JP5184257B2 - Beverages containing eggshell membrane powder - Google Patents
Beverages containing eggshell membrane powder Download PDFInfo
- Publication number
- JP5184257B2 JP5184257B2 JP2008212448A JP2008212448A JP5184257B2 JP 5184257 B2 JP5184257 B2 JP 5184257B2 JP 2008212448 A JP2008212448 A JP 2008212448A JP 2008212448 A JP2008212448 A JP 2008212448A JP 5184257 B2 JP5184257 B2 JP 5184257B2
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- JP
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- Prior art keywords
- beverage
- powder
- eggshell membrane
- mass
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
本発明は卵殻膜粉末を含有する飲料に関する。より詳細には、本発明は、卵殻膜粉末と共に、魚類由来コラーゲンペプチドおよびＮ−アセチルグルコサミンを含有する、皮膚の老化や肌荒れを防止して皮膚を滑らかで、柔らかく、シットリとした、張り、艶のある美肌にし、しかも健康の増進効果や病気の予防効果などを有する飲料に関する。 The present invention relates to a beverage containing eggshell membrane powder. More specifically, the present invention contains a fish-derived collagen peptide and N-acetylglucosamine together with eggshell membrane powder to prevent skin aging and rough skin, making the skin smooth, soft, soft, tight, glossy The present invention relates to a beverage having a beautiful skin and having a health promotion effect and a disease prevention effect.
ヒトの皮膚は、表面にある上皮層と、その下の結合組織性の真皮層からなっている。そのうち、真皮層はコラーゲンを主体とするタンパク質から主として構成されており、真皮層を構成するコラーゲンは、主としてα1（Ｉ）型コラーゲン［以下「（Ｉ）型コラーゲン」という］およびα1（III）型コラーゲン［以下「（III）型コラーゲン」という］である。（Ｉ）型コラーゲンは主として皮膚の構造維持機能を有し、（III）型コラーゲンは主として皮膚への柔軟性の付与機能を有する。
皮膚における（Ｉ）型コラーゲンと（III）型コラーゲンの割合は加齢に伴って変化し、（III）型コラーゲンは胎児のときに最も多く、１０代から徐々に減少する。
皮膚における（III）型コラーゲンの割合を増すことができれば、加齢による皮膚の老化を止め、肌荒れを防止し、皮膚を滑らかで、柔らかく、シットリとした状態に保つことができる。
Human skin consists of an epithelial layer on the surface and a connective tissue dermis layer below it. Among them, the dermis layer is mainly composed of a protein mainly composed of collagen, and the collagen constituting the dermis layer is mainly α 1 (I) type collagen (hereinafter referred to as “(I) type collagen”) and α 1 (III ) Type collagen [hereinafter referred to as "(III) type collagen"]. Type (I) collagen mainly has a skin structure maintaining function, and type (III) collagen mainly has a function of imparting flexibility to the skin.
The proportion of type (I) collagen and type (III) collagen in the skin changes with aging, and type (III) collagen is most common in the fetus and gradually decreases from the teenager.
If the proportion of type (III) collagen in the skin can be increased, it is possible to stop aging of the skin due to aging, prevent rough skin, and keep the skin smooth, soft and tight.
卵殻膜は、鶏卵などの鳥類の卵の卵殻の内側にある膜で、内外２枚からなり、外卵殻膜は卵殻内面に密着し、内卵殻膜は卵白を包んでいる。
卵殻膜は、強靭な繊維性のタンパク質から主としてなり、昔から相撲部屋で擦り傷などの手当にも使われていたように、皮膚の再生を促進する働きを有することが知られており、近年、胎児性コラーゲンとも称される（III）型コラーゲンの生成を促進させる作用を有することが報告されている。
The eggshell membrane is a membrane inside the eggshell of avian eggs such as chicken eggs, and consists of two inside and outside. The outer eggshell membrane is in close contact with the inner surface of the eggshell, and the inner eggshell membrane wraps the egg white.
Eggshell membranes are mainly composed of tough fibrous proteins, and have been known to have a function of promoting skin regeneration, as used for medical care such as scratches in sumo rooms. It has been reported to have an action of promoting the production of type (III) collagen, also called fetal collagen.
また、卵殻膜およびそれを部分加水分解した加水分解卵殻膜は、上記した美肌効果や皮膚再生作用以外に、育毛、発毛促進、脱毛防止効果があることが知られている。さらに卵殻膜および加水分解卵殻膜は、生体内に生成した活性酸素を低減または消去する機能を有していて活性酸素によって引き起こされる種々の疾病や不良な身体症状の改善や予防効果があることも知られており、例えば、活性酸素によって傷んだ赤血球の正常状態への回復、ヘモグロビンの増加、肩凝りの解消、食欲増進、疲労の除去、生体の活性化、健康増進、健康の維持などに有効であるとされている。 Moreover, it is known that an eggshell membrane and a hydrolyzed eggshell membrane obtained by partially hydrolyzing it have effects of hair growth, hair growth promotion, and hair loss prevention in addition to the above-described skin beautifying effect and skin regenerating effect. Furthermore, eggshell membranes and hydrolyzed eggshell membranes have a function of reducing or eliminating active oxygen generated in the living body, and may have an effect of improving or preventing various diseases and bad physical symptoms caused by active oxygen. For example, it is effective for restoring red blood cells damaged by active oxygen to normal state, increasing hemoglobin, eliminating shoulder stiffness, increasing appetite, removing fatigue, revitalizing the body, promoting health, maintaining health, etc. It is said that.
卵殻膜および加水分解卵殻膜が有する上記した優れた作用に注目して、卵殻膜または加水分解卵殻膜を配合した、経口で摂取する肌改善剤や肌改善用飲食物が知られている（特許文献１〜３）。
卵殻膜および加水分解卵殻膜のうち、加水分解卵殻膜は、水溶性で取り扱い性にも優れることから、他の成分と混合して固形状の食品や剤（錠剤、カプセル剤、顆粒剤など）にして用いるだけでなく、水に溶解させて飲料にして用いることが行なわれている。
Paying attention to the above-mentioned excellent action of eggshell membranes and hydrolyzed eggshell membranes, skin improving agents and foods for skin improvement that are ingested orally containing eggshell membranes or hydrolyzed eggshell membranes are known (patents) Literatures 1-3).
Among eggshell membranes and hydrolyzed eggshell membranes, hydrolyzed eggshell membranes are water-soluble and easy to handle, so they are mixed with other ingredients to form solid foods and agents (tablets, capsules, granules, etc.) In addition to being used, it is used by dissolving in water and using it as a beverage.
一方、加水分解処理を行なっていない卵殻膜は、加水分解処理を行なわないために加水分解卵殻膜に比べて低コストで入手できるが、水に溶解せず、しかも水に安定に分散しないため、飲料にして用いることは実際上行なわれておらず、固形状の食品中に添加したり、固形剤にして用いられている。しかしながら、本発明者が調べたところ、固形状の食品や固形剤中に含有されている未加水分解の卵殻膜は、消化吸収性に劣り、卵殻膜が本来有する上記した優れた特性を十分には発揮しにくいことが判明した。 On the other hand, eggshell membranes that have not been hydrolyzed can be obtained at a lower cost than hydrolyzed eggshell membranes because they are not hydrolyzed, but they do not dissolve in water and are not stably dispersed in water. It is not practically used as a beverage, but is added to a solid food or used as a solid agent. However, as a result of investigation by the present inventor, unhydrolyzed eggshell membranes contained in solid foods and solid preparations are inferior in digestive absorbability and sufficiently exhibit the above-described excellent characteristics inherent in eggshell membranes. Proved difficult to demonstrate.
また、コラーゲンは、真皮、靭帯、腱、骨、軟骨などを構成するタンパク質の１つで、動物の細胞外マトリックス（細胞外基質）の主成分であり、ヒトでは全タンパク質のほぼ３０％を占めているといわれている。
近年、魚類などから得られるコラーゲンまたは当該コラーゲンから調製したゼラチンを加水分解処理によって低分子化して、溶解性、消化吸収性、分散性を向上させた可溶性のコラーゲンペプチドが広く製造、販売されるようになっている。
コラーゲンペプチドは、加水分解する前のコラーゲンと同様に、保湿性および保水性を有し、摂取すると、皮膚に弾力性、張り、艶、潤いなどを与える美肌効果があり、また関節炎の症状の緩和作用、骨の形成促進作用なども有するとされていることから、コラーゲンペプチドを添加した飲食品が色々知られている（特許文献４〜８）。
Collagen is one of the proteins that make up the dermis, ligaments, tendons, bones, cartilage, etc., and is the main component of the extracellular matrix (extracellular matrix) of animals, accounting for almost 30% of all proteins in humans. It is said that
In recent years, soluble collagen peptides that have been improved in solubility, digestibility and dispersibility by reducing the molecular weight of collagen obtained from fish or the like, or gelatin prepared from the collagen, by hydrolysis treatment will be widely manufactured and sold. It has become.
Collagen peptide, like collagen before hydrolysis, has moisturizing and water-holding properties, and when ingested, has a skin-beautifying effect that gives skin elasticity, tension, luster, moisture, etc., and alleviates arthritis symptoms Various foods and beverages to which a collagen peptide is added are known (Patent Documents 4 to 8) because they are said to have an action and a bone formation promoting action.
そして、上記した特許文献４〜８のうち、特許文献５には、コラーゲンペプチドとビタミンＣおよびビタミンＢ２を併用することが記載され、特許文献６には、コラーゲンペプチドとＮ−アセチルグルコサミンを併用することが記載され、また特許文献８には、コラーゲンペプチドと大豆多糖類を併用することが記載されている。 And among patent document 4-8 mentioned above, patent document 5 describes using a collagen peptide, vitamin C, and vitamin B2 together, and patent document 6 uses a collagen peptide and N-acetylglucosamine together. In addition, Patent Document 8 describes that a collagen peptide and soybean polysaccharide are used in combination.
コラーゲンペプチドを摂取すると、またコラーゲンペプチドと共にビタミンＣやＮ−アセチルグルコサミンを摂取すると、摂取しない場合に比べて、皮膚の弾力性、張り、艶、潤いなどが増すが、近年、美肌効果に対する消費者の要求度合がますます高くなっており、消費者の要求を十分に満足するには至っていない。 Ingestion of collagen peptide and ingestion of vitamin C and N-acetylglucosamine together with collagen peptide increase skin elasticity, tension, luster, moisture, etc. compared to the case of not ingesting, but in recent years consumers for beautiful skin effects The degree of demand is increasing, and the demands of consumers are not fully satisfied.
本発明の目的は、加水分解卵殻膜に比べて低コストで入手可能な卵殻膜（加水分解されていな卵殻膜）を用いて、加水分解卵殻膜を含有する上記した従来の飲料、コラーゲンペプチドを含有する上記した従来の飲料、コラーゲンペプチドと共にビタミンＣやＮ−アセチルグルコサミンなどを含有する上記した飲料に比べて、皮膚への弾力性、張り、艶、潤いなどの付与作用が一層高くて、近年の消費者の美肌効果に対する強い要求を満たすことのできる飲料を提供することである。
さらに、本発明の目的は、卵殻膜などの成分が飲料中に均一に安定に分散していて長期間経っても成分の沈殿や凝集が生じず、しかも飲料に配合した卵殻膜やその他の成分の性能の低下や変質などがなく、卵殻膜やその他の成分の上記した種々の優れた作用が長期にわたって維持される高品質の飲料を提供することである。
また、本発明の目的は、美肌効果と共に、湿疹、炎症、ヤケドなどの皮膚疾患の予防や治癒の促進、育毛、発毛促進、脱毛防止、筋肉、腱、靭帯、骨、その他の身体内の組織や器官に生じた損傷や障害などの疾病や不良な身体症状の改善や予防、生体の活性化、健康増進、健康の維持などの他の優れた効果をも有する飲料を提供することである。
An object of the present invention is to use the above-described conventional beverage and collagen peptide containing a hydrolyzed eggshell membrane using an eggshell membrane (an unhydrolyzed eggshell membrane) that is available at a lower cost than the hydrolyzed eggshell membrane. Compared to the above-mentioned conventional beverages containing the above-mentioned beverages containing vitamin C and N-acetylglucosamine together with collagen peptides, the action of imparting elasticity, tension, luster, moisture, etc. to the skin is much higher. It is providing the drink which can satisfy the strong request | requirement with respect to the skin beautifying effect of consumers.
Furthermore, the object of the present invention is that eggshell membranes and other components are uniformly and stably dispersed in the beverage, and the components do not precipitate or aggregate even after a long period of time, and eggshell membranes and other components blended in the beverage It is intended to provide a high-quality beverage in which the above-described various excellent actions of eggshell membranes and other components are maintained over a long period of time without deterioration in performance or alteration.
Further, the object of the present invention is to prevent skin diseases such as eczema, inflammation, burns, and promote healing, hair growth, hair growth promotion, hair loss prevention, muscles, tendons, ligaments, bones and other in-body bodies, as well as skin beautifying effects. It is to provide a beverage having other excellent effects such as amelioration and prevention of diseases and bad physical symptoms such as damage and disorders in tissues and organs, vitalization, health promotion, health maintenance, etc. .
上記の目的を達成すべく、本発明者は卵殻膜入り飲料の試作を色々行ってきた。その結果、加水分解されていない卵殻膜粉末と共に、魚類由来コラーゲンペプチドおよびＮ−アセチルグルコサミンを用いて飲料をつくると、卵殻膜粉末が水中に安定に分散するようになって、長期間経っても沈殿や凝集が生じないこと、しかも卵殻膜粉末を固形食品や固形剤の形で摂取する場合に比べて卵殻膜粉末の消化吸収性が向上すること、その上卵殻膜、コラーゲンペプチドおよびＮ−アセチルグルコサミンが本来有する優れた特性が相乗的に発揮されて、上記した従来の飲料（加水分解卵殻膜を含有する飲料、コラーゲンペプチドを含有する飲料、コラーゲンペプチドと共にビタミンＣやＮ−アセチルグルコサミンを含有する飲料）に比べて、皮膚への弾力性、張り、艶、潤い、しっとり感、滑らかさなどの付与効果が一層強くなり、美肌効果に一層優れる飲料が得られることを見出した。
また、本発明者は、卵殻膜粉末、魚類由来コラーゲンペプチドおよびＮ−アセチルグルコサミンを含有する当該飲料は、美肌効果だけでなく、湿疹、炎症、ヤケドなどの皮膚疾患の予防や治癒の促進、育毛、発毛促進、脱毛防止、筋肉、腱、靭帯、骨、その他の身体内の組織や器官に生じた損傷や障害などの疾病や不良な身体症状の改善や予防、生体の活性化、健康増進、健康の維持などにも優れた効果を発揮することを見出した。
In order to achieve the above object, the present inventor has made various trials of beverages containing eggshell membranes. As a result, when a beverage is made using fish-derived collagen peptide and N-acetylglucosamine together with non-hydrolyzed eggshell membrane powder, the eggshell membrane powder will be stably dispersed in water, There is no precipitation or aggregation, and the digestibility and absorption of eggshell membrane powder is improved compared to the case where eggshell membrane powder is ingested in the form of solid food or solid agent. In addition, eggshell membrane powder, collagen peptide and N-acetyl The superior properties inherent to glucosamine are synergistically exhibited, and include the conventional beverages described above (beverages containing hydrolyzed eggshell membranes, beverages containing collagen peptides, and vitamin C and N-acetylglucosamine together with collagen peptides. Compared to beverages), the effects on skin such as elasticity, tension, luster, moisture, moistness and smoothness are stronger. , It found that more excellent drink to beautiful skin effect is obtained.
In addition, the present inventor said that the beverage containing eggshell membrane powder, fish-derived collagen peptide and N-acetylglucosamine has not only a beautifying effect but also prevention of skin diseases such as eczema, inflammation and burns, promotion of healing, hair growth , Hair growth promotion, hair loss prevention, amelioration and prevention of diseases and bad physical symptoms such as muscles, tendons, ligaments, bones and other tissues and organs in the body, and bad physical symptoms, vitalization, health promotion It has been found that it exhibits excellent effects in maintaining health.
さらに、本発明者は、卵殻膜粉末、魚類由来コラーゲンペプチドおよびＮ−アセチルグルコサミンを含有する上記した飲料において、大豆多糖類を分散剤として用いると、卵殻膜粉末の分散安定性が一層向上することを見出した。
また、本発明者は、飲料中に、卵殻膜粉末、魚類由来コラーゲンペプチドおよびＮ−アセチルグルコサミンと共に、Ｌ−アスコルビン酸類、ビタミンＥ、ローヤルゼリー、アセロラパウダー、アロエエキスパウダーおよびビタミンＥの１種または２種以上を含有させると、美肌効果が一層向上し、しかも生体の活性化、健康増進、健康の維持などに効果があることを見出した。
さらに、本発明者は、卵殻膜粉末、魚類由来コラーゲンペプチドおよびＮ−アセチルグルコサミンを含有する飲料において、魚類由来コラーゲンペプチドとして魚鱗由来コラーゲンペプチドを用いるのが美肌効果の点でより好ましいことを見出し、それらの種々の知見に基づいて本発明を完成した。
Furthermore, when the present inventors use soybean polysaccharide as a dispersant in the beverage containing eggshell membrane powder, fish-derived collagen peptide, and N-acetylglucosamine, the dispersion stability of the eggshell membrane powder is further improved. I found.
In addition, the present inventor used one or two of L-ascorbic acid, vitamin E, royal jelly, acerola powder, aloe extract powder and vitamin E together with eggshell membrane powder, fish-derived collagen peptide and N-acetylglucosamine in the beverage. It has been found that when more than seeds are contained, the skin beautifying effect is further improved, and further, there is an effect on vitalization, health promotion, health maintenance and the like.
Furthermore, the present inventors have found that in a beverage containing eggshell membrane powder, fish-derived collagen peptide and N-acetylglucosamine, it is more preferable in terms of skin beautifying effect to use fish scale-derived collagen peptide as fish-derived collagen peptide, Based on these various findings, the present invention has been completed.
すなわち、本発明は、
（１） 卵殻膜粉末、魚類由来コラーゲンペプチドおよびＮ−アセチルグルコサミンを有効成分として含有することを特徴とする飲料である。
そして、本発明は、
（２） 飲料の質量に基づいて、卵殻膜粉末を０．０５〜２．５質量％、魚類由来コラーゲンペプチドを０．１〜１０質量％およびＮ−アセチルグルコサミンを０．０５〜５質量％の割合で含有する前記（１）の飲料である。
That is, the present invention
(1) A beverage characterized by containing eggshell membrane powder, fish-derived collagen peptide and N-acetylglucosamine as active ingredients.
And this invention,
(2) 0.05 to 2.5% by mass of eggshell membrane powder, 0.1 to 10% by mass of fish-derived collagen peptide and 0.05 to 5% by mass of N-acetylglucosamine based on the mass of the beverage It is a drink of said (1) contained in a ratio.
さらに、本発明は、
（３） 大豆多糖類よりなる分散安定剤を含有する前記（１）または（２）の飲料；
（４） Ｌ−アスコルビン酸類及びビタミンＥの一方または両方を更に含有する前記（１）〜（３）のいずれかの飲料；
（５） ローヤルゼリー、アセロラパウダーおよびアロエエキスパウダーから選ばれる１種または２種以上を更に含有する前記（１）〜（４）のいずれかの飲料；および、
（６） 甘味料、香味料及び保存料のうちの１種または２種以上を更に含有する前記（１）〜（５）のいずれかの飲料；
である。
Furthermore, the present invention provides
(3) The beverage according to (1) or (2) above, which contains a dispersion stabilizer made of soybean polysaccharide;
(4) The beverage according to any one of (1) to (3), further containing one or both of L-ascorbic acid and vitamin E;
(5) The beverage according to any one of the above (1) to (4), further comprising one or more selected from royal jelly, acerola powder and aloe extract powder; and
(6) The beverage according to any one of (1) to (5), further containing one or more of sweeteners, flavors and preservatives;
It is.
そして、本発明は、
（７） 卵殻膜粉末、魚類由来コラーゲンペプチド、Ｎ−アセチルグルコサミン、Ｌ−アスコルビン酸類、ビタミンＥ、ローヤルゼリー、アセロラパウダー、アロエエキスパウダー、大豆多糖類、甘味料、香味料および保存料を含有する飲料である。
さらに、本発明は、
（８） 魚類由来コラーゲンペプチドが、魚鱗由来コラーゲンペプチドである前記（１）〜（７）のいずれかの飲料である。
And this invention,
(7) Beverage containing eggshell membrane powder, fish-derived collagen peptide, N-acetylglucosamine, L-ascorbic acid, vitamin E, royal jelly, acerola powder, aloe extract powder, soybean polysaccharide, sweetener, flavoring agent and preservative It is.
Furthermore, the present invention provides
(8) The beverage according to any one of (1) to (7), wherein the fish-derived collagen peptide is a fish scale-derived collagen peptide.
本発明の飲料では、卵殻膜粉末などの成分が水中に安定に分散または溶解し、長期間経っても、成分の沈殿や凝集が生じず、保存安定性に優れている。
卵殻膜粉末が水中に分散している本発明の飲料は、卵殻膜粉末を固形食品や固形剤の形で摂取する場合に比べて卵殻膜粉末の消化吸収性に優れている。
本発明の飲料では、卵殻膜粉末、コラーゲンペプチドおよびＮ−アセチルグルコサミンが本来有する優れた特性が相乗的に発揮されて、従来の飲料（加水分解卵殻膜を含有する飲料、コラーゲンペプチドを含有する飲料、コラーゲンペプチドと共にビタミンＣやＮ−アセチルグルコサミンを含有する飲料など）に比べて、皮膚への弾力性、張り、艶、潤い、しっとり感、滑らかさなどの付与効果が一層強くなり、美肌効果に極めて優れている。
本発明の飲料は、美肌効果だけでなく、湿疹、炎症、ヤケドなどの皮膚疾患の予防や治癒の促進、育毛、発毛促進、脱毛防止、筋肉、腱、靭帯、骨、その他の身体内の組織や器官に生じた損傷や障害などの疾病や不良な身体症状の改善や予防、生体の活性化、健康増進、健康の維持などにも優れた効果を発揮する。
In the beverage of the present invention, components such as eggshell membrane powder are stably dispersed or dissolved in water, and the components do not precipitate or aggregate even after a long period of time, and are excellent in storage stability.
The beverage of the present invention in which the eggshell membrane powder is dispersed in water is superior in digestibility and absorbability of the eggshell membrane powder compared to the case where the eggshell membrane powder is ingested in the form of a solid food or a solid preparation.
In the beverage of the present invention, the excellent properties inherent in eggshell membrane powder, collagen peptide and N-acetylglucosamine are synergistically exhibited, and conventional beverages (beverages containing hydrolyzed eggshell membranes, beverages containing collagen peptides) Compared with collagen peptides and beverages containing vitamin C and N-acetylglucosamine, etc.), skin elasticity, tension, luster, moisture, moisturizing, smoothness, etc. can be applied more effectively, resulting in a beautiful skin effect. Very good.
The beverage of the present invention has not only a skin beautifying effect, but also prevention and healing of skin diseases such as eczema, inflammation, burns, hair growth, hair growth promotion, hair loss prevention, muscles, tendons, ligaments, bones, and other in-body It also has excellent effects in improving and preventing diseases and bad physical symptoms such as damage and disorders in tissues and organs, revitalizing the body, promoting health, and maintaining health.
本発明の飲料のうち、大豆多糖類を分散剤として含有する飲料は、卵殻膜粉末などの分散安定性に一層優れている。
本発明の飲料のうち、卵殻膜粉末、魚類由来コラーゲンペプチドおよびＮ−アセチルグルコサミンと共に、Ｌ−アスコルビン酸類、ビタミンＥ、ローヤルゼリー、アセロラパウダー、アロエエキスパウダーおよびビタミンＥの１種または２種以上を更に含有するものは、美肌効果に一層優れ、しかも生体の活性化、健康増進、健康の維持などに一層優れている。
Among the beverages of the present invention, beverages containing soybean polysaccharide as a dispersant are more excellent in dispersion stability such as eggshell membrane powder.
Among the beverages of the present invention, one or more of L-ascorbic acid, vitamin E, royal jelly, acerola powder, aloe extract powder and vitamin E are further added together with eggshell membrane powder, fish-derived collagen peptide and N-acetylglucosamine. What is contained is further excellent in the skin beautifying effect, and further excellent in the activation of the living body, health promotion, health maintenance and the like.
以下に本発明について詳細に説明する。
本発明では、卵殻膜粉末として、鳥類の卵から得られる、加水分解処理を行なっていない卵殻膜の粉末のいずれもが使用でき、そのうちでも鶏卵から得られる卵殻膜粉末が汎用性、入手容易性などの点から好ましく用いられる。
本発明で用いる卵殻膜粉末としては、飲料中に含有させた際の分散安定性、飲料を摂取した際の消化吸収性などの点から、微粒子状の卵殻膜粉末が好ましく用いられる。
特に、１５０メッシュの標準篩（１５０Ｔｙｌｅｒ篩；目開き１０４μｍ）を通過する粒子の含有割合が７０質量％以上である微粒子状の卵殻膜粉末は、飲料中での分散安定性に優れており、しかも消化吸収性に優れていて、卵殻膜が有する上記した美肌効果、育毛、発毛促進、脱毛防止、疾病や不良な身体症状の改善や予防、生体の活性化、健康増進、健康の維持などの優れた機能をより良好に発揮することができる点から好ましく用いられる。
The present invention is described in detail below.
In the present invention, any eggshell membrane powder obtained from avian eggs that has not been hydrolyzed can be used as the eggshell membrane powder. Among them, eggshell membrane powder obtained from chicken eggs is versatile and readily available. It is preferably used from the point of view.
The eggshell membrane powder used in the present invention is preferably a particulate eggshell membrane powder from the viewpoints of dispersion stability when contained in a beverage, digestibility and absorbability when a beverage is ingested, and the like.
In particular, the fine eggshell membrane powder containing 70 mass% or more of the particles passing through a 150 mesh standard sieve (150 Tyler sieve; mesh size 104 μm) is excellent in dispersion stability in beverages. It has excellent digestibility and absorbs the skin-beautifying effects of eggshell membranes, hair growth, hair growth promotion, hair loss prevention, improvement and prevention of diseases and bad physical symptoms, vitalization, health promotion, health maintenance, etc. It is preferably used because it can exhibit excellent functions more satisfactorily.
卵殻膜粉末自体は既に商品化されており、例えば、キューピー株式会社製「ＥＭパウダー３００」［１５０メッシュの標準篩（１５０メッシュのＴｙｌｅｒ篩；目開き１０４μｍ）を通過する粒子の含有割合が７０質量％以上］を挙げることができ、本発明では前記した市販の卵殻膜粉末をそのまま使用することができる。また、前記した市販の卵殻膜粉末を更に粉砕して、１５０メッシュの標準篩（１５０メッシュＴｙｌｅｒ篩；目開き１０４μｍ）を通過する粒子の含有割合が例えば８０質量％以上、更には９０質量％以上の微粒子状の卵殻膜粉末を調製してそれを用いてもよいし、或いは１５０メッシュ標準篩よりも目開きの小さな標準篩［例えば、１７０メッシュの標準篩（１７０メッシュのＴｙｌｅｒ篩；目開き８８μｍ）、２００メッシュの標準篩（２００メッシュのＴｙｌｅｒ篩；目開き７４μｍ）、２５０メッシュの標準篩（２５０メッシュのＴｙｌｅｒ篩；目開き６１μｍ）、２７０メッシュの標準篩（２７０メッシュのＴｙｌｅｒ篩；目開き５３μｍ）、３２５メッシュの標準篩（３２５メッシュのＴｙｌｅｒ篩；目開き４３μｍ）など］を用いて篩分け（分級）して、前記したいずれかの標準篩を通過する微粒子の含有割合が８０質量％以上、更には９０質量％以上の微粒子状の卵殻膜粉末を用いてもよい。 The eggshell membrane powder itself has already been commercialized. For example, the content ratio of particles passing through “EM Powder 300” [150 mesh standard sieve (150 mesh Tyler sieve; mesh opening 104 μm) manufactured by Kewpie Co., Ltd. is 70 mass. In the present invention, the above-described commercially available eggshell membrane powder can be used as it is. Further, the above-mentioned commercially available eggshell membrane powder is further pulverized, and the content ratio of particles passing through a 150 mesh standard sieve (150 mesh Tyler sieve; mesh size 104 μm) is, for example, 80% by mass or more, and further 90% by mass or more A finely divided eggshell membrane powder may be prepared and used, or a standard sieve having a smaller mesh size than a 150 mesh standard sieve [for example, a 170 mesh standard sieve (170 mesh Tyler sieve; ), 200 mesh standard sieve (200 mesh Tyler sieve; mesh size 74 μm), 250 mesh standard sieve (250 mesh Tyler sieve; mesh size 61 μm), 270 mesh standard sieve (270 mesh Tyler sieve; mesh size) 53 μm), 325 mesh standard sieve (325 mesh Tyler sieve; mesh opening 43 μm, etc.) Sieving and (classification), the content of fine particles passing through one of the standard sieves described above is 80 wt% or more, and further may be used particulate eggshell membrane powder 90 mass% or more.
ここで、本明細書でいう卵殻膜粉末の粒径に係る「Ａメッシュの標準篩を通過する粒子の含有割合」とは、卵殻膜粉末をＡメッシュの標準篩（Ｔｙｌｅｒ篩）を用いて篩分け（分級）したときに、篩分け（分級）する前の卵殻膜粉末の全質量に対する、Ａメッシュの標準篩（Ｔｙｌｅｒ篩）を通過した粒子の質量割合（質量％）をいう。 Here, “the content ratio of the particles that pass through the A mesh standard sieve” relating to the particle diameter of the eggshell membrane powder in the present specification means that the eggshell membrane powder is sieved using an A mesh standard sieve (Tyler sieve). It means the mass ratio (mass%) of the particles that have passed through the A mesh standard sieve (Tyler sieve) to the total mass of the eggshell membrane powder before sieving (classification).
本発明で用いる魚類由来コラーゲンペプチドは、魚類の皮、骨および／または鱗から得られるコラーゲンまたは当該コラーゲンから得られるゼラチンを、酵素などを用いて部分加水分解処理して得られるコラーゲンペプチドである。そのうちでも、魚類由来コラーゲンペプチドとしては、魚類の鱗から得られるコラーゲンを用いて調製した魚鱗由来コラーゲンペプチドが、美肌効果などの本発明の効果をより良好に発揮させることができる点から好ましく用いられる。 The fish-derived collagen peptide used in the present invention is a collagen peptide obtained by subjecting collagen obtained from fish skin, bones and / or scales or gelatin obtained from the collagen to partial hydrolysis using an enzyme or the like. Among these, as fish-derived collagen peptides, fish-scale-derived collagen peptides prepared using collagen obtained from fish scales are preferably used from the viewpoint that the effects of the present invention such as a skin beautifying effect can be exhibited better. .
本発明で用いる魚類由来コラーゲンペプチドの分子量は特に制限されないが、消化吸収性、飲料のベース媒体をなす水への溶解性、取り扱い性などの点から、平均分子量が５００〜１５，０００のものが好ましく用いられ、１，０００〜１０，０００のものがより好ましく用いられ、１，５００〜５，０００のものがより好ましく用いられる。
前記した魚類由来コラーゲンペプチド、そのうちでも魚鱗由来コラーゲンペプチドとしては、種々の製品が既に製造されて市場で販売されている。
本発明では、食品への使用が許可されている魚類由来コラーゲンペプチドであればいずれを用いてもよい。
The molecular weight of the fish-derived collagen peptide used in the present invention is not particularly limited, but those having an average molecular weight of 500 to 15,000 are preferable in terms of digestibility and absorbability, solubility in water that forms the base medium of beverages, and handling properties. It is preferably used, those having 1,000 to 10,000 are more preferably used, and those having 1,500 to 5,000 are more preferably used.
Various products have already been manufactured and sold in the market as the aforementioned fish-derived collagen peptides, and among them, fish scale-derived collagen peptides.
In the present invention, any collagen peptide derived from fish that is permitted to be used in foods may be used.
本発明で用いるＮ−アセチルグルコサミン（すなわち２−アセトアミド−２−デオキシグルコース）は、天然アミノ糖の１種で、糖タンパク質、糖脂質、ムコ多糖類などの構成成分として人体中に広く分布している。Ｎ−アセチルグルコサミンは、生体内でグリコーゲンから代謝分解されて生成され、ヒアルロン酸やコンドロイチン硫酸の原料となることが知られている。また、自然界では、Ｎ−アセチルグルコサミンは、カニ、エビなどの甲殻類の外皮を形成するキチン質に多量に含まれている。
Ｎ−アセチルグルコサミンを経口で摂取すると、軟骨や皮膚組織に取り込まれて、肌の潤いや滑らかさを改善する美肌効果や、関節の痛みや軋みを防止する効果があることが報告されている。
N-acetylglucosamine (that is, 2-acetamido-2-deoxyglucose) used in the present invention is a kind of natural amino sugar and widely distributed in the human body as a component such as glycoprotein, glycolipid, mucopolysaccharide. Yes. N-acetylglucosamine is known to be produced by metabolic decomposition from glycogen in vivo and used as a raw material for hyaluronic acid and chondroitin sulfate. In the natural world, N-acetylglucosamine is contained in a large amount in the chitin that forms the crust of crustaceans such as crabs and shrimps.
It has been reported that when N-acetylglucosamine is taken orally, it is taken into cartilage and skin tissue and has a skin beautifying effect that improves the moisture and smoothness of the skin, and an effect that prevents joint pain and itching.
Ｎ−アセチルグルコサミンの製法としては、カニやエビなどの甲殻類の殻に含まれるキチン質を原料とする方法などが挙げられる。
Ｎ−アセチルグルコサミンとしては、種々の製品が既に製造されて市場で販売されており、本発明では、食品への使用が許可されているＮ−アセチルグルコサミンであれば、いずれを用いてもよい。
Examples of the method for producing N-acetylglucosamine include a method using chitin as a raw material contained in shells of crustaceans such as crabs and shrimps.
As N-acetylglucosamine, various products have already been produced and sold in the market. In the present invention, any N-acetylglucosamine may be used as long as it is permitted to be used for food.
本発明の飲料は、飲料の質量（媒体である水を含めた総質量）に基づいて、卵殻膜粉末を０．０５〜２．５質量％、魚類由来コラーゲンペプチドを０．１〜１０質量％およびＮ−アセチルグルコサミンを０．０５〜５質量％の割合で含有することが好ましく、卵殻膜粉末を０．１〜１質量％、魚類由来コラーゲンペプチドを０．５〜５質量％およびＮ−アセチルグルコサミンを０．１〜２質量％の割合で含有することがより好ましく、卵殻膜粉末を０．２〜０．５質量％、魚類由来コラーゲンペプチドを０．７〜２質量％およびＮ−アセチルグルコサミンを０．２〜１質量％の割合で含有することが更に好ましい。 The beverage of the present invention is 0.05 to 2.5% by mass of eggshell membrane powder and 0.1 to 10% by mass of fish-derived collagen peptide based on the mass of the beverage (total mass including water as a medium). And N-acetylglucosamine in a proportion of 0.05 to 5% by mass, eggshell membrane powder 0.1 to 1% by mass, fish-derived collagen peptide 0.5 to 5% by mass and N-acetyl More preferably, glucosamine is contained in a proportion of 0.1 to 2% by mass, eggshell membrane powder is 0.2 to 0.5% by mass, fish-derived collagen peptide is 0.7 to 2% by mass and N-acetylglucosamine Is more preferably contained in a proportion of 0.2 to 1% by mass.
卵殻膜粉末の含有量が少なすぎると、皮膚に弾力性、張り、艶、潤い、滑らかさなどを与える美肌効果が十分に発揮されず、しかも湿疹、炎症、ヤケドなどの皮膚疾患の予防や治癒の促進、育毛、発毛促進、脱毛防止、筋肉、腱、靭帯、骨、その他の身体内の組織や器官に生じた損傷や障害などの疾病や不良な身体症状の改善や予防、生体の活性化、健康増進、健康の維持などの効果も低下し易くなる。一方、卵殻膜粉末の含有量が多すぎると、卵殻膜粉末が飲料中に安定に分散せず、沈殿や凝集などが生じ易くなり、しかも飲料の食味の低下、コストの上昇などが生ずる。
また、魚類由来コラーゲンペプチドの含有量が少なすぎると、前記したような美肌効果が十分に発揮されにくくなり、しかも飲料中に卵殻膜粉末が安定に分散しにくくなる。一方、魚類由来コラーゲンペプチドの含有量が多すぎると、飲料の食味の低下、コストの上昇、異臭などが生じ易くなる。
Ｎ−アセチルグルコサミンの含有量が少なすぎると、前記した美肌効果が十分に発揮されにくくなり、しかも体内での保水や潤滑が良好に行なわれにくくなる。一方、Ｎ−アセチルグルコサミンの含有量が多すぎると、飲料の食味の低下、コストの上昇、味の低下などが生じ易くなる。
If the content of eggshell membrane powder is too small, the skin-beautifying effect that gives the skin elasticity, tension, gloss, moisture, smoothness, etc. will not be fully exhibited, and prevention and healing of skin diseases such as eczema, inflammation, burns, etc. , Hair growth, hair growth prevention, hair loss prevention, amelioration and prevention of diseases and bad physical symptoms such as muscles, tendons, ligaments, bones, and other tissues and organs in the body and bad physical symptoms, biological activity Effects such as aging, health promotion, and health maintenance tend to be reduced. On the other hand, if the content of the eggshell membrane powder is too large, the eggshell membrane powder is not stably dispersed in the beverage, and precipitation or aggregation is likely to occur, and the beverage taste and cost are increased.
Moreover, when there is too little content of a fish origin collagen peptide, the above-mentioned skin beautifying effect will not fully be exhibited, and it will become difficult to disperse | distribute eggshell membrane powder stably in a drink. On the other hand, if the content of the fish-derived collagen peptide is too large, the beverage taste, cost and off-flavor are likely to occur.
When the content of N-acetylglucosamine is too small, the above-mentioned skin beautifying effect is not sufficiently exhibited, and water retention and lubrication in the body are difficult to be performed well. On the other hand, when there is too much content of N-acetylglucosamine, it will become easy to produce the fall of the taste of a drink, the raise of cost, the fall of a taste, etc.
本発明の飲料は、卵殻膜粉末を飲料中に安定に分散させるために、必要に応じて分散安定剤を含有することができる。分散安定剤としては、大豆多糖類、カラギーナン、ペクチン、アラビアガムなどの多糖類などを挙げることができる。
そのうちでも、水溶性の大豆多糖類が、卵殻膜粉末を飲料中により安定に分散させることができる点から好ましく用いられる。水溶性の大豆多糖類は、種々のものが市場で販売されており、本発明ではそれらのいずれを用いてもよい。
分散安定剤、特に大豆多糖類を用いる場合は、飲料の全質量に基づいて、分散安定剤（特に大豆多糖類）を、０．０２〜１質量％、特に０．０５〜０．５質量％の割合で用いることが、飲料の分散安定性、食味、香りなどの点から好ましい。
The beverage of the present invention can contain a dispersion stabilizer as necessary in order to stably disperse the eggshell membrane powder in the beverage. Examples of the dispersion stabilizer include polysaccharides such as soybean polysaccharide, carrageenan, pectin, and gum arabic.
Among these, a water-soluble soybean polysaccharide is preferably used because the eggshell membrane powder can be more stably dispersed in the beverage. Various water-soluble soybean polysaccharides are sold on the market, and any of them may be used in the present invention.
In the case of using a dispersion stabilizer, particularly soybean polysaccharide, 0.02 to 1 mass%, particularly 0.05 to 0.5 mass% of the dispersion stabilizer (especially soybean polysaccharide) based on the total mass of the beverage. It is preferable to use at a ratio of from the viewpoints of the dispersion stability, taste, aroma and the like of the beverage.
本発明の飲料は、卵殻膜粉末、魚類由来コラーゲンペプチドおよびＮ−アセチルグルコサミンと共に、必要に応じてＬ−アスコルビン酸類およびビタミンＥの一方または両方を更に含有していてもよく、Ｌ−アスコルビン酸類およびビタミンＥの両方を含有していることが好ましい。 The beverage of the present invention may further contain one or both of L-ascorbic acid and vitamin E together with eggshell membrane powder, fish-derived collagen peptide and N-acetylglucosamine as necessary. It preferably contains both vitamin E.
その際に、Ｌ−アスコルビン酸類としては、Ｌ−アスコルビン酸、Ｌ−アスコルビン酸の塩、Ｌ−アスコルビン酸の誘導体（例えば、アスコルビン酸の２，３，５，６位の水酸基の１つ又は２つ以上がリン酸、ポリリン酸、硫酸、脂肪酸、その他製薬学上許容される化合物のエステルとなったものなど）の１種または２種以上を用いることができる。
Ｌ−アスコルビン酸類は、代表的な抗酸化物質の１つであって、黒メラニンを無色の還元メラニンに変化させて、皮膚に生じたシミやソバカスを目立たなくする働きがあり、また生体内でのコラーゲンの生成を助ける働きもあると言われている。
かかる点から、本発明の飲料中にＬ−アスコルビン酸類を更に含有させた場合は、その美肌効果が一層向上する。
本発明の飲料中にＬ−アスコルビン酸類を含有させる場合は、その含有量は、飲料の全質量に基づいて、０．０２〜５質量％が好ましく、０．０５〜１質量％がより好ましい。
In that case, as L-ascorbic acid, L-ascorbic acid, a salt of L-ascorbic acid, a derivative of L-ascorbic acid (for example, one or two hydroxyl groups at 2, 3, 5, and 6 positions of ascorbic acid) One or more of phosphoric acid, polyphosphoric acid, sulfuric acid, fatty acid, and other pharmaceutically acceptable compounds can be used.
L-ascorbic acid is one of the typical antioxidants, and it changes black melanin to colorless reduced melanin to make the spots and freckles generated on the skin inconspicuous. It is said that it also has a function to help the production of collagen.
From this point, when L-ascorbic acid is further contained in the beverage of the present invention, the skin beautifying effect is further improved.
When L-ascorbic acids are contained in the beverage of the present invention, the content is preferably 0.02 to 5 mass%, more preferably 0.05 to 1 mass%, based on the total mass of the beverage.
また、ビタミンＥ（トコフェロール）は強い抗酸化作用を有し、老化防止ビタミンとも称され、摂取することによって血流が改善されて栄養が各組織にゆきわたり、組織自体が若返るといわれている。
かかる点から、本発明の飲料中にビタミンＥを更に含有させた場合は、組織の若返りにより美肌効果が一層向上する。
本発明の飲料中にビタミンＥを含有させる場合は、その含有量は、飲料の全質量に基づいて、０．００１〜０．１質量％が好ましく、０．００５〜０．０５質量％より好ましい。
Vitamin E (tocopherol) has a strong antioxidant action and is also referred to as an anti-aging vitamin, and is said to improve blood flow by ingestion and transfer nutrients to each tissue or rejuvenate the tissue itself.
From this point, when vitamin E is further contained in the beverage of the present invention, the skin beautifying effect is further improved by rejuvenating the tissue.
When vitamin E is contained in the beverage of the present invention, the content is preferably 0.001 to 0.1 mass%, more preferably 0.005 to 0.05 mass%, based on the total mass of the beverage. .
また、本発明の飲料は、必要に応じて、ローヤルゼリー、アセロラパウダーおよびアロエエキスパウダーから選ばれる１種または２種以上を更に含有していてもよく、ローヤルゼリー、アセロラパウダーおよびアロエエキスパウダーのうちの２種以上を含有していることが好ましく、ローヤルゼリー、アセロラパウダーおよびアロエエキスパウダーの３者を含有していることがより好ましい。 Moreover, the beverage of the present invention may further contain one or more selected from royal jelly, acerola powder and aloe extract powder, if necessary, of the royal jelly, acerola powder and aloe extract powder. It is preferable to contain 2 or more types, and it is more preferable to contain three of royal jelly, acerola powder and aloe extract powder.
ローヤルゼリーは、多くのビタミン類、ミネラル、アミノ酸を含み、高タンパクで様々な栄養素を含んでいて、健康増進作用があるとされている。
本発明の飲料中にローヤルゼリーを含有させる場合は、その含有量は、飲料の全質量に基づいて、０．０５〜２質量％が好ましく、０．１〜１質量％がより好ましい。
Royal jelly contains many vitamins, minerals and amino acids, is high protein and contains various nutrients, and is said to have health promoting effects.
When the royal jelly is contained in the beverage of the present invention, the content is preferably 0.05 to 2% by mass, more preferably 0.1 to 1% by mass, based on the total mass of the beverage.
アセロラパウダーは、キントラシオ科の植物であるアセロラの果実から調製した粉末であり、レモンの１０倍のビタミンＣを含んでいるといわれている。
本発明の飲料中にアセロラパウダーを含有させる場合は、その含有量は、飲料の全質量に基づいて、０．０２〜２質量％が好ましく、０．０５〜１質量％がより好ましい。
Acerola powder is a powder prepared from the fruits of acerola, a plant of the family Kintracio, and is said to contain vitamin C 10 times that of lemon.
When the acerola powder is contained in the beverage of the present invention, the content thereof is preferably 0.02 to 2 mass%, more preferably 0.05 to 1 mass%, based on the total mass of the beverage.
アロエエキスパウダーは、日本薬局方に基原植物として収載されているアロエフェロックス（A.ferox、別名：ケープアロエ）、或いはこれとアロエアフリカーナ（A.africana）またはアロエスピカータ（A.spicate）との雑種の葉の汁を濃縮乾燥させたもので、健胃効果、便秘解消効果があるとされており、種々の製品が従来から販売されている。
本発明の飲料中にアロエエキスパウダーを含有させる場合は、その含有量は、飲料の全質量に基づいて、０．０２〜２質量％が好ましく、０．０５〜１質量％より好ましい。
Aloe extract powder is Aloe Ferrox (aka Cape Aloe) listed as a basic plant in the Japanese Pharmacopoeia, Aloe Africana (A.africana) or Aloe Spicata (A.spicate) Concentrated and dried soup of mixed leaf juice, and is said to have a stomachic and constipation-reducing effect, and various products have been sold.
When the aloe extract powder is contained in the beverage of the present invention, the content is preferably 0.02 to 2 mass%, more preferably 0.05 to 1 mass%, based on the total mass of the beverage.
本発明の飲料は、食味および風味を良好なものにして、本発明の飲料を摂取し易くするために、甘味料および／または香味料を含有することが好ましい。
甘味料としては、飲食物において従来から用いられている甘味料のいずれもが使用でき、例えば、ショ糖、グルコース、フラクトース、マルトース、ラクトース、水あめ、蜂蜜、フラクトオリゴ糖、果糖ブドウ糖液、スクラロース、アスパラテーム、果汁などを挙げることができ、これらの１種または２種以上を用いることができる。
そのうちでも、本発明の飲料では、甘味料として、フラクトオリゴ糖、果糖ブドウ糖液糖およびスクラロースの１種または２種以上が好ましく用いられ、これら３種類を併用することがより好ましい。
The beverage of the present invention preferably contains a sweetener and / or a flavoring agent in order to improve the taste and flavor and make it easy to consume the beverage of the present invention.
As the sweetener, any of the sweeteners conventionally used in foods and drinks can be used. For example, sucrose, glucose, fructose, maltose, lactose, syrup, honey, fructooligosaccharides, fructose glucose solution, sucralose, asparagus Examples thereof include thames and fruit juices, and one or more of these can be used.
Among them, in the beverage of the present invention, one or more of fructooligosaccharide, fructose glucose liquid sugar and sucralose are preferably used as a sweetener, and it is more preferable to use these three in combination.
本発明の飲料で甘味料として好ましく用いられるフラクトオリゴ糖は、善玉菌であるビフィズス菌には作用し、悪玉菌であるウェルシュ菌には作用しないという性質があり、そのため整腸作用を補助する働きがあり、便秘やダイエットに効果があるとされており、その延長として脂質を改善する働きをなし、動脈硬化、高脂血症の改善に役立つといわれている。
本発明の飲料中にフラクトオリゴ糖を含有させる場合は、その含有量は、飲料の全質量に基づいて、０．０５〜４質量％が好ましく、０．１〜１質量％がより好ましい。
The fructooligosaccharide preferably used as a sweetener in the beverage of the present invention has the property that it acts on Bifidobacterium, which is a good bacterium, and does not act on Welsh, which is a bad bacterium. It is said to be effective for constipation and diet, and as an extension of it, it works to improve lipids and is said to be useful for improving arteriosclerosis and hyperlipidemia.
When fructooligosaccharide is contained in the beverage of the present invention, the content thereof is preferably 0.05 to 4 mass%, more preferably 0.1 to 1 mass%, based on the total mass of the beverage.
また、本発明の飲料で甘味料として好ましく用いられる果糖ブドウ糖液糖は、果糖の含有率が５０％以上の異性化糖液糖であり、キレのよい味質で、温度が低くなるほど甘みが強くなるという性質を有するため、常温または低温で摂取される本発明の飲料用の甘味料として適している。
本発明の飲料中に果糖ブドウ糖液糖を含有させる場合は、その含有量は、飲料の全質量に基づいて、１〜１５質量％が好ましく、３〜１０質量％がより好ましい。
In addition, the fructose glucose liquid sugar preferably used as a sweetener in the beverage of the present invention is an isomerized sugar liquid sugar having a fructose content of 50% or more, a good taste and a stronger sweetness as the temperature is lower. Therefore, it is suitable as a sweetener for beverages of the present invention taken at room temperature or low temperature.
When the fructose-glucose liquid sugar is contained in the beverage of the present invention, the content thereof is preferably 1 to 15% by mass, and more preferably 3 to 10% by mass based on the total mass of the beverage.
本発明の飲料で甘味料として好ましく用いられるスクラロースは、その正式名はトリクロロガラクトスクロースであり、天然の糖をベースとし、砂糖の約６００倍の甘味度を有し、砂糖に近い味質を有する、ノンカロリー甘味料である。そのため、スクラロースは、極めて少量の使用で且つ飲料のカロリーを上昇させずに、本発明の飲料に甘味を付与することができる。
本発明の飲料中にスクラロースを含有させる場合は、その含有量は、飲料の全質量に基づいて、０．００２〜０．２質量％が好ましく、０．００５〜０．１質量％がより好ましい。
The sucralose preferably used as a sweetener in the beverage of the present invention is trichlorogalactosucrose, its official name is based on natural sugar, has a sweetness about 600 times that of sugar, and has a taste similar to sugar. A non-caloric sweetener. Therefore, sucralose can give sweetness to the beverage of the present invention by using a very small amount and without increasing the calorie of the beverage.
When sucralose is contained in the beverage of the present invention, the content is preferably 0.002 to 0.2 mass%, more preferably 0.005 to 0.1 mass%, based on the total mass of the beverage. .
本発明の飲料は、飲料の食味および風味を向上させるために、必要に応じて香味料を含有することができる。
香味料としては、飲料中に含まれる卵殻膜粉末、魚類由来コラーゲンペプチド、Ｎ−アセチルグルコサミンおよびその他の成分の変質、沈殿などを生じず、飲料に適した香味料であればいずれも使用でき、例えば、リンゴ果汁、柑橘類果汁、ブドウ果汁、パイナップル果汁、イチゴ果汁などの果汁類、アップル香料、柑橘類香料、ブドウ香料、パイナップル香料、イチゴ香料、天然香料などの香料、乳酸、発酵乳酸などの酸味調整剤などを挙げることができる。
飲料中の香味料の含有量は、香味料の種類、形態、飲料に付与しようとする風味や食味の内容などに応じて調整すればよい。
The beverage of the present invention can contain a flavoring agent as necessary in order to improve the taste and flavor of the beverage.
As the flavoring agent, eggshell membrane powder contained in the beverage, fish-derived collagen peptide, N-acetylglucosamine and other components are not altered and precipitated, and any flavoring suitable for beverages can be used. For example, fruit juices such as apple juice, citrus juice, grape juice, pineapple juice, strawberry juice, apple flavor, citrus flavor, grape flavor, pineapple flavor, strawberry flavor, natural flavor, flavor adjustment such as lactic acid and fermented lactic acid An agent etc. can be mentioned.
What is necessary is just to adjust the content of the flavor in a drink according to the kind of flavor, the form, the content of the flavor or taste which is going to be provided to a drink.
本発明の飲料は、必要に応じて、保存料を含有していてもよい。本発明の飲料に用いる保存料としては、例えば、ユッカサポニン、安息香酸とその塩、ジフェニル、ソルビン酸、ソルビン酸カリウム、デヒドロ酢酸、デヒドロ酢酸ナトリウム、パラオキシ安息香酸エチル、パラオキシ安息香酸プロピル、パラオキシ安息香ブチルなどのパラオキシ安息香酸エステルなどを挙げることができ、これらの１種または２種以上を用いることができる。
そのうちでも、本発明では、保存料として、ユッカサポニンが、抗菌作用の外、脂質低下作用、体脂肪の蓄積抑制効果、コレステロール低下作用、善玉コレステロール増加作用、腸内細菌の増殖、関節炎予防効果などを有すると点から好ましく用いられる。
本発明の飲料中に保存料（好ましくはユッカサポニン）を含有させる場合は、その含有量は、飲料の全質量に基づいて、０．０２〜１質量％が好ましく、０．０５〜０．５質量％がより好ましい。
The beverage of the present invention may contain a preservative as necessary. Examples of the preservative used in the beverage of the present invention include yucca saponin, benzoic acid and salts thereof, diphenyl, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, ethyl paraoxybenzoate, propyl paraoxybenzoate, paraoxybenzoate. Paraoxybenzoic acid esters such as butyl can be mentioned, and one or more of these can be used.
Among them, in the present invention, as a preservative, yucca saponin has antibacterial action, lipid lowering action, body fat accumulation inhibiting effect, cholesterol lowering action, good cholesterol increasing action, intestinal bacterial growth, arthritis preventing effect, etc. When it has, it is preferably used from a point.
When the preservative (preferably yucca saponin) is included in the beverage of the present invention, the content is preferably 0.02 to 1% by mass, based on the total mass of the beverage, 0.05 to 0.5. The mass% is more preferable.
本発明の飲料は、本発明の目的および効果を妨げない範囲で、必要に応じて、上記した成分以外の成分を含有することができる。
本発明の飲料のｐＨは、飲料中に含まれる成分の沈殿、凝集、変質、性能低下などを招かず、しかもヒトが摂取し易いｐＨであればよく、一般的にはｐＨが２〜７であることが好ましく、３〜６．５であることが好ましい。
The drink of this invention can contain components other than an above-described component as needed in the range which does not prevent the objective and effect of this invention.
The pH of the beverage of the present invention may be any pH that does not cause precipitation, aggregation, alteration, performance degradation, etc. of components contained in the beverage and is easy for humans to take, and generally has a pH of 2-7. It is preferable that it is 3 to 6.5.
本発明の飲料の製法は特に制限されず、水に、上記した成分を加えて均一に混合し、水に溶解する成分は水に溶解させ、水に溶解しない成分は水中に均一に分散させることにより製造することができる。
本発明の飲料の製造時に用いる水の量は適宜調節できるが、上記した美肌効果やその他の効果を十分に発揮し且つ成分の沈殿や凝集などが生じないようにするために、最終的に得られる飲料の質量に対して、水を６５〜９０質量％、更には７０〜８５質量％、特に７５〜８２質量％の量で用いて飲料を製造することが好ましい。
また、飲料を製造する際の混合温度としては、好ましくは５〜３０℃、より好ましくは５〜２５℃、更に好ましくは５〜２０℃の温度が採用される。温度が低過ぎると、成分の溶解および分散が均一に行なわれにくくなり、一方温度が高すぎると成分の変質などを招くことがある。
飲料を製造する際の混合方法や混合装置は特に制限されず、飲料の製造において従来から用いられている混合方法および混合装置を用いて行なうことができる。
The method for producing the beverage of the present invention is not particularly limited, and the above-mentioned components are added to water and mixed uniformly. Components that dissolve in water are dissolved in water, and components that do not dissolve in water are uniformly dispersed in water. Can be manufactured.
Although the amount of water used during the production of the beverage of the present invention can be adjusted as appropriate, it is finally obtained in order to sufficiently exhibit the above-mentioned skin beautifying effect and other effects and prevent precipitation or aggregation of ingredients. It is preferable to produce a beverage using 65 to 90% by mass, further 70 to 85% by mass, and particularly 75 to 82% by mass of water based on the mass of the beverage to be produced.
Moreover, as mixing temperature at the time of manufacturing a drink, Preferably it is 5-30 degreeC, More preferably, it is 5-25 degreeC, More preferably, the temperature of 5-20 degreeC is employ | adopted. If the temperature is too low, it is difficult to uniformly dissolve and disperse the components, while if the temperature is too high, the components may be altered.
The mixing method and the mixing device in producing the beverage are not particularly limited, and can be performed using a mixing method and a mixing device conventionally used in beverage production.
本発明の飲料の摂取量は、摂取するヒトの性別、年齢、体調、身体状況、体重などに応じて異なり得るが、例えば、一般的には、成人女子の場合は、卵殻膜粉末の摂取量で、１日に当たり、５０ｍｇ〜２０００ｍｇ程度になるような量で摂取するとよい。 The intake of the beverage of the present invention may vary depending on the sex, age, physical condition, physical condition, weight, etc. of the human being ingested, but generally, for example, in the case of an adult girl, the intake of eggshell membrane powder Therefore, it is recommended to take in an amount of about 50 mg to 2000 mg per day.
以下に本発明について実施例などによって具体的に説明するが、本発明は以下の例により何ら限定されない。
また、以下の実施例および比較例では、それぞれの成分（物質）として、下記のものを使用した。
Hereinafter, the present invention will be specifically described with reference to examples and the like, but the present invention is not limited to the following examples.
In the following examples and comparative examples, the following were used as the respective components (substances).
（１）卵殻膜粉末：
キューピー株式会社製「ＥＭパウダー３００」（１５０メッシュの標準篩を通過する粒子の含有割合７０質量％以上）
（２）魚鱗由来コラーゲンペプチド：
株式会社ラビジェ販売「マリンコラーゲンリッチ５００−Ｆ」
（３）Ｎ−アセチルグルコサミン：
焼津水産化学工業株式会社製「マリンスウィート」（登録商標）
（４）Ｌ−アスコルビン酸：
ＢＡＳＦ武田ビタミン株式会社製「ビタミンＣ１００」
（５）ビタミンＥ：
理研ビタミン株式会社製「ビタミンＥアルファー５０（Ａ）」
（６）ローヤルゼリー：
有限会社マルオ食研製「水溶性ローヤルゼリー末Ｉ−６０Ｍ」
（７）アセロラパウダー：
マリーンバイオ株式会社製「アセロラパウダー（ＡＰ）」
（８）アロエエキスパウダー：
丸善製薬株式会社製「アロエエキスパウダーＣ−ＭＦ」
（９）フラクトオリゴ糖：
明治製菓株式会社製「メイオリゴＰ粉末」
（１０）果糖ブドウ糖液糖：
日本コーンスターチ株式会社製「ハイフラクトＭ７５Ｃ」
（１１）スクラロース：
三栄源エフ・エフ・アイ株式会社製「スクラロース」
（１２）リンゴ果汁：
青森りんご加工株式会社製「１／５りんご濃縮果汁」
（１３）発酵乳酸：
昭和化工株式会社製「発酵乳酸（５０％）」（乳酸含有量５０質量％）
（１４）アップル香料：
株式会社サンアロマ製「アップルフレーバー７０７２８」
（１５）大豆多糖類：
三栄源エフ・エフ・アイ株式会社製「ＳＭ−１２００」
（１６）ユッカサポニン：
丸善製薬株式会社製「サラキープＰＥ」
(1) Eggshell membrane powder:
“EM Powder 300” manufactured by Kewpie Co., Ltd. (content ratio of particles passing through a 150-mesh standard sieve is 70% by mass or more)
(2) Fish scale-derived collagen peptide:
Lavigge Co., Ltd. “Marine Collagen Rich 500-F”
(3) N-acetylglucosamine:
"Marine Sweet" (registered trademark) manufactured by Yaizu Fisheries Chemical Industries, Ltd.
(4) L-ascorbic acid:
“Vitamin C100” manufactured by BASF Takeda Vitamin Co., Ltd.
(5) Vitamin E:
"Vitamin E Alpha 50 (A)" manufactured by Riken Vitamin Co., Ltd.
(6) Royal jelly:
"Water-soluble royal jelly powder I-60M" manufactured by Maruo Shokuken Co., Ltd.
(7) Acerola powder:
“Acerola Powder (AP)” by Marine Bio Inc.
(8) Aloe extract powder:
"Aloe extract powder C-MF" manufactured by Maruzen Pharmaceutical Co., Ltd.
(9) Fructooligosaccharide:
“Mayoligo P powder” manufactured by Meiji Seika Co., Ltd.
(10) Fructose glucose liquid sugar:
“High Fract M75C” manufactured by Nippon Corn Starch Co., Ltd.
(11) Sucralose:
“Sucralose” manufactured by San-Ei Gen FFI Co., Ltd.
(12) Apple juice:
"1/5 apple concentrated fruit juice" manufactured by Aomori Apple Processing Co., Ltd.
(13 ) Fermented lactic acid :
"Fermented lactic acid (50%)" manufactured by Showa Kako Co., Ltd. (lactic acid content 50% by mass)
(14) Apple fragrance:
"Apple Flavor 70728" manufactured by Sun Aroma Co., Ltd.
(15) Soy polysaccharide:
“SM-1200” manufactured by San-Ei Gen FFI Co., Ltd.
(16) Yucca saponin:
“Sarakeep PE” manufactured by Maruzen Pharmaceutical Co., Ltd.
《実施例１》
（１） 以下の表１に示す量の水に、表１に示すそれぞれの成分を表１に示す割合で添加して、計量ミキサーを使用して２０℃で均一に混合して、卵殻膜粉末、魚類由来コラーゲンペプチド（魚鱗由来コラーゲンペプチド）、Ｎ−アセチルグルコサミンおよびその他の成分を含有する飲料（分散液）を製造した。
（２） 上記（１）で得られた飲料を、ドリンク剤用のガラスビンに１２０ｍｌずつ充填して、８０℃で２０分間滅菌処理し、密栓して、ガラスビン入り飲料を製造した。
Example 1
(1) Add each component shown in Table 1 to the amount of water shown in Table 1 below in the proportion shown in Table 1, and mix uniformly at 20 ° C. using a measuring mixer to make eggshell membrane powder. A beverage (dispersion) containing fish-derived collagen peptide (fish scale-derived collagen peptide), N-acetylglucosamine and other components was produced.
(2) 120 ml of the beverage obtained in (1) above was filled into a glass bottle for a drink, sterilized at 80 ° C. for 20 minutes, and sealed to produce a glass bottled beverage.
《比較例１〜５》
卵殻膜粉末、魚類由来コラーゲンペプチド（魚鱗由来コラーゲンペプチド）および／またはＮ−アセチルグルコサミンの配合量を以下の表１に示す量に変えた以外は、実施例１の（１）と同様にして飲料を製造し、それを実施例１の（２）と同様にしてドリンク剤用のガラスビンに充填し、滅菌および密栓してガラスビン入り飲料を製造した。
<< Comparative Examples 1-5 >>
Beverage in the same manner as (1) of Example 1 except that the blending amount of eggshell membrane powder, fish-derived collagen peptide (fish scale-derived collagen peptide) and / or N-acetylglucosamine was changed to the amounts shown in Table 1 below. In the same manner as (2) of Example 1, it was filled into a glass bottle for a drink, sterilized and sealed, to produce a glass bottled beverage.
《試験例１》［保存安定性の試験］
実施例１および比較例１〜５で得られたガラスビン入りの飲料を、常温下（２５℃）で１週間静置し、１週間後に飲料の状態を目視で観察して、以下の評価基準に従って保存安定性を評価したところ、下記の表２に示すとおりであった。
<< Test Example 1 >> [Test for Storage Stability]
The beverages contained in the glass bottles obtained in Example 1 and Comparative Examples 1 to 5 were allowed to stand at room temperature (25 ° C.) for 1 week, and after 1 week, the state of the beverage was visually observed, according to the following evaluation criteria. When the storage stability was evaluated, it was as shown in Table 2 below.
［飲料の保存安定性の評価基準］
○：成分の沈殿および凝集が全くなく、均一な分散状態または溶液状態を維持しており、保存安定性に優れている。
△：成分の沈殿および／または凝集が少し生じており、保存安定性にやや劣っている。
×：成分の沈殿および／または凝集がかなり生じており、保存安定性に劣っている。
[Evaluation criteria for storage stability of beverages]
○: Precipitation and aggregation of components are completely absent, a uniform dispersed state or a solution state is maintained, and the storage stability is excellent.
Δ: Precipitation and / or agglomeration of the components is slightly caused and storage stability is slightly inferior.
X: Precipitation and / or agglomeration of the components are considerably generated, and the storage stability is poor.
《試験例２》［美肌効果の試験］
（１） 年齢が４０歳から５０歳までの女性６０名を、年齢構成がほぼ同じになるようにして１０名ずつ６組に分け、第１組の１０名には実施例1の飲料を、第２組の１０名には比較例１の飲料を、第３組の１０名には比較例２の飲料を、第４組の１０名には比較例３の飲料を、第５組の１０名には比較例４の飲料を、第６組の１０名には比較例５の飲料を、１日１回（１本）の割合で２週間にわたって継続して飲んでもらい、２週間後に顔の肌の状態を以下の評価基準にしたがって評価してもらい、各評価結果に該当する人数を数えたところ、下記の表２に示すとおりであった。
<< Test Example 2 >> [Beautiful skin effect test]
(1) Sixty women aged 40 to 50 years are divided into 6 groups of 10 people so that the age composition is almost the same, and the drink of Example 1 is given to 10 people of the first group. Beverages of Comparative Example 1 are used for the second group of 10 persons, Beverages of Comparative Example 2 are used for the 10 persons of the 3rd group, Beverages of Comparative Example 3 are used for the 10 persons of the 4th group, and 10 The name of the drink of Comparative Example 4 was given to the first person, and the drink of Comparative Example 5 was given to the 10th group of the sixth group once a day (one bottle) for 2 weeks. When the number of persons corresponding to each evaluation result was counted according to the following evaluation criteria, it was as shown in Table 2 below.
［飲料の美肌効果の評価基準］
肌の張り：
◎：飲料を飲む前と比べて肌の張りが大きく増した。
○：飲料を飲む前と比べて肌の張りが少し増した。
×：飲料を飲む前と比べて肌の張りが増していない。
肌の潤い：
◎：飲料を飲む前と比べて肌の潤いが大きく増し、しっとり感が大きくなった。
○：飲料を飲む前と比べて肌の潤いが少し増し、しっとり感が付与された。
×：飲料を飲む前と比べて肌の潤いが増しておらず、しっとり感の向上がない。
肌の艶：
◎：飲料を飲む前と比べて肌の艶が大きく増した。
○：飲料を飲む前と比べて肌の艶が少し増した。
×：飲料を飲む前と比べて肌の艶が増していない。
[Evaluation criteria for the skin beautifying effect of beverages]
Skin tension :
(Double-circle): The tension of the skin increased greatly compared with before drinking a drink.
○: Skin tension increased slightly compared to before drinking.
X: Skin tension is not increased compared to before drinking.
Moisturizing skin :
A: The moisture of the skin was greatly increased and the moist feeling increased compared to before drinking.
○: Moisture increased slightly compared to before drinking, giving a moist feeling.
X: The moisture of the skin is not increased compared to before drinking, and the moist feeling is not improved.
Skin gloss :
(Double-circle): The glossiness of the skin increased greatly compared with before drinking a drink.
○: The gloss of the skin was slightly increased compared to before drinking.
X: The gloss of the skin is not increased compared to before drinking.
上記の表２の結果にみるように、実施例１の飲料は、卵殻膜粉末、魚類由来コラーゲンペプチド（魚鱗由来コラーゲンペプチド）およびＮ−アセチルグルコサミンを含有していることにより、保存安定性に優れていて、長期間経っても、成分の沈殿および凝集が生じていない。
それに対して、比較例３および４の飲料は、卵殻膜粉末およびＮ−アセチルグルコサミンを含有し、魚類由来コラーゲンペプチド（魚鱗由来コラーゲンペプチド）を含有していないために、成分の沈殿および／または凝集が生じ、保存安定性に劣っている。
As seen from the results in Table 2 above, the beverage of Example 1 has excellent storage stability because it contains eggshell membrane powder, fish-derived collagen peptide (fish scale-derived collagen peptide) and N-acetylglucosamine. Even after a long period of time, the components do not precipitate or aggregate.
On the other hand, the beverages of Comparative Examples 3 and 4 contain eggshell membrane powder and N-acetylglucosamine, and do not contain fish-derived collagen peptides (fish scale-derived collagen peptides). And storage stability is inferior.
さらに、実施例１の飲料は、卵殻膜粉末、魚類由来コラーゲンペプチド（魚鱗由来コラーゲンペプチド）およびＮ−アセチルグルコサミンを含有していることにより、比較例１および２の飲料（魚類由来コラーゲンペプチドおよびＮ−アセチルグルコサミンを含有するが、卵殻膜粉末を含有しない飲料）、比較例３および４の飲料（卵殻膜粉末およびＮ−アセチルグルコサミンを含有するが、魚類由来コラーゲンペプチドを含有しない飲料）、並びに比較例５の飲料（卵殻膜粉末および魚類由来コラーゲンペプチドを含有するがＮ−アセチルグルコサミンを含有しない飲料）に比べて、美肌効果に大きく優れており、肌の張り、潤いおよび艶を良好に向上させることができる。 Furthermore, the beverage of Example 1 contains eggshell membrane powder, fish-derived collagen peptide (fish scale-derived collagen peptide) and N-acetylglucosamine, so that the beverages of Comparative Examples 1 and 2 (fish-derived collagen peptide and N -Beverages containing acetylglucosamine but no eggshell membrane powder), beverages of Comparative Examples 3 and 4 (beverages containing eggshell membrane powder and N-acetylglucosamine but no fish-derived collagen peptide), and comparison Compared to the beverage of Example 5 (a beverage containing eggshell membrane powder and fish-derived collagen peptide but not containing N-acetylglucosamine), it has a great skin effect and improves skin tension, moisture and gloss. be able to.
本発明の飲料は、卵殻膜粉末などの成分が水中に安定に分散または溶解し、長期間経っても、成分の沈殿や凝集が生じず、保存安定性に優れており、しかも皮膚への弾力性、張り、艶、潤い、しっとり感、滑らかさなどの付与効果が一層強くて美肌効果に極めて優れており、更には湿疹、炎症、ヤケドなどの皮膚疾患の予防や治癒の促進、育毛、発毛促進、脱毛防止、筋肉、腱、靭帯、骨、その他の身体内の組織や器官に生じた損傷や障害などの疾病や不良な身体症状の改善や予防、生体の活性化、健康増進、健康の維持などにも優れた効果を発揮するので、美容飲料および健康増進飲料などとして有用である。 In the beverage of the present invention, ingredients such as eggshell membrane powder are stably dispersed or dissolved in water, the ingredients do not precipitate or aggregate even after a long period of time, have excellent storage stability, and have elasticity to the skin. It has a strong effect on skin, such as eczema, inflammation, burns, hair growth, hair growth Hair promotion, hair loss prevention, amelioration and prevention of diseases and bad physical symptoms such as damage and injury to muscles, tendons, ligaments, bones and other tissues and organs in the body, vitalization of the body, health promotion, health It is also useful as a beauty drink and a health promotion drink.
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| JP2012153614A (en) * | 2011-01-24 | 2012-08-16 | Unitika Ltd | Collagen production promoter |
| JP6122667B2 (en) * | 2012-03-14 | 2017-04-26 | 長谷部 由紀夫 | Eggshell membrane-containing fine powder, tablet, method for producing eggshell membrane-containing fine powder, and method for producing tablet |
| CN102813115B (en) * | 2012-09-10 | 2014-12-03 | 北京姿美堂生物技术有限公司 | Compound active cosmetic collagen powder |
| JP5998350B2 (en) * | 2013-03-27 | 2016-09-28 | 国立大学法人 東京大学 | Hepatoprotectant containing eggshell membrane component and pharmaceutical composition, food additive and food using the same |
| JP6543046B2 (en) * | 2014-03-10 | 2019-07-10 | キユーピー株式会社 | Collagen peptide-containing powdered food |
| CN103993061B (en) * | 2014-05-20 | 2018-03-23 | 海南美合泰生物科技有限公司 | A kind of production method of Isin glue collagen |
| WO2015195060A1 (en) * | 2014-06-19 | 2015-12-23 | Ercan Durmus | A powder formed natural material that contains phytochemicals in high concentration which can be found in fruits and vegetables and its preparation method |
| JP6774732B2 (en) * | 2014-08-21 | 2020-10-28 | ポッカサッポロフード＆ビバレッジ株式会社 | Non-carbonated beverages, methods for producing them, and methods for suppressing changes in the composition of retronasal aromas in non-carbonated beverages. |
| JP6619153B2 (en) * | 2015-05-15 | 2019-12-11 | 株式会社 アルマード | Green juice |
| JP7086517B2 (en) * | 2016-09-29 | 2022-06-20 | 株式会社 アルマード | Composition for improving intestinal flora containing powder containing eggshell membrane as an active ingredient |
| JP2018052855A (en) * | 2016-09-29 | 2018-04-05 | 株式会社 アルマード | Intestinal flora improving agent comprising shell membrane-containing powder |
| WO2018062354A1 (en) * | 2016-09-29 | 2018-04-05 | 株式会社 アルマード | Intestinal microbiota improving agent and intestinal microbiota improving composition that include eggshell membrane–containing powder |
| CN112237243A (en) * | 2019-07-16 | 2021-01-19 | 广州尔湾微科国际商贸有限公司 | Health plant beverage |
| JP7389529B1 (en) * | 2023-08-25 | 2023-11-30 | 日本メナード化粧品株式会社 | beverage |
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| JP4738856B2 (en) * | 2005-03-23 | 2011-08-03 | 焼津水産化学工業株式会社 | Method for producing N-acetylglucosamine-containing composition |
| JP2006311804A (en) * | 2005-05-06 | 2006-11-16 | Sunstar Inc | Skin-whitening composition formulated with zinc gluconate |
| JP2007167079A (en) * | 2007-03-30 | 2007-07-05 | Sanei Gen Ffi Inc | Collagen-including acidic food and drink |
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