JP4147404B2 - 血漿量増加促進剤 - Google Patents
血漿量増加促進剤 Download PDFInfo
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- JP4147404B2 JP4147404B2 JP2003332955A JP2003332955A JP4147404B2 JP 4147404 B2 JP4147404 B2 JP 4147404B2 JP 2003332955 A JP2003332955 A JP 2003332955A JP 2003332955 A JP2003332955 A JP 2003332955A JP 4147404 B2 JP4147404 B2 JP 4147404B2
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- plasma volume
- weight
- volume increase
- protein
- plasma
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Description
高齢者では、本発明者が、18週間の持久性運動後の血漿蛋白総量と循環血漿量について測定したところ、それらはいずれも増加しなかった(第56回日本体力医学会(2001年9月20日)において学会発表)。同様に、Zappeらは、若年者は持久性トレーニング後に血漿蛋白総量とともに循環血漿量が増加するが、高齢者はいずれも増加しないことを報告している(非特許文献1参照)。また、Takamataらも同様に若年者は持久性トレーニング後に循環血漿量が増加するが、高齢者は増加しないことを報告している(非特許文献2参照)。
Zappe Dh et al.,'Age and regulation of fluid and electrolyte b alance during repeated exercise sessions', Am J Physiol. 1996 Jan;270(1 Pt 2): R71-9 Takamata A et al., 'Effect of an exercise-heat acclimation pro gram on body fluid regulatory responses to dehydration in older men' Am J Phys iol. 1999 Oct;277(4 Pt 2):R1041-R1050
pH3〜4で凝集しない蛋白質又はその加水分解物 3〜8重量%
カルシウム 0.1〜0.5重量%
酸味料 0.5〜3重量%
糖質 4〜20重量%
脂質 0〜5重量%
乳化剤 0〜0.5重量%
寒天 0.1〜1重量%
水 65〜90重量%。
蛋白質
ゲル状組成物においては、蛋白質を必須成分とする。蛋白質は、糖質および脂質と共に、三大栄養素の一つである。蛋白質は、本発明におけるゲル状組成物のpH、即ちpH3〜4の範囲において凝集しないものから選択される。
本発明のゲル状組成物においては、カルシウムを必須成分とする。カルシウムは、骨や歯を作り、血液のカルシウムレベルを正常に維持し、骨や歯の健康を維持する。また血液や心臓、筋肉などの機能を円滑に作用させる重要な栄養成分である。
本発明におけるゲル状組成物においては、pHを3〜4、好ましくは3.5〜4に調整するために、酸味料を配合する。
本発明のゲル状組成物においては、糖質を必須成分とする。糖質は三大栄養素の一つであり、肝臓や筋肉にグリコーゲンとして貯蔵され、運動時などにエネルギー源として消費される。
本発明のゲル状組成物には、脂質を含有してもよい。脂質は、例えば長期に亘る運動時などにおいて、前記糖質成分に代わってエネルギー源として消費される。
脂質は油性であり、水中に容易に溶解しないので、脂質をゲル状組成物に含有させる場合には、ゲル状組成物の調製にあたって、脂質を乳化させるための乳化剤を含有する。
本発明のゲル状組成物は、寒天を必須成分として含有する。
ゲル状組成物においては、更に必要に応じて、従来より食品分野でゲル化剤又は増粘剤として汎用されている各種の物質を、寒天と併用して配合することができる。ゲル化剤としては、例えばジェランガム、カラギーナン、ペクチン、ゼラチンなどを例示することができる。また、増粘剤としては、例えばファーセレラン、ローカストビーンガム、グアーガム、アラビアガム、キサンタンガムなどを例示することができる。
本発明のゲル状組成物においては、更にマスキング剤を含有することが好ましい。
ゲル状組成物においては、カルシウムの吸収を高めるために、更に、ビタミンDを配合することが好ましい。カルシウムとビタミンDを併用して配合することで、腸管カルシウム吸収促進作用や血中カルシウム濃度上昇作用などの有意な効果が示される。
本発明におけるゲル状組成物は、まず上記各成分の所定量を、加温下に所定量の水と混合して乳化し、次いで冷却することにより調製される。上記乳化は、すべての成分を同時に水中に投入した後、例えば撹拌などの若干の機械的操作を加えることによって行うことができる。また予め水溶性成分を水溶液形態に調製し、これに油溶性成分、乳化剤または油溶性成分と乳化剤との混合物を加えて同様に撹拌などの機械的操作を行う方法によっても行うことができる。より均質な乳化混合液を得るためには後者の方法によるのが好ましい。
本発明の血漿量増加促進剤は、上記ゲル状組成物を有効成分として含有するものであって、特定の成分の摂取と運動との相乗的な作用に基づくと考えられる血漿量増加作用を奏する。
本発明の血漿量増加促進剤は、上記のように製剤として提供されるだけでなく、食品に含有させて用いることができる。
ビタミンB1 0.01〜3.0mg
ビタミンB2 0.01〜3.1mg
ビタミンB6 0.01〜3.2mg
ビタミンB12 0.1〜30μg
ビタミンE 1〜100IU
ニコチン酸アミド 0.1〜30mg
パントテン酸カルシウム 0.1〜31mg
葉酸 0.01〜3.0mg
下記に示す各成分の所定量、およびその他の成分としてパイン果汁、総合ビタミン1及びパインフレーバーを、それぞれ適量水に投入し、混合撹拌して乳化させた後、80℃に昇温し、その200gをスパウチ(大日本印刷株式会社製)に充填し、80℃で10分間加熱殺菌後、冷却して、パウチ入りの血漿量増加促進剤含有ゲル状飲料を得た。
カルシウム :ミルクカルシウム0.4%(カルシウム分140mg%)
酸味料 :クエン酸0.5%、グルコン酸0.3%、リン酸0.4%
糖質 :砂糖10%、デキストリン2%
脂質 :大豆油0.3%
乳化剤 :グリセリン脂肪酸エステル0.02%
寒天 :0.3%
マスキング剤:果汁1.0%、還元難消化性デキストリン0.5%
ビタミンD :3.7×10-6%
(1)被験者
若年者8名(平均年齢21.1±1.0)と高齢者8名(平均年齢68.1±1.7)を対象とした。被験者の年齢、身長、体重、BMI値、最大酸素摂取量(VO2max)を表2に示す。
永島らの方法(Nagashima K et al.,Journal of Applied Physiology,2000Jan;88(1);p.41−46.)における運動負荷の方法を改良し、72分間の持久性運動を、自転車エルゴメーターを用いて行った。運動は80%Vo2 peak強度で4分間行う運動と20%Vo2 peak強度で5分間行う運動を合わせて1セットとし、合計8セット行った。
実験は、運動負荷終了直後(5−10分後)に、実施例1で作成した血漿量増加促進剤又はプラセボを摂取することを条件として行った。実験の詳細な工程は図1に示した通りである。
運動実施前日の夕食より運動実施翌日の朝食までを規定食とし、被験者は定められた時間に規定食を摂取した。また、被験者は、運動負荷終了2.5時間後から10分毎に16回に分けて間食を摂取した。規定食、間食、血漿量増加促進剤及びプラセボの総エネルギー量、タンパク質量は表3に示したとおりである。
運動負荷直前、運動負荷直後、さらに運動負荷終了後1−5時間の間に1時間毎、さらに運動負荷翌日となる23時間後に、被験者の採血を、計8回行った。採血した血液を遠心分離後、血漿量(PV)、血漿アルブミン含量(Alb content)、血漿総蛋白含量(TP content)を測定した。
(1)血漿量
運動開始前(図1のCの時点:1回目の採血)の血漿量を基準(0)とする、運動終了23時間後(8回目の採血)の血漿量(PV)の変化量を図2に示した。
運動開始前(図1のCの時点:1回目の採血)の血漿総蛋白含量を基準(0)とする、運動終了23時間後(8回目の採血)の血漿総蛋白含量(TP content)の変化量を図3に示した。
運動開始前(図1のCの時点:1回目の採血)の血漿アルブミン含量を基準(0)とする、運動終了23時間後(8回目の採血)の血漿アルブミン含量(Alb content)の変化量を図4に示した。
Claims (3)
- 下記各成分を含有し、pHの範囲が3〜4のゲル状組成物を有効成分とする血漿量増加促進剤:
ホエイ蛋白濃縮物、ホエイ蛋白単離物又は脱塩ホエイ、および数平均分子量が500〜10000であるゼラチンの加水分解物 3〜8重量%
カルシウム 0.1〜0.5重量%
酸味料 0.5〜3重量%
糖質 4〜20重量%
脂質 0〜5重量%
乳化剤 0〜0.5重量%
寒天 0.1〜1重量%
水 65〜90重量% - ゲル状組成物が、果汁、醗酵乳、難消化性デキストリン、還元難消化性デキストリン、ニゲロオリゴ糖及びトレハロースからなる群から選ばれる少なくとも1種のマスキング剤0.1〜20重量%を更に含有している請求項1に記載の血漿量増加促進剤。
- ゲル状組成物が、ビタミンD0.1×10-6〜10×10-6重量%を更に含有している請求項1又は2のいずれかに記載の血漿量増加促進剤。
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JP5162812B2 (ja) * | 2004-07-08 | 2013-03-13 | 大正製薬株式会社 | 亜鉛含有経口投与用組成物 |
JP4815798B2 (ja) * | 2004-12-17 | 2011-11-16 | 大正製薬株式会社 | 銅含有経口投与用組成物 |
SG11201601776WA (en) * | 2013-09-12 | 2016-04-28 | Meiji Co Ltd | Body fluid retaining agent |
CN108697125A (zh) * | 2016-02-23 | 2018-10-23 | 株式会社明治 | 水分补充用剂 |
JPWO2018124202A1 (ja) * | 2016-12-28 | 2019-10-31 | 株式会社明治 | 発汗促進用食品組成物 |
WO2018123873A1 (ja) * | 2016-12-28 | 2018-07-05 | 株式会社明治 | 発汗促進用組成物 |
JP2019123706A (ja) | 2018-01-11 | 2019-07-25 | 武田コンシューマーヘルスケア株式会社 | 経口ゲル状組成物 |
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