JP4972336B2 - Gip分泌抑制剤 - Google Patents
Gip分泌抑制剤 Download PDFInfo
- Publication number
- JP4972336B2 JP4972336B2 JP2006119048A JP2006119048A JP4972336B2 JP 4972336 B2 JP4972336 B2 JP 4972336B2 JP 2006119048 A JP2006119048 A JP 2006119048A JP 2006119048 A JP2006119048 A JP 2006119048A JP 4972336 B2 JP4972336 B2 JP 4972336B2
- Authority
- JP
- Japan
- Prior art keywords
- monoacylglycerol
- gip
- gip secretion
- acid
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 108010004460 Gastric Inhibitory Polypeptide Proteins 0.000 title claims description 31
- 230000028327 secretion Effects 0.000 title claims description 23
- 239000003112 inhibitor Substances 0.000 title claims description 10
- 150000002759 monoacylglycerols Chemical class 0.000 claims description 26
- 210000002784 stomach Anatomy 0.000 claims description 8
- 230000000291 postprandial effect Effects 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 2
- 102100039994 Gastric inhibitory polypeptide Human genes 0.000 description 28
- 235000013305 food Nutrition 0.000 description 14
- 150000004665 fatty acids Chemical class 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 9
- 239000008280 blood Substances 0.000 description 8
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- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 3
- MRPXYRDSKAJHTH-UHFFFAOYSA-N 3-bromo-5-methyl-2-phenyl-1h-pyrazolo[1,5-a]pyrimidin-7-one Chemical compound BrC=1C2=NC(C)=CC(=O)N2NC=1C1=CC=CC=C1 MRPXYRDSKAJHTH-UHFFFAOYSA-N 0.000 description 3
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- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 3
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- DUCVQOXJVCRDDH-UHFFFAOYSA-N (2-acetyloxy-3-hydroxypropyl) tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CO)OC(C)=O DUCVQOXJVCRDDH-UHFFFAOYSA-N 0.000 description 2
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- RXACEEPNTRHYBQ-UHFFFAOYSA-N 2-[[2-[[2-[(2-sulfanylacetyl)amino]acetyl]amino]acetyl]amino]acetic acid Chemical compound OC(=O)CNC(=O)CNC(=O)CNC(=O)CS RXACEEPNTRHYBQ-UHFFFAOYSA-N 0.000 description 2
- 102100024017 Glycerol-3-phosphate acyltransferase 3 Human genes 0.000 description 2
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- 102100024733 Reticulophagy regulator 2 Human genes 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 description 2
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 2
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- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
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- 239000008187 granular material Substances 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 239000000944 linseed oil Substances 0.000 description 2
- 235000021388 linseed oil Nutrition 0.000 description 2
- JQAACYUZYRBHGG-QHTZZOMLSA-L magnesium;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Mg+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 JQAACYUZYRBHGG-QHTZZOMLSA-L 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
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- 239000003549 soybean oil Substances 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 2
- 229940117972 triolein Drugs 0.000 description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 2
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 238000011891 EIA kit Methods 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 241000233805 Phoenix Species 0.000 description 1
- 241000218657 Picea Species 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 241000533293 Sesbania emerus Species 0.000 description 1
- 241001168730 Simo Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- -1 Sucrose ester Chemical class 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 235000019577 caloric intake Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 235000020186 condensed milk Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000030135 gastric motility Effects 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 239000003629 gastrointestinal hormone Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000009200 high fat diet Nutrition 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000013310 margarine Nutrition 0.000 description 1
- 239000003264 margarine Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Food Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Non-Alcoholic Beverages (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
しかしながら、モノアシルグリセロールとGIP分泌との関係については知られていなかった。
上記各剤中のモノアシルグリセロールの配合量は、全組成物中通常0.1質量%以上、好ましくは1質量%以上、さらに好ましくは5重量%以上である。
トリアシルグリセロール(TAG)としてトリオレイン、モノアシルグリセロール(MAG)として1−モノオレインを用い、下記の実験を行った。
マウス(C57BL/6J雄、8週令)を1群12または14匹とし、グルコース2mg/g体重のみ、及びさらにトリオレイン2mg/g体重を0.02mg/g体重卵黄レシチンにより乳化させたもの(それぞれグルコース,TAG1)、またはTAG1の乳化物にそれぞれ0.08,0.2,0.4mg/g体重の1−モノオレイン(それぞれMAG1,MAG2,MAG3)を添加したものを、ゾンデにより経口投与した。乳化物の組成を表1に示す。10分後、腹部大静脈より採血し、血中GIPを、ELISA法(Gastric Inhibitory Peptide EIA Kit, Phoenix Pharmaceutical Inc.)により測定した。乳化剤を投与しなかったマウスの血中GIP値を初期値と仮定して、10分後のマウス血中のGIP増加量を表2に示す。
製剤例
(1)コーヒー飲料
1−MAG 0.1 質量%
コーヒー豆 5.5 質量%
牛乳 7.0 質量%
砂糖 6.0 質量%
香料 若干量
重曹 (pH6.5に調整)
水 残分
(2)キャンデー
1−MAG 0.1 質量%
ショ糖エステル(乳化剤) 0.2 質量%
水飴 35 質量%
砂糖 35 質量%
小麦粉 5 質量%
練乳 17 質量%
ミルク 6 質量%
バター 2 質量%
香料 適量
Claims (2)
- モノアシルグリセロールを有効成分とする食後GIP分泌抑制剤。
- 胃もたれ改善のために使用される請求項1記載の食後GIP分泌抑制剤。
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006119048A JP4972336B2 (ja) | 2006-04-24 | 2006-04-24 | Gip分泌抑制剤 |
EP07737021A EP2011492B1 (en) | 2006-04-24 | 2007-04-04 | Gip secretion inhibitor |
US12/298,366 US20090192223A1 (en) | 2006-04-24 | 2007-04-04 | Gip secretion inhibitor |
PCT/JP2007/000364 WO2007122801A1 (ja) | 2006-04-24 | 2007-04-04 | Gip分泌抑制剤 |
CN2007800143766A CN101426491B (zh) | 2006-04-24 | 2007-04-04 | Gip分泌抑制剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006119048A JP4972336B2 (ja) | 2006-04-24 | 2006-04-24 | Gip分泌抑制剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007290989A JP2007290989A (ja) | 2007-11-08 |
JP4972336B2 true JP4972336B2 (ja) | 2012-07-11 |
Family
ID=38624720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006119048A Expired - Fee Related JP4972336B2 (ja) | 2006-04-24 | 2006-04-24 | Gip分泌抑制剤 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20090192223A1 (ja) |
EP (1) | EP2011492B1 (ja) |
JP (1) | JP4972336B2 (ja) |
CN (1) | CN101426491B (ja) |
WO (1) | WO2007122801A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8283338B2 (en) * | 2007-11-30 | 2012-10-09 | Kao Corporation | GIP secretion inhibitor |
JP2010222284A (ja) * | 2009-03-23 | 2010-10-07 | Kao Corp | 血中gip上昇抑制剤 |
JP5576694B2 (ja) * | 2009-04-10 | 2014-08-20 | 花王株式会社 | Gip上昇抑制剤 |
JP5317919B2 (ja) * | 2009-10-05 | 2013-10-16 | 花王株式会社 | Gip上昇抑制剤の評価又は選択方法 |
JP5328595B2 (ja) * | 2009-10-05 | 2013-10-30 | 花王株式会社 | Gip上昇抑制剤の評価又は選択方法 |
CN103260440B (zh) * | 2010-12-29 | 2017-03-29 | 雅培制药有限公司 | 包括含有甘油单酯的脂肪***的营养型产品 |
JP6026723B2 (ja) * | 2011-02-22 | 2016-11-16 | 花王株式会社 | Gip上昇抑制剤 |
JP5718293B2 (ja) * | 2011-09-15 | 2015-05-13 | 花王株式会社 | Gip上昇抑制剤 |
EP3569248B1 (en) | 2016-12-26 | 2023-12-06 | Kao Corporation | Gip inhibitors for improving cognitive function |
JP7165495B2 (ja) | 2016-12-26 | 2022-11-04 | 花王株式会社 | 運動調節機能向上剤 |
US20190330332A1 (en) | 2016-12-26 | 2019-10-31 | Kao Corporation | Hypothermia Ameliorating Agent |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05310567A (ja) * | 1992-05-07 | 1993-11-22 | Kao Corp | 血清トリグリセリド濃度低下剤 |
US5660842A (en) * | 1994-10-04 | 1997-08-26 | Bristol-Myers Squibb Company | Inhibition of helicobacter |
US6762203B2 (en) * | 1999-08-03 | 2004-07-13 | Kao Corporation | Oil composition |
JP2001064672A (ja) * | 1999-08-26 | 2001-03-13 | Kao Corp | 体脂肪燃焼促進剤 |
KR20020093150A (ko) | 2000-05-16 | 2002-12-13 | 가부시키가이샤산와카가쿠켄큐쇼 | 인슐린 저항성 및/또는 비만 예방제 혹은 개선제 |
JP5226912B2 (ja) * | 2000-06-12 | 2013-07-03 | 花王株式会社 | Ppar活性化剤 |
EP1430783B1 (en) * | 2000-08-08 | 2006-10-11 | Kao Corporation | Oil/fat composition |
BRPI0113105B1 (pt) * | 2000-08-08 | 2018-03-27 | Kao Corporation | Composição de óleo/gordura, alimento, ração e produto farmacêutico compreendendo dita composição e processo de preparação de uma composição de alimento compreendendo uma gordura ou óleo |
JP4031219B2 (ja) * | 2000-08-08 | 2008-01-09 | 花王株式会社 | 油脂組成物 |
JP4031218B2 (ja) * | 2000-08-08 | 2008-01-09 | 花王株式会社 | 油脂組成物 |
JP4381037B2 (ja) * | 2003-06-04 | 2009-12-09 | 花王株式会社 | 油脂組成物 |
JP4824347B2 (ja) * | 2005-06-08 | 2011-11-30 | 花王株式会社 | Gip分泌抑制剤 |
JP2006342085A (ja) * | 2005-06-08 | 2006-12-21 | Kao Corp | Gip分泌抑制剤 |
-
2006
- 2006-04-24 JP JP2006119048A patent/JP4972336B2/ja not_active Expired - Fee Related
-
2007
- 2007-04-04 EP EP07737021A patent/EP2011492B1/en active Active
- 2007-04-04 WO PCT/JP2007/000364 patent/WO2007122801A1/ja active Application Filing
- 2007-04-04 US US12/298,366 patent/US20090192223A1/en not_active Abandoned
- 2007-04-04 CN CN2007800143766A patent/CN101426491B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
US20090192223A1 (en) | 2009-07-30 |
WO2007122801A1 (ja) | 2007-11-01 |
EP2011492B1 (en) | 2012-10-03 |
CN101426491B (zh) | 2012-03-07 |
JP2007290989A (ja) | 2007-11-08 |
EP2011492A4 (en) | 2009-08-19 |
EP2011492A1 (en) | 2009-01-07 |
CN101426491A (zh) | 2009-05-06 |
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