に存在することが多い石灰化組織および石灰化構造を含む。
はその付近に、および/または象牙質細管で満たされている象牙質表面内部に、圧力波、動揺(oscillation)、および/または振動を発生させることがある。細管にまたはその付近に形成されたキャビテーション気泡の成長、動揺、および崩壊を含め、別のキャビテーション効果を可能とし得る(例えば、おそらく、細管の表面エネルギーが高い部位において)。これらの(および/または他の)効果によって歯の歯髄腔を効果的に洗浄し得る。一部の実装例では、圧力波発生器は、治療されている所望の歯に対して圧力波発生器を位置するまたは向きを決めるように、患者の口腔内で操作し得るハンドピースまたは携帯型噴射ハウジングに結合され得る。
図1は、典型的なヒトの歯10を概略的に示す断面であり、歯は、歯肉組織14より上方に延在する歯冠12と、顎骨18内の歯槽(socket)(歯槽(alveolus))にはまっている少なくとも1個の歯根16とを含む。図1に概略的に示す歯10は臼歯であるが、本明細書で説明する装置および方法は、切歯、犬歯、小臼歯、または臼歯などの任意のタイプの歯に使用し得る。歯10の硬組織は、歯10の一次構造を提供する象牙質20と、非常に硬いエナメル層22であって、歯肉14付近のセメント質とエナメル質の境界部15まで歯冠12を覆っているエナメル層22と、セメント質とエナメル質の境界部15の下側にある歯10の象牙質20を覆うセメント質24とを含む。
、キャビテーションの音響効果を低下させ得る溶解ガスが実質的に含まれていない場合には(例えば、約0.1%容積未満、1リットルの溶液当たり約1mg未満のガス、または他の何らかの値未満)、噴射形成にとって有利である。一部の実施形態では、流体源44は脱気蒸留水を含む。流体源44とポンプ46との間に気泡検出器(図示せず)を配置して、液体内の気泡を検出してもおよび/または流体源44からの液体流が中断されたかどうかまたは容器が空になったかどうかを判断してもよい。流体源44の液体は室温にあっても、または異なる温度まで加熱および/または冷却されてもよい。例えば、一部の実施形態では、流体源44の液体は冷却されて、システム38によって生成される高速噴射の温度を低下させることがあり、これにより、歯の内側の流体の温度を低下または制御し得る。一部の治療方法では、流体源44の液体を加熱することがあり、これにより、治療中に歯に発生し得る化学反応率を増加させ得る。
より援用する。
っかりとねじ込まれ、通路52の遠位端部に隣接してノズル64を固定し得る。図11A〜図11Cを参照して説明するように、ハンドピースの他の実施形態では、ノズル64は、異なる個所に配置できる。
、比較的先の鋭い、錐体オリフィス66を使用できる。他の実施形態では、他の形状、例えば、円錐形オリフィス、毛管オリフィス、錐体−毛管オリフィスなどを使用できる。矢印72は、液体噴射装置の動作中にオリフィス66を通る流体流の方向を示す。
分68bの直径D2は、近位部分68aの直径D1よりも大きい。他の実施形態では、遠位部分68bの直径D2は、近位部分68aの直径D1よりも小さくし得る。近位部分68aまたは遠位部分68bを実質的にシリンダーに付形することは、好都合にも、オリフィスの製造を簡単にし得る。他の実施形態では、約0度〜約20度、約20度〜約45度、約45度〜約90度、約90度〜約120度の範囲、または他の何らかの範囲の円錐角を使用できる。
れ子」構成を形成する)。例えば、ガイドチューブ100は、少なくとも第1のチューブおよび第2のチューブを含み、第2のチューブの近位端部が、第1のチューブの遠位端部内に配置されるように構成されている(例えば、図22Aに示す例を参照のこと)。
範囲とし得る。ガイドチューブ100の長さは、ガイドチューブ100の遠位端部104を口腔内の所望の個所に配置できるように、選択できる。例えば、近位端部102と遠位端部104との間のガイドチューブ100の長さは、約1mm〜約50mmの範囲、約10mm〜約25mmの範囲、または他の何らかの範囲とし得る。一部の実施形態では、長さは約18mmであり、これにより、ガイドチューブ100の遠位端部104が、広範囲な歯の髄質床の近傍に達することができるようになる。歯髄室または髄質床を有しない歯(例えば、前歯)の場合、ガイドチューブ100の遠位端部104は、歯10の根管空間に挿入できる。
数(例えば、約数kHz〜数百kHzまたはそれ以上)にわたる音響パワーを含み得る。歯内の水中音場は、例えば、音響キャビテーション(例えば、気泡形成および崩壊、マイクロジェット形成)、流体撹拌、流体循環、ソノポレーション、音化学などを含む効果に影響を与え、それらを引き起こし、またはそれらの強度を強め得る。必須ではないが、水中音場、前述の効果の一部またはすべて、またはこれらの組み合わせが、歯の有機物を破壊するまたは引き離すように作用し、それにより、効果的に歯髄腔26および/または根管空間30を洗浄し得ると考えられている。
ズル64が配置されているハンドピース50の実施形態を概略的に示す。他の実施形態では、ノズル64は、ハンドピース50またはガイドチューブ50の他の位置に配置できる。図9A〜図9Dは、ハンドピース50、ガイドチューブ100、およびノズル64の位置の様々な実施形態を概略的に示す断面図である。図9A〜図9Dでは、ハンドピース50は導管57を含み、導管は、システム38によって送られた加圧液体が流れることができる通路54を有する。図9A、図9B、および図9Dに示すハンドピース50の実施形態では、導管57の外側部分57aが、ハンドピースの遠位端部58から離れるように延在する。ガイドチューブ100は、導管57の外側部分57aと、(任意選択により)端部分57bとを含む。図9A、図9B、および図9Dに示す実施形態では、端部分57bは、衝突部材100および開口部120を含む。図9A、図9B、および図9Dに示す実施形態では、ノズル64は、外部導管57aの遠位端部に配置されている。図9Aおよび図9Bに示す例示的な実施形態では、それぞれ図9Aおよび図9Bにおいて、ガイドチューブ100の全長はほぼ同じであり、外部導管57aが長く(短く)、かつ端部分57bが短い(長い)。他の実施形態では、外部導管57a(ある場合)と端部分57b(ある場合)との相対的長さは、所望通りに選択し得る。例えば、場合によっては、外部導管57aは端部分57bよりも剛体とすることができ(例えば、導管は壁を厚くし得るため)、かつ剛性が高いことが望まれる場合、外部導管57aの長さを端部分57b(ある場合)の長さよりも長くしてもよい。別の例として、他の場合では、端部分57bに開口部120を形成することが容易であり(例えば、端部分の壁を薄くし得るため)、およびそのような一部の場合には、端部分57bは、比較的長く作製し得る。一部の実施形態では、ノズル64は、導管57または57aと一体的に形成できる。一部のそのような実施形態では、オリフィス66は、導管57または57aの遠位端部面に形成され得る(例えば、レーザー切断またはEDMによって)。
の遠位部分に配置でき、遠位部分が、ノズル64を越えて遠位に延在するようにする。ノズル64を越えて遠位に延在する遠位部分は、衝突部材110を含む。一部のそのような実施形態では、近位部分はガイドチューブ100の近位の半分を含み、および遠位部分はガイドチューブ100の遠位の半分を含む。
らオフセットしている。他の実施形態では、1つ(またはそれ以上)の噴射軸が、長手軸86と実質的に位置合わせされ得る。図11Cに示すガイドチューブ100の一部の実施形態では、複数のオリフィス66(例えば、図11Cに示す例では2個のオリフィス)を含む単一のノズル64が使用されて、噴射をもたらす。他の実施形態では、複数のノズルを使用できる。
分136は撓むことができる(矢印138で示すように)。例えば、必須ではないが、噴射が衝突面114の方へ伝搬すると噴射が流体を取り込み、および噴射は、流体の取り込みの可変性ゆえに、時間の経過につれて同じ個所に正確に衝突しないことがある(例えば、衝突点は衝突面114にわたってふらつき得る)と考えられている。それゆえ、可撓性部分136を通過した流体流もまた可変、振動性、または動揺性とし、および可撓性部分136は、得られる可変の流体の力に応答して、可撓性部分の形状および位置を調整し得る。それゆえ、可撓性部分136の撓み、振動、または動きは、ガイドチューブ100の遠位端部104付近で衝突部材110が流体循環または流体撹拌を発生するのを助け得る。一部の実施形態では、可撓性部分136は、レーザー加工、ワイヤEDM切断、または射出成形によって形成できる。図15Cに示す実施形態では、可撓性部分136は、衝突部材110に取り付けられ得るまたは接合され得る可撓性材料(例えば、エラストマー)を含む。
部120は、ガイドチューブ100からレーザー切断され、それにより支柱160を形成する。支柱160は、実質的に開口部120の近位端部106から遠位端部108まで延在し得る。衝突部材110は、別個に形成してガイドチューブ100の本体130に取り付けることも、またはガイドチューブ100と一体的に形成することもできる(例えば、ガイドチューブの金属射出成形中に)。
部120a〜120cは実質的に対称的に離間して、実質的に3つの、回転対称を有する噴霧をもたらす。図20Dでは、支柱160a、160bが支柱160cの近くに位置決めされて(例えば、開口部120aの角度幅は、開口部120b、120cの角度幅よりも大きい)、より多くの液体が、噴霧90b、90cよりも噴霧90aへそらされるようにしている。図20Eでは、4個の支柱160a〜160dおよび4個の開口部120a〜120dが使用されて、実質的に4つの、回転対称を有する噴霧90a〜90dをもたらす。他の実施形態では、1つまたは複数の支柱160および/または1つまたは複数の開口部120は、図20A〜図20Eに示すものとは異なるように構成して、所望の特徴を有する噴霧90を生じることができる。
個、4個またはそれ以上の湾曲した衝突部材を使用できる。
液体流チューブ200を使用できる。一部の実施形態では、液体流チューブ200に加えてまたはその代わりに、液体のストリームは、ガイドチューブ100のチャネル84に沿ってもたらすことができる。
、フェライト系またはマルテンサイト系のステンレス鋼)、炭素鋼、チタン、またはニッケルから形成できる。一部の実施形態では、ガイドチューブ100は、Special Metals Corporation,New Hartford,New Yorkから入手できるINCONEL(登録商標)、例えば、INCONEL625またはINCONEL750Xから形成される。ガイドチューブ100の実施形態に使用できる材料の別の例は、限定はされないが、ジルコニアYTZB、コバルト合金、例えば、CoCrWNiまたはCoCrMo MP35Nなど、ステライト合金、例えば、Deloro Stellite,Goshen,Indianaから入手できるSTELLITE(登録商標)33、Haynes International,Inc.,Kokomo,Indianaから入手できるHASTELLOY(登録商標)合金など、グラフェン、ダイアモンド、窒化ケイ素、ナノ粒子ステンレス鋼、ナノ結晶合金、例えば、Integran,Pittsburgh,Pennsylvaniaから入手できるNANOVATE(登録商標)など、セラミックなどを含む。一部の実施形態では、他の材料、例えば、硬質ポリマー材料、カーボンナノチューブ、ホウ素繊維複合体チューブ、タングステン繊維複合体チューブなどを使用してもよい。一部の実装例では、材料は、硬質ポリマー材料および/または金属に埋め込まれた繊維を含むことができる。他の材料は、金属マトリクス複合材料および/またはセラミック金属複合材料を含む。一部の実施形態では、ガイドチューブ100の異なる部分が、異なる材料からおよび/または上述の材料のいずれかの組み合わせから形成される。
、歯の歯髄腔26に配置され得る。ハンドピース50は、歯10または根管系30を通って伝搬できかつ歯10または象牙質表面から有機物を引き離すことができる圧力波を発生させ得る高速の液体ビーム(例えば、一部の治療ではCC噴射)をもたらすように使用できる。液体ビームおよび/または圧力波は、限定はされないが、音響キャビテーション(例えば、気泡形成および崩壊、マイクロジェット形成)、流体撹拌、流体循環、ソノポレーション、音化学、などを含む、歯に発生し得る様々な効果を発生させ得るかまたはそれらの有効性を高め得る。一部の治療方法では、ガイドチューブ100の遠位端部104を、治療されている歯10内の流体に沈めることは、上述の効果のいくつかまたは全ての有効性を高め、これにより、根管空間30は効果的に洗浄され得る。いくつかの治療方法では、ノズル64は、ガイドチューブ100の遠位端部104の方に位置決めされて、ノズル64のオリフィス66が、治療されている歯内の流体に沈められるようにし得る。いくつかのそのような実施形態では、オリフィス66から噴出する液体噴射は、空気、環境ではなく流体に送られ、および、場合によっては、歯内の流体に後で影響を及ぼす空気環境に形成される液体噴射から得られる音場よりも大きくし得る音場を提供し得る。
からの流体の逆流を低下させるまたは防止するように使用できる(例えば、歯冠のアクセス用開口部)。
Claims (34)
- 高速の液体噴射を歯の洞(cavity)に送るように構成されたチャネルを有する位置決め部材であって、前記位置決め部材は近位端部分および遠位端部分を有し、前記遠位端部分が、前記液体噴射を前記歯の前記洞に向けるように構成される、位置決め部材と、
前記位置決め部材の前記遠位端部分に配置された衝突部材であって、凹面の衝突面を有し、前記高速の液体噴射の動作中に、前記高速の液体噴射が前記衝突面に衝突するように構成された衝突部材と、
前記位置決め部材の前記遠位端部分を貫く複数の開口部であって、前記衝突面の外周のまわりに配置され、前記衝突面に衝突した後の前記液体噴射が当該開口部から流出するように構成された複数の開口部と、
を含み、
前記衝突部材は、前記位置決め部材の前記近位端部部分に向かって角度が付けられた又は湾曲した、1つ以上の角度が付けられたまたは湾曲した部分を含み、当該1つ以上の角度が付けられたまたは湾曲した部分は、前記開口部の遠位端よりも遠位側にある、
歯科用器具。 - 前記位置決め部材が、長手軸を有する細長い部材を含み
前記チャネルがチャネル軸を有し、および前記チャネル軸が前記細長い部材の長手軸に実質的に平行である、請求項1に記載の歯科用器具。 - 前記高速の液体噴射が噴射軸に沿って伝搬し、前記噴射軸が、前記チャネル軸または前記細長い部材の長手軸に実質的に平行であるように前記位置決め部材が配置される、請求項2に記載の歯科用器具。
- 前記高速の液体噴射を出力するように構成されたノズルをさらに含む、請求項1から3のいずれか1項に記載の歯科用器具。
- 前記ノズルが、前記位置決め部材の前記近位端部分に配置されている、請求項4に記載の歯科用器具。
- 前記液体噴射が前記衝突部材に衝突した後に、前記液体噴射の少なくとも一部分を、前記位置決め部材の前記近位端部分の方へ少なくとも部分的に向けるように、前記衝突面の
前記1つ以上の角度が付けられたまたは湾曲した部分が構成されている、請求項1から5のいずれか1項に記載の歯科用器具。 - 前記衝突面の前記1つ以上の角度が付けられたまたは湾曲した部分が、前記衝突面に衝撃を与える前記液体噴射の少なくとも一部分に渦まきまたは循環を与えるように構成されている、請求項1から6のいずれか1項に記載の歯科用器具。
- 前記衝突部材が、前記液体噴射が衝撃を与えると、液体の噴霧を生じるように構成されている、請求項1から7のいずれか1項に記載の歯科用器具。
- 前記液体の噴霧が、第1の方向に向けられた第1の噴霧と、第2の方向に向けられた第2の噴霧とを含み、前記第2の方向が、前記第1の方向とは実質的に異なる、請求項8に記載の歯科用器具。
- 前記液体噴射の動作中に、前記歯にあてがわれ、かつ前記歯の開口部からの流体の逆流を抑止するように構成された逆流制限器であって、少なくとも一部分が、大略、前記位置決め部材の前記近位端部分と前記遠位端部分との間に配置されている、逆流制限器をさらに含む、請求項1から9のいずれか1項に記載の歯科用器具。
- 前記逆流制限器が、実質的に前記位置決め部材の周りに配置されている、請求項10に記載の歯科用器具。
- 前記逆流制限器が、少なくとも部分的に多孔性であるかまたは少なくとも部分的に吸収性である材料を含む、請求項10または11に記載の歯科用器具。
- 前記逆流制限器が、圧縮可能な材料を含む、請求項10から12のいずれか1項に記載の歯科用器具。
- ハンドピースを更に含み、前記位置決め部材が、前記ハンドピースに取り付けられるように構成されている、請求項1から13のいずれか1項に記載の歯科用器具。
- 前記位置決め部材の前記遠位端部分のサイズおよび形状は、前記複数の開口部を歯髄腔内に配置しつつ、前記遠位端部分を前記歯髄腔に位置決めできる、サイズおよび形状である、請求項1から14のいずれか1項に記載の歯科用器具。
- 前記位置決め部材および前記衝突部材を有する音響波発生器を更に含み、前記音響波発生器は、歯内に水中音場を生成するように構成される、請求項1から15のいずれか1項に記載の歯科用器具。
- 前記音響波発生器は、広範囲の音響周波数にわたる音響パワーを生成するように構成される、請求項16に記載の歯科用器具。
- 前記音響波発生器は、歯内の有機物を歯から引き離すのに十分なパワーを生成するように構成される、請求項16または17に記載の歯科用器具。
- 位置決め部材を有する圧力波発生器を備える歯科治療のための装置であって、
前記位置決め部材の遠位端部分は衝突面を含み、
前記位置決め部材は、高速の液体噴射ビームを出力するための大きさおよび形状を有するオリフィスを備えるノズルを有し、前記液体噴射ビームが前記衝突面に向かうように、前記衝突面に対して配置され、
前記遠位端部分のサイズは、歯内の空洞に入るようなサイズであり、
前記液体噴射ビームがビーム軸に沿って伝搬し、前記ビーム軸に対して実質的に垂直な前記衝突面の部分において前記衝突面に衝突するように構成され、
前記衝突面は、前記位置決め部材の近位端に向かって角度が付けられたまたは湾曲した面を1つ以上含む、
歯科治療のための装置。 - 前記液体噴射のビームは、脱気液体を含む、請求項19に記載の装置。
- 前記衝突面は、大略、凹型形状である、請求項19または20に記載の装置。
- 前記位置決め部材はガイドチューブを含み、該ガイドチューブは、該ガイドチューブの遠位端部分に開口部を有するチャネルを有する、請求項19から21のいずれか1項に記載の装置。
- 前記圧力波発生器は、歯の空洞において少なくともいくらかの液体キャビテーションを引き起こすために十分なエネルギーを出力するように構成される、請求項19から22のいずれか1項に記載の装置。
- オリフィスと衝突面を備える液体ビーム形成部を有する圧力波発生器であって、前記オリフィスは高速の液体噴射ビームを出力するための大きさおよび形状を有し、前記衝突面は前記オリフィスから離され、前記オリフィスの軸が前記衝突面を通るように配置され、前記衝突面は歯内の空洞に挿入されるように構成されている、圧力波発生器を備える歯科治療のための装置であって、
前記液体ビーム形成部は、前記液体噴射ビームが、前記衝突面の最遠位部分に衝突するように構成され、
前記衝突面は、前記液体噴射ビームの噴霧を、前記衝突面の近くに配置された1つまたは複数の開口部に向けるように構成された十分な剛性を有する材料を含み、
前記衝突面は、大略、前記液体噴射の軸に対して対称に配置される、
歯科治療のための装置。 - 前記液体ビーム形成部は、前記液体噴射ビームが前記衝突面に衝突したときに、歯の空洞において少なくともいくらかの液体キャビテーションを引き起こすために十分なエネルギーを有する液体噴射ビームを形成するように構成される、請求項24に記載の装置。
- 前記軸に沿って延びるチャネルを有し、該チャネルに沿って前記液体噴射ビームを流すことができるガイドチューブをさらに備える、請求項24または25に記載の装置。
- 前記圧力波発生器の周りに配置され、前記歯内の空洞に少なくともいくらかの液体を保持するように構成された流れ制限器をさらに備える、請求項24から26のいずれか1項に記載の装置。
- 前記液体ビーム形成部に結合されたハンドピースをさらに備える、請求項24から27のいずれか1項に記載の装置。
- 前記衝突面は、前記液体ビーム形成部の近位端に向かって角度が付けられたまたは湾曲した面を1つ以上含む、請求項24から28のいずれか1項に記載の装置。
- 前記凹面の衝突面は、前記長手軸に対して実質的に対称である、請求項2に記載の歯科用器具。
- 前記衝突面は、前記液体噴射が前記衝突面の最遠位部分において前記衝突部材に衝突するように、前記歯科用器具に配置される、請求項1から18および30のうちのいずれか1項に記載の歯科用器具。
- 前記高速の液体噴射が、噴射軸に沿って伝搬し、前記噴射軸に対して実質的に垂直な前記衝突面の部分において前記衝突面に衝突するように、前記位置決め部材が構成される、請求項1から18および30から31のうちのいずれか1項に記載の歯科用器具。
- 前記衝突面は、前記位置決め部材の近位端に向かって角度が付けられたまたは湾曲した面を1つ以上含む、請求項29または31のうちのいずれか1項に記載の歯科用器具。
- 前記衝突面は、前記液体噴射ビーム軸に対して実質的に対称に配置される、請求項21に記載の装置。
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US61/261,293 | 2009-11-13 | ||
PCT/US2010/056620 WO2011060327A1 (en) | 2009-11-13 | 2010-11-12 | Liquid jet apparatus and methods for dental treatments |
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JP2013510688A5 JP2013510688A5 (ja) | 2013-12-26 |
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EP (3) | EP2498713B1 (ja) |
JP (1) | JP5902096B2 (ja) |
KR (1) | KR20120099717A (ja) |
CN (1) | CN102724929B (ja) |
AU (1) | AU2010319321B2 (ja) |
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EP3878398A3 (en) | 2021-12-22 |
US9492244B2 (en) | 2016-11-15 |
EP2498713A4 (en) | 2015-11-18 |
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EP3384870A1 (en) | 2018-10-10 |
EP3878398B1 (en) | 2024-03-06 |
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CN102724929A (zh) | 2012-10-10 |
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CA2780800A1 (en) | 2011-05-19 |
WO2011060327A1 (en) | 2011-05-19 |
US20220296346A1 (en) | 2022-09-22 |
EP2498713B1 (en) | 2018-04-04 |
US20200146774A1 (en) | 2020-05-14 |
KR20120099717A (ko) | 2012-09-11 |
JP2013510688A (ja) | 2013-03-28 |
IL219648A0 (en) | 2012-07-31 |
CA2780800C (en) | 2023-09-12 |
US11160645B2 (en) | 2021-11-02 |
CN102724929B (zh) | 2016-04-13 |
AU2010319321A1 (en) | 2012-06-14 |
US20110117517A1 (en) | 2011-05-19 |
EP3878398A2 (en) | 2021-09-15 |
EP3384870B1 (en) | 2020-12-23 |
EP2498713A1 (en) | 2012-09-19 |
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