JP5544293B2 - 吸入装置 - Google Patents
吸入装置 Download PDFInfo
- Publication number
- JP5544293B2 JP5544293B2 JP2010529010A JP2010529010A JP5544293B2 JP 5544293 B2 JP5544293 B2 JP 5544293B2 JP 2010529010 A JP2010529010 A JP 2010529010A JP 2010529010 A JP2010529010 A JP 2010529010A JP 5544293 B2 JP5544293 B2 JP 5544293B2
- Authority
- JP
- Japan
- Prior art keywords
- vibration
- vibration mechanism
- dry powder
- control device
- power
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Percussion Or Vibration Massage (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catching Or Destruction (AREA)
- Special Spraying Apparatus (AREA)
Description
(1)サイズの小さい粒子は、製造および保管中に自然に帯電する。これは粒子を凝集させる、つまり集合させ、結果的に5ミクロンを超える有効サイズを持つ粒子の塊体が生じる。すると、これら大きな塊体が肺深部に達する可能性が低下する。今度はこれが、封入薬品が患者に吸収される割合が低くなるという結果を生む。
(2)患者へ送達される必要のある活性薬品の量は、数十マイクログラム程度である。例えば喘息に使用される薬品であるアルブテロールの場合には、通常、これは25から50マイクログラムである。最新の製造設備では、ミリグラム用量範囲の均等量の薬品を許容精度で有効に生産することができる。そのため標準的な作業は、活性薬品を充填材またはラクトースなどの膨張性薬剤と混合することである。この添加剤はまた、薬品を「流れやすく」する。この充填材は、静電気または化学結合により薬品粒子がこれらの粒子に固着するので、キャリアとも呼ばれる。これらキャリア粒子のサイズは、薬品粒子よりも非常に大きい。乾燥粉末吸入器がキャリアから薬品を分離する能力は、設計の有効性において重要な性能パラメータである。
(3)5ミクロンを超えるサイズの活性薬品粒子は、口と喉のいずれかに付着する。すると、これらの箇所における薬品の生物学的利用能および吸収は肺と異なるので、別のレベルの不確実性が生じる。乾燥粉末吸入器では、これらの箇所での薬品の付着を最小限に抑えて、薬品の生物学的利用能に関連する不確実性を低下させる必要がある。
10 空気
12 気流通路
14 末端部
16 第3開口部
20 容器
22 電気結線
26 電源
28 振動機構
32 トグルスイッチ
40 気流センサ
46 基端部
48 制御回路構成
50 粉末
70 作動制御装置
72 制御サブシステム
74 制御可能回路
76 周波数掃引発生器
78 周波数発生器
80 ポンプ回路
82 初期設定メモリ
84 サンプルホールドフィードバック制御装置
86 ピーク電力検出器
88 センサ
200 フローチャート
500 メモリ
Claims (9)
- 振動機構と、
前記振動機構に機能的に結合された乾燥粉末の供給源と、
使用者がいつ吸い込んでいるかを検知することのための、および使用者が吸い込んでいる時に前記振動機構に電力を誘発することのための気流センサを含む作動制御装置と、
前記振動機構と連通する電源と、
前記振動機構と通信する振動センサであって、前記振動機構の振動を検出するために設けられている前記振動センサと、
前記振動センサおよび前記電源と通信するフィードバック制御装置であって、前記振動機構へ送達される電力を制御する前記フィードバック制御装置と、
前記フィードバック制御装置と通信するメモリであって、前記フィードバック制御装置から前記電源への少なくとも1回の通信に対して前記振動センサから前記フィードバック制御装置への少なくとも1回の通信を記憶する前記メモリと、
を包含する、
乾燥粉末吸入器。 - 前記振動機構がさらに圧電トランスデューサを包含する、請求項1に記載の乾燥粉末吸入器。
- 前記振動センサがさらに電圧計を包含する、請求項1の乾燥粉末吸入器。
- 前記フィードバック制御装置が、前記電源と前記振動機構との間に接続された周波数掃引発生器をさらに包含することにより、前記振動機構へ送達される電力の特性を制御する、請求項1の乾燥粉末吸入器。
- 前記振動センサと通信するピーク電力検出器をさらに包含する、請求項1の乾燥粉末吸入器。
- 以下の特徴、すなわち、
前記振動機構が圧電トランスデューサをさらに包含して、前記振動センサが前記圧電トランスデューサからの電圧出力を検出する、
ことを特徴とする、請求項1の乾燥粉末吸入器。 - 乾燥粉末吸入器においてフィードバック制御を行う方法であって、
第1入電力を用いて振動機構を略定常状態まで駆動するステップと、
前記第1入電力を除去し、前記振動機構の少なくとも一部分の振動は継続するステップと、
前記電圧入力が除去された後に前記振動機構の振動を検知するステップと、
複数の異なる入電力による駆動、除去、検知のステップを反復するステップと、
最大検知振動を発生させたのはどの電圧入力かを判断するステップと、
乾燥粉末を分解させるように前記振動機構を配置するステップと、
を包含する方法。 - 前記配置ステップが前記除去ステップに先行する、請求項7の方法。
- 以下の特徴、すなわち、
(a)前記振動機構駆動ステップがさらに、振動するように圧電トランスデューサを駆動するステップを包含する、
(b)前記振動検知ステップが、前記圧電トランスデューサからの出力電圧を検出することを包含する、
(c)前記複数の異なる入電力が周波数によって異なる、
(d)前記複数の異なる入電力が振幅によって異なる、
のうち一つ以上を特徴とする、
請求項7の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97867207P | 2007-10-09 | 2007-10-09 | |
US60/978,672 | 2007-10-09 | ||
US12/246,208 US8439033B2 (en) | 2007-10-09 | 2008-10-06 | Inhalation device |
US12/246,208 | 2008-10-06 | ||
PCT/US2008/079236 WO2009048975A1 (en) | 2007-10-09 | 2008-10-08 | Inhalation device |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011500160A JP2011500160A (ja) | 2011-01-06 |
JP5544293B2 true JP5544293B2 (ja) | 2014-07-09 |
Family
ID=40522227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010529010A Expired - Fee Related JP5544293B2 (ja) | 2007-10-09 | 2008-10-08 | 吸入装置 |
Country Status (20)
Country | Link |
---|---|
US (3) | US8439033B2 (ja) |
EP (1) | EP2209511B1 (ja) |
JP (1) | JP5544293B2 (ja) |
KR (1) | KR101474589B1 (ja) |
CN (1) | CN101820939B (ja) |
AR (2) | AR068771A1 (ja) |
AU (1) | AU2008310916B2 (ja) |
BR (1) | BRPI0818345A2 (ja) |
CA (1) | CA2702066C (ja) |
CL (1) | CL2008002989A1 (ja) |
ES (1) | ES2767971T3 (ja) |
HK (1) | HK1147705A1 (ja) |
IL (1) | IL204955A (ja) |
MX (1) | MX2010003737A (ja) |
NZ (1) | NZ584531A (ja) |
PE (1) | PE20091275A1 (ja) |
RU (1) | RU2478405C2 (ja) |
TW (1) | TWI524907B (ja) |
WO (1) | WO2009048975A1 (ja) |
ZA (1) | ZA201002479B (ja) |
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