JP5529415B2 - ジェランシームレス崩壊可能カプセル、及びその製造方法 - Google Patents
ジェランシームレス崩壊可能カプセル、及びその製造方法 Download PDFInfo
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- JP5529415B2 JP5529415B2 JP2008517632A JP2008517632A JP5529415B2 JP 5529415 B2 JP5529415 B2 JP 5529415B2 JP 2008517632 A JP2008517632 A JP 2008517632A JP 2008517632 A JP2008517632 A JP 2008517632A JP 5529415 B2 JP5529415 B2 JP 5529415B2
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- shell
- seamless
- capsule
- capsule according
- disintegratable
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- ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 description 1
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- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 description 1
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- DYUUPIKEWLHQGQ-SDXBLLFJSA-N paprika oleoresin Chemical compound C(\[C@]12[C@@](O1)(C)C[C@@H](O)CC2(C)C)=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=C[C@H]1C(C)=C[C@H](O)CC1(C)C DYUUPIKEWLHQGQ-SDXBLLFJSA-N 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
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- 235000013975 turmeric oleoresin Nutrition 0.000 description 1
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Images
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Description
Claims (26)
- コア及びシェルを含有するシームレス崩壊可能カプセルであって、
内側の親油性の相を含有するコア及び外側の親水性の相を含有するシェルで構成されるカプセルを形成するために、外側の親水性の液相及び内側の親油性の液相を共押出する工程と、得られたカプセルを、硬化剤を含有する水溶液中に浸漬する工程と、を含む共押出工程により、前記カプセルが製造され、
前記シェルが、シェルの全乾燥質量に対して4質量%以上のゲル化剤であって、ジェランガムを単独で、又は他のゲル化剤と共に含むゲル化剤と、
シェルの全乾燥質量に対して25〜95質量%の充填剤と、
クエン酸三ナトリウム、リン酸三ナトリウム、ピロリン酸四ナトリウム、ヘキサメタリン酸ナトリウム及びこれらの混合物からなる群より選択される、シェルの全乾燥質量に対して2質量%までの二価の金属イオン封鎖剤と、を含む、
シームレス崩壊可能カプセル。 - 前記ゲル化剤は、ジェランと、ゼラチン、寒天、カラギーナン、ペクチン、キサンタンガム、セルロースガム、アルギン酸塩、デキストラン、カードラン、ウェランガム、ラムザンガム、又は改質デンプンからなる群より選択される1種類のゲル化剤との混合物である請求項1に記載のシームレス崩壊可能カプセル。
- 前記シェルに存在する前記ゲル化剤の量は、シェルの全乾燥質量に対して5〜75質量%である請求項1又は2に記載のシームレス崩壊可能カプセル。
- 前記ゲル化剤は、ジェランガム単独である請求項3に記載のシームレス崩壊可能カプセル。
- 少なくとも他のゲル化剤との混合物として用いた場合に、ジェランガムと他のゲル化剤との質量比は、80:20〜20:80である請求項1から3のいずれかに記載のシームレス崩壊可能カプセル。
- 前記充填剤は、デンプン誘導体としてデキストリン、マルトデキストリン、シクロデキストリン、及び/又はセルロース誘導体としてヒドロキシプロピルメチルセルロース(HPMC)、ヒドロキシプロピルセルロース(HPC)、メチルセルロース(MC)、ポリビニルアルコール、ポリオール、又はこれらの混合物である請求項1から5のいずれかに記載のシームレス崩壊可能カプセル。
- シェルに存在する前記充填剤の量は、シェルの全乾燥質量に対して、50〜80質量%である請求項1から6のいずれかに記載のシームレス崩壊可能カプセル。
- 前記金属イオン封鎖剤の量は、シェルの全乾燥質量に対して、1質量%以下である請求項1から7のいずれかに記載のシームレス崩壊可能カプセル。
- 前記シェルは、クエン酸塩、グルクロン酸塩、アジピン酸塩、フマル酸塩、グルコン酸塩、及びグルコノデルタラクトン塩、並びにこれらの混合物を含む群から選択される1種類の酸性塩をさらに含有する請求項1から8のいずれかに記載のシームレス崩壊可能カプセル。
- 0.098〜49N(0.01〜5kp)の崩壊強度を有する請求項1から9のいずれかに記載のシームレス崩壊可能カプセル。
- 前記シェルは、シェルの全乾燥質量に対して、0.1〜30質量%の可塑剤をさらに含有する請求項1から10のいずれかに記載のシームレス崩壊可能カプセル。
- 0.098〜49N(0.01〜5kp)の崩壊強度を有する請求項1から11のいずれかに記載のシームレス崩壊可能カプセル。
- 請求項1に記載のシームレス崩壊可能カプセルの製造方法であって、
内側の親油性の相を含有するコア及び外側の親水性の相を含有するシェルで構成されるカプセルを形成するために、外側の親水性の液相及び内側の親油性の液相を共押出する工程と、
硬化剤を含有する水溶液中に浸漬する工程と、
を含み、
前記シェルが、シェルの全乾燥質量に対して4質量%以上のゲル化剤であって、ジェランガムを単独で、又は他のゲル化剤と共に含むゲル化剤と、
シェルの全乾燥質量に対して25〜95質量%の充填剤と、
クエン酸三ナトリウム、リン酸三ナトリウム、ピロリン酸四ナトリウム、ヘキサメタリン酸ナトリウム及びこれらの混合物からなる群より選択される、シェルの全乾燥質量に対して2質量%までの二価の金属イオン封鎖剤と、を含む、シームレス崩壊可能カプセルの製造方法。 - 内側の親油性の相を含有するコア及び外側の親水性の相を含有するシェルで構成されるカプセルを形成するために、外側の親水性の液相及び内側の親油性の液相を共押出する工程と、任意にカプセルを低温条件に保つことによってシェルの表面を固化し、且つ/又はゲル化する工程と、任意にこのようにして得られたカプセルを有機溶媒によって洗浄する工程と、硬化剤を含有する水溶液中に浸漬する工程と、任意にカプセルを乾燥する工程と、を含む請求項13に記載のシームレス崩壊可能カプセルの製造方法。
- 前記シェルの表面を固化し、且つ/又はゲル化する工程では、カプセルを低温の油浴に接触させる請求項14に記載のシームレス崩壊可能カプセルの製造方法。
- 前記シェルの表面を固化し、且つ/又はゲル化する工程では、カプセルを低温の油浴に接触させた後、余分な油を除去するためにカプセルを遠心分離にかける請求項15に記載のシームレス崩壊可能カプセルの製造方法。
- 前記硬化剤は、二価イオンとしてカルシウムイオンを含有する請求項13から16のいずれかに記載のシームレス崩壊可能カプセルの製造方法。
- 前記硬化剤を含有する水溶液は、pHが3〜4である塩化カルシウム溶液である請求項13から17のいずれかに記載のシームレス崩壊可能カプセルの製造方法。
- 前記ゲル化剤は、ジェランと、ゼラチン及び親水性コロイドとして寒天、カラギーナン、ペクチン類、キサンタンガム、セルロースガム、アルギン酸塩、デキストラン、カードラン、ウェランガム、ラムザンガム、又は改質デンプン類及びこれらの混合物からなる群より選択される少なくとも1種類のゲル化剤との組み合わせである請求項13から18のいずれかに記載のシームレス崩壊可能カプセルの製造方法。
- 前記充填剤は、デンプン誘導体としてデキストリン、マルトデキストリン、シクロデキストリン、セルロース誘導体としてHPMC、HPC、MC、及びこれらの混合物である請求項13から19のいずれかに記載のシームレス崩壊可能カプセルの製造方法。
- 前記外側の親水性の液相は、グリセロール、ソルビトール、マルチトール、トリアセチン若しくはPEGタイプ、又は可塑性を有する他のポリオール、及びこれらの混合物からなる群より選択される可塑剤をさらに含む請求項13から20のいずれかに記載のシームレス崩壊可能カプセルの製造方法。
- 請求項1から12のいずれかに記載の崩壊可能カプセルを含むスラリーであって、ゲル化剤としてCMC、キサンタンガム、又はカルボポールを用いて形成されたゲル中に懸濁され、且つ任意に保存料及び安定剤を含むスラリー。
- 請求項1から12のいずれかに記載の崩壊可能カプセルを含む食品。
- 請求項1から12のいずれかに記載の崩壊可能カプセルを含む口腔ケア用品。
- 請求項1から12のいずれかに記載の崩壊可能カプセルを含む医薬品。
- 請求項1から12のいずれかに記載の崩壊可能カプセルを含む香料。
Applications Claiming Priority (5)
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PCT/EP2005/008502 WO2006136196A1 (en) | 2005-06-21 | 2005-06-21 | Gellan seamless breakable capsule and process for manufacturing thereof |
EPPCT/EP2005/008502 | 2005-06-21 | ||
PCT/EP2005/009226 WO2006136198A1 (en) | 2005-06-21 | 2005-08-05 | Gellan seamless breakable capsule and process for manufacturing thereof |
EPPCT/EP2005/009226 | 2005-08-05 | ||
PCT/IB2006/002905 WO2007012981A2 (en) | 2005-06-21 | 2006-06-21 | Gellan seamless breakable capsule and process for manufacturing thereof |
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KR (1) | KR101430018B1 (ja) |
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AU (1) | AU2006273701B2 (ja) |
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KR20080016889A (ko) | 2008-02-22 |
AU2006273701B2 (en) | 2012-11-01 |
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JP2008546756A (ja) | 2008-12-25 |
AP2876A (en) | 2014-03-31 |
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