JP5162812B2 - 亜鉛含有経口投与用組成物 - Google Patents
亜鉛含有経口投与用組成物 Download PDFInfo
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- JP5162812B2 JP5162812B2 JP2005196924A JP2005196924A JP5162812B2 JP 5162812 B2 JP5162812 B2 JP 5162812B2 JP 2005196924 A JP2005196924 A JP 2005196924A JP 2005196924 A JP2005196924 A JP 2005196924A JP 5162812 B2 JP5162812 B2 JP 5162812B2
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- Prior art keywords
- zinc
- acid
- oral administration
- solution
- purified water
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- 239000000203 mixture Substances 0.000 title claims description 17
- 239000011701 zinc Substances 0.000 title description 9
- 229910052725 zinc Inorganic materials 0.000 title description 9
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- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 17
- 239000008213 purified water Substances 0.000 claims description 17
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- 239000011670 zinc gluconate Substances 0.000 claims description 7
- 235000011478 zinc gluconate Nutrition 0.000 claims description 7
- 229960000306 zinc gluconate Drugs 0.000 claims description 7
- 240000008042 Zea mays Species 0.000 claims description 5
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- 229940042585 tocopherol acetate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- IMADFOKPISWXKN-UHFFFAOYSA-K trisodium benzoic acid 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound C(CC(O)(C(=O)[O-])CC(=O)[O-])(=O)[O-].[Na+].C(C1=CC=CC=C1)(=O)O.[Na+].[Na+] IMADFOKPISWXKN-UHFFFAOYSA-K 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011667 zinc carbonate Substances 0.000 description 1
- 235000004416 zinc carbonate Nutrition 0.000 description 1
- 229910000010 zinc carbonate Inorganic materials 0.000 description 1
- 229940043825 zinc carbonate Drugs 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229960001939 zinc chloride Drugs 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 description 1
- 229910000165 zinc phosphate Inorganic materials 0.000 description 1
- 229940077935 zinc phosphate Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
Images
Landscapes
- General Preparation And Processing Of Foods (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Description
グルコン酸亜鉛 0.04g
コーンペプチド 1.00g
ポリグリセリン脂肪酸エステル 0.20g
酢酸トコフェロール 0.10g
硝酸チアミン 0.01g
リン酸リボフラビンナトリウム 0.01g
塩酸ピリドキシン 0.01g
アスコルビン酸 1.00g
アミノエチルスルホン酸 2.00g
キシリトール 4.00g
トレハロース 5.00g
エリスリトール 5.00g
クエン酸 0.80g
クエン酸ナトリウム 適量
安息香酸ナトリウム 0.06g
グリセリン 0.20g
ミックスフルーツフレーバー 0.10g
上記成分を精製水に溶解した後、pHを3.0に調整し、精製水を加えて全量を100mLとした。この液をろ紙でろ過し、滅菌装置を用いて、ろ液を80℃で25分間加熱滅菌した後、ガラス瓶に充填しキャップを施して内服液剤を得た。
グルコン酸亜鉛 0.08g
コラーゲンペプチド 1.00g
グルコン酸カルシウム 2.00g
アスパラギン酸マグネシウム 1.00g
硝酸チアミン 0.01g
リボフラビン 0.01g
塩酸ピリドキシン 0.10g
アスコルビン酸 1.00g
アミノエチルスルホン酸 1.00g
ソルビトール 4.00g
トレハロース 5.00g
キシリトール 4.00g
ステビア抽出物 0.03g
アセスルファムカリウム 0.03g
リンゴ酸 0.10g
クエン酸 0.40g
クエン酸ナトリウム 適量
安息香酸 0.06g
パラオキシ安息香酸ブチル 0.006g
パラオキシ安息香酸プロピル 0.006g
アップルフレーバー 0.10g
上記成分を精製水に溶解した後、pHを4.0に調整し、精製水を加えて全量を100mLとした。この液をろ紙でろ過し、滅菌装置を用いて、ろ液を80℃で25分間加熱滅菌した後、ガラス瓶に充填しキャップを施して内服液剤を得た。
グルコン酸亜鉛 0.08g
コーンペプチド 0.50g
ポリグリセリン脂肪酸エステル 0.20g
ポリオキシエチレン硬化ヒマシ油 0.10g
トリカプリリン 0.05g
グルコン酸カルシウム 0.80g
アスパラギン酸マグネシウム 0.40g
硝酸チアミン 0.01g
リン酸リボフラビンナトリウム 0.01g
塩酸ピリドキシン 0.01g
ニコチン酸アミド 0.10g
無水カフェイン 0.10g
アミノエチルスルホン酸 2.00g
塩化カルニチン 0.20g
アルギニン塩酸塩 0.20g
ヨクイニン流エキス 2.00mL
ブドウ糖 5.00g
難消化性デキストリン 4.00g
エリスリトール 5.00g
キシリトール 2.00g
ステビア抽出物 0.02g
アセスルファムカリウム 0.03g
スクラロース 0.05g
クエン酸 0.80g
クエン酸ナトリウム 適量
安息香酸ナトリウム 0.06g
パラオキシ安息香酸ブチル 0.006g
パラオキシ安息香酸プロピル 0.006g
グリセリン 0.20g
ミックスフルーツフレーバー 0.10g
上記成分を精製水に溶解した後、pHを3.5に調整し、精製水を加え全量を100mLとした。この液をろ紙でろ過し、滅菌装置を用いて、ろ液を80℃で25分間加熱滅菌した後、ガラス瓶に充填しキャップを施して内服液剤を得た。
グルコン酸亜鉛 0.01g
コーンペプチド 0.30g
ポリグリセリン脂肪酸エステル 0.20g
ポリオキシエチレン硬化ヒマシ油 0.10g
トリカプリリン 0.05g
乳酸カルシウム 0.30g
塩化マグネシウム 0.06g
クエン酸鉄アンモニウム 0.04g
硝酸チアミン 0.01g
リン酸リボフラビンナトリウム 0.02g
塩酸ピリドキシン 0.03g
ニコチン酸アミド 0.05g
無水カフェイン 0.10g
アミノエチルスルホン酸 2.00g
ヨクイニン流エキス 2.00mL
ローヤルゼリー 0.60g
ブドウ糖 5.00g
ソルビトール 5.00g
キシリトール 5.00g
ステビア抽出物 0.02g
アセスルファムカリウム 0.03g
クエン酸 0.80g
クエン酸ナトリウム 0.10g
リン酸 0.30g
塩酸 適量
安息香酸ナトリウム 0.06g
パラオキシ安息香酸ブチル 0.006g
パラオキシ安息香酸プロピル 0.006g
グリセリン 0.20g
ミックスフルーツフレーバー 0.10g
上記成分を精製水に溶解した後、pHを3.5に調整し、精製水を加え全量を100mLとした。この液をろ紙でろ過し、滅菌装置を用いて、ろ液を80℃で25分間加熱滅菌した後、ガラス瓶に充填しキャップを施して内服液剤を得た。
Hagermanらは、溶液中のタンパク(ウシ血清アルブミン:BSA)がタンニンにより凝集し、その沈澱量はタンニンの量に比例することを報告した(J.Agric.Food.Chem.,1978,Vol.26,809-812)。本発明者らは、亜鉛イオン溶液にBSA溶液を加えると、この溶液が懸濁し、吸光度が上昇すること、この吸光度の上昇が、亜鉛イオンの濃度に相関することを見出した。これは、ある物質を添加した亜鉛イオン溶液をBSA溶液に混合したときの吸光度が無添加の場合と比較して減少すると、その物質の添加により、タンパク−亜鉛イオン相互作用による凝集(収斂性)が減少したこと、すなわち収斂味が減少したことを意味すると考えられる。
(1)BSA溶液の調製:BSA(Sigma Chemical Co.;fraction V,fatty acid free)10gを適量の精製水に溶解し、クエン酸100mgを加え、NaOH溶液(1mol/L)でpHを4.8に調整し、精製水で100mLとした。
(2)希釈液の調製:クエン酸100mgを適量の水に溶解し、NaOH溶液(1mol/L)でpHを4.8に調整し、精製水で100mLとした。
(3)亜鉛イオン溶液の調製:グルコン酸亜鉛0.04g、0.19gおよび0.39gにクエン酸0.10gを加えた。それぞれを適量の精製水に溶解し、NaOH溶液(1mol/L)でpHを4.8に調整し、精製水で100mLとした。
(4)タンパク−亜鉛イオン相互作用(収斂性)の評価
各亜鉛イオン溶液2mLにBSA溶液6mLを加え、希釈液でそれぞれ全量を10mLとした。これを40℃で30分間振とうした。石英セル(L=1cm)を使用し、分光光度計(日立製作所製:U−3300)により、各透明溶液では吸収されない波長である500nmにおける吸光度を測定した。結果を(図1)に示す。
上記と同様の試験方法により、表1に示す処方のタンパク凝集性を評価した。
Claims (2)
- グルコン酸亜鉛、コラーゲンペプチドおよびコーンペプチドから選ばれる1種又は2種のペプチドを精製水で溶解した後、pHを調整し、残りの精製水を加えて、亜鉛イオン濃度が0.001〜0.05W/V%となるように調製した内服液剤であることを特徴とする経口投与用組成物。
- pHが2.5〜7.0である請求項1に記載の経口投与用組成物。
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JP4889782B2 (ja) | 2008-12-24 | 2012-03-07 | 株式会社マルハニチロ食品 | プロタミン及び/またはその塩と酸性高分子化合物とを含む生理活性複合体及びその用途 |
JP5636199B2 (ja) * | 2010-03-02 | 2014-12-03 | 三基商事株式会社 | アムラの渋味を低減する方法 |
SG10201609131YA (en) | 2016-11-01 | 2018-06-28 | Xylonix Ip Holdings Pte Ltd | Zinc-pga compositions and methods for treating cancer |
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US5059416A (en) * | 1989-06-26 | 1991-10-22 | Warner-Lambert Company | Zinc compound delivery system with improved taste and texture |
US4992259A (en) * | 1990-01-03 | 1991-02-12 | Johnson & Johnson Consumer Products, Inc. | Stable oral composition of zinc |
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