JP4748912B2 - アルキルおよびアリールアラニンp2部分を含むc型肝炎ウイルスに対する大員環ns3−セリンプロテアーゼ阻害剤 - Google Patents
アルキルおよびアリールアラニンp2部分を含むc型肝炎ウイルスに対する大員環ns3−セリンプロテアーゼ阻害剤 Download PDFInfo
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- JP4748912B2 JP4748912B2 JP2001578418A JP2001578418A JP4748912B2 JP 4748912 B2 JP4748912 B2 JP 4748912B2 JP 2001578418 A JP2001578418 A JP 2001578418A JP 2001578418 A JP2001578418 A JP 2001578418A JP 4748912 B2 JP4748912 B2 JP 4748912B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19820400P | 2000-04-19 | 2000-04-19 | |
US60/198,204 | 2000-04-19 | ||
PCT/US2001/012530 WO2001081325A2 (en) | 2000-04-19 | 2001-04-17 | Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising alkyl and aryl alanine p2 moieties |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2003531199A JP2003531199A (ja) | 2003-10-21 |
JP2003531199A5 JP2003531199A5 (es) | 2008-02-28 |
JP4748912B2 true JP4748912B2 (ja) | 2011-08-17 |
Family
ID=22732422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001578418A Expired - Fee Related JP4748912B2 (ja) | 2000-04-19 | 2001-04-17 | アルキルおよびアリールアラニンp2部分を含むc型肝炎ウイルスに対する大員環ns3−セリンプロテアーゼ阻害剤 |
Country Status (22)
Country | Link |
---|---|
US (1) | US6914122B2 (es) |
EP (1) | EP1274724A2 (es) |
JP (1) | JP4748912B2 (es) |
KR (1) | KR20020097220A (es) |
CN (3) | CN1432022A (es) |
AR (1) | AR030558A1 (es) |
AU (1) | AU2001253621A1 (es) |
BR (1) | BR0110104A (es) |
CA (1) | CA2406532A1 (es) |
CZ (1) | CZ20023473A3 (es) |
HK (1) | HK1048479A1 (es) |
HU (1) | HUP0302957A2 (es) |
IL (1) | IL151935A0 (es) |
MX (1) | MXPA02010375A (es) |
NO (1) | NO20025030L (es) |
NZ (1) | NZ521456A (es) |
PE (1) | PE20011288A1 (es) |
PL (1) | PL358591A1 (es) |
RU (1) | RU2002131163A (es) |
SK (1) | SK14952002A3 (es) |
WO (1) | WO2001081325A2 (es) |
ZA (1) | ZA200208014B (es) |
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US7119072B2 (en) | 2002-01-30 | 2006-10-10 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis C virus |
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PE20011288A1 (es) | 2001-12-12 |
IL151935A0 (en) | 2003-04-10 |
HUP0302957A2 (hu) | 2003-12-29 |
KR20020097220A (ko) | 2002-12-31 |
CZ20023473A3 (cs) | 2003-01-15 |
JP2003531199A (ja) | 2003-10-21 |
US6914122B2 (en) | 2005-07-05 |
AR030558A1 (es) | 2003-08-27 |
NZ521456A (en) | 2004-07-30 |
BR0110104A (pt) | 2003-01-07 |
HK1048479A1 (zh) | 2003-04-04 |
WO2001081325A3 (en) | 2002-08-01 |
NO20025030L (no) | 2002-12-18 |
MXPA02010375A (es) | 2003-04-25 |
PL358591A1 (en) | 2004-08-09 |
CN1935833A (zh) | 2007-03-28 |
US20020016294A1 (en) | 2002-02-07 |
CA2406532A1 (en) | 2001-11-01 |
SK14952002A3 (sk) | 2003-03-04 |
EP1274724A2 (en) | 2003-01-15 |
ZA200208014B (en) | 2004-02-12 |
RU2002131163A (ru) | 2004-06-27 |
WO2001081325A2 (en) | 2001-11-01 |
AU2001253621A1 (en) | 2001-11-07 |
CN101580536A (zh) | 2009-11-18 |
NO20025030D0 (no) | 2002-10-18 |
CN1432022A (zh) | 2003-07-23 |
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