AU2001253621A1 - Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties - Google Patents

Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties

Info

Publication number
AU2001253621A1
AU2001253621A1 AU2001253621A AU5362101A AU2001253621A1 AU 2001253621 A1 AU2001253621 A1 AU 2001253621A1 AU 2001253621 A AU2001253621 A AU 2001253621A AU 5362101 A AU5362101 A AU 5362101A AU 2001253621 A1 AU2001253621 A1 AU 2001253621A1
Authority
AU
Australia
Prior art keywords
alkyl
aryl
mmol
compound
conhch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001253621A
Other languages
English (en)
Inventor
Ashok Arasappan
Tin-Yau Chan
Kevin X. Chen
Viyyoor M. Girijavallabhan
Vincent S. Madison
Brian A. Mckittrick
F. George Njoroge
Andrew J. Prongay
Srikanth Venkatraman
Nanhua Hugh Yao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AU2001253621A1 publication Critical patent/AU2001253621A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2001253621A 2000-04-19 2001-04-17 Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties Abandoned AU2001253621A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19820400P 2000-04-19 2000-04-19
US60/198,204 2000-04-19
PCT/US2001/012530 WO2001081325A2 (en) 2000-04-19 2001-04-17 Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising alkyl and aryl alanine p2 moieties

Publications (1)

Publication Number Publication Date
AU2001253621A1 true AU2001253621A1 (en) 2001-11-07

Family

ID=22732422

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001253621A Abandoned AU2001253621A1 (en) 2000-04-19 2001-04-17 Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties

Country Status (22)

Country Link
US (1) US6914122B2 (es)
EP (1) EP1274724A2 (es)
JP (1) JP4748912B2 (es)
KR (1) KR20020097220A (es)
CN (3) CN1432022A (es)
AR (1) AR030558A1 (es)
AU (1) AU2001253621A1 (es)
BR (1) BR0110104A (es)
CA (1) CA2406532A1 (es)
CZ (1) CZ20023473A3 (es)
HK (1) HK1048479A1 (es)
HU (1) HUP0302957A2 (es)
IL (1) IL151935A0 (es)
MX (1) MXPA02010375A (es)
NO (1) NO20025030L (es)
NZ (1) NZ521456A (es)
PE (1) PE20011288A1 (es)
PL (1) PL358591A1 (es)
RU (1) RU2002131163A (es)
SK (1) SK14952002A3 (es)
WO (1) WO2001081325A2 (es)
ZA (1) ZA200208014B (es)

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US6914122B2 (en) 2005-07-05
AR030558A1 (es) 2003-08-27
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