JP4653131B2 - 多糖類抗原−キャリア蛋白接合体および遊離キャリア蛋白を有してなるワクチン - Google Patents
多糖類抗原−キャリア蛋白接合体および遊離キャリア蛋白を有してなるワクチン Download PDFInfo
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- JP4653131B2 JP4653131B2 JP2007061946A JP2007061946A JP4653131B2 JP 4653131 B2 JP4653131 B2 JP 4653131B2 JP 2007061946 A JP2007061946 A JP 2007061946A JP 2007061946 A JP2007061946 A JP 2007061946A JP 4653131 B2 JP4653131 B2 JP 4653131B2
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- SYECJBOWSGTPLU-UHFFFAOYSA-N hexane-1,1-diamine Chemical compound CCCCCC(N)N SYECJBOWSGTPLU-UHFFFAOYSA-N 0.000 description 1
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- A61K39/092—Streptococcus
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- A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
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- A—HUMAN NECESSITIES
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- A61K39/02—Bacterial antigens
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2730/10011—Hepadnaviridae
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Description
QS21は南米の木キラヤサポナリアモリナの樹皮由来のサポニンのHp1c精製非毒性フラクションであり、その製造法はUS特許番号5057540に開示されている(QA21として)。
・フェノキシ−エタノール(静菌剤)含量を5mg/mlに調整する
・pHを6.1±0.1に調整する
・PRP濃度を最高100mcg/mlに調整する
・DTPaHBV(0.5ml)を0.1mlのPRP−CDAP−TT溶液に添加する。
・PRP'P 10mcg
・D 25Lf
・T 10Lf
・PT 25mcg
・FHA 25mcg
・69K 8mcg
・Hep B 10mcg
・Al(OH)3Behring 0.35mg
・Al(OH)3Superpos 0.15mg
・AlPO4Superpos 0.20mg
・NaCl 150mM
・2ΨEtOH 3mg(5mg/ml)
・pH 6.1±0.1
・体積 0.6ml
Claims (7)
- (a)キャリア蛋白に接合した、ストレプトコッカス・ニューモニアまたはナイセリア・メニンジチジスA、BまたはC由来の多糖類抗原と、
(b)遊離抗原としても存在するキャリア蛋白とを含む複合ワクチンであって、
接合体中の多糖類のキャリア蛋白に対する比が1:0.3ないし1:2(w/w)であり、キャリア蛋白が、ジフテリアトキソイドまたは破傷風トキソイドあるいはジフテリアまたは破傷風から由来の毒素の非毒性誘導体であることを特徴とする複合ワクチン。 - 多糖類:キャリア蛋白の比が1:0.5ないし1:1.5(w/w)である、請求項1に記載の複合ワクチン。
- さらに、ジフテリア、破傷風、および百日咳感染症に対して防御的な抗原を含む、請求項1または2に記載の複合ワクチン。
- さらにB型肝炎ウイルス由来の抗原を含む、請求項1ないし3のいずれか一項に記載の複合ワクチン。
- さらにA型肝炎ウイルス由来の抗原を含む、請求項1ないし4のいずれか一項に記載の複合ワクチン。
- さらにポリオに対する免疫力を提供する抗原を含む、請求項1ないし5のいずれか一項に記載の複合ワクチン。
- 付加的に適当なアジュバントを含む、請求項1ないし6のいずれか一項に記載の複合ワクチン。
Applications Claiming Priority (4)
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US47263995A | 1995-06-07 | 1995-06-07 | |
GBGB9512827.8A GB9512827D0 (en) | 1995-06-23 | 1995-06-23 | Vaccines |
GBGB9513443.3A GB9513443D0 (en) | 1995-07-01 | 1995-07-01 | Vaccines |
GBGB9525657.4A GB9525657D0 (en) | 1995-12-15 | 1995-12-15 | Vaccines |
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JP50014697A Division JP4233113B2 (ja) | 1995-06-07 | 1996-06-04 | 多糖類抗原−キャリア蛋白接合体および遊離キャリア蛋白を有してなるワクチン |
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JP2007061946A Expired - Lifetime JP4653131B2 (ja) | 1995-06-07 | 2007-03-12 | 多糖類抗原−キャリア蛋白接合体および遊離キャリア蛋白を有してなるワクチン |
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EP (2) | EP0831901B2 (ja) |
JP (2) | JP4233113B2 (ja) |
AT (2) | ATE400295T1 (ja) |
AU (1) | AU695720B2 (ja) |
BR (1) | BR9608612A (ja) |
CA (1) | CA2221511C (ja) |
CZ (1) | CZ390297A3 (ja) |
DE (2) | DE69615362T3 (ja) |
DK (1) | DK1090642T3 (ja) |
ES (2) | ES2164251T5 (ja) |
HU (1) | HUP9802199A3 (ja) |
IL (1) | IL122431A0 (ja) |
NO (1) | NO975555L (ja) |
NZ (1) | NZ311000A (ja) |
PT (1) | PT1090642E (ja) |
SI (1) | SI1090642T1 (ja) |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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