TW201635920A - Muscle synthesis promoter - Google Patents

Muscle synthesis promoter Download PDF

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TW201635920A
TW201635920A TW105102895A TW105102895A TW201635920A TW 201635920 A TW201635920 A TW 201635920A TW 105102895 A TW105102895 A TW 105102895A TW 105102895 A TW105102895 A TW 105102895A TW 201635920 A TW201635920 A TW 201635920A
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weight
protein
liquid composition
casein
muscle synthesis
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TWI741975B (en
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Kyosuke Nakayama
Atsushi Kanda
Chiaki Sanbongi
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Meiji Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

The present invention pertains to a muscle synthesis promoter which exhibits a muscle synthesis promotion action, and with which it is possible to efficiently ingest milk protein. More specifically, the present invention pertains to a muscle synthesis promoter containing, as active ingredients, 0.2-1.2 wt.% of a soybean polysaccharide, 0.1-0.5 wt.% of a HM pectin, 0.01-0.1 wt.% of a fibrous insoluble cellulose, and an acidic liquid composition that contains a milk protein mixture including a casein protein and a whey protein. This muscle synthesis promoter is capable of improving the muscle synthesis promotion effect by preventing the curdling of the milk protein and promoting the absorption of the milk protein in the stomach.

Description

肌肉合成促進劑 Muscle synthesis promoter 〔關連申請參照〕 [Related application reference]

本案專利申請案是基於先前所申請之日本國特許出願之特願2015-016093號(申請日：2015年1月29日)而主張優先權，並引用相關之先前專利申請案之所有揭示內容作為本案發明之揭示的一部分。 The patent application in this case is based on the Japanese Patent Application No. 2015-016093 (Application Date: January 29, 2015), which was previously filed by the Japanese Patent Application, and all the disclosures of the related prior patent applications are cited as Part of the disclosure of the present invention.

本發明為關於一種肌肉合成促進劑。 The present invention relates to a muscle synthesis promoter.

近年來，以健康增進或運動能力提升作為目的，為了肌肉合成之促進、肌肉喪失之預防、以及肌肉量之恢復促進，以經口攝取以蛋白質作為主要成分的營養補助劑(補充劑)，並且做運動的人(對象)較多。作為如此之營養補助劑，有蛋白質粉末，作為其主要成分，已知為將牛奶作為原料的乳清蛋白(乳清蛋白質)以及酪蛋白。 In recent years, in order to promote the promotion of muscle growth, the prevention of muscle loss, and the recovery of muscle mass, we have taken a dietary supplement (supplement) containing protein as a main ingredient, and There are more people (objects) who exercise. As such a nutritional supplement, there is a protein powder, and as a main component thereof, whey protein (whey protein) and casein which use milk as a raw material are known.

乳清蛋白自經口攝取至消化吸收為止的速度(吸收速度)較快(時間較短)，且包含較多的BCAA (分支狀胺基酸：纈胺酸、白胺酸、異白胺酸)，故防止肌肉疲勞的同時，也能夠效率良好地增強肌肉。另一方面，酪蛋白相較於乳清蛋白，會較緩慢且持續性地被代謝，故自經口攝取至消化吸收為止的速度(吸收速度)較慢(時間較長)，對於必須要即效性地促進肌肉合成之對象來說較不適合(參照專利文獻1：日本特表2009-507044號公報)。因此，蛋白質粉末主要是使用乳清蛋白。 Whey protein has a faster rate (absorption rate) from oral ingestion to digestion and absorption (short time) and contains more BCAA (Branched amino acids: valine, leucine, and isoleucine) prevent muscle fatigue and enhance muscles efficiently. On the other hand, casein is metabolized more slowly and continuously than whey protein, so the rate (absorption rate) from oral ingestion to digestion and absorption is slower (longer time), It is less suitable for a subject that effectively promotes muscle synthesis (see Patent Document 1: JP-A-2009-507044). Therefore, protein powder mainly uses whey protein.

另一方面，對於以特定量含有酪蛋白與乳清蛋白之乳蛋白，也熟知有肌肉合成促進效果。具體來說，運動後之乳蛋白的攝取會隨著其用量而促進骨格肌的合成，並抑制骨格肌分解(參照非專利文獻1：日本體育學為第64回大會預稿集，2013年，166頁)。進而非專利文獻1：日本體育學會第64回大會預稿集，2013年，166頁中有表示，作為運動後馬上攝取的食品，相較於一般的牛奶，乳蛋白強化乳飲料對於鍛鍊伴有運動負荷的身體來說，有更進一步的效果。 On the other hand, for the milk protein containing casein and whey protein in a specific amount, a muscle synthesis promoting effect is also known. Specifically, the intake of milk protein after exercise promotes the synthesis of skeletal muscle and inhibits the decomposition of the skeletal muscle (see Non-Patent Document 1: Japanese Physical Education for the 64th Conference Pre-Collection, 2013, Page 166). In addition to Patent Document 1: The 64th General Assembly of the Japan Physical Education Association, 2013, 166 pages, as a food that is taken immediately after exercise, milk protein fortified milk drink is accompanied by exercise compared to normal milk. For the body with exercise load, there is a further effect.

亦即，攝取乳蛋白，並為了促進肌肉合成，攝取高濃度之乳蛋白強化乳飲料、或是大量地攝取一般的牛奶等，提高總合乳蛋白之攝取量較為有效。 In other words, it is effective to increase the intake of milk protein by ingesting milk protein and in order to promote muscle synthesis, ingesting a high-concentration milk protein-fortified milk beverage, or ingesting a large amount of general milk.

〔先前技術文獻〕 [Previous Technical Literature] 〔專利文獻〕 [Patent Document]

〔專利文獻1〕日本特表2009-507044號公報 [Patent Document 1] Japanese Patent Publication No. 2009-507044

〔非專利文獻〕 [Non-patent literature]

〔非特許文獻1〕日本體育學會第64回大會預稿集，2013年，166頁 [Non-licensed document 1] Pre-collection of the 64th General Meeting of the Japan Physical Education Association, 2013, 166 pages

為了攝取高濃度之乳蛋白強化乳飲料、或攝取大量一般的牛奶等，提高總合乳蛋白之攝取量時，會產生不得不攝取大量乳蛋白之問題。攝取如此大量之乳蛋白時，有時對於無法攝取大量乳蛋白作為能量的乳幼兒或高齡者來說，其攝取本身變得較困難，進而，伴隨著過多的攝取能量，也會有以肥滿為首的生活慢性病發病之虞。並且認為，不管各年齡，攝取大量的乳蛋白本身就會造成負担。尤其是運動後，儘管必須要快速地促進肌肉合成，但由於運動後的荷爾蒙分泌作用會使食欲減退，大量的乳蛋白之攝取會造成負担。 In order to ingest a high-concentration milk protein fortified milk beverage, or to take in a large amount of general milk, and to increase the intake of the total milk protein, there is a problem that a large amount of milk protein has to be ingested. When such a large amount of milk protein is ingested, it is difficult for the infant or the elderly who cannot take in a large amount of milk protein as energy to take up itself, and further, with too much energy, it may be plump. Headed by the chronic diseases of life. It is also believed that regardless of age, the intake of large amounts of milk protein itself creates a burden. Especially after exercise, although it is necessary to promote muscle synthesis rapidly, the loss of appetite is caused by the secretion of hormones after exercise, and the intake of a large amount of milk protein causes a burden.

如此，達到與包含將攝取大量乳蛋白作為目的之非專利文獻1：日本體育學會第64回大會預稿集，2013年，166頁中的乳蛋白之中性液狀組成物作為有效成分的肌肉合成促進效果相同，或達到其以上之肌肉合成促進效果，且一定不需要攝取大量乳蛋白之肌肉合成促進劑，至目前為止尚無人知曉。於此，本發明課題為提供一種達到如此之效果之新穎的肌肉合成促進劑。 In this way, the non-patent document 1 containing the purpose of ingesting a large amount of milk protein: the 64th conference of the Japanese Sports Association, 2013, 166 pages of the milk protein neutral liquid composition as an active ingredient of the muscle It has not been known until now that the synthesis promoting effect is the same, or the muscle synthesis promoting effect of the above is achieved, and the muscle synthesis promoter which does not require a large amount of milk protein is necessarily required. Accordingly, an object of the present invention is to provide a novel muscle synthesis accelerator which achieves such an effect.

本發明者們欲解決前述課題重覆縝密研究之 結果發現，包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含特定蛋白質量比之酪蛋白與乳清蛋白之乳蛋白混合物之酸性液狀組成物，較容易攝取，且不需攝取大量的乳蛋白，也能夠達到肌肉合成促進效果之現象。 The present inventors intend to solve the aforementioned problems and repeat the research. As a result, it was found to contain 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and casein and whey protein containing specific protein ratio. The acidic liquid composition of the milk protein mixture is easy to ingest, and it is possible to achieve a muscle synthesis promoting effect without ingesting a large amount of milk protein.

具體來說，本發明者們發現，目前已知以往技術中的肌肉合成促進效果會隨著乳蛋白的用量而有所貢獻，但包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含特定蛋白質量比之酪蛋白與乳清蛋白之乳蛋白混合物的酸性液狀組成物，相較於脫脂奶粉溶液，亦即僅由大量的乳蛋白混合物而成之中性液狀組成物作為有效成分之肌肉合成促進劑(例如參照非特許文獻1：日本體育學會第64回大會預稿集，2013年，166頁)，會有預想外即效性肌肉合成促進作用之現象。且意外地發現，包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含特定蛋白質量比之酪蛋白與乳清蛋白之乳蛋白混合物的酸性液狀組成物，即使是乳蛋白濃度較低的酸性液狀組成物，相較於僅由大量乳蛋白混合物而成之中性液狀組成物作為有效成分之肌肉合成促進劑，會有同等的肌肉合成促進作用之現象。上述現象是令人訝異之結果。本發明是根據相關之知識所得。 Specifically, the present inventors have found that the muscle synthesis promoting effect in the prior art is known to contribute to the amount of milk protein, but contains 0.2 to 1.2% by weight of soybean polysaccharides, 0.1 to 0.5% by weight. HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and an acidic liquid composition containing a milk protein mixture of casein and whey protein in a specific protein amount, compared with the skim milk powder solution That is, a muscle synthesis promoter which is composed of a large amount of a mixture of milk proteins and an intermediate liquid composition as an active ingredient (for example, refer to Unlicensed Document 1: The 64th Conference of the Japanese Sports Association, 2013, 166 pages) There will be a phenomenon in which the immediate effect of muscle synthesis is promoted. Surprisingly, it is found that 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and casein and milk containing specific protein ratio An acidic liquid composition of a milk protein mixture of albumin, even an acidic liquid composition having a low milk protein concentration, as compared with a muscle composed of only a large amount of a milk protein mixture as an active ingredient Synthetic accelerators have the same phenomenon of promoting muscle synthesis. The above phenomenon is a surprising result. The present invention has been made based on the relevant knowledge.

亦即，本發明如以下所述。 That is, the present invention is as follows.

〔1〕一種肌肉合成促進劑，其係包含酸性液狀組成物作為有效成分而成之肌肉合成促進劑，該酸性液狀組成物包含：0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20，〔2〕如〔1〕之肌肉合成促進劑酸性液狀組成物，其中進一步包含0.5~5重量%之海藻糖而成，〔3〕如〔1〕或〔2〕之肌肉合成促進劑，其中，酸性液狀組成物之pH值為3~6，〔4〕如〔1〕~〔3〕中任1項之肌肉合成促進劑，其中，纖維狀的不溶性纖維素為發酵纖維素，〔5〕如〔1〕~〔4〕中任1項之肌肉合成促進劑，其中，酸性液狀組成物中所包含之乳蛋白混合物以總蛋白質量來說，每一餐攝取0.06~0.7g/kg體重，〔6〕如〔1〕~〔5〕中任1項之肌肉合成促進劑，其係以每一餐之單位包裝形態而成，該單位包裝形態中，包含每一餐攝取量以總蛋白質量來說為3~40g之乳蛋白混合物，〔7〕如〔1〕~〔6〕中任1項之肌肉合成促進劑，其係用於運動之對象，〔8〕如〔7〕之肌肉合成促進劑，其中，運動為肌肉訓練，〔9〕一種肌肉合成促進方法，其係包含使必須要促進肌肉合成之對象攝取酸性液狀組成物而成之肌肉合成促進方 法，該酸性液狀組成物包含：0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20，〔10〕一種肌肉合成促進方法，其係包含使必須要促進肌肉合成之對象攝取酸性液狀組成物而成之肌肉合成促進方法(排除對人類的醫療行為)，該酸性液狀組成物包含：0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20，〔11〕一種使用，其係用來促進肌肉合成，且係包含酸性液狀組成物作為有效成分而成之肌肉合成促進劑的使用，該酸性液狀組成物包含：0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20，〔12〕一種使用，其係用於製造用來促進肌肉合成之食品或醫藥品，且係包含酸性液狀組成物作為有效成分而成之肌肉合成促進劑的使用，該酸性液狀組成物包含：0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋 白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20，〔13〕一種酸性液狀組成物，其係包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物之酸性液狀組成物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。 [1] A muscle synthesis promoter comprising a muscle liquid accelerator comprising an acidic liquid composition as an active ingredient, the acidic liquid composition comprising: 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5 weight. % HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and a milk protein mixture comprising casein and whey protein, and protein ratio of casein relative to whey protein (casein/milk The albumin) is 2 to 20, [2] the acidic liquid composition of the muscle synthesis promoter according to [1], which further comprises 0.5 to 5% by weight of trehalose, and [3] as [1] or [2] a muscle synthesis accelerator, wherein the acidic liquid composition has a pH of 3 to 6, [4] a muscle synthesis accelerator according to any one of [1] to [3], wherein the fibrous insoluble fiber [5] The muscle synthesis accelerator according to any one of [1] to [4], wherein the milk protein mixture contained in the acidic liquid composition is in terms of total protein amount, each Meal intake of 0.06~0.7g/kg body weight, [6] such as [1]~[5] The agent is formed in the form of a unit package of each meal, and the unit package form includes a milk protein mixture of 3 to 40 g in total protein amount per meal, [7] as [1]~ [6] A muscle synthesis promoter according to any one of the items, which is used for exercise, [8] a muscle synthesis promoter according to [7], wherein exercise is muscle training, [9] a method for promoting muscle synthesis, It consists of a muscle synthesis promoter that allows an object that must promote muscle synthesis to take up an acidic liquid composition. The acidic liquid composition comprises: 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and casein and whey. Protein milk protein mixture, and protein ratio of casein (whey protein/whey protein) relative to whey protein is 2-20, [10] a muscle synthesis promoting method, which comprises making it necessary to promote muscle synthesis A method for promoting muscle synthesis by excluding an acidic liquid composition (excluding medical behavior for humans), the acidic liquid composition comprising: 0.2 to 1.2% by weight of soybean polysaccharides, and 0.1 to 0.5% by weight of HM fruit Gel, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and milk protein mixture comprising casein and whey protein, and protein ratio (casein/whey protein) relative to casein of whey protein 2~20, [11] is a use of a muscle synthesis accelerator which is used to promote muscle synthesis and contains an acidic liquid composition as an active ingredient, and the acidic liquid composition comprises: 0.2 to 1.2 % by weight of soybean polysaccharides, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and a milk protein mixture comprising casein and whey protein, and a protein amount ratio relative to casein of whey protein ( Casein/whey protein) is 2-20, [12] is used for the manufacture of foods or pharmaceuticals for promoting muscle synthesis, and is composed of an acidic liquid composition as an active ingredient. The use of the accelerator, the acidic liquid composition comprising: 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and containing casein a milk protein mixture of white and whey protein, and a protein amount ratio (casein/whey protein) relative to whey protein of 2 to 20, [13] an acidic liquid composition comprising 0.2 ~1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and an acidic liquid composition comprising a mixture of casein and whey protein milk protein And the protein amount ratio (casein/whey protein) relative to the casein of whey protein is 2-20.

藉由本發明，能夠防止在胃內乳蛋白的凝乳化，並促進乳蛋白之吸收，提高肌肉合成促進效果，且能夠達到與將包含相同濃度之乳蛋白的中性液狀組成物作為有效成分之肌肉合成促進效果相同，且達到其以上之肌肉合成促進效果。且，藉由本發明，即使不需攝取大量乳蛋白，也必定能夠達到肌肉合成促進效果。 According to the present invention, it is possible to prevent coagulation of milk protein in the stomach, promote absorption of milk protein, improve muscle synthesis promoting effect, and achieve a neutral liquid composition containing milk protein of the same concentration as an active ingredient. Muscle synthesis promotes the same effect and achieves the above-mentioned muscle synthesis promoting effect. Moreover, according to the present invention, even if a large amount of milk protein is not required to be ingested, the muscle synthesis promoting effect can be achieved.

〔圖1〕表示經口投予本發明之肌肉合成促進劑(乳蛋白3.4重量%)、與脫脂奶粉溶液(乳蛋白3.4重量%)時，骨格肌合成速度(FSR(%/day))之推移。 Fig. 1 is a graph showing the rate of synthesis of bone muscle (FSR (%/day)) when the muscle synthesis promoter (milk protein 3.4% by weight) of the present invention and the skim milk powder solution (milk protein 3.4% by weight) were orally administered. Go on.

〔圖2〕表示經口投予本發明之肌肉合成促進劑(乳蛋白3.4重量%)、與高用量脫脂奶粉溶液(乳蛋白6.8重量%)時，骨格肌合成速度(FSR(%/day))之推移。 Fig. 2 shows the rate of synthesis of bone muscle (FSR (%/day) when the muscle synthesis promoter (milk protein 3.4% by weight) of the present invention is administered orally with a high-dose skim milk powder solution (milk protein 6.8 wt%). ).

〔發明之具體說明〕 [Specific description of the invention]

以下，詳細地說明本發明，本發明並不限定於各個形態。 Hereinafter, the present invention will be described in detail, and the present invention is not limited to the respective embodiments.

本發明之肌肉合成促進劑是包含酸性液狀組成物作為有效成分而成，較佳為將酸性液狀組成物作為有效成分之肌肉合成促進劑。具體來說，本發明之肌肉合成促進劑是包含酸性液狀組成物作為有效成分而成之肌肉合成促進劑，該酸性液狀組成物包含大豆多糖類、HM果膠、纖維狀的不溶性纖維素、以及包含特定蛋白質量比之酪蛋白與乳清蛋白的乳蛋白混合物。更具體來說，本發明之肌肉合成促進劑是包含酸性液狀組成物作為有效成分而成之肌肉合成促進劑，該酸性液狀組成物包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。藉由本發明較佳之型態，本發明之肌肉合成促進劑使用於必須要即效性地促進肌肉合成之對象。 The muscle synthesis promoter of the present invention is an active ingredient comprising an acidic liquid composition as an active ingredient, and preferably an acidic liquid composition as an active ingredient. Specifically, the muscle synthesis promoter of the present invention is a muscle synthesis accelerator comprising an acidic liquid composition containing an soybean polysaccharide, HM pectin, and fibrous insoluble cellulose. And a milk protein mixture comprising casein and whey protein in a specific protein ratio. More specifically, the muscle synthesis promoter of the present invention is a muscle synthesis accelerator comprising an acidic liquid composition as an active ingredient, and the acidic liquid composition contains 0.2 to 1.2% by weight of soybean polysaccharides, 0.1 to 0.5. 5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and a mixture of milk protein containing casein and whey protein, and protein ratio of casein relative to whey protein (casein/ Whey protein) is 2-20. By the preferred form of the invention, the muscle synthesis promoting agent of the present invention is used for a subject which must promote muscle synthesis in a timely manner.

「有效成分」意指達到肌肉合成促進效果時，所必要之成分。作為一個較佳之形態，「有效成分」意指用於必須要即效性地促進肌肉合成之對象，且達到肌肉合成促進效果時，所必要之成分。 "Active ingredient" means a component necessary for achieving a muscle synthesis promoting effect. As a preferred embodiment, the "active ingredient" means a component which is necessary for a subject which must promote muscle synthesis in an immediate manner and which achieves a muscle synthesis promoting effect.

「肌肉合成促進」意指藉由攝取乳蛋白作為營養素，並於體內吸收，來促進肌肉之合成。因此，本發 明之肌肉合成促進劑是使用於此事由以及起因於此事由之狀態。例如，肌肉合成促進之目的，有舉出肌肉增量、肌肉成長助長、肌肉組織修復、肌肉增強、肌力提升、肌肉合成促進所伴隨之健康增進效果以及運動能力提升，較佳為肌肉組織修復、肌力向上、肌肉合成促進所伴隨之健康增進效果以及運動能力提升。肌肉合成促進有包含自胺基酸之肌肉蛋白質之同化。「即效性地促進肌肉合成」意指促進乳蛋白之即時性吸收所伴隨的肌肉合成。 "Muscle synthesis promotion" means promoting the synthesis of muscle by taking milk protein as a nutrient and absorbing it in the body. Therefore, this issue The muscle synthesis promoter of Ming is used for this reason and the cause of this. For example, for the purpose of promoting muscle synthesis, there are muscle growth, muscle growth, muscle tissue repair, muscle augmentation, muscle strength, muscle growth promotion, health promotion effects, and exercise capacity improvement, preferably muscle tissue repair. , the muscle strength is upward, the health promotion effect accompanied by the promotion of muscle synthesis and the improvement of exercise ability. Muscle synthesis promotes assimilation of muscle proteins containing amino acids. "Properly promoting muscle synthesis" means promoting muscle synthesis accompanying the immediate absorption of milk proteins.

「必須要促進肌肉合成之對象」意指為了要修復肌肉組織，並且助長肌肉成長，必須要促進肌肉蛋白質之合成的對象，意指例如將健康增進或運動能力提升作為目的，且為了肌肉合成之促進、肌肉喪失之預防、以及肌肉量之回復促進而運動之對象。於此，藉由對肌力施予一定負荷，來促進肌肉之合成的觀點來說，運動較佳為肌力訓練(阻力運動)，再較佳為長期性的肌力訓練，例如連續30分鐘~5小時，1星期內以1日~7日之頻率而持續的肌力訓練。肌力訓練有舉例如啞鈴運動、蹲坐運動、拉力訓練。 "A subject that must promote muscle synthesis" means a subject that promotes the synthesis of muscle protein in order to repair muscle tissue and promote muscle growth, meaning, for example, to promote health promotion or exercise capacity, and for muscle synthesis. The promotion, the prevention of muscle loss, and the recovery of muscle mass promote the object of exercise. Here, from the viewpoint of exerting a certain load on the muscle force to promote muscle synthesis, the exercise is preferably muscle strength training (resistance exercise), and more preferably long-term muscle strength training, for example, for 30 minutes in a row. ~5 hours, continuous strength training for 1 week to 7 days. Muscle strength training includes, for example, dumbbell exercise, squat exercise, and pull training.

本發明中必須要促進肌肉合成之對象，有舉例如運動選手、運動愛好者(運動員)、為了改善生活慢性病而必須要運動者、高齡者等為了健康增進而必須要運動者、或必須要促進肌肉合成之疾病，例如患有肌肉損傷疾病(例如肌肉減少症)，必須要藉由運動而促進肌肉合成之患者。且，此對象亦可為人類以外之動物(馬、牛等 家畜、狗、貓等寵物動物、於動物園等所飼養的觀賞動物等)。 In the present invention, it is necessary to promote the object of muscle synthesis, such as sports players, sports enthusiasts (athletes), those who must exercise in order to improve chronic diseases, elderly people, etc., who must exercise for health promotion, or must promote Muscle-synthesized diseases, such as those with muscle-damaged diseases (such as sarcopenia), must be promoted by exercise to promote muscle synthesis. Moreover, this object can also be an animal other than humans (horse, cattle, etc.) Pet animals such as livestock, dogs, and cats, and ornamental animals raised in zoos, etc.).

本發明中，使必須要促進肌肉合成之對象攝取(投予)肌肉合成促進劑之時期，亦可為運動前，亦可為運動後，亦可為運動中。於此，如此之攝取時期，較佳為運動後，再較佳為運動後馬上。且，以抑制因運動所產生的骨格肌分解(異化)，且促進自胺基酸至蛋白質的同化之觀點來看，此攝取時期，較佳為運動後馬上，其中為自運動結束後3小時以內，再較佳為自運動結束後2小時以內，更較佳為自運動結束後1小時以內，特別佳為自運動結束後30分鐘以內(參照Levenhagen et al.Am J physiol Endocrinol Metab(2001),280,E982-E993)。 In the present invention, the period during which the muscle synthesis promoter is ingested (administered) by the subject who is required to promote muscle synthesis may be used before exercise, after exercise, or during exercise. Here, the period of ingestion is preferably after exercise, and preferably after exercise. Further, in order to suppress decomposition of the bone muscle (isolation) caused by exercise and to promote assimilation from amino acid to protein, the period of ingestion is preferably immediately after exercise, wherein it is 3 hours after the end of exercise. Preferably, it is within 2 hours after the end of exercise, more preferably within 1 hour after the end of exercise, especially preferably within 30 minutes after the end of exercise (refer to Levenhagen et al. Am J physiol Endocrinol Metab (2001) , 280, E982-E993).

肌肉合成促進效果中，與包含相同濃度之乳蛋白的中性液狀組成物相同的肌肉合成促進效果意指與經口攝取(投予)包含相同濃度之乳蛋白的中性液狀組成物(例如牛奶、脫脂牛奶、濃縮牛奶、脫脂濃縮牛奶)時，所見的蛋白質吸收速度相同程度之速度、以及與此吸收所伴隨的肌肉合成促進作用相同程度之效果。且，在肌肉合成促進效果中，與包含相同濃度之乳蛋白的中性液狀組成物相同的即效性肌肉合成促進效果作用意指與經口攝取(投予)包含相同濃度之乳蛋白的中性液狀組成物(例如牛奶、脫脂牛奶、濃縮牛奶、脫脂濃縮牛奶等)時，所見的蛋白質吸收速度相同程度之速度、以及與此吸收所伴隨的肌肉合成促進作用相同程度之效果。於此，肌肉合成促 進效果能夠藉由例如在小鼠游泳試驗後，投予試驗物質，1小時以內測定試驗群的上肢三頭肌合成速度(FSR)來確認。亦即，相較於對照群FSR，該對照群FSR係經口攝取包含相同濃度之被認為具有即效性肌肉合成促進作用的乳蛋白之中性液狀組成物，試驗群FSR為相同程度或相同程度以上時，能夠判斷作為肌肉合成促進作用是有意義的。此時，即效性的肌肉合成促進效果能夠藉由測定較佳為攝取本發明之肌肉合成促進劑後短時間內合成肌肉之速度，再較佳為攝取後30分鐘至3小時以內，更較佳為攝取後30分鐘至2小時以內，更較佳為攝取後30分鐘至1小時以內，特別佳為攝取後30分鐘時合成肌肉之速度來確認。 In the muscle synthesis promoting effect, the same muscle synthesis promoting effect as the neutral liquid composition containing the same concentration of milk protein means a neutral liquid composition containing the same concentration of milk protein by oral ingestion (administerment) ( For example, milk, skim milk, concentrated milk, and defatted condensed milk have the same effect as the rate of protein absorption and the same degree of muscle synthesis promotion as the absorption. Further, in the muscle synthesis promoting effect, the same immediate muscle synthesis promoting effect effect as the neutral liquid composition containing the same concentration of milk protein means that the same concentration of milk protein is contained by oral ingestion (administerment). In the case of a neutral liquid composition (for example, milk, skim milk, concentrated milk, defatted condensed milk, etc.), the rate of protein absorption is similar to that of the same rate as the muscle synthesis promoting effect accompanying the absorption. Here, muscle synthesis promotes The effect can be confirmed by, for example, administering a test substance after a mouse swimming test, and measuring the upper limb triceps synthesis rate (FSR) of the test group within one hour. That is, compared to the control group FSR, the control group FSR is orally ingested to contain the same concentration of the milk protein neutral liquid composition which is considered to have a potent muscle synthesis promoting effect, and the test group FSR is the same degree or When it is the same level or more, it can be judged that it is meaningful as a muscle synthesis promoting action. At this time, the effect of the immediate muscle synthesis promoting effect can be determined by measuring the speed of synthesizing the muscle in a short time after ingesting the muscle synthesis promoter of the present invention, and preferably 30 minutes to 3 hours after the ingestion, more preferably Preferably, it is within 30 minutes to 2 hours after ingestion, more preferably within 30 minutes to 1 hour after ingestion, and it is particularly preferable to confirm the speed of muscle synthesis at 30 minutes after ingestion.

「蛋白質量」意指作為乳蛋白、乳清蛋白或酪蛋白之各種蛋白質中所包含的胺基酸之高分子的蛋白質之量。「蛋白質量比」意指作為乳蛋白、乳清蛋白或酪蛋白之各種蛋白質中所包含的胺基酸之高分子的蛋白質之量的比率。於此，蛋白質量亦可例如基於食品成分表等公知的情報來算出，或亦可藉由克耳達(Kjeldahl)法或勞立(Lowry)法等慣用之方法測定來算出。實際上，為克耳達(Kjeldahl)法時，能夠測定各種蛋白質中所包含的氮，再對此值乘上氮-蛋白質換算係數(通常為6.25)來算出。 The "protein amount" means the amount of a protein which is a polymer of an amino acid contained in various proteins of milk protein, whey protein or casein. The "protein amount ratio" means a ratio of the amount of protein of a polymer of an amino acid contained in various proteins of milk protein, whey protein or casein. Here, the amount of protein may be calculated based on, for example, a known information such as a food ingredient table, or may be calculated by a conventional method such as a Kjeldahl method or a Lowry method. Actually, in the case of the Kjeldahl method, nitrogen contained in various proteins can be measured, and this value is multiplied by a nitrogen-protein conversion coefficient (usually 6.25).

本發明中所使用之酸性液狀組成物意指包含下述之酸性化後的液狀組成物：0.2~1.2重量%之大豆多糖 類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含特定蛋白質量比之酪蛋白與乳清蛋白的乳蛋白混合物。本發明所使用之酸性液狀組成物亦可為完全之液狀、亦可為包含一部分固形狀以及/或膠狀者之者。 The acidic liquid composition used in the present invention means a liquid composition comprising the following acidified: 0.2 to 1.2% by weight of soybean polysaccharide And 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and a milk protein mixture containing casein and whey protein in a specific protein amount ratio. The acidic liquid composition used in the present invention may be completely liquid or may be a part of a solid shape and/or a gel.

本發明中所使用之酸性液狀組成物中，所含有的乳蛋白混合物只要是以特定之蛋白質量比包含乳清蛋白與酪蛋白即可，並無特別限定，亦可使分別分離或純化後之乳清蛋白與酪蛋白以成為特定蛋白質量比來混合並調製，或者亦可將已經以特定蛋白質量比包含分別沒有經過分離或純化之乳清蛋白與酪蛋白之原料(素材)或食品等混合並調製。此時，本發明中所使用之乳蛋白混合物中，並不需要乳清蛋白或酪蛋白的分離步驟或純化步驟，以此等之製造費較便宜之觀點來看，將已經以特定蛋白質量比包含乳清蛋白與酪蛋白之原料或食品等作為主要成分，再因應必要，使分別純化後之乳清蛋白或酪蛋白以成為特定蛋白質量比來混合並調製較佳。 The milky protein mixture contained in the acidic liquid composition used in the present invention is not particularly limited as long as it contains whey protein and casein in a specific protein amount ratio, and may be separately isolated or purified. The whey protein and casein are mixed and prepared in a specific protein amount ratio, or may contain raw materials (materials) or foods which have not been isolated or purified separately from whey protein and casein. Mix and modulate. At this time, in the milk protein mixture used in the present invention, the separation step or the purification step of whey protein or casein is not required, and the ratio of the specific protein is already obtained from the viewpoint that the manufacturing cost is relatively low. A raw material containing whey protein and casein, a food or the like is used as a main component, and if necessary, the separately purified whey protein or casein is preferably mixed and prepared in a specific protein amount ratio.

與酪蛋白分別分離或純化之乳清蛋白能夠使用例如乳清之原液(甘性乳清、酸乳清等)、其濃縮物、其乾燥物(乳清粉等)、其凍結物、其水解物等、以及此等之還原溶液等。進而，能夠使用去鹽乳清、乳清蛋白濃縮物(WPC)、乳清蛋白純化物(WPI)、α-乳白蛋白(α-La)、β-乳球蛋白(β-Lg)、免疫球蛋白、乳鐵蛋白等、以及此等之還原溶液。且，與乳清蛋白分別分離或純 化之酪蛋白能夠使用例如乾酪素之分離物(新鮮乾酪等天然乾酪、酪蛋白鈉、酪蛋白鈣等)、其濃縮物、其乾燥物、其凍結物、其水解物等、以及此等之還原溶液等。進而，能夠使用α-乾酪素、β-乾酪素、k-乾酪素等之純化物、以及此等之還原溶液。且，已經以特定蛋白質量比包含乳清蛋白與酪蛋白之原料或食品，能夠使用例如生乳、殺菌乳(牛奶等)、脫脂牛奶、成分調整牛奶、加工乳、乳製品(濃縮牛奶、奶粉、煉乳、發酵乳(優格等)、乳酸菌飲料、加工乾酪類、冰淇淋類、奶油類)、乳蛋白濃縮物(MPC)、其濃縮物、其乾燥物、其凍結物、其水解物等、以及此等之還原溶液等。此等之中，以容易調製含有乳蛋白混合物之酸性液狀組成物，且該乳蛋白混合物包含高濃度之酪蛋白的觀點來看，乳蛋白混合物為使用含有豐富酪蛋白之乳原料的乳蛋白濃縮物(MPC)較佳。此乳蛋白濃縮物中，酪蛋白與乳清蛋白之蛋白質量比(酪蛋白/乳清蛋白)為4。此時，此等亦可購入市售品來使用，亦可自己調製來使用。 The whey protein separately isolated or purified from casein can be used, for example, a whey stock solution (sweet whey, acid whey, etc.), a concentrate thereof, a dried product thereof (whey powder, etc.), a frozen product thereof, and a hydrolysis thereof. Etc., etc., and such reducing solutions. Further, desalted whey, whey protein concentrate (WPC), whey protein purified (WPI), α-lactalbumin (α-La), β-lactoglobulin (β-Lg), and immunoglobulin can be used. Protein, lactoferrin, etc., and such reducing solutions. And separate from whey protein or pure As the casein, for example, a casein (natural cheese such as fresh cheese, casein sodium, casein calcium, etc.), a concentrate thereof, a dried product thereof, a frozen product thereof, a hydrolyzate thereof, and the like, and the like can be used. Reduction solution, etc. Further, a purified product such as α-casein, β-casein, k-casein or the like, and a reducing solution thereof can be used. Further, raw materials or foods containing whey protein and casein have been used in specific protein amount ratios, and for example, raw milk, sterilized milk (milk, etc.), skimmed milk, ingredient-adjusted milk, processed milk, dairy products (condensed milk, milk powder, etc.) can be used. Condensed milk, fermented milk (Yug, etc.), lactic acid bacteria beverage, processed cheese, ice cream, cream), milk protein concentrate (MPC), concentrate thereof, dried product, frozen product thereof, hydrolyzate thereof, and the like Such reducing solutions and the like. Among these, in order to easily prepare an acidic liquid composition containing a milk protein mixture, and the milk protein mixture contains a high concentration of casein, the milk protein mixture is a milk protein using a milk material rich in casein. The concentrate (MPC) is preferred. In this milk protein concentrate, the protein ratio of casein to whey protein (casein/whey protein) was 4. At this time, these products can also be purchased for use as a commercial product, or can be used by themselves.

本發明所使用之酸性液狀組成物中所含有的乳蛋白混合物是由特定蛋白質量比之乳清蛋白與酪蛋白而構成，具體來說，酪蛋白與乳清蛋白之蛋白質量比(酪蛋白/乳清蛋白)為2~20，較佳為2~10，再較佳為2~6，更較佳為2~4。本發明中，酪蛋白與乳清蛋白之蛋白質量比意指肌肉合成促進劑中所包含的酸性液狀組成物中，所包含之乳蛋白混合物內的蛋白質量比。且，本發明所使用之 乳蛋白混合物中，酪蛋白與乳清蛋白之蛋白質量比(酪蛋白/乳清蛋白)是經意圖地調整(設計)，進而以調製成酸性液狀組成物之觀點來看，與以往技術有很大的差異。 The milk protein mixture contained in the acidic liquid composition used in the present invention is composed of specific protein amount ratio of whey protein and casein, specifically, protein ratio of casein to whey protein (casein) / whey protein) is 2 to 20, preferably 2 to 10, more preferably 2 to 6, more preferably 2 to 4. In the present invention, the protein amount ratio of casein to whey protein means the ratio of the amount of protein in the milk protein mixture contained in the acidic liquid composition contained in the muscle synthesis accelerator. And used in the present invention In the milk protein mixture, the protein ratio of casein to whey protein (casein/whey protein) is intentionally adjusted (designed), and further prepared into an acidic liquid composition, and the prior art has Great difference.

一般來說，由於乳蛋白中的酪蛋白較容易酸凝固，且會產生酸凝固所造成的分離以及沉澱，本發明所使用之酸性液狀組成物，即使為含有乳蛋白混合物之酸性液狀組成物，且該乳蛋白混合物包含高濃度之酪蛋白，也能夠抑制分離以及沉澱，再分散性良好，並且為容易以低黏度攝取(投予)之形態。只要是相當於此形態之範圍，其詳細的性質(pH值、黏度等)能夠任意地設計。 In general, since casein in milk protein is more susceptible to acid coagulation and separation and precipitation due to acid coagulation, the acidic liquid composition used in the present invention is an acidic liquid composition containing a milk protein mixture. The milk protein mixture contains a high concentration of casein, and can also inhibit separation and precipitation, has good redispersibility, and is in a form that is easily ingested (sowed) with low viscosity. The detailed properties (pH value, viscosity, etc.) can be arbitrarily designed as long as it is equivalent to the range of this form.

本發明所使用之酸性液狀組成物的pH值，例如為3~6、3.1~5.8、3.2~5.6、3.3~5.4、3.4~5.2、3.5~5、3.6~4.8、3.7~4.6、3.8~4.4。本發明之酸性液狀組成物的pH值若超過3，能夠防止感覺到較強的酸味而變得較難攝取，故較佳。且，本發明之酸性液狀組成物的pH值若低於6，則酸味感覺較弱，並能夠防止損及爽口度而使作為酸性液狀組成物變得較難攝取，故較佳。 The pH of the acidic liquid composition used in the present invention is, for example, 3 to 6, 3.1 to 5.8, 3.2 to 5.6, 3.3 to 5.4, 3.4 to 5.2, 3.5 to 5, 3.6 to 4.8, 3.7 to 4.6, and 3.8. 4.4. When the pH of the acidic liquid composition of the present invention exceeds 3, it is possible to prevent a strong sour taste from being perceived and it is difficult to ingest, which is preferable. Further, when the pH of the acidic liquid composition of the present invention is less than 6, the sour taste is weak, and it is preferable to prevent the loss of the mouthiness and to make the acidic liquid composition difficult to ingest.

本發明所使用之酸性液狀組成物的黏度(10℃)為B型旋轉黏度計所測定之酸性液狀組成物的黏度。本發明所使用之酸性液狀組成物的黏度(10℃)，例如為3~30mPa．s、3.5~30mPa．s、4~30mPa．s、4.5~30mPa．s、5~30mPa．s、5.5~29mPa．s、6~28mPa．s、6.5~27mPa．s、7~26mPa．s、7.5~25mPa．s、8~24mPa．s、8.5~23mPa．s、9~22mPa．s、9.5~21mPa．s、10~20mPa．s。本發明所使用 之酸性液狀組成物的黏度(10℃)若超過3mPa．s，能夠防止酸性液狀組成物之酪蛋白變得較難安定而容易發生酸性液狀組成物之分離以及沉澱，故較佳。且，本發明所使用之酸性液狀組成物的黏度(10℃)若低於30mPa．s，則能夠防止損及爽口度而變得較難攝取，故較佳。且，本發明所使用之酸性液狀組成物的黏度(10℃)為以布魯克非(Brookfield)黏度計等廣用之B型旋轉黏度計等所測定之酸性液狀組成物的黏度。 The viscosity (10 ° C) of the acidic liquid composition used in the present invention is the viscosity of the acidic liquid composition measured by a B-type rotational viscometer. The viscosity (10 ° C) of the acidic liquid composition used in the present invention is, for example, 3 to 30 mPa. s, 3.5~30mPa. s, 4~30mPa. s, 4.5~30mPa. s, 5~30mPa. s, 5.5~29mPa. s, 6~28mPa. s, 6.5~27mPa. s, 7~26mPa. s, 7.5~25mPa. s, 8~24mPa. s, 8.5~23mPa. s, 9~22mPa. s, 9.5~21mPa. s, 10~20mPa. s. Used by the present invention The viscosity of the acidic liquid composition (10 ° C) if more than 3 mPa. s, it is preferable to prevent the casein of the acidic liquid composition from being difficult to be settled and to easily separate and precipitate the acidic liquid composition. Moreover, the viscosity (10 ° C) of the acidic liquid composition used in the present invention is less than 30 mPa. s is preferable because it can prevent damage and refreshment and is difficult to ingest. Further, the viscosity (10 ° C) of the acidic liquid composition used in the present invention is the viscosity of the acidic liquid composition measured by a B-type rotational viscometer or the like which is widely used, such as a Brookfield viscometer.

本發明所使用之酸性液狀組成物係包含以特定蛋白質量比包含酪蛋白與乳清蛋白之乳蛋白混合物而成。於此，乳蛋白混合物中所包含之酪蛋白，一般來說，在中性區域較安定，但在比等電點之pH值4.6附近更低的pH區域之環境中，會因為酸凝固而使酪蛋白彼此凝集，這會關係到酸性液狀組成物的分離或沉澱之發生。另一方面，本發明所使用之特定組成而成的酸性液狀組成物即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，並且為容易以低黏度攝取之形態。於此所述，本發明所使用之酸性液狀組成物中所含有之包含酪蛋白之乳蛋白混合物的濃度為高濃度時，例如為3重量%以上、3.2重量%以上、3.4重量%以上、3.6重量%以上、3.8重量%以上、4重量%以上、4.2重量%以上、4.4重量%以上、3~10重量%、3~9.5重量%、3~9重量%、3~8.5重量%、3~8重量%、3~7.5重量%、3~7重量%、3.2~10 重量%、3.2~9.5重量%、3.2~9重量%、3.2~8.5重量%、3.2~8重量%、3.2~7.5重量%、3.2~7重量%、3.4~10重量%、3.4~9.5重量%、3.4~9重量%、3.4~8.5重量%、3.4~8重量%、3.4~7.5重量%、3.4~7重量%、3.6~10重量%、3.6~9.5重量%、3.6~9重量%、3.6~8.5重量%、3.6~8重量%、3.6~7.5重量%、3.6~7重量%、3.8~10重量%、3.8~9.5重量%、3.8~9重量%、3.8~8.5重量%、3.8~8重量%、3.8~7.5重量%、3.8~7重量%、4~10重量%、4~9.5重量%、4~9重量%、4~8.5重量%、4~8重量%、4~7.5重量%、4~7重量%、4.2~10重量%、4.2~9.5重量%、4.2~9重量%、4.2~8.5重量%、4.2~8重量%、4.2~7.5重量%、4.2~7重量%、4.4~10重量%、4.4~9.5重量%、4.4~9重量%、4.4~8.5重量%、4.4~8重量%、4.4~7.5重量%、4.4~7重量%。且，本發明所使用之酸性液狀組成物中所含有之包含酪蛋白之乳蛋白混合物的濃度並非高濃度時，例如為3重量%以下、2.8重量%以下、2.6重量%以下、2.4重量%以下、2.2重量%以下、2重量%以下、0.5~3重量%、1~3重量%、1.2~3重量%、1.4~3重量%、1.6~3重量%、1.8~3重量%、0.5~2.8重量%、1~2.8重量%、1.2~2.8重量%、1.4~2.8重量%、1.6~2.8重量%、1.8~2.8重量%、0.5~2.6重量%、1~2.6重量%、1.2~2.6重量%、1.4~2.6重量%、1.6~2.6重量%、1.8~2.6重量%、0.5~2.4重量%、1~2.4重量%、1.2~2.4重量%、1.4~2.4重量%、1.6~2.4重量%、1.8~2.4重量%、0.5~2.2重量%、1~2.2重量%、 1.2~2.2重量%、1.4~2.2重量%、1.6~2.2重量%、1.8~2.2重量%、0.5~2重量%、1~2重量%、1.2~2重量%、1.4~2重量%、1.6~2重量%、1.8~2重量%。於此，乳蛋白混合物所包含之酪蛋白以及乳清蛋白的各濃度能夠輕易地由前述酪蛋白與乳清蛋白之蛋白質量比來算出。 The acidic liquid composition used in the present invention comprises a mixture of milk protein containing casein and whey protein in a specific protein amount ratio. Herein, the casein contained in the milk protein mixture is generally stable in the neutral region, but in an environment lower than the pH of the isoelectric point of 4.6, the acid is solidified. Casein aggregates with each other, which is related to the separation or precipitation of acidic liquid compositions. On the other hand, the acidic liquid composition having a specific composition used in the present invention can suppress the separation and precipitation of the acidic liquid composition even if it contains an acidic liquid composition containing a milk protein mixture containing a high concentration of casein. The redispersibility is also good, and it is in a form that is easy to ingest with low viscosity. As described above, when the concentration of the milk protein mixture containing casein contained in the acidic liquid composition used in the present invention is at a high concentration, for example, it is 3% by weight or more, 3.2% by weight or more, and 3.4% by weight or more. 3.6 wt% or more, 3.8 wt% or more, 4 wt% or more, 4.2 wt% or more, 4.4 wt% or more, 3 to 10 wt%, 3 to 9.5% by weight, 3 to 9 wt%, 3 to 8.5% by weight, 3 ~8wt%, 3~7.5wt%, 3~7wt%, 3.2~10 % by weight, 3.2 to 9.5% by weight, 3.2 to 9% by weight, 3.2 to 8.5 % by weight, 3.2 to 8% by weight, 3.2 to 7.5% by weight, 3.2 to 7% by weight, 3.4 to 10% by weight, 3.4 to 9.5 % by weight 3.4 to 9% by weight, 3.4 to 8.5 % by weight, 3.4 to 8% by weight, 3.4 to 7.5 % by weight, 3.4 to 7% by weight, 3.6 to 10% by weight, 3.6 to 9.5 % by weight, 3.6 to 9% by weight, 3.6 ~8.5 wt%, 3.6-8 wt%, 3.6-7.5 wt%, 3.6-7 wt%, 3.8-10 wt%, 3.8-9.5 wt%, 3.8-9 wt%, 3.8-8.5 wt%, 3.8-8 % by weight, 3.8 to 7.5% by weight, 3.8 to 7% by weight, 4 to 10% by weight, 4 to 9.5% by weight, 4 to 9% by weight, 4 to 8.5% by weight, 4 to 8% by weight, 4 to 7.5% by weight 4 to 7 wt%, 4.2 to 10 wt%, 4.2 to 9.5% by weight, 4.2 to 9 wt%, 4.2 to 8.5% by weight, 4.2 to 8 wt%, 4.2 to 7.5% by weight, 4.2 to 7 wt%, 4.4 ~10% by weight, 4.4 to 9.5% by weight, 4.4 to 9% by weight, 4.4 to 8.5 % by weight, 4.4 to 8% by weight, 4.4 to 7.5 % by weight, and 4.4 to 7% by weight. Further, when the concentration of the milk protein mixture containing casein contained in the acidic liquid composition used in the present invention is not high, for example, it is 3% by weight or less, 2.8% by weight or less, 2.6% by weight or less, and 2.4% by weight. Hereinafter, 2.2% by weight or less, 2% by weight or less, 0.5 to 3% by weight, 1 to 3% by weight, 1.2 to 3% by weight, 1.4 to 3% by weight, 1.6 to 3% by weight, 1.8 to 3% by weight, 0.5% 2.8 wt%, 1 to 2.8% by weight, 1.2 to 2.8% by weight, 1.4 to 2.8% by weight, 1.6 to 2.8% by weight, 1.8 to 2.8% by weight, 0.5 to 2.6% by weight, 1 to 2.6% by weight, 1.2 to 2.6 by weight %, 1.4 to 2.6% by weight, 1.6 to 2.6% by weight, 1.8 to 2.6% by weight, 0.5 to 2.4% by weight, 1 to 2.4% by weight, 1.2 to 2.4% by weight, 1.4 to 2.4% by weight, 1.6 to 2.4% by weight, 1.8 to 2.4% by weight, 0.5 to 2.2% by weight, 1 to 2.2% by weight, 1.2~2.2% by weight, 1.4~2.2% by weight, 1.6~2.2% by weight, 1.8~2.2% by weight, 0.5~2% by weight, 1-2% by weight, 1.2~2% by weight, 1.4~2% by weight, 1.6~ 2% by weight, 1.8 to 2% by weight. Here, each concentration of casein and whey protein contained in the milk protein mixture can be easily calculated from the ratio of the protein amount of the casein to the whey protein.

本發明所使用之酸性液狀組成物之特徵為即使為含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，並且為容易以低黏度攝取之形態，且為了防止胃內乳蛋白的凝乳化，且促進乳蛋白之吸收後，提升肌肉合成促進效果，能夠含有0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素。 The acidic liquid composition used in the present invention is characterized in that even if it is an acidic liquid composition containing a milk protein mixture containing a high concentration of casein, the separation and precipitation of the acidic liquid composition can be suppressed, and the redispersibility is also good. In order to prevent the ingestion of the milk protein in the stomach and to promote the absorption of the milk protein, and to enhance the muscle synthesis promoting effect, it is possible to contain 0.2 to 1.2% by weight of soybean polysaccharides, 0.1~. 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose.

本發明之大豆多糖類意指包含1種或2種以上的來自大豆之鼠李糖、半乳糖、***糖、木糖、葡萄糖、糖醛酸即可，大豆中，以來自子葉者較佳。本發明之大豆多糖類並沒有特別限制其分子量，但以高分子之分子量較佳，平均分子量為數千~數百萬，具體來說為5千~100萬較佳。且，此大豆多糖類之平均分子量為極限黏度法所求出之值，該極限黏度法係將標準支鏈澱粉(昭和電工股份公司)作為標準物質來測定0.1M之NaNO3溶液中的黏度。相關之大豆多糖類能夠以商業性購入，例如有SM-700(San-Ei Gen F.F.I.公司製)、SM-900(San-Ei Gen F.F.I.公司製)。大豆多糖類被認為因為其側鏈之構 造，能夠抑制酸性液狀組成物中酪蛋白彼此的酸凝固之原因所造成的酸性液狀組成物之分離以及沉澱。 The soybean polysaccharide of the present invention means one or more kinds of rhamnose, galactose, arabinose, xylose, glucose, and uronic acid derived from soybean, and in soybean, preferably from cotyledon. The soybean polysaccharide of the present invention is not particularly limited in molecular weight, but the molecular weight of the polymer is preferably and the average molecular weight is from several thousands to several millions, specifically, from 5,000 to 1,000,000. Further, the average molecular weight of the soybean polysaccharide is a value obtained by an ultimate viscosity method in which a standard amylopectin (Showa Denko Co., Ltd.) is used as a standard substance to measure the viscosity in a 0.1 M NaNO 3 solution. The related soybean polysaccharides can be commercially purchased, and are, for example, SM-700 (manufactured by San-Ei Gen FFI Co., Ltd.) and SM-900 (manufactured by San-Ei Gen FFI Co., Ltd.). The soybean polysaccharide is considered to be capable of inhibiting the separation and precipitation of the acidic liquid composition caused by the acid coagulation of casein in the acidic liquid composition due to the structure of the side chain.

本發明之大豆多糖類的添加量，相對於本發明所使用之酸性液狀組成物，含有0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素時，例如為0.2~1.2重量%、0.25~1.15重量%、0.3~1.1重量%、0.35~1.05重量%、0.4~1重量%、0.4~0.9重量%。本發明之大豆多糖類的添加量若低於1.2重量%，則酸性液狀組成物能夠感受到大豆獨特的風味，並能避免作為酸性液狀組成物而難以攝取之缺點，故較佳。且，本發明之大豆多糖類的添加量若高於0.2重量%，則即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制本發明所使用之酸性液狀組成物的分離以及沉澱之發生，進而，再分散性亦良好，最後，作為本發明之肌肉合成促進劑來攝取時，以能防止胃內乳蛋白的凝乳化，促進乳蛋白的吸收，且提高肌肉合成促進效果之觀點來說，較佳。 When the amount of the soybean polysaccharide to be added in the present invention is 0.1 to 0.5% by weight of HM pectin and 0.01 to 0.1% by weight of fibrous insoluble cellulose, the acidic liquid composition used in the present invention is, for example, 0.2 to 1.2% by weight, 0.25 to 1.15% by weight, 0.3 to 1.1% by weight, 0.35 to 1.05% by weight, 0.4 to 1% by weight, and 0.4 to 0.9% by weight. When the amount of the soybean polysaccharide to be added in the present invention is less than 1.2% by weight, the acidic liquid composition can be perceived as a unique flavor of soybean and can be prevented from being ingested as an acidic liquid composition, which is preferable. Further, when the amount of the soybean polysaccharide to be added of the present invention is more than 0.2% by weight, the acidic liquid composition used in the present invention can be suppressed even in the case of an acidic liquid composition containing a milk protein mixture containing a high concentration of casein. In the case of the separation of the substance and the precipitation, the redispersibility is also good. Finally, when the muscle synthesis promoter of the present invention is ingested, it can prevent the emulsification of the milk protein in the stomach, promote the absorption of the milk protein, and improve the muscles. From the viewpoint of the synthesis promoting effect, it is preferred.

本發明之HM果膠意指、作為細胞壁成分而存在蔬菜或水果中，且將α-D-半乳糖醛酸作為主鏈成分之酸性多糖類。構成果膠之半乳糖醛酸部分被甲基酯化，並因酯化度而分成LM果膠與HM果膠。HM果膠一般來說，酯化度50%以上。相關之HM果膠能夠以商業性購入，例如有SM-478(San-Ei Gen F.F.I.公司製)、SM-666(San-Ei Gen F.F.I.公司製)、AYD5110SB(Unitecfoods公司製)等。HM果膠之特徵為帶有負電荷，且藉由與酪 蛋白結合，結合後的酪蛋白彼此會因電荷而排斥，以此來防止酪蛋白彼此的凝集。 The HM pectin of the present invention means an acidic polysaccharide which is present as a cell wall component in vegetables or fruits and has α-D-galacturonic acid as a main chain component. The galacturonic acid moiety constituting the pectin is methylated, and is classified into LM pectin and HM pectin due to the degree of esterification. HM pectin generally has a degree of esterification of 50% or more. The related HM pectin can be commercially purchased, and examples thereof include SM-478 (manufactured by San-Ei Gen F.F.I.), SM-666 (manufactured by San-Ei Gen F.F.I.), and AYD5110SB (manufactured by Unitecfoods Co., Ltd.). HM pectin is characterized by a negative charge and is used with cheese Protein binding, combined casein will repel each other by charge, thereby preventing casein from agglutinating each other.

本發明之HM果膠得添加量，相對於本發明所使用之酸性液狀組成物，含有0.2~1.2重量%之大豆多糖類、0.01~0.1重量%之纖維狀的不溶性纖維素時，例如為0.1~0.5重量%、0.1~0.45重量%、0.1~0.4重量%、0.1~0.35重量%、0.1~0.3重量%、0.12~0.29重量%、0.14~0.28重量%、0.16~0.27重量%、0.18~0.26重量%、0.2~0.25重量%。本發明之HM果膠的添加量若低於0.5重量%，則即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也會成為容易以低黏度攝取之形態，故較佳。且，本發明之HM果膠的添加量若高於0.1重量%，則即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能夠抑制本發明所使用之酸性液狀組成物的分離以及沉澱之發生，進而，再分散性亦良好，最後，作為本發明之肌肉合成促進劑來攝取時，以用來防止胃內乳蛋白的凝乳化、促進乳蛋白的吸收、提高肌肉合成促進效果之觀點來說，較佳。 When the HM pectin of the present invention is added in an amount of 0.2 to 1.2% by weight of soybean polysaccharides and 0.01 to 0.1% by weight of fibrous insoluble cellulose, the amount of the HM pectin added to the present invention is, for example, 0.1 to 0.5% by weight, 0.1 to 0.45% by weight, 0.1 to 0.4% by weight, 0.1 to 0.35% by weight, 0.1 to 0.3% by weight, 0.12 to 0.29% by weight, 0.14 to 0.28% by weight, 0.16 to 0.27% by weight, 0.18~ 0.26% by weight, 0.2 to 0.25% by weight. When the amount of the HM pectin added in the present invention is less than 0.5% by weight, even if it is an acidic liquid composition containing a milk protein mixture containing a high concentration of casein, it is preferable to take it in a form having a low viscosity. . Further, when the amount of the HM pectin added in the present invention is more than 0.1% by weight, even if it is an acidic liquid composition containing a milk protein mixture containing a high concentration of casein, the acidic liquid composition used in the present invention can be suppressed. The separation of the substance and the occurrence of precipitation, and the redispersibility are also good. Finally, when taken up as a muscle synthesis promoter of the present invention, it is used to prevent coagulation of milk protein in the stomach, promote absorption of milk protein, and improve muscles. From the viewpoint of the synthesis promoting effect, it is preferred.

本發明所使用之酸性液狀組成物，即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，並為容易以低黏度攝取之形態，且作為本發明之肌肉合成促進劑來攝取時，為了防止胃內乳蛋白的凝乳化，且促進乳蛋白之吸收後，提升肌肉合成促進效果，能夠併用 大豆多糖類以及/或HM果膠，或添加羧甲纖維素鈉以及/或海藻酸丙二醇酯等之其他安定劑來取代大豆多糖類以及/或HM果膠。尤其是羧甲纖維素鈉以及/或海藻酸丙二醇酯等之其他安定劑，相較於大豆多糖類以及/或HM果膠，黏度更低，能夠抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，且作為肌肉合成促進劑攝取時，為了防止胃內乳蛋白的凝乳化，且促進乳蛋白之吸收後，提升肌肉合成促進效果，可併用大豆多糖類以及/或HM果膠，或取代大豆多糖類以及/或HM果膠來使用較佳。 The acidic liquid composition used in the present invention can suppress the separation and precipitation of the acidic liquid composition even if it contains an acidic liquid composition containing a milk protein mixture containing a high concentration of casein, and the redispersibility is also good. In order to prevent ingestion of milk protein in the stomach and to promote absorption of milk protein, the muscle synthesis promoting effect can be promoted in the form of a low-viscosity ingestion. Soy polysaccharides and/or HM pectin are replaced by soy polysaccharides and/or HM pectin, or other stabilizers such as sodium carboxymethylcellulose and/or propylene glycol alginate. In particular, other stabilizers such as sodium carboxymethylcellulose and/or propylene glycol alginate have lower viscosity than soybean polysaccharides and/or HM pectin, and can inhibit the separation and precipitation of acidic liquid compositions. The dispersibility is also good, and when ingested as a muscle synthesis promoter, in order to prevent coagulation of the milk protein in the stomach and promote absorption of the milk protein, the muscle synthesis promoting effect can be enhanced, and soybean polysaccharides and/or HM pectin can be used in combination. It is preferred to use or replace soy polysaccharides and/or HM pectin.

本發明所使用之酸性液狀組成物中能夠添加羧甲纖維素鈉。羧甲纖維素鈉為將纖維素之葡萄糖的羥基取代為羧甲基者，通常為醚化度0.6~1.5左右者。相關之羧甲纖維素鈉，能夠以商業性購入，例如有Celogen F-SL(第一工業製藥公司製)、Celogen F-810A(第一工業製藥公司製)、Celogen F-SB(第一工業製藥公司製)、Celogen F-820B(第一工業製藥公司製)、Celogen F-1220B(第一工業製藥公司製)等。 Carboxymethylcellulose sodium can be added to the acidic liquid composition used in the present invention. Carboxymethylcellulose sodium is a compound in which the hydroxyl group of cellulose glucose is substituted with a carboxymethyl group, and the degree of etherification is usually about 0.6 to 1.5. The related sodium carboxymethyl cellulose can be commercially purchased, for example, Celogen F-SL (manufactured by First Industrial Pharmaceutical Co., Ltd.), Celogen F-810A (manufactured by First Industrial Pharmaceutical Co., Ltd.), and Celogen F-SB (first industrial) Manufactured by a pharmaceutical company, Celogen F-820B (manufactured by Daiichi Kogyo Co., Ltd.), Celogen F-1220B (manufactured by Daiichi Kogyo Co., Ltd.), and the like.

本發明所使用之酸性液狀組成物中能夠添加海藻酸丙二醇酯。海藻酸丙二醇酯為將自昆布、海帶芽等海藻類中純化的多糖類海藻酸化學修飾所得之物質。相關之海藻酸丙二醇酯能夠以商業性購入，例如有Tuck Lloyd LF-M(Kikkoman bio Chemifa公司製)、Tuck Lloyd EF(Kikkoman bio Chemifa公司製)、Tuck Lloyd PF(Kikkoman bio Chemifa公司製)、Tuck Lloyd PF-H (Kikkoman bio Chemifa公司製)等。 The propylene glycol alginate can be added to the acidic liquid composition used in the present invention. The propylene glycol alginate is a substance obtained by chemically modifying a polysaccharide alginic acid purified from seaweed such as kelp and kelp buds. The related propylene glycol alginate can be commercially purchased, for example, Tuck Lloyd LF-M (Kikkoman bioChemifa), Tuck Lloyd EF (Kikkoman bioChemifa), Tuck Lloyd PF (Kikkoman bioChemifa), Tuck Lloyd PF-H (Kikkoman bio Chemifa company) and the like.

本發明之羧甲纖維素鈉或海藻酸丙二醇酯的添加量只要是本發明所使用之酸性液狀組成物的特徵，且即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，並為容易以低黏度攝取之形態，且作為肌肉合成促進劑攝取時，能防止胃內乳蛋白的凝乳化，且促進乳蛋白之吸收後，提高肌肉合成促進效果的話，其添加量並無制限。添加於本發明所使用之酸性液狀組成物中，羧甲纖維素鈉或海藻酸丙二醇酯的添加量，例如為0.01~2重量%、0.01~1.5重量%、0.01~1.2重量%、0.01~1.0重量%。本發明之羧甲纖維素鈉或海藻酸丙二醇酯的添加量只要是2重量%，即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能夠成為容易以低黏度攝取之形態，故較佳。且，本發明之羧甲纖維素鈉或海藻酸丙二醇酯的添加量若超過0.01重量%，則即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能夠抑制本發明所使用之酸性液狀組成物的分離以及沉澱之發生，進而，再分散性亦良好，最後作為肌肉合成促進劑攝取時，能防止胃內乳蛋白的凝乳化，促進乳蛋白的吸收，並提高本發明之肌肉合成促進效果，故較佳。 The amount of the sodium carboxymethylcellulose or the propylene glycol alginate to be added according to the present invention is as long as it is a characteristic of the acidic liquid composition used in the present invention, and even an acidic liquid composition containing a milk protein mixture containing a high concentration of casein. It also inhibits the separation and precipitation of the acidic liquid composition, has good redispersibility, and is easily ingested at a low viscosity, and can prevent coagulation of milk protein in the stomach when ingested as a muscle synthesis promoter. When the absorption of milk protein is promoted and the effect of promoting muscle synthesis is promoted, the amount of addition is not limited. The amount of sodium carboxymethylcellulose or propylene glycol alginate added to the acidic liquid composition used in the present invention is, for example, 0.01 to 2% by weight, 0.01 to 1.5% by weight, 0.01 to 1.2% by weight, 0.01%. 1.0% by weight. The addition amount of the sodium carboxymethylcellulose or the propylene glycol alginate of the present invention is 2% by weight, and even if it is an acidic liquid composition containing a milk protein mixture containing a high concentration of casein, it can be easily ingested with low viscosity. Form, so it is better. Further, when the amount of the sodium carboxymethylcellulose or the propylene glycol alginate of the present invention is more than 0.01% by weight, the present invention can be inhibited even if it contains an acidic liquid composition containing a milk protein mixture of a high concentration of casein. The separation of the acidic liquid composition used and the occurrence of precipitation, and further, the redispersibility is also good. Finally, when taken up as a muscle synthesis promoter, it can prevent coagulation of milk protein in the stomach, promote absorption of milk protein, and improve the present. The muscle synthesis promoting effect of the invention is preferred.

本發明之纖維狀的不溶性纖維素意指一種安定劑，其係藉由含有於本發明所使用之酸性液狀組成物當中，能夠於酸性液狀組成物中構築三維網狀結構，藉此來 提升沉澱等不溶性成分的分散性。本發明之纖維狀的不溶性纖維素只要是本發明所使用之酸性液狀組成物的特徵，且即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，並為容易以低黏度攝取之形態，作為肌肉合成促進劑攝取時，能夠防止胃內乳蛋白的凝乳化，且促進乳蛋白之吸收後，提高肌肉合成促進效果的話，其來源等並無限制，能夠使用來自植物以及/或來自微生物者。來自微生物之纖維狀的不溶性纖維素例如為自培養基培將微生物所產生之發酵纖維素進行分離處理、洗淨、適當地純化之纖維狀。此纖維狀的不溶性纖維素，例如為微纖維化至平均直徑0.01~0.1μm的纖維狀不溶性纖維素(參照特開2005-245217號公報)、或發酵纖維素。本發明之纖維狀的不溶性纖維素能夠以商業性購入，例如SANARTISTPG(San-Ei Gen F.F.I.公司製)、SANARTIST PN(San-Ei Gen F.F.I.公司製)。 The fibrous insoluble cellulose of the present invention means a stabilizer which is capable of constructing a three-dimensional network structure in an acidic liquid composition by being contained in the acidic liquid composition used in the present invention. Improve the dispersibility of insoluble components such as precipitates. The fibrous insoluble cellulose of the present invention is characterized by an acidic liquid composition used in the present invention, and can suppress an acidic liquid state even if it contains an acidic liquid composition containing a milk protein mixture of a high concentration of casein. The composition is separated and precipitated, and the redispersibility is also good, and it is easy to take up at a low viscosity. When taken up as a muscle synthesis promoter, it can prevent coagulation of milk protein in the stomach and promote absorption of milk protein. When the muscle synthesis promoting effect is used, the source and the like are not limited, and those from plants and/or from microorganisms can be used. The fibrous insoluble cellulose derived from the microorganism is, for example, a fibrous form obtained by separating, washing, and appropriately purifying the fermented cellulose produced by the microorganism from the culture medium. The fibrous insoluble cellulose is, for example, a fibrous insoluble cellulose which is microfibrillated to an average diameter of 0.01 to 0.1 μm (see JP-A-2005-245217) or fermented cellulose. The fibrous insoluble cellulose of the present invention can be commercially purchased, for example, SANARTISTPG (manufactured by San-Ei Gen F.F.I.) and SANARTIST PN (manufactured by San-Ei Gen F.F.I.).

本發明之纖維狀的不溶性纖維素的添加量，於本發明所使用之酸性液狀組成物中含有0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠時，例如為0.01~0.1重量%、0.015~0.09重量%、0.02~0.08重量%、0.025~0.085重量%、0.03~0.07重量%、0.03~0.065重量%、0.03~0.06重量%、0.03~0.055重量%、0.03~0.05重量%。本發明之纖維狀的不溶性纖維素的添加量只要是0.1重量%，即使是含有包含高濃度酪蛋白之乳蛋白混合物的 酸性液狀組成物，也會成為容易以低黏度攝取之形態，故較佳。且，本發明之纖維狀的不溶性纖維素的添加量若超過0.01重量%，尤其即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能夠抑制酸性液狀組成物之分離以及沉澱的發生，進而，再分散性亦良好，最後，作為肌肉合成促進劑攝取時，能夠防止胃內乳蛋白的凝乳化，促進乳蛋白的吸收，提高本發明之肌肉合成促進效果，故較佳。 When the amount of the fibrous insoluble cellulose to be used in the present invention is 0.2 to 1.2% by weight of soybean polysaccharide and 0.1 to 0.5% by weight of HM pectin in the acidic liquid composition used in the present invention, for example, 0.01 ~0.1% by weight, 0.015~0.09% by weight, 0.02~0.08% by weight, 0.025~0.085% by weight, 0.03~0.07% by weight, 0.03~0.065% by weight, 0.03~0.06% by weight, 0.03~0.055% by weight, 0.03~0.05 weight%. The fibrous insoluble cellulose of the present invention is added in an amount of 0.1% by weight, even if it contains a milk protein mixture containing a high concentration of casein. The acidic liquid composition is also preferred because it is easily taken up at a low viscosity. Further, when the amount of the fibrous insoluble cellulose of the present invention is more than 0.01% by weight, the acidic liquid composition can be inhibited even in an acidic liquid composition containing a milk protein mixture containing a high concentration of casein. And the occurrence of precipitation, and further, the redispersibility is also good. Finally, when taken up as a muscle synthesis promoter, it is possible to prevent coagulation of milk protein in the stomach, promote absorption of milk protein, and improve the muscle synthesis promoting effect of the present invention. good.

本發明所使用之酸性液狀組成物能夠進一步添加海藻糖，藉由添加海藻糖，即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能夠抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，並進一步賦予容易以低黏度攝取之形態的特徵，最後，作為本發明之肌肉合成促進劑來攝取時，能夠防止胃內乳蛋白的凝乳化，促進乳蛋白的吸收，更提高肌肉合成促進效果。具體來說，藉由在本發明所使用之酸性液狀組成物中進一步添加海藻糖，將本發明之酸性液狀組成物的pH值提高至超過4，即使是接近乾酪素之等電點的pH值，且即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，並成為容易以低黏度飲用之形態，且作為肌肉合成促進劑攝取時，能夠防止胃內乳蛋白的凝乳化，且促進乳蛋白之吸收後，提升肌肉合成促進效果。本發明之海藻糖能夠以商業性購入，例如有TREHA(林原公司製)。 The acidic liquid composition used in the present invention can further contain trehalose, and by adding trehalose, it is possible to suppress the acidic liquid composition even if it contains an acidic liquid composition containing a milk protein mixture containing a high concentration of casein. Separation and precipitation, and the redispersibility is also good, and further imparts a characteristic that it is easy to take up at a low viscosity. Finally, when taken up as a muscle synthesis promoter of the present invention, it can prevent coagulation of milk protein in the stomach and promote milk protein. The absorption enhances the muscle synthesis promoting effect. Specifically, by further adding trehalose to the acidic liquid composition used in the present invention, the pH of the acidic liquid composition of the present invention is raised to more than 4, even if it is close to the isoelectric point of casein. The pH value and the acidic liquid composition containing a milk protein mixture containing a high concentration of casein can inhibit the separation and precipitation of the acidic liquid composition, and the redispersibility is also good, and it is easy to drink at a low viscosity. When it is taken up as a muscle synthesis promoter, it can prevent the emulsification of milk protein in the stomach and promote the absorption of milk protein, thereby improving the muscle synthesis promoting effect. The trehalose of the present invention can be commercially purchased, for example, TREHA (manufactured by Hayashibara Co., Ltd.).

本發明之海藻糖的添加量，在本發明所使用之酸性液狀組成物中含有0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素時，例如有0.1~5重量%、0.2~4.5重量%、0.3~4重量%、0.4~3.5重量%、0.5~3重量%、0.6~2.5重量%、0.7~2重量%、0.8~1.5重量%、0.9~1.3重量%、0.9~1.1重量%。本發明之海藻糖的添加量只要為5重量%，則不會對本發明之酸性液狀組成物帶來來自海藻糖之風味以及食感，並為容易以低黏度攝取之形態，故較佳。且，本發明之海藻糖的添加量若超過0.01重量%，即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制本發明所使用之酸性液狀組成物的分離以及沉澱之發生，進而，再分散性亦良好，最後，作為本發明之肌肉合成促進劑，在胃內乳蛋白不會凝乳化，且能促進乳蛋白的吸收，提高本發明之肌肉合成促進效果，故較佳。 The trehalose to be added in the present invention contains 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, and 0.01 to 0.1% by weight of fibrous form in the acidic liquid composition used in the present invention. For the insoluble cellulose, for example, 0.1 to 5% by weight, 0.2 to 4.5% by weight, 0.3 to 4% by weight, 0.4 to 3.5% by weight, 0.5 to 3% by weight, 0.6 to 2.5% by weight, 0.7 to 2% by weight, 0.8 to 1.5% by weight, 0.9 to 1.3% by weight, and 0.9 to 1.1% by weight. When the amount of the trehalose added in the present invention is 5% by weight, the flavor and texture of trehalose are not brought to the acidic liquid composition of the present invention, and it is preferably in a form which is easily ingested at a low viscosity. Further, when the amount of the trehalose added in the present invention exceeds 0.01% by weight, the acidic liquid composition containing the milk protein mixture containing a high concentration of casein can suppress the separation of the acidic liquid composition used in the present invention. And the occurrence of the precipitation, and the redispersibility is also good. Finally, as the muscle synthesis promoter of the present invention, the milk protein in the stomach is not condensed, and the absorption of the milk protein is promoted, and the muscle synthesis promoting effect of the present invention is improved. Therefore, it is better.

本發明所使用之酸性液狀組成物的製造方法之特徵為含有將含乳溶液的pH值調整至酸性之步驟、以及均質化步驟，該含乳溶液包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物。 The method for producing an acidic liquid composition used in the present invention is characterized by comprising a step of adjusting the pH of the milk-containing solution to an acidity, and a homogenization step, the milk-containing solution comprising 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and a milk protein mixture comprising casein and whey protein.

本發明所使用之酸性液狀組成物的製造方法中，將pH值調整至酸性，只要是在能夠得到本發明之特 徵之酸性液狀組成物的範圍內，且該酸性液狀組成物即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，並為容易以低黏度飲用之形態，且作為本發明之肌肉合成促進劑來攝取時，能夠防止胃內乳蛋白的凝乳化，且促進乳蛋白之吸收後，提升肌肉合成促進效果，只要能夠將含乳溶液降低至特定的pH值，其手段或方法並無特別限制。將此含乳溶液的pH值調整至酸性之方法，有例如使含乳溶液以乳酸菌等發酵微生物發酵之方法、以及於含乳溶液中添加酸之方法。 In the method for producing an acidic liquid composition used in the present invention, the pH is adjusted to be acidic as long as the present invention can be obtained. In the range of the acidic liquid composition, the acidic liquid composition can inhibit the separation and precipitation of the acidic liquid composition even if it contains an acidic liquid composition containing a high concentration of casein milk protein mixture. The redispersibility is also good, and it is easy to drink in a low-viscosity form, and when it is taken as a muscle synthesis promoter of the present invention, it can prevent coagulation of milk protein in the stomach and promote absorption of milk protein, thereby improving muscle synthesis. The promoting effect is not particularly limited as long as the milk-containing solution can be lowered to a specific pH. The method of adjusting the pH of the milk-containing solution to be acidic is, for example, a method of fermenting the milk-containing solution with a fermenting microorganism such as lactic acid bacteria, and a method of adding an acid to the milk-containing solution.

本發明所使用之酸性液狀組成物的製造方法中，為了得到本發明之酸性液狀組成物的一個特徵之即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，並為容易以低黏度飲用之形態，且作為肌肉合成促進劑攝取時，能防止胃內乳蛋白的凝乳化，且促進乳蛋白之吸收後，提升肌肉合成促進效果之特徵，在含乳溶液中含有0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素較佳。本發明之酸性液狀組成物之製造方法中，含乳溶液中所含有的大豆多糖類、HM果膠、以及纖維狀的不溶性纖維素亦可一邊與其他原料的一部分或全部一起添加，一邊以加溫至50~100℃之狀態使其溶解，亦可準備預先以溫水等所溶解者。本發明之酸性液狀組成物之製造方法中， 含乳溶液可藉由例如混合乳蛋白混合物以水所溶解之乳液、與大豆多糖類、HM果膠、以及纖維狀的不溶性纖維素以水所溶解之安定劑液所得。 In the method for producing an acidic liquid composition used in the present invention, in order to obtain a characteristic of the acidic liquid composition of the present invention, even an acidic liquid composition containing a milk protein mixture containing a high concentration of casein can be used. The separation and precipitation of the acidic liquid composition are suppressed, the redispersibility is also good, and it is easy to drink in a low viscosity form, and when taken up as a muscle synthesis promoter, it can prevent coagulation of milk protein in the stomach and promote milk protein. After absorption, the muscle synthesis promoting effect is improved, and the milk-containing solution contains 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, and 0.01 to 0.1% by weight of fibrous insoluble cellulose. Preferably. In the method for producing an acidic liquid composition of the present invention, the soybean polysaccharide, the HM pectin, and the fibrous insoluble cellulose contained in the milk-containing solution may be added together with some or all of the other raw materials. It can be dissolved by heating to 50 to 100 ° C, or it can be prepared by dissolving it in warm water or the like in advance. In the method for producing an acidic liquid composition of the present invention, The milk-containing solution can be obtained by, for example, an emulsion in which water is dissolved in a mixed milk protein mixture, a stabilizer solution in which water is dissolved with soybean polysaccharides, HM pectin, and fibrous insoluble cellulose.

本發明所使用之酸性液狀組成物之製造方法中，除了於含乳溶液中添加酸來調整pH值之外，為了提升本發明之肌肉合成促進效果，能夠將含乳溶液以機械性的切斷處理來均質化。藉由均質化，能夠將pH值經調整的含乳溶液之酪蛋白微粒化，與預先所含有的0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、以及0.01~0.1重量%之纖維狀的不溶性纖維素進行結合，得到酸性液狀組成物，該酸性液狀組成物是本發明酸性液狀組成物之一個特徵，且即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，並為容易以低黏度飲用之形態，且作為肌肉合成促進劑攝取時，能防止胃內乳蛋白的凝乳化，且促進乳蛋白之吸收後，會提高肌肉合成促進效果。均質化能夠使用牛奶等之脂肪球的均質化、以及發酵乳之液狀化所使用之廣用的均質機。 In the method for producing an acidic liquid composition used in the present invention, in addition to adding an acid to the milk-containing solution to adjust the pH value, in order to enhance the muscle synthesis promoting effect of the present invention, the milk-containing solution can be mechanically cut. Disconnected to homogenize. By homogenization, it is possible to atomize the casein protein of the pH-adjusted milk-containing solution, and 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, and 0.01 to 0.1 in advance. The weight % of the fibrous insoluble cellulose is combined to obtain an acidic liquid composition which is a characteristic of the acidic liquid composition of the present invention, and even contains a milk protein mixture containing a high concentration of casein The acidic liquid composition can also inhibit the separation and precipitation of the acidic liquid composition, has good redispersibility, and is easy to drink in a low viscosity form, and can prevent intragastric milk when taken as a muscle synthesis promoter. The emulsification of the protein and the absorption of the milk protein increase the muscle synthesis promoting effect. Homogenization can be achieved by homogenization of fat globules such as milk and a widely used homogenizer for liquefying fermented milk.

本發明所使用之酸性液狀組成物之製造方法中，除了於含乳溶液中添加酸來調整pH值之外，為了提高本發明之效果，使用均質機將含乳溶液均質化時，其均質化壓為例如1~100MPa、2~80MPa、3~60MPa、4~40MPa、5~20MPa、6~19MPa、7~18MPa、8~17MPa、9~16MPa、10~15MPa。且，均質化之溫度為例如50~100 ℃、55~95℃、60~90℃、65~85℃、70~80℃。且，本發明所使用之酸性液狀組成物之製造方法中，於含乳溶液中添加酸來調整pH值之步驟、以及使用均質機將含乳溶液均質化之步驟，其順序並無限制。亦即，本發明所使用之酸性液狀組成物之製造方法中，能夠於含乳溶液中添加酸來調整pH值之後，使用均質機將其含乳溶液均質化，也能夠在使用均質機將含乳溶液均質化後，於此含乳溶液中添加酸來調整pH值。且，本發明所使用之酸性液狀組成物之製造方法中，均質化處理之步驟，只要在能夠得到酸性液狀組成物之範圍內，且該酸性液狀組成物為酸性液狀組成物之一個特徵，且即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，並為容易以低黏度攝取之形態，且作為肌肉合成促進劑攝取時，能防止胃內乳蛋白的凝乳化，且促進乳蛋白之吸收後，提升肌肉合成促進效果之特徵，能夠於後述加熱殺菌之前或之後來設定。 In the method for producing an acidic liquid composition used in the present invention, in addition to adding an acid to the milk-containing solution to adjust the pH value, in order to improve the effect of the present invention, when the homogenizer is used to homogenize the milk-containing solution, the homogenization is performed. The chemical pressure is, for example, 1 to 100 MPa, 2 to 80 MPa, 3 to 60 MPa, 4 to 40 MPa, 5 to 20 MPa, 6 to 19 MPa, 7 to 18 MPa, 8 to 17 MPa, 9 to 16 MPa, and 10 to 15 MPa. Moreover, the temperature of homogenization is, for example, 50 to 100 °C, 55~95°C, 60~90°C, 65~85°C, 70~80°C. Further, in the method for producing an acidic liquid composition used in the present invention, the step of adjusting the pH by adding an acid to the milk-containing solution and the step of homogenizing the milk-containing solution using a homogenizer are not limited. In other words, in the method for producing an acidic liquid composition used in the present invention, it is possible to adjust the pH value by adding an acid to the milk-containing solution, and then homogenizing the milk-containing solution using a homogenizer, and it is also possible to use a homogenizer. After the milk-containing solution is homogenized, an acid is added to the milk-containing solution to adjust the pH. Further, in the method for producing an acidic liquid composition used in the present invention, the step of homogenization treatment is in the range in which an acidic liquid composition can be obtained, and the acidic liquid composition is an acidic liquid composition. One characteristic, and even an acidic liquid composition containing a milk protein mixture containing a high concentration of casein, can inhibit the separation and precipitation of the acidic liquid composition, has good redispersibility, and is easy to ingest with low viscosity. When it is ingested as a muscle synthesis promoter, it can prevent the emulsification of the milk protein in the stomach, and promotes the absorption of the milk protein, thereby improving the muscle synthesis promoting effect, and can be set before or after the heat sterilization described later.

本發明所使用之酸性液狀組成物之製造方法中，為了提高酸性液狀組成物之保存性，能夠進行加熱殺菌。本發明所使用之酸性液狀組成物之製造方法中，酸性液狀組成物之加熱殺菌的方法能夠設定為周知的牛奶以及/或飲料之殺菌方法以及殺菌條件。殺菌方法為例如平板式加熱殺菌、管式加熱殺菌、批式加熱殺菌、通電加熱殺菌、微波之加熱殺菌、殺菌釜加熱等之間接加熱殺菌、蒸汽注入、蒸汽浸出等之直接加熱殺菌。殺菌條件與牛奶相 同，例如於60~65℃保持20~30分鐘、於80~100℃保持15秒~10分鐘、於110℃~150℃保持2~15秒，只要是與此相同等之殺菌條件，能夠適當地變更。 In the method for producing an acidic liquid composition used in the present invention, heat sterilization can be performed in order to improve the storage stability of the acidic liquid composition. In the method for producing an acidic liquid composition used in the present invention, the method of heat sterilization of the acidic liquid composition can be set to a known sterilization method and sterilization conditions of milk and/or beverage. The sterilization method is, for example, flat type heat sterilization, tube type heat sterilization, batch type heat sterilization, electric heating sterilization, microwave heat sterilization, sterilization kettle heating, etc., direct heat sterilization such as heat sterilization, steam injection, steam leaching, and the like. Sterilization conditions and milk phase Same as, for example, 60 to 65 ° C for 20 to 30 minutes, 80 to 100 ° C for 15 seconds to 10 minutes, and 110 to 150 ° C for 2 to 15 seconds, as long as it is the same sterilization conditions, can be appropriate Change.

本發明所使用之酸性液狀組成物之製造方法中，為了提高酸性液狀組成物之保存性，能夠進行非加熱殺菌。本發明之酸性液狀組成物之製造方法中，本發明之酸性液狀組成物之非加熱殺菌的方法能夠設定為周知之殺菌方法以及殺菌條件。非加熱殺菌之殺菌方法為例如光照射殺菌、放射線照射殺菌、高電壓脈衝殺菌等。非加熱殺菌之殺菌條件與牛奶之加熱殺菌具有相同殺菌效果，例如於60~65℃保持20~30分鐘，於80~100℃保持15秒~10分鐘、於110℃~150℃保持2~15秒鐘，只要與此具有相同的殺菌效果，能夠適當地變更非加熱殺菌之殺菌條件。 In the method for producing an acidic liquid composition used in the present invention, in order to improve the storage stability of the acidic liquid composition, non-heat sterilization can be performed. In the method for producing an acidic liquid composition of the present invention, the method for non-heat sterilization of the acidic liquid composition of the present invention can be set to a known sterilization method and sterilization conditions. The sterilization method for non-heat sterilization is, for example, light irradiation sterilization, radiation irradiation sterilization, high voltage pulse sterilization, and the like. The sterilization conditions of non-heat sterilization have the same bactericidal effect as the heat sterilization of milk, for example, 20~30 minutes at 60~65°C, 15 seconds~10 minutes at 80~100°C, and 2~15 at 110°C~150°C. In the second, as long as the sterilization effect is the same as this, the sterilization conditions of the non-heat sterilization can be appropriately changed.

本發明所使用之酸性液狀組成物之製造方法中，為了提高酸性液狀組成物之保存性，能夠冷卻酸性液狀組成物，該酸性液狀組成物係以包含將含有0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素之含乳溶液的pH值調整至酸性之步驟與均質化步驟之步驟所得。最後，經冷卻後的酸性液狀組成物之溫度為例如0~30℃、0~25℃、0~20℃、0~15℃、0~12℃、0~10℃。 In the method for producing an acidic liquid composition used in the present invention, in order to improve the storage stability of the acidic liquid composition, the acidic liquid composition can be cooled, and the acidic liquid composition contains 0.2 to 1.2% by weight. The pH of the soybean milk polysaccharide, 0.1 to 0.5% by weight of HM pectin, and 0.01 to 0.1% by weight of the fibrous insoluble cellulose is adjusted to an acidic step and a homogenization step. Finally, the temperature of the cooled acidic liquid composition is, for example, 0 to 30 ° C, 0 to 25 ° C, 0 to 20 ° C, 0 to 15 ° C, 0 to 12 ° C, and 0 to 10 ° C.

本發明所使用之酸性液狀組成物只要是本發明酸性液狀組成物之一個特徵，且即使是含有包含高濃度酪蛋白之乳蛋白混合物的酸性液狀組成物，也能抑制酸性 液狀組成物之分離以及沉澱，再分散性亦良好，並為容易以低黏度飲用之形態，且作為肌肉合成促進劑攝取時，能防止胃內乳蛋白的凝乳化，且促進乳蛋白之吸收後，提高肌肉合成促進效果的話，能夠添加其他食品原料以及/或食品添加物原料。例如，為了賦予本發明之酸性液狀組成物的嗜好性之目的，能夠添加甜味料(砂糖類、液糖類、果糖、麥芽糖、三溫糖等)、糖醇(赤藻糖醇等)、高感度甜味料(甜菊、阿斯巴甜、三氯蔗糖、愛沙芬克)、香料、果汁、蔬菜汁等。且，為了賦予本發明之酸性液狀組成物的機能性之目的，能夠添加礦物類(鈣、鐵、錳、鎂、鋅等)、維生素類、機能性素材、益生菌乳酸菌等，來作為本發明之肌肉合成促進劑。 The acidic liquid composition used in the present invention can inhibit acidity as long as it is a characteristic of the acidic liquid composition of the present invention and even an acidic liquid composition containing a milk protein mixture containing a high concentration of casein. Separation and precipitation of the liquid composition, good redispersibility, and easy to drink in a low viscosity form, and when taken up as a muscle synthesis promoter, can prevent coagulation of milk proteins in the stomach and promote absorption of milk proteins. After that, when the muscle synthesis promoting effect is improved, other food materials and/or food additive materials can be added. For example, in order to impart preference to the acidic liquid composition of the present invention, sweeteners (salt, liquid sugar, fructose, maltose, triple warm sugar, etc.), sugar alcohols (erythritol, etc.), High-sensitivity sweeteners (stevia, aspartame, sucralose, esavif), spices, fruit juices, vegetable juices, etc. Further, in order to impart the functional properties of the acidic liquid composition of the present invention, minerals (calcium, iron, manganese, magnesium, zinc, etc.), vitamins, functional materials, probiotic lactic acid bacteria, and the like can be added as the present invention. The muscle synthesis promoter of the invention.

本發明之肌肉合成促進劑，以提供於市場為目的，能夠為容器裝飲料、置入容器之飲料的形態。容器能夠使用紙容器(山型頂部型容器、磚頭型容器等)、軟袋、寶特瓶、罐、瓶等周知者。容器之容量並無特別限制，為例如10~5000g、20~4000g、30~3000g、40~2000g、50~1500g、60~1400g、70~1300g、80~1200g、90~1100g。其中，為家庭號(複數飲用)時，為例如300~5000g、300~4000g、300~3000g、300~2000g、300~1500g、300~1400g、300~1300g、300~1200g、300~1100g，為單人用(個別飲用)時，為10~500g、20~500g、30~500g、40~500g、50~500g、60~500g、70~500g、80~500g、90~500g。 The muscle synthesis accelerator of the present invention is in the form of a beverage that can be placed in a container and placed in a container for the purpose of providing a market. The container can use a paper container (mountain type top container, brick type container, etc.), a soft bag, a bottle, a can, a bottle, and the like. The capacity of the container is not particularly limited, and is, for example, 10 to 5000 g, 20 to 4000 g, 30 to 3000 g, 40 to 2000 g, 50 to 1500 g, 60 to 1400 g, 70 to 1300 g, 80 to 1200 g, and 90 to 1100 g. In the case of the family number (multiple drinking), for example, 300 to 5000 g, 300 to 4000 g, 300 to 3000 g, 300 to 2000 g, 300 to 1500 g, 300 to 1400 g, 300 to 1300 g, 300 to 1200 g, and 300 to 1100 g are For single use (individual drinking), it is 10~500g, 20~500g, 30~500g, 40~500g, 50~500g, 60~500g, 70~500g, 80~500g, 90~500g.

本發明之肌肉合成促進劑，只要能夠為其特徵之一，且即使是含有包含高濃度乾酪素之乳蛋白的酸性液狀組成物，也能抑制酸性液狀組成物之分離以及沉澱，再分散性亦良好，並為容易以低黏度飲用之形態，且作為肌肉合成促進劑，能防止胃內乳蛋白的凝乳化，且促進乳蛋白之吸收後，能提高肌肉合成促進效果的話，則提供至市場之形態並無限制。例如，本發明之肌肉合成促進劑能夠為10℃以下之低溫流通、常溫流通。且，本發明之肌肉合成促進劑亦具有耐熱效果。因此，摻混(添加、混合)有本發明之肌肉合成促進劑的組成物時，由於本發明之肌肉合成促進劑會達到耐熱效果，故較佳能夠以作為液狀之製品形態來提供，同時能夠作為使用寶特瓶等之加溫販賣用的製品形態來提供。 The muscle synthesis promoter of the present invention can inhibit the separation, precipitation, and redispersion of the acidic liquid composition as long as it can be one of its characteristics and even an acidic liquid composition containing milk protein containing a high concentration of casein. It is also good in nature, and it is easy to drink in a low-viscosity form, and as a muscle synthesis promoter, it can prevent the emulsification of milk protein in the stomach and promote the absorption of milk protein, thereby improving the muscle synthesis promoting effect. There is no limit to the form of the market. For example, the muscle synthesis accelerator of the present invention can be circulated at a low temperature of 10 ° C or lower and can be circulated at a normal temperature. Further, the muscle synthesis promoter of the present invention also has a heat-resistant effect. Therefore, when the composition of the muscle synthesis promoter of the present invention is blended (added or mixed), since the muscle synthesis accelerator of the present invention achieves a heat-resistant effect, it is preferably provided in the form of a liquid product, and at the same time It can be provided as a product form for heating and selling using a PET bottle or the like.

由本發明之一個實施型態，例如本發明之肌肉合成促進劑，前述乳蛋白混合物以總蛋白質量來說，每一餐攝取(投予)0.06g以上/kg體重，具體來說為攝取(投予)0.06~0.7g/kg體重，較佳為0.06~0.6g/kg體重，再較佳為0.06~0.5g/kg體重，更較佳為0.08~0.4g/kg體重，特別佳為0.1~0.4g/kg體重。於此，對象之代表體重預計為約60kg。 According to one embodiment of the present invention, for example, the muscle synthesis promoter of the present invention, the milk protein mixture is ingested (administered) in a total protein amount of 0.06 g or more per kg body weight, specifically for ingestion (injection). It is 0.06-0.7 g/kg body weight, preferably 0.06-0.6 g/kg body weight, more preferably 0.06-0.5 g/kg body weight, more preferably 0.08-0.4 g/kg body weight, especially preferably 0.1~ 0.4 g / kg body weight. Here, the representative body weight of the subject is expected to be about 60 kg.

「一餐」意指必須要即效性地促進肌肉合成之狀態的每一次，例如本發明之肌肉合成促進劑中，不需要一餐中以一口氣(一次)來攝取，亦可分成數次來攝取。使必須要即效性地促進肌肉合成之對象攝取(投予) 本發明之肌肉合成促進劑的時期，並分成數次來攝取時，以即效性地提高血流中胺基酸濃度之觀點來說，較佳為運動結束後2小時以內，再較佳為運動結束後1小時以內，更較佳為運動結束後30分鐘以內，特別佳為運動結束後5分鐘以內。 "One meal" means each time a state in which muscle synthesis must be promoted in a timely manner, for example, in the muscle synthesis promoter of the present invention, it is not required to take one breath (once) in one meal, or may be divided into several times. Come to ingest. Ingestion (administration) of a subject that must promote muscle synthesis in a timely manner When the period of the muscle synthesis promoter of the present invention is taken up in several times, it is preferably within 2 hours after the end of exercise, from the viewpoint of effectively increasing the concentration of the amino acid in the bloodstream, and more preferably Within 1 hour after the end of exercise, it is more preferably within 30 minutes after the end of exercise, especially within 5 minutes after the end of exercise.

使必須要即效性地促進肌肉合成之對象攝取(投予)本發明肌肉合成促進劑之方法，可以自經口攝取(經口投予)、經腸投予、胃瘻等因應其對象以及用途進行適當地選擇，但較佳為經口攝取。 A method for ingesting (administering) a muscle synthesis promoter of the present invention in a subject that is required to promote muscle synthesis in an immediate manner, and can be administered by oral administration (oral administration), enteral administration, gastric fistula, etc. The use is suitably selected, but it is preferably oral.

由本發明之其他實施型態，例如，本發明之肌肉合成促進劑以每一餐之單位包裝形態而成，該單位中，將前述乳蛋白混合物調整在一餐攝取量以總蛋白質量來說為3g以上較期望，具體來說，係調製成3~40g，較佳為3~20g，再較佳為4~20g，更較佳為4~15g，特別佳為5~15g而成。於此，「每一餐之單位包裝形態」而成意指每一餐的攝取量是預先固定之形態，例如，將特定量作為能夠經口攝取之食品，不僅有一般食品，也有飲料(飲品劑等)、健康補助食品、保健機能食品、補充劑等形態。「每一餐之單位包裝形態」中，例如為液狀之飲料、膠狀．糊狀．膏狀之果凍、粉末狀．顆粒狀．膠囊狀．塊狀之固體狀食品等時，有舉出能夠以金屬罐、玻璃瓶(瓶子等)、塑膠容器(寶特瓶等)、包裝盒、囊狀物、薄膜容器、紙箱等包裝容器來規定特定量(用量)之形態、或能夠藉由將每一餐之攝取量(用法、用量)表示於包裝容器 或官網等，來規定特定量之形態。 According to another embodiment of the present invention, for example, the muscle synthesis promoter of the present invention is formed in a unit package form per meal, wherein the milk protein mixture is adjusted in a unit to a meal intake in terms of total protein amount. More preferably, 3 g or more is more preferably 3 to 40 g, more preferably 3 to 20 g, still more preferably 4 to 20 g, still more preferably 4 to 15 g, particularly preferably 5 to 15 g. Here, the "unit packaging form for each meal" means that the intake amount of each meal is a pre-fixed form. For example, a specific amount is used as a food that can be orally ingested, and not only general food but also drinks (drinks) Agents, etc.), health supplement foods, health functional foods, supplements, etc. In the "package form per unit", for example, liquid beverage, gelatinous. Pasty. Paste jelly, powder. Granular. Capsule. In the case of a solid food such as a block, it is possible to specify a specific container such as a metal can, a glass bottle (such as a bottle), a plastic container (such as a bottle), a package, a capsule, a film container, or a carton. The amount (amount) of the form, or can be expressed in the packaging container by taking the intake (usage, amount) of each meal Or the official website, etc., to specify the form of a specific amount.

由本發明之較佳型態，本發明之肌肉合成促進劑係含有酸性液狀組成物作為有效成分而成之肌肉合成促進劑，該酸性液狀組成物包含0.4~0.9重量%之大豆多糖類、0.2~0.25重量%之HM果膠、0.03~0.05重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~6。 According to a preferred embodiment of the present invention, the muscle synthesis promoter of the present invention comprises a muscle composition promoter comprising an acidic liquid composition as an active ingredient, and the acidic liquid composition comprises 0.4 to 0.9% by weight of soybean polysaccharides. 0.2 to 0.25 wt% of HM pectin, 0.03 to 0.05 wt% of fibrous insoluble cellulose, and a milk protein mixture comprising casein and whey protein, and a protein ratio of casein relative to whey protein ( Casein/whey protein) is 2-6.

由本發明之再較佳的型態，本發明之肌肉合成促進劑係包含酸性液狀組成物作為有效成分而成之肌肉合成促進劑，該酸性液狀組成物包含0.4~0.9重量%之大豆多糖類、0.2~0.25重量%之HM果膠、0.03~0.05重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~4。 According to a still further preferred aspect of the present invention, the muscle synthesis promoter of the present invention comprises a muscle composition promoter comprising an acidic liquid composition as an active ingredient, and the acidic liquid composition comprises 0.4 to 0.9% by weight of soybeans. a sugar, 0.2 to 0.25 wt% of HM pectin, 0.03 to 0.05% by weight of fibrous insoluble cellulose, and a milk protein mixture comprising casein and whey protein, and a protein amount relative to casein of whey protein The ratio (casein/whey protein) is 2~4.

由本發明之更較佳的型態，本發明之肌肉合成促進劑係包含酸性液狀組成物作為有效成分而成之肌肉合成促進劑，該酸性液狀組成物包含0.4~0.9重量%之大豆多糖類、0.2~0.25重量%之HM果膠、0.03~0.05重量%之纖維狀的不溶性纖維素、海藻糖0.9~1.1重量%以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~4。 According to a more preferred aspect of the present invention, the muscle synthesis promoter of the present invention comprises an acidic liquid composition as an active ingredient, and the acidic liquid composition comprises 0.4 to 0.9% by weight of soybeans. Sugar, 0.2 to 0.25 wt% HM pectin, 0.03 to 0.05 wt% fibrous insoluble cellulose, trehalose 0.9 to 1.1% by weight, and a milk protein mixture comprising casein and whey protein, and relative to whey The protein ratio of protein casein (casein/whey protein) is 2~4.

由本發明之一個實施型態，例如，本發明之肌肉合成促進劑中，能夠提供一種包含肌肉合成促進劑而 成之組成物。亦即，本發明之肌肉合成促進劑也能夠直接單獨使用，但只要能發揮肌肉合成促進機能，對於食品或醫藥品等各種經口攝取用(經口投予用)之組成物，亦能夠作為原料(素材)或添加劑等而包含於其中，得到具有肌肉合成促進效果之組成物。因此，由本發明之一個實施型態，能提供一種包含本發明之肌肉合成促進劑而成之組成物。 According to an embodiment of the present invention, for example, in the muscle synthesis promoter of the present invention, it is possible to provide a muscle synthesis promoting agent. The composition of the composition. In other words, the muscle synthesis promoter of the present invention can be used as it is, but it can also be used as a composition for various oral ingestion (orally administered) such as foods or pharmaceuticals as long as it can exert a muscle synthesis promoting function. A raw material (material), an additive, or the like is contained therein to obtain a composition having a muscle synthesis promoting effect. Therefore, according to an embodiment of the present invention, a composition comprising the muscle synthesis promoter of the present invention can be provided.

由本發明之一個實施型態，能夠提供一種肌肉合成促進用組成物，其係將酸性液狀組成物作為有效成分之組成物，該酸性液狀組成物包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。本發明之組成物亦可為食品組成物或醫藥組成物。 According to one embodiment of the present invention, it is possible to provide a composition for promoting muscle synthesis, which comprises an acidic liquid composition comprising 0.2 to 1.2% by weight of soybean polysaccharides, which is an active ingredient composition. 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, a milk protein mixture comprising casein and whey protein, and a protein amount ratio relative to casein of whey protein Protein/whey protein) is 2-20. The composition of the present invention may also be a food composition or a pharmaceutical composition.

食品組成物意指亦可為醫藥組成物以外者，且只要是溶液、懸濁液、乳濁液、粉末、固體成形物等能夠經口攝取之形態即可，並無特別限定。具體來說有舉例如泡麵、殺菌釜食品、罐頭、微波食品、速食湯．味增湯類、冷凍乾燥食品等之速食食品類；清涼飲料、果汁飲料、蔬菜飲料、豆漿飲料、咖啡飲料、茶飲料、粉末飲料、濃縮飲料、酒精飲料等之飲料類；麵包、義大利麵、麵、蛋糕混料粉、麵包粉等之小麵粉製品；糖果、膠糖、口香糖、巧克力、餅乾、脆餅、蛋糕、派類、零食、脆餅 乾、日式點心、甜點點心等點心類；醬料、番茄加工調味料、風味調味料、調理混料粉、沾醬類、沙拉醬類、堅魚醬油類、咖哩．燉菜之原味料類等之調味料；加工油脂、黃油、人造奶油、美乃滋等之油脂類；乳飲料、優格類、乳酸菌飲料、冰淇淋類、鮮奶油類等之乳製品；農產罐頭、果醬．果皮醬類、麥片等農產加工品；冷凍食品等。較佳為食品係乳製品，再較佳為乳飲料、乳酸菌飲料。 The food composition is not particularly limited as long as it can be orally ingested, such as a solution, a suspension, an emulsion, a powder, or a solid molded product. Specifically, for example, instant noodles, sterilized food, canned food, microwave food, instant soup. Instant foods such as miso soups, freeze-dried foods; beverages such as refreshing drinks, fruit drinks, vegetable drinks, soy milk drinks, coffee drinks, tea drinks, powdered drinks, concentrated drinks, alcoholic beverages, etc.; bread, Italy Small flour products such as noodles, noodles, cake mixes, bread flours, etc.; candies, gums, chewing gum, chocolate, biscuits, shortbread, cakes, pies, snacks, shortbread Dry snacks, Japanese snacks, dessert snacks, etc.; sauces, tomato processing seasonings, flavor seasonings, conditioning powders, sauces, salad dressings, squid sauces, curries. Seasonings such as raw materials for stewing vegetables; oils and fats such as processed fats, butters, margarines, and mayonnaise; dairy products such as milk beverages, yoghurt, lactic acid bacteria beverages, ice creams, and fresh cream; canned agricultural products ,jam. Processed agricultural products such as peel sauces and cereals; frozen foods, etc. It is preferably a food dairy product, and more preferably a milk beverage or a lactic acid bacteria beverage.

且，食品中有包含健康食品、機能性食品、營養補助食品、機能性表示食品、特定保健用食品、患者用食品、嬰幼兒用調整奶粉、懷孕婦女或布乳婦女用奶粉、或如附有疾病風險降低表示之食品之分類者。 Moreover, the food includes healthy foods, functional foods, nutritional supplement foods, functional foods, specific health foods, patient foods, infant milk powder, pregnant women or women's milk powder, or A classification of foods indicated by a reduction in disease risk.

由本發明之其他實施型態，為提供一種肌肉合成促進用食品，其係將酸性液狀組成物作為有效成分，該酸性液狀組成物包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。本發明之肌肉合成促進用食品包含有表示肌肉合成促進效果、或起因於此之效果的食品。由本發明之較佳實施型態，為提供一種肌肉合成促進用乳製品，其係將酸性液狀組成物作為有效成分之肌肉合成促進用飲料(較佳為乳製品，再較佳為乳飲料或乳酸菌飲料)，該酸性液狀組成物包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖 維素、包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。 According to another embodiment of the present invention, there is provided a food for promoting muscle synthesis, which comprises an acidic liquid composition comprising 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5 by weight, as an active ingredient. % HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, milk protein mixture containing casein and whey protein, and protein ratio of casein relative to whey protein (casein/whey) Protein) is 2-20. The food for promoting muscle synthesis of the present invention contains a food indicating an effect of promoting muscle synthesis or an effect caused thereby. According to a preferred embodiment of the present invention, there is provided a milk product for promoting muscle synthesis, which is a muscle synthesis promoting beverage having an acidic liquid composition as an active ingredient (preferably a dairy product, more preferably a milk beverage or The lactic acid bacteria beverage) comprises 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, and 0.01 to 0.1% by weight of fibrous insoluble fiber. A vitamin, a milk protein mixture comprising casein and whey protein, and a protein ratio (casein/whey protein) of 2 to 20 relative to casein of whey protein.

醫藥組成物意指併用能夠容許用於製劑化之添加劑，根據常法，而作為經口製劑或非經口製劑來調製者。為經口製劑時，能夠設成錠劑、散劑、微粒劑、顆粒劑、膠囊劑、丸劑、徐放劑等固態製劑、溶液、懸濁液、乳濁液等液狀製劑之形態。且，為非經口製劑時，能夠設成注射劑或栓劑之形態。由簡易性之觀點來看，較佳為經口製劑。作為能夠容許用於製劑化之添加劑，有舉例如賦形劑、安定劑、防腐劑、濕潤劑、乳化劑、潤滑劑、甜味料、著色料、香料、緩衝劑、氧化防止劑、pH調整劑等。本發明之醫藥組成物中，有包含必須要促進肌肉合成之疾病，具體來說為肌肉損傷疾病，例如肌肉減少症之處置用組成物，更具體來說有包含預防用組成物以及治療用組成物。 The pharmaceutical composition means an additive which can be used for formulation, and which is prepared as an oral preparation or a parenteral preparation according to a usual method. In the case of the oral preparation, it can be in the form of a liquid preparation such as a solid preparation such as a tablet, a powder, a microparticle, a granule, a capsule, a pill or a sputum, or a solution, a suspension or an emulsion. Further, in the case of a parenteral preparation, it can be in the form of an injection or a suppository. From the standpoint of simplicity, an oral preparation is preferred. As an additive which can be tolerated for formulation, there are mentioned, for example, an excipient, a stabilizer, a preservative, a wetting agent, an emulsifier, a lubricant, a sweetener, a coloring agent, a fragrance, a buffer, an oxidation inhibitor, and a pH adjustment. Agents, etc. The pharmaceutical composition of the present invention contains a composition which is required to promote muscle synthesis, specifically, a composition for the treatment of muscle-damaged diseases such as muscle reduction, and more specifically, a composition for prevention and a composition for treatment. Things.

由本發明之再其他之實施型態，為提供一種肌肉合成促進方法，其係包含使必須要促進肌肉合成之對象同時或分次攝取酸性液狀組成物而成之肌肉合成促進方法，該酸性液狀組成物包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。本發明之肌肉合成促進方法為排除 對人類的醫療行為方法較佳。於此，「對人類的醫療行為」意指必須要有醫師等之處方，使人類攝取(投予)醫藥品之行為等。本發明之肌肉合成促進方法係關於本發明之肌肉合成促進劑，能夠根據本案說明書所記載之內容來實施。 According to still another embodiment of the present invention, there is provided a method for promoting muscle synthesis, which comprises a method for promoting muscle synthesis by simultaneously or sequentially ingesting an acidic liquid composition for a subject who is required to promote muscle synthesis, the acidic liquid The composition comprises 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and a milk protein mixture comprising casein and whey protein, and The protein amount ratio (casein/whey protein) relative to the casein of whey protein is 2-20. The method for promoting muscle synthesis of the present invention is to exclude The method of medical behavior for humans is better. Here, "medical behavior to humans" means that there is a need for a doctor or the like to enable humans to ingest (administer) pharmaceuticals. The muscle synthesis promoting method of the present invention relates to the muscle synthesis promoting agent of the present invention, which can be carried out according to the contents described in the present specification.

由本發明之一個較佳實施型態，在本發明之肌肉合成促進方法中，酸性液狀組成物能夠含有0.5~5重量%之海藻糖。且，由本發明之一個較佳型態，在本發明之肌肉合成促進方法中，能夠將酸性液狀組成物之pH值設在3~6。進而，由本發明之一個較佳型態，本發明之肌肉合成促進方法中，酸性液狀組成物能夠包含發酵纖維素作為纖維狀之不要性纖維素。 According to a preferred embodiment of the present invention, in the muscle synthesis promoting method of the present invention, the acidic liquid composition can contain 0.5 to 5% by weight of trehalose. Further, in a preferred embodiment of the present invention, in the method for promoting muscle synthesis of the present invention, the pH of the acidic liquid composition can be set to 3 to 6. Further, according to a preferred aspect of the present invention, in the muscle synthesis promoting method of the present invention, the acidic liquid composition can comprise fermented cellulose as fibrous fibrous cellulose.

由本發明之一個較佳實施型態，本發明之肌肉合成促進方法中，能夠攝取(投予)前述乳蛋白混合物至以總蛋白質量來說每一餐為0.06g以上/kg體重，具體來說為攝取至0.06~0.7g/kg體重，較佳為0.06~0.6g/kg體重，再較佳為0.06~0.5g/kg體重，更較佳為0.08~0.4g/kg體重，特別佳為0.1~0.4g/kg體重。 According to a preferred embodiment of the present invention, in the method for promoting muscle synthesis of the present invention, the milk protein mixture can be ingested (administered) to 0.06 g/kg body weight per meal in terms of total protein amount, specifically For ingestion to 0.06-0.7 g/kg body weight, preferably 0.06-0.6 g/kg body weight, more preferably 0.06-0.5 g/kg body weight, more preferably 0.08-0.4 g/kg body weight, especially preferably 0.1. ~0.4g/kg body weight.

由本發明之一個較佳實施型態，本發明之肌肉合成促進方法中，能夠攝取前述乳蛋白混合物至以總蛋白質量來說每一餐為3g以上，具體來說，能夠攝取至3~40g，較佳為3~20g，再較佳為4~20g，更較佳為4~15g，特別佳為5~15g。 According to a preferred embodiment of the present invention, in the method for promoting muscle synthesis of the present invention, the milk protein mixture can be ingested to 3 g or more per meal in terms of total protein amount, and specifically, can be ingested to 3 to 40 g. It is preferably 3 to 20 g, more preferably 4 to 20 g, still more preferably 4 to 15 g, particularly preferably 5 to 15 g.

由本發明之一個較佳實施型態，本發明之肌 肉合成促進方法中，能夠使必須要促進肌肉合成之對象攝取，較佳為必須要即效性地促進肌肉合成之對象，再較佳為運動之對象，更較佳為肌肉訓練之對象。 According to a preferred embodiment of the invention, the muscle of the invention In the meat synthesis promoting method, it is possible to ingest a subject which is required to promote muscle synthesis, and it is preferably a subject which is required to promote muscle synthesis in an instant, and is preferably a subject of exercise, and more preferably a subject of muscle training.

由本發明之一個實施型態，本發明之肌肉合成促進方法中，能夠使必須要促進肌肉合成之對象以加溫之液狀形態攝取前述酸性液狀組成物。 According to one embodiment of the present invention, in the method for promoting muscle synthesis of the present invention, the acidic liquid composition can be ingested in a warm liquid form in a subject which is required to promote muscle synthesis.

由本發明之其他實施形態，能夠提供一種處置方法，其係包含使必須要促進肌肉合成之疾病對象攝取酸性液狀組成物而成之必須要促進肌肉之疾病的處置方法，該酸性液狀組成物包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。本發明之必須要促進肌肉合成之疾病的處置方法中包含肌肉損傷疾病的處置方法，例如肌肉減少症的處置方法。處置方法包含預防方法以及治療方法。本發明之處置方法為關於本發明之肌肉合成促進方法，能夠根據本案說明書所記載之內容來實施。 According to another embodiment of the present invention, it is possible to provide a treatment method comprising a method for treating a disease in which muscles are required to be ingested by a diseased subject which is required to promote muscle synthesis, which is an acidic liquid composition. Containing 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, milk protein mixture containing casein and whey protein, and relative to milk The protein ratio of casein of albumin (casein/whey protein) is 2-20. In the method for treating a disease which promotes muscle synthesis of the present invention, a method for treating a muscle-damaged disease, for example, a method for treating muscle wasting, is included. Disposal methods include prophylactic methods and treatment methods. The treatment method of the present invention relates to a method for promoting muscle synthesis of the present invention, which can be carried out according to the contents described in the present specification.

由本發明之一個實施形態，為提供一種肌肉合成促進劑或包含其而成之組成物的使用，其係用來促進肌肉合成，且為包含酸性液狀組成物作為有效成分而成之肌肉合成促進劑或包含其而成之組成物，該酸性液狀組成物包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以 及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。由本發明之一個較佳實施型態，本發明之使用為非治療性之使用。本發明之肌肉合成促進劑或包含其而成之組成物的使用為關於本發明之肌肉合成促進劑以及肌肉合成促進方法，能夠根據本說明書所記載之內容來實施。 According to an embodiment of the present invention, there is provided a muscle synthesis promoter or a composition comprising the same, which is used for promoting muscle synthesis and is a muscle synthesis promoting comprising an acidic liquid composition as an active ingredient. Or a composition comprising the same, the acidic liquid composition comprising 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, Take And a milk protein mixture comprising casein and whey protein, and a protein ratio (casein/whey protein) of 2 to 20 relative to casein of whey protein. In a preferred embodiment of the invention, the use of the invention is non-therapeutic. The muscle synthesis promoter of the present invention or the composition comprising the same is a muscle synthesis promoter and a muscle synthesis promotion method according to the present invention, and can be carried out according to the contents described in the present specification.

由本發明之一個實施形態，為提供一種肌肉合成促進劑或包含其而成之組成物的使用，其係用於製造用來促進肌肉合成之食品或醫藥品，且為包含酸性液狀組成物作為有效成分而成之肌肉合成促進劑或包含其而成之組成物，該酸性液狀組成物包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。本發明之肌肉合成促進劑或組成物之使用為關於本發明之肌肉合成促進劑以及肌肉合成促進方法，能夠根據本說明書所記載之內容來實施。 According to one embodiment of the present invention, there is provided a use of a muscle synthesis promoter or a composition comprising the same, which is used for producing a food or a medicine for promoting muscle synthesis, and comprising an acidic liquid composition as a muscle synthesis accelerator comprising the active ingredient or a composition comprising the same, the acidic liquid composition comprising 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight The fibrous insoluble cellulose and the milk protein mixture containing casein and whey protein have a protein ratio (casein/whey protein) of 2 to 20 with respect to casein of whey protein. The use of the muscle synthesis promoter or composition of the present invention is a muscle synthesis promoter and a muscle synthesis promotion method according to the present invention, and can be carried out in accordance with the contents described in the present specification.

由本發明之一個較佳實施型態，本發明之使用中，酸性液狀組成物能夠含有0.5~5重量%之海藻糖。且，由本發明之一個較佳型態，本發明之使用中，能夠將酸性液狀組成物之pH值設在3~6。進而，本發明之一個較佳型態，本發明之使用中，酸性液狀組成物能夠包含發酵纖維素作為纖維狀之不要性纖維素。 According to a preferred embodiment of the present invention, in the use of the present invention, the acidic liquid composition can contain 0.5 to 5% by weight of trehalose. Further, in a preferred embodiment of the present invention, in the use of the present invention, the pH of the acidic liquid composition can be set at 3 to 6. Further, in a preferred embodiment of the present invention, in the use of the present invention, the acidic liquid composition can comprise fermented cellulose as fibrous fibrous cellulose.

由本發明之一個較佳實施型態，本發明之使 用中，能夠攝取(投予)前述乳蛋白混合物至以總蛋白質量來說每一餐為0.06g以上/kg體重，具體來說，能夠攝取至0.06~0.7g/kg體重，較佳為0.06~0.6g/kg體重，再較佳為0.06~0.5g/kg體重，更較佳為0.08~0.4g/kg體重，特別佳為0.1~0.4g/kg體重。 According to a preferred embodiment of the present invention, the present invention In use, the milk protein mixture can be ingested (administered) to a total protein amount of 0.06 g or more per kg of body weight, specifically, it can be ingested to 0.06 to 0.7 g/kg body weight, preferably 0.06. ~0.6 g/kg body weight, more preferably 0.06 to 0.5 g/kg body weight, more preferably 0.08 to 0.4 g/kg body weight, particularly preferably 0.1 to 0.4 g/kg body weight.

由本發明之一個較佳實施型態，本發明之使用中，能夠攝取前述乳蛋白混合物至以總蛋白質量來說每一餐為3g以上，具體來說能夠攝取至3~40g，較佳為3~20g，再較佳為4~20g，更較佳為4~15g，特別佳為5~15g。 According to a preferred embodiment of the present invention, in the use of the present invention, the milk protein mixture can be ingested to 3 g or more per meal in total protein amount, specifically, up to 3 to 40 g, preferably 3 ~20g, more preferably 4~20g, more preferably 4~15g, especially preferably 5~15g.

由本發明之一個較佳實施型態，本發明之使用中，對象為運動之對象，較佳為肌肉訓練之對象。 In a preferred embodiment of the invention, in the use of the invention, the subject is a subject of exercise, preferably a subject for muscle training.

由本發明之一個實施型態，為提供一種用來促進肌肉合成之酸性液狀組成物，其係包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物之酸性液狀組成物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。本發明之用來促進肌肉合成之酸性液狀組成物為關於本發明之肌肉合成促進劑，能夠根據本說明書所記載之內容來設計。 According to one embodiment of the present invention, there is provided an acidic liquid composition for promoting muscle synthesis, which comprises 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1 weight. % fibrous insoluble cellulose, and an acidic liquid composition comprising a milk protein mixture of casein and whey protein, and a protein amount ratio (casein/whey protein) relative to casein of whey protein 2~20. The acidic liquid composition for promoting muscle synthesis of the present invention is a muscle synthesis promoter of the present invention, and can be designed according to the contents described in the present specification.

於此，本發明之肌肉合成促進劑相較於基於非專利文獻1之知識的肌肉合成促進劑(以下為「包含僅由乳蛋白混合物而成之中性液狀組成物作為有效成分的肌 肉合成促進劑」)，肌肉合成促進效果更高，該肌肉合成促進劑例如不包含0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素，且為不經氧化之包含包含酪蛋白與乳清蛋白之乳蛋白混合物作為有效成分而成之肌肉合成促進劑，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為4。例如在後述動物實驗之實施例(試驗例1)中，攝取(投予)相同量之乳蛋白時，本發明之肌肉合成促進劑，相較於包含僅由乳蛋白混合物而成之中性液狀組成物作為有效成分的肌肉合成促進劑，表示具有較高的效果。且，在後述動物實驗之實施例(試驗例2)中，將本發明之肌肉合成促進劑以0.85g乳蛋白/kg體重這種低用量來攝取(投予)時，與將包含僅由乳蛋白混合物而成之中性液狀組成物作為有效成分之肌肉合成促進劑以1.8g乳蛋白/kg體重這種高用量來攝取(投予)時，作為其肌肉合成促進劑之效果為相同程度。 Here, the muscle synthesis promoter of the present invention is compared with the muscle synthesis promoter based on the knowledge of Non-Patent Document 1 (hereinafter, "the muscle containing the neutral liquid composition only composed of the milk protein mixture as an active ingredient" The meat synthesis promoting agent has a higher muscle synthesis promoting effect, and the muscle synthesis promoting agent does not contain, for example, 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, and 0.01 to 0.1% by weight of fibrous material. Insoluble cellulose, which is a muscle synthesis promoter comprising a milk protein mixture comprising casein and whey protein as an active ingredient without oxidation, and a protein ratio of casein relative to whey protein (casein) / whey protein) is 4. For example, in the example of the animal experiment described later (Test Example 1), when the same amount of milk protein is ingested (administered), the muscle synthesis promoter of the present invention is compared with the medium containing only the milk protein mixture. The muscle composition promoter as an active ingredient of the composition shows a high effect. Further, in the example of the animal experiment described later (Test Example 2), when the muscle synthesis promoter of the present invention is ingested (administered) at a low dose of 0.85 g of milk protein/kg body weight, it will contain only milk. When the protein mixture is used as an active ingredient, the muscle synthesis promoter is ingested (administered) at a high dose of 1.8 g of milk protein/kg body weight, and the effect as a muscle synthesis promoter is the same. .

亦即，本發明之肌肉合成促進劑相較於將僅由乳蛋白混合物而成之中性液狀組成物作為有效成分之肌肉合成促進劑，若攝取(投予)一定量之乳蛋白，即能夠期待較強之肌肉合成促進效果。且，本發明之肌肉合成促進劑，為了得到與將僅由乳蛋白混合物而成之中性液狀組成物作為有效成分之肌肉合成促進劑相同的效果，能夠降低應攝取之乳蛋白混合物的量，且變的更容易攝取(投予)。進而，本發明之肌肉合成促進劑具有適度酸味之爽 口度，相較於將僅由乳蛋白混合物而成之中性液狀組成物作為有效成分之肌肉合成促進劑，含有相同濃度之乳蛋白混合物時，變得更容易攝取(投予)。 In other words, the muscle synthesis promoter of the present invention is a muscle synthesis promoter which is an active ingredient composed only of a milky protein mixture, and if a certain amount of milk protein is ingested (administered), A strong muscle synthesis promoting effect can be expected. Further, the muscle synthesis accelerator of the present invention can reduce the amount of the milk protein mixture to be ingested in order to obtain the same effect as the muscle synthesis promoter which is an intermediate liquid composition which is only a mixture of milk proteins and an active ingredient. And it becomes easier to ingest (administer). Further, the muscle synthesis promoter of the present invention has a moderate sour taste The mouth-feeling is easier to ingest (administer) when it contains a milk protein mixture having the same concentration as a muscle-promoting agent which is an active liquid component only composed of a milk protein mixture.

〔實施例〕 [Examples]

以下舉出實施例，進一步詳細說明本發明，但本發明不限定於此等。 Hereinafter, the present invention will be described in further detail with reference to examples but the present invention is not limited thereto.

〔實施例1〕 [Example 1]

將乳蛋白濃縮物(乳蛋白80重量%、乳糖6.5重量%)4.25kg加熱溶解於40.75kg之水中，設為溶液A。將大豆多糖類(SM-900、San-Ei Gen F.F.I.公司製)0.45kg、HM果膠(AYD5110SB、Unitecfoods公司製)0.2kg、發酵纖維素(SANARTIST PG、San-Ei Gen F.F.I.公司製)0.05kg、海藻糖1kg、砂糖3.3kg三氯蔗糖0.0063kg加溫溶解於39.99kg之水中，設為溶液B。將檸檬酸0.64kg溶解至9.36kg之水中，設為溶液C。將溶液A與溶液B混合後，將此混合液一邊攪拌，一邊將溶液C分成10次於5分鐘內進行添加，設為殺菌前的基底混合液。將此基底混合液以平板殺菌機進行15MPa之均質化處理(70~80℃)，於130℃ 2秒鐘殺菌之後，將冷卻至10℃以下者設為實施例1之肌肉合成促進劑(乳蛋白3.4重量%、大豆多糖類0.45重量%、HM果膠0.2重量%、發酵纖維素0.05重量%、海藻糖1重量%)。實施例1之肌 肉合成促進劑的pH值為4.1、黏度為10mPa．s(10℃)。「口感」、「沉澱」、「再分散性」皆良好。以下，試驗例1、2中，將實施例1稱作「肌肉合成促進劑」。且，於此，此處所使用之乳蛋白濃縮物是將脫脂牛奶膜分離處理(UF處理、MF處理等)後，去除乳糖或灰分，將酪蛋白與乳清蛋白作為主體並濃縮後之酪蛋白與乳清蛋白之混合物，其形態為乾燥粉末。且，乳蛋白濃縮物之蛋白質量比與生乳(牛奶)相同，酪蛋白：乳清蛋白=約8：2(參照山內邦男以及橫山健吉編，牛奶綜合辭典)。 4.25 kg of a milk protein concentrate (milk protein 80% by weight, lactose 6.5% by weight) was dissolved in 40.75 kg of water to prepare a solution A. 0.45 kg of soybean polysaccharides (SM-900, manufactured by San-Ei Gen FFI Co., Ltd.), 0.2 kg of HM pectin (AYD 5110SB, manufactured by Unitecfoods Co., Ltd.), and 0.05 kg of fermented cellulose (SANARTIST PG, manufactured by San-Ei Gen FFI Co., Ltd.) 1 kg of trehalose, 3.3 kg of sucralose and 0.0063 kg of sucrose were dissolved in 39.99 kg of water to prepare a solution B. 0.64 kg of citric acid was dissolved in 9.36 kg of water to prepare a solution C. After the solution A and the solution B were mixed, the solution C was added to the mixture for 10 times in 5 minutes while stirring, and the mixture was added as a base mixture before sterilization. The base mixture was subjected to homogenization treatment (70 to 80 ° C) at 15 MPa in a plate sterilizer, and sterilized at 130 ° C for 2 seconds, and then cooled to 10 ° C or lower, and the muscle synthesis accelerator (milk of Example 1) was used. Protein 3.4% by weight, soybean polysaccharide 0.45 wt%, HM pectin 0.2% by weight, fermented cellulose 0.05% by weight, and trehalose 1% by weight). The muscle of the embodiment 1 The meat synthesis accelerator has a pH of 4.1 and a viscosity of 10 mPa. s (10 ° C). "Taste," "precipitation," and "redistribution" are all good. Hereinafter, in Test Examples 1 and 2, Example 1 is referred to as "muscle synthesis promoter". Here, the milk protein concentrate used here is a casein which is obtained by separating the skim milk film (UF treatment, MF treatment, etc.), removing lactose or ash, and using casein and whey protein as a main body and concentrating the casein. A mixture with whey protein in the form of a dry powder. Furthermore, the protein content of the milk protein concentrate is the same as that of the raw milk (milk), and casein: whey protein = about 8:2 (refer to Yamauchi Ken and Yokoyama Kenji, milk comprehensive dictionary).

〔試驗例1〕 [Test Example 1]

如以下所述，驗證實施例1之肌肉合成促進劑所達成之肌肉合成促進效果。 The muscle synthesis promoting effect achieved by the muscle synthesis promoter of Example 1 was verified as described below.

(1)小鼠之游泳試驗 (1) Swimming test of mice

實驗動物中使用初期體重為130~170g之SD系雄性小鼠(自日本CLEA股份公司取得)。所有的小鼠被分成亮期7點~19點、暗期19點~7點，在室溫之22±2℃的條件下，於不鏽鋼製籠子內分別個體飼養。 SD male mice (acquired from CLEA AG, Japan) having an initial body weight of 130 to 170 g were used in the experimental animals. All the mice were divided into 7 to 19 points in the bright period and 19 to 7 in the dark period, and were individually housed in stainless steel cages at room temperature of 22 ± 2 °C.

使用固態飼料(Oriental酵母工業股份公司製)，預備飼養小鼠3~5天後，為了使其適應游泳運動，對小鼠提供30分鐘的游泳運動(水溫34℃)。適應游泳運動實施日的隔天開始至後天，使其絕食16小時後，將小鼠以每個試驗群不產生體重差之條件來分成9群(各試 驗群各6~8隻)。之後，對小鼠提供2小時的游泳運動。游泳運動結束後，馬上使小鼠經口攝取24.24mL/kg體重之肌肉合成促進劑或乳蛋白3.4重量%之脫脂奶粉溶液。自經口攝取開始15分鐘後、或45分鐘後、或75分鐘後、或105分鐘後，將氘標誌***酸溶液(將氘標誌***酸225mg溶解於生理食鹽水10mL中所調製)以2.0mL/kg體重尾靜脈投予至小鼠。尾靜脈投予15分鐘後(亦即，自經口攝取30分鐘後、或60分鐘後、或90分鐘後、或120分鐘後)，在氟醚麻醉下將小鼠解剖。於腹部大靜脈全採血之後，將上肢三頭肌摘出，以生理食鹽水洗淨後，直接以液態氮凍結。正確地記錄尾靜脈投予的時間以及上肢三頭肌之凍結保存的時間。上肢三頭肌到分析時之前保存於-80℃。 Using a solid feed (Oriental Yeast Co., Ltd.), the mice were prepared to feed the mice for 3 to 5 days, and in order to adapt to swimming, the mice were provided with a swimming exercise for 30 minutes (water temperature 34 ° C). On the day after the start of the swimming exercise, the day after the hunger strike, the mice were divided into 9 groups on the condition that the test group did not produce a difference in body weight after 16 hours of hunger strike. The test group is 6-8 each). After that, the mice were given 2 hours of swimming. Immediately after the end of the swimming exercise, the mice were orally administered a 24.24 mL/kg body weight muscle synthesis promoter or a milk protein 3.4% by weight skim milk powder solution. 15 minutes after the oral ingestion, or after 45 minutes, or after 75 minutes, or after 105 minutes, the guanidine-labeled phenylalanine solution (prepared by dissolving 225 mg of phenylalanine in 10 mL of physiological saline) to 2.0 mL /kg body weight was administered to the tail vein. After 15 minutes of tail vein administration (i.e., 30 minutes after oral administration, or 60 minutes later, or 90 minutes later, or 120 minutes later), the mice were dissected under fluoroether anesthesia. After collecting blood from the abdomen and large veins, the upper limb triceps muscles were removed, washed with physiological saline, and directly frozen in liquid nitrogen. The time of tail vein administration and the time of frozen preservation of the upper limb triceps were correctly recorded. Upper limb triceps were stored at -80 °C until analysis.

(2)骨格肌合成速度(FSR)之測定 (2) Determination of the rate of synthesis of bone muscle (FSR)

基於先前文獻(A.Kanda et al.,Br J Nutr,Sep.28,981-987,2013)之記載，測定關於摘出並保存之上肢三頭肌的骨格肌合成速度(FSR)。具體來說，使用LC/MS/MS(Waters公司製)，分別定量同化成骨格肌細胞之蛋白質而存在之、或骨格肌細胞中以遊離狀態存在之***酸(Phe)以及氘標誌***酸(Phe(Ring-D5))的量。此測定條件如以下所述。亦即，裝置：LC/MS/MS(Waters公司製)，管柱：ACQUITY UPLC BEH C18(Waters公司製)，移動相：0.05%TFA水 /0.05%含有TFA之乙腈，注入量3μL，流速0.3mL/min，UV 215nm。 Based on the description of the prior literature (A. Kanda et al., Br J Nutr, Sep. 28, 981-987, 2013), the rate of synovial muscle synthesis (FSR) with respect to the removal and preservation of the upper extremity triceps was determined. Specifically, LC/MS/MS (manufactured by Waters Co., Ltd.) was used to quantitatively quantify the protein which was formed into the skeletal muscle cells, or the phenylalanine (Phe) which is present in the free state of the skeletal muscle cells, and the oxime-labeled phenylalanine ( The amount of Phe (Ring-D5)). The measurement conditions are as follows. That is, the apparatus: LC/MS/MS (manufactured by Waters), column: ACQUITY UPLC BEH C18 (manufactured by Waters), mobile phase: 0.05% TFA water /0.05% acetonitrile containing TFA, injection amount 3 μL, flow rate 0.3 mL/min, UV 215 nm.

於此，由以下之式，算出骨格肌合成速度(FSR)。 Here, the skeletal muscle synthesis rate (FSR) was calculated by the following formula.

FSR(%/day)=(Eb×100)/(Ea×t) FSR (%/day) = (Eb × 100) / (Ea × t)

Ea：增濃因數(骨格肌細胞中以遊離狀態存在) Ea: enrichment factor (exist in free state in skeletal muscle cells)

Eb：增濃因數(同化成骨格肌細胞之蛋白質而存在) Eb: enrichment factor (associated with the protein of the skeletal muscle cells)

t：自尾靜脈投予至凍結保存上肢三頭肌為止之時間(單位：天) t: time from the tail vein administration to the freezing and preservation of the upper limb triceps (unit: day)

增濃因數=Phe(Ring-D5)/(Phe+Phe(Ring-D5)) Concentration factor = Phe(Ring-D5)/(Phe+Phe(Ring-D5))

自所得之數值求出各試驗群之平均值±標準誤差。統計處理是在各時間點(經口攝取後30分鐘或60分鐘或90分鐘或120分鐘)時，於肌肉合成促進劑群與脫脂奶粉溶液群之間進行Student之t檢定。有效位準是未滿5%(p<0.05)。將其結果表示於圖1。 From the obtained values, the mean value ± standard error of each test group was determined. The statistical treatment was performed with Student's t-test between the muscle synthesis promoter group and the skim milk powder solution group at each time point (30 minutes or 60 minutes or 90 minutes or 120 minutes after oral ingestion). The effective level is less than 5% (p < 0.05). The result is shown in Fig. 1.

藉由肌肉合成促進劑之攝取，攝取30分鐘後小鼠的骨格肌合成速度相較於脫脂奶粉溶液，顯示有意義的高值(p<0.05、圖1)。且，藉由肌肉合成促進劑之攝取，攝取60分鐘、90分鐘、120分鐘後，相較於脫脂奶粉溶液，骨格肌合成速度之值也發現有比較高的傾向(p<0.10、圖1)。由此等之結果表示肌肉合成促進劑相較於脫脂奶粉溶液，具有較高的骨格肌合成促進效果。 By the uptake of the muscle synthesis promoter, the rate of synthesis of the bone muscle of the mice after 30 minutes of ingestion showed a significant high value compared to the skim milk powder solution (p<0.05, Fig. 1). Moreover, after 60 minutes, 90 minutes, and 120 minutes of ingestion by the muscle synthesis promoter, the value of the rate of synthesis of the bone muscle was found to be higher than that of the skim milk powder solution (p<0.10, Fig. 1). . As a result of this, it is shown that the muscle synthesis promoter has a higher effect of promoting the synthesis of the bone muscle than the skim milk powder solution.

〔試驗例2〕 [Test Example 2]

如以下所述，驗證實施例1之肌肉合成促進劑到達的肌肉合成促進效果。 The muscle synthesis promoting effect reached by the muscle synthesis promoter of Example 1 was verified as described below.

(1)小鼠之游泳試驗 (1) Swimming test of mice

實驗動物中使用初期體重為130~170g之SD系雄性小鼠(自日本CLEA股份公司取得)。所有的小鼠被分成亮期7點~19點、暗期19點~7點，在室溫之22±2℃的條件下，於不鏽鋼製籠子內分別個體飼養。 SD male mice (acquired from CLEA AG, Japan) having an initial body weight of 130 to 170 g were used in the experimental animals. All the mice were divided into 7 to 19 points in the bright period and 19 to 7 in the dark period, and were individually housed in stainless steel cages at room temperature of 22 ± 2 °C.

使用固態飼料(Oriental酵母工業股份公司製)，預備飼養小鼠3~5天後，為了使其適應游泳運動，對小鼠提供30分鐘的游泳運動(水溫34℃)。適應游泳運動實施日的隔天開始至後天，使其絕食16小時後，將小鼠以每個試驗群不產生體重差之條件來分成9群(各試驗群各6~8隻)。之後，對小鼠提供2小時的游泳運動。游泳運動結束後，馬上使小鼠經口攝取24.24mL/kg體重之肌肉合成促進劑或乳蛋白6.8重量%之脫脂奶粉溶液(高用量脫脂奶粉溶液)。自經口攝取開始15分鐘後、或45分鐘後、或75分鐘後、或105分鐘後，將氘標誌***酸溶液(將氘標誌***酸225mg溶解於生理食鹽水10mL中所調製)以2.0mL/kg體重尾靜脈投予至小鼠。尾靜脈投予15分鐘後(亦即，自經口攝取30分鐘後、或60分鐘後、或90分鐘後、或120分鐘後)，在氟醚麻醉下將小鼠解剖。於腹部大靜脈全採血之後，將上肢三頭肌摘出，以生理食鹽.水洗淨後，直接以液態氮凍結。 正確地記錄尾靜脈投予的時間以及上肢三頭肌之凍結保存的時間。上肢三頭肌到分析時之前保存於-80℃。 Using a solid feed (Oriental Yeast Co., Ltd.), the mice were prepared to feed the mice for 3 to 5 days, and in order to adapt to swimming, the mice were provided with a swimming exercise for 30 minutes (water temperature 34 ° C). The day after the start of the swimming exercise day, the day after the eclipse, the rats were hunger-fasted for 16 hours, and the mice were divided into 9 groups (each of which was 6 to 8 each) under the condition that the test group did not produce a difference in body weight. After that, the mice were given 2 hours of swimming. Immediately after the end of the swimming exercise, the mice were orally administered a 24.24 mL/kg body weight muscle synthesis promoter or a milk protein 6.8% by weight skim milk powder solution (high-volume skim milk powder solution). 15 minutes after the oral ingestion, or after 45 minutes, or after 75 minutes, or after 105 minutes, the guanidine-labeled phenylalanine solution (prepared by dissolving 225 mg of phenylalanine in 10 mL of physiological saline) to 2.0 mL /kg body weight was administered to the tail vein. After 15 minutes of tail vein administration (i.e., 30 minutes after oral administration, or 60 minutes later, or 90 minutes later, or 120 minutes later), the mice were dissected under fluoroether anesthesia. After collecting blood from the abdomen and large veins, the upper limb triceps muscles are removed, washed with physiological salt and water, and directly frozen in liquid nitrogen. The time of tail vein administration and the time of frozen preservation of the upper limb triceps were correctly recorded. Upper limb triceps were stored at -80 °C until analysis.

(2)骨格肌合成速度(FSR)之測定 (2) Determination of the rate of synthesis of bone muscle (FSR)

基於先前文獻(A.Kanda et al.,Br J Nutr,Sep.28,981-987,2013)之記載，測定關於摘出並保存之上肢三頭肌的骨格肌合成速度(FSR)。具體來說，使用LC/MS/MS(Waters公司製)，分別定量同化成骨格肌細胞之蛋白質而存在之、或骨格肌細胞中以遊離狀態存在之***酸(Phe)以及氘標誌***酸(Phe(Ring-D5))的量。此測定條件如以下所述。亦即，裝置：LC/MS/MS(Waters公司製)，管柱：ACQUITY UPLC BEH C18(Waters公司製)，移動相：0.05%TFA水/0.05%含有TFA之乙腈，注入量3μL，流速0.3mL/min，UV 215nm。 Based on the description of the prior literature (A. Kanda et al., Br J Nutr, Sep. 28, 981-987, 2013), the rate of synovial muscle synthesis (FSR) with respect to the removal and preservation of the upper extremity triceps was determined. Specifically, LC/MS/MS (manufactured by Waters Co., Ltd.) was used to quantitatively quantify the protein which was formed into the skeletal muscle cells, or the phenylalanine (Phe) which is present in the free state of the skeletal muscle cells, and the oxime-labeled phenylalanine ( The amount of Phe (Ring-D5)). The measurement conditions are as follows. That is, the apparatus: LC/MS/MS (manufactured by Waters), column: ACQUITY UPLC BEH C18 (manufactured by Waters), mobile phase: 0.05% TFA water / 0.05% acetonitrile containing TFA, injection amount 3 μL, flow rate 0.3 mL/min, UV 215 nm.

於此，由以下之式，算出骨格肌合成速度(FSR)。 Here, the skeletal muscle synthesis rate (FSR) was calculated by the following formula.

FSR(%/day)=(Eb×100)/(Ea×t) FSR (%/day) = (Eb × 100) / (Ea × t)

Ea：增濃因數(骨格肌細胞中以遊離狀態存在) Ea: enrichment factor (exist in free state in skeletal muscle cells)

Eb：增濃因數(同化成骨格肌細胞之蛋白質而存在) Eb: enrichment factor (associated with the protein of the skeletal muscle cells)

t：自尾靜脈投予至凍結保存上肢三頭肌為止之時間(單位：天) t: time from the tail vein administration to the freezing and preservation of the upper limb triceps (unit: day)

增濃因數=Phe(Ring-D5)/(Phe+Phe(Ring-D5)) Concentration factor = Phe(Ring-D5)/(Phe+Phe(Ring-D5))

自所得之數值求出各試驗群之平均值±標準誤 差。統計處理是在各時間點(經口攝取後30分鐘或60分鐘或90分鐘或120分鐘)時，於肌肉合成促進劑群與脫脂奶粉溶液群之間進行Student之t檢定。有效位準是未滿5%(p<0.05)。將其結果表示於圖2。 Calculate the mean ± standard error of each test group from the obtained value difference. The statistical treatment was performed with Student's t-test between the muscle synthesis promoter group and the skim milk powder solution group at each time point (30 minutes or 60 minutes or 90 minutes or 120 minutes after oral ingestion). The effective level is less than 5% (p < 0.05). The result is shown in Fig. 2.

肌肉合成促進劑與高用量脫脂奶粉溶液表示同樣的骨格肌合成促進效果。活性本體之乳蛋白的攝取量，肌肉合成促進劑群為0.85g/kg體重，高用量脫脂奶粉溶液群為1.8g/kg體重，肌肉合成促進劑顯示以比脫脂奶粉溶液少的乳蛋白攝取量促進骨格肌合成。 The muscle synthesis promoter and the high-dose skim milk powder solution express the same effect of promoting bone synthesis. The intake of milk protein in the active body was 0.85 g/kg body weight of the muscle synthesis promoter group, 1.8 g/kg body weight of the high-mass skim milk powder solution group, and the muscle synthesis promoter showed less milk protein intake than the skim milk powder solution. Promote bone muscle synthesis.

〔試驗例3〕 [Test Example 3]

將人工胃液(含有胃蛋白酶0.6%，pH1.2)與肌肉合成促進劑混合成以重量比為(人工胃液)：(肌肉合成促進劑)=1：1.6，在37℃下保持10分鐘。此時，與人工胃液混合之肌肉合成促進劑中，來自肌肉合成促進劑的乳蛋白不會凝集。作為對照，將相同的試驗也進行使用試驗例1所使用之乳蛋白3.4重量%的脫脂奶粉溶液、試驗例2所使用之乳蛋白6.8重量%的脫脂奶粉溶液(高用量脫脂奶粉溶液)之試驗。將人工胃液(含有胃蛋白酶0.6%，pH1.2)與脫脂奶粉溶液混合成以重量比為(人工胃液)：(脫脂奶粉溶液)=1：1.6，在37℃下保持10分鐘。此時，與人工胃液混合之脫脂奶粉溶液中，來自脫脂奶粉溶液之乳蛋白皆凝集。 Artificial gastric juice (containing pepsin 0.6%, pH 1.2) was mixed with a muscle synthesis promoter to a weight ratio (artificial gastric juice): (muscle synthesis promoter) = 1:1.6, and kept at 37 ° C for 10 minutes. At this time, in the muscle synthesis promoter mixed with the artificial gastric juice, the milk protein derived from the muscle synthesis promoter does not aggregate. As a control, the same test was also carried out using the skim milk powder solution of 3.4% by weight of milk protein used in Test Example 1, and the 6.8% by weight of skim milk powder solution (high-volume skim milk powder solution) of milk protein used in Test Example 2. . The artificial gastric juice (containing pepsin 0.6%, pH 1.2) and the skim milk powder solution were mixed to a weight ratio (artificial gastric juice): (skimmed milk powder solution) = 1:1.6, and kept at 37 ° C for 10 minutes. At this time, the milk protein from the skim milk powder solution is agglomerated in the skim milk powder solution mixed with the artificial gastric juice.

由試驗例1~3觀察到，本發明之肌肉合成促 進劑相較於脫脂奶粉溶液，攝取(投予)後，由於胃內乳蛋白不會凝集(凝乳化)，之後在腸管內的乳蛋白吸收性較高，肌肉合成促進效果也提高。 It was observed from Test Examples 1 to 3 that the muscle synthesis of the present invention promoted Compared with the skim milk powder solution, the milk is not agglomerated (coagulated) in the stomach, and the milk protein absorption in the intestinal tract is higher, and the muscle synthesis promoting effect is also improved.

Claims (13)

一種肌肉合成促進劑，其係包含酸性液狀組成物作為有效成分而成之肌肉合成促進劑，該酸性液狀組成物包含：0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。 A muscle synthesis accelerator comprising a muscle liquid accelerator comprising an acidic liquid composition as an active ingredient, the acidic liquid composition comprising: 0.2 to 1.2% by weight of soybean polysaccharides, 0.1 to 0.5% by weight of HM Pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and a mixture of milk protein containing casein and whey protein, and protein ratio of casein relative to whey protein (casein/whey protein) It is 2~20. 如請求項1之肌肉合成促進劑，其中，酸性液狀組成物進一步包含0.5~5重量%之海藻糖而成。 The muscle synthesis promoter according to claim 1, wherein the acidic liquid composition further comprises 0.5 to 5% by weight of trehalose. 如請求項1或2之肌肉合成促進劑，其中，酸性液狀組成物之pH值為3~6。 The muscle synthesis promoter according to claim 1 or 2, wherein the acidic liquid composition has a pH of 3 to 6. 如請求項1至3中任1項之肌肉合成促進劑，其中，纖維狀的不溶性纖維素為發酵纖維素。 The muscle synthesis promoter according to any one of claims 1 to 3, wherein the fibrous insoluble cellulose is fermented cellulose. 如請求項1至4中任1項之肌肉合成促進劑，其中，酸性液狀組成物中所包含之乳蛋白混合物以總蛋白質量來說，每一餐攝取0.06~0.7g/kg體重。 The muscle synthesis promoter according to any one of claims 1 to 4, wherein the milk protein mixture contained in the acidic liquid composition has a total protein amount of 0.06 to 0.7 g/kg body weight per meal. 如請求項1至5中任1項之肌肉合成促進劑，其係以每一餐之單位包裝形態而成，該單位包裝形態中，包含每一餐攝取量以總蛋白質量來說為3~40g之乳蛋白混合物。 The muscle synthesis promoter according to any one of the items 1 to 5, which is obtained in the form of a unit package of each meal, wherein the unit package form includes the amount of each meal in terms of total protein amount of 3~ 40 g of milk protein mixture. 如請求項1至6中任1項之肌肉合成促進劑，其 係用於運動之對象。 A muscle synthesis promoter according to any one of claims 1 to 6, which It is used for moving objects. 如請求項7之肌肉合成促進劑，其中，運動為肌肉訓練。 The muscle synthesis promoter of claim 7, wherein the exercise is muscle training. 一種肌肉合成促進方法，其係包含使必須要促進肌肉合成之對象攝取酸性液狀組成物而成之肌肉合成促進方法，該酸性液狀組成物包含：0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。 A method for promoting muscle synthesis, which comprises a method for promoting muscle synthesis by ingesting an acidic liquid composition for a subject who is required to promote muscle synthesis, the acidic liquid composition comprising: 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 ~0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and a milk protein mixture comprising casein and whey protein, and protein ratio of casein relative to whey protein Protein/whey protein) is 2-20. 一種肌肉合成促進方法，其係包含使必須要促進肌肉合成之對象攝取酸性液狀組成物之肌肉合成促進方法(排除對人類的醫療行為)，該酸性液狀組成物包含：0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。 A method for promoting muscle synthesis, which comprises a method for promoting muscle synthesis (excluding medical behavior to humans) for ingesting an acidic liquid composition for a subject who is required to promote muscle synthesis, the acidic liquid composition comprising: 0.2 to 1.2% by weight Soy polysaccharides, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and milk protein mixture comprising casein and whey protein, and casein relative to whey protein The protein ratio (casein/whey protein) is 2-20. 一種使用，其係用來促進肌肉合成，且係包含酸性液狀組成物作為有效成分而成之肌肉合成促進劑之使用，該酸性液狀組成物包含： 0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。 A use for promoting muscle synthesis and comprising a muscle synthesis promoter comprising an acidic liquid composition as an active ingredient, the acidic liquid composition comprising: 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and a milk protein mixture comprising casein and whey protein, and relative to milk The protein ratio of casein of albumin (casein/whey protein) is 2-20. 一種使用，其係用於製造用來促進肌肉合成之食品或醫藥品，且係包含酸性液狀組成物作為有效成分而成之肌肉合成促進劑之使用，該酸性液狀組成物包含：0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20。 A use for use in the manufacture of a food or a pharmaceutical product for promoting muscle synthesis, and a muscle synthesis promoter comprising an acidic liquid composition as an active ingredient, the acidic liquid composition comprising: 0.2~ 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and a milk protein mixture comprising casein and whey protein, and relative to whey protein The protein content ratio of casein (casein/whey protein) is 2-20. 一種酸性液狀組成物，其係包含：0.2~1.2重量%之大豆多糖類、0.1~0.5重量%之HM果膠、0.01~0.1重量%之纖維狀的不溶性纖維素、以及包含酪蛋白與乳清蛋白之乳蛋白混合物之酸性液狀組成物，且相對於乳清蛋白之酪蛋白的蛋白質量比(酪蛋白/乳清蛋白)為2~20，並用來促進肌肉合成。 An acidic liquid composition comprising: 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of fibrous insoluble cellulose, and comprising casein and milk The acidic liquid composition of the albumin milk protein mixture and the protein ratio of casein (whey protein/whey protein) relative to whey protein is 2-20, and is used to promote muscle synthesis.
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