JP4584715B2 - 持続放出性医薬組成物 - Google Patents
持続放出性医薬組成物 Download PDFInfo
- Publication number
- JP4584715B2 JP4584715B2 JP2004545913A JP2004545913A JP4584715B2 JP 4584715 B2 JP4584715 B2 JP 4584715B2 JP 2004545913 A JP2004545913 A JP 2004545913A JP 2004545913 A JP2004545913 A JP 2004545913A JP 4584715 B2 JP4584715 B2 JP 4584715B2
- Authority
- JP
- Japan
- Prior art keywords
- cefquinome
- composition
- sustained release
- oil
- body weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- YWKJNRNSJKEFMK-PQFQYKRASA-N (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(5,6,7,8-tetrahydroquinolin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound N([C@@H]1C(N2C(=C(C[N+]=3C=4CCCCC=4C=CC=3)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 YWKJNRNSJKEFMK-PQFQYKRASA-N 0.000 claims description 86
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- 125000005456 glyceride group Chemical group 0.000 description 1
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229940102213 injectable suspension Drugs 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000008180 pharmaceutical surfactant Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- VILMUCRZVVVJCA-UHFFFAOYSA-M sodium glycolate Chemical compound [Na+].OCC([O-])=O VILMUCRZVVVJCA-UHFFFAOYSA-M 0.000 description 1
- 239000011973 solid acid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940071117 starch glycolate Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000001797 sucrose acetate isobutyrate Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000002132 β-lactam antibiotic Substances 0.000 description 1
- 229940124586 β-lactam antibiotics Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
1)油状賦形剤のみ[オレイン酸エチル(実施例6〜9)、ミグリオール(登録商標)(実施例9)]、
2)本発明のジステアリン酸アルミニウム以外の増粘剤(単独で、またはオイルと一緒に)[セルロースベースの賦形剤(実施例5〜8)、スターチグリコレートナトリウムベースの賦形剤(実施例8)]、
3)マイクロカプセル化/ミクロスフェア(実施例7)、
4)SABER(登録商標)デリバリーシステム(実施例10)
を含むセフキノムベース組成物の使用が含まれる。
(79.8%のセフキノムを含有する)硫酸セフキノム 9.4kg、
ジステアリン酸アルミニウムM 123 H6 3.0kg、
ミグリオール(登録商標)812 100Lまで。
1.ミグリオール(登録商標)812を130℃まで加熱する;
2.ミグリオール(登録商標)812中に連続撹拌しながらジステアリン酸アルミニウムを分散し、ジステアリン酸アルミニウムが完全に溶解するまで維持する;
3.混合物をホモジナイゼーション下で60℃に冷却する;
4.硫酸セフキノムをホモジナイゼーション下で添加する;
5.混合物をホモジナイゼーション下で25℃に冷却する。
0)Cobactan 2.5%−硫酸セフキノムをオレイン酸エチルに懸濁させたもの(基準製剤);
a)Z2/78 硫酸セフキノム(237.1mg)をオレイン酸エチル+ヒドロキシメチルセルロース(50mg)中に懸濁させたもの;
b)Z2/79 硫酸セフキノム(237.1mg)をオレイン酸エチル+スターチグリコレートナトリウム(300mg)中に懸濁させたもの;
c)Z2/80 ナフトエ酸セフキノム(271.2mg)をオレイン酸エチル+高粘度のヒドロキシメチルセルロース(50mg)中に懸濁させたもの;
d)Z2/81 ナフトエ酸セフキノム(271.2mg)をオレイン酸エチル+スターチグリコレートナトリウム(300mg)中に懸濁させたもの;
であった。
Claims (10)
- 持続放出性ビヒクルがオイルとジステアリン酸アルミニウムの混合物を含むことを特徴とする、セフキノム及び持続放出性ビヒクルを含む注射用医薬組成物。
- 1.0〜4.0重量%の量のジステアリン酸アルミニウムを含むことを特徴とする特許請求の範囲第1項に記載の組成物。
- 2.5〜3.5重量%の量のジステアリン酸アルミニウムを含むことを特徴とする特許請求の範囲第2項に記載の組成物。
- オイルが中鎖トリグリセリドまたは中鎖トリグリセリドの混合物であることを特徴とする特許請求の範囲第1項〜第3項のいずれかに記載の組成物。
- オイルがカプリン酸/カプリル酸トリグリセリドであることを特徴とする特許請求の範囲第4項に記載の組成物。
- 2.0〜20.0重量%のセフキノムを含むことを特徴とする特許請求の範囲第1項から第5項のいずれかに記載の組成物。
- 7.5〜10.0重量%のセフキノムを含むことを特徴とする特許請求の範囲第6項に記載の組成物。
- セフキノムが硫酸セフキノムであることを特徴とする特許請求の範囲第1項から第7項のいずれかに記載の組成物。
- オイル及びジステアリン酸アルミニウムを混合して持続放出性ビヒクルを作成するステップ及び前記持続放出性ビヒクル中にセフキノムを懸濁させるステップを含む特許請求の範囲第1項から第8項のいずれかに記載の医薬組成物の製造方法。
- 動物における伝染病の治療薬または予防薬の製造のためのオイルとジステアリン酸アルミニウムの混合物を含む持続放出性ビヒクル中のセフキノムの使用。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP02079477 | 2002-10-25 | ||
PCT/EP2003/011644 WO2004037265A1 (en) | 2002-10-25 | 2003-10-20 | Prolonged release pharmaceutical composition |
Publications (3)
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JP2006510607A JP2006510607A (ja) | 2006-03-30 |
JP2006510607A5 JP2006510607A5 (ja) | 2006-11-30 |
JP4584715B2 true JP4584715B2 (ja) | 2010-11-24 |
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JP2004545913A Expired - Lifetime JP4584715B2 (ja) | 2002-10-25 | 2003-10-20 | 持続放出性医薬組成物 |
Country Status (18)
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EP (1) | EP1558263B1 (ja) |
JP (1) | JP4584715B2 (ja) |
CN (1) | CN1326526C (ja) |
AR (1) | AR041713A1 (ja) |
AT (1) | ATE327759T1 (ja) |
AU (1) | AU2003279302B2 (ja) |
BR (2) | BR0315513A (ja) |
CA (1) | CA2501395C (ja) |
CO (1) | CO5700769A2 (ja) |
DE (1) | DE60305728T2 (ja) |
ES (1) | ES2265590T3 (ja) |
MX (1) | MXPA05004219A (ja) |
NO (1) | NO334158B1 (ja) |
NZ (1) | NZ539478A (ja) |
PL (1) | PL208585B1 (ja) |
PT (1) | PT1558263E (ja) |
WO (1) | WO2004037265A1 (ja) |
ZA (1) | ZA200502956B (ja) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2059231A1 (en) * | 2006-08-30 | 2009-05-20 | Intervet International BV | Pharmaceutical compositions comprising cefquinome |
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
EP2187932B1 (en) | 2007-08-07 | 2015-01-28 | DePuy Synthes Products, LLC | Protein formulations comprising gdf-5 in aqueous acidic solution |
CA2720845A1 (en) | 2008-04-14 | 2009-10-22 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered gdf-5 formulations |
AR077320A1 (es) * | 2009-07-20 | 2011-08-17 | Intervet Int Bv | Metodo para la preparacion de particulas de cefquinoma y formulaciones farmaceuticas que las comprenden. |
WO2012095438A1 (en) * | 2011-01-12 | 2012-07-19 | Intervet International B.V. | Particles and suspensions of cephalosporin antibiotics |
CA2823972C (en) * | 2011-01-12 | 2019-05-28 | Intervet International B.V. | Use of liquid medium exchange by cross flow filtration in the preparation of drug suspensions |
CN102319210B (zh) * | 2011-09-29 | 2013-05-01 | 武汉回盛生物科技有限公司 | 一种兽用长效硫酸头孢喹肟注射液及其制备方法 |
CN104546703B (zh) * | 2013-12-10 | 2017-06-23 | 中国农业科学院饲料研究所 | 一种奶牛泌乳期用硫酸头孢喹肟***注入剂及其制备方法 |
CN104000783B (zh) * | 2014-05-14 | 2017-12-05 | 河南牧翔动物药业有限公司 | 头孢喹肟脂质体 |
CN104873462B (zh) * | 2014-11-18 | 2017-04-05 | 中国农业科学院饲料研究所 | 一种奶牛干乳期用硫酸头孢喹肟***注入剂及其制备方法 |
CN107157927A (zh) * | 2017-05-31 | 2017-09-15 | 合肥中龙神力动物药业有限公司 | 动物用硫酸头孢喹肟注射液及其制备方法 |
CN109044970A (zh) * | 2018-11-08 | 2018-12-21 | 遂宁市中通实业集团动物药业有限公司 | 一种硫酸头孢喹肟注射液及其制备方法 |
CN113209014A (zh) * | 2020-01-21 | 2021-08-06 | 江西邦诚动物药业有限公司 | 长效硫酸头孢喹肟混悬注射液及其制备工艺 |
CN113952298B (zh) * | 2021-12-08 | 2023-02-17 | 江苏农牧科技职业学院 | 硫酸头孢喹肟纳米混悬液及其制备方法 |
CN117982413B (zh) * | 2024-04-03 | 2024-06-18 | 山东恒邦中科生物工程有限公司 | 一种硫酸头孢喹肟注射液的制备方法 |
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US3920819A (en) * | 1974-12-02 | 1975-11-18 | Lilly Co Eli | Nonaqueous vehicle for oral pharmaceutical suspensions |
IL59948A0 (en) * | 1979-05-21 | 1980-06-30 | Rech Applications Therap | Penicillanic acid derivatives,their production and pharmaceutical compositions containing them |
IE51846B1 (en) * | 1980-11-17 | 1987-04-15 | Leo Pharm Prod Ltd | Pharmaceutical preparation for veterinary use and an appliance containing it |
GB8531609D0 (en) * | 1985-12-23 | 1986-02-05 | Beecham Group Plc | Compounds |
JP3022692B2 (ja) * | 1992-10-13 | 2000-03-21 | 三菱マテリアル株式会社 | リーク検査装置 |
GB9306106D0 (en) * | 1993-03-24 | 1993-05-12 | Norbrook Lab Ltd | Sustained release veterinary composition |
DE4440141A1 (de) * | 1994-11-10 | 1996-05-15 | Hoechst Ag | Neue kristalline Cephem-Säureadditionssalze und Verfahren zu ihrer Herstellung |
GB9907916D0 (en) * | 1999-04-07 | 1999-06-02 | Takeda Chemical Industries Ltd | Long-acting antibacterial composition |
WO2003063877A1 (en) * | 2002-02-01 | 2003-08-07 | Akzo Nobel N.V. | Cefquinome composition for intra-mammary administration in cattle |
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PL208585B1 (pl) | 2011-05-31 |
AU2003279302B2 (en) | 2008-10-16 |
AR041713A1 (es) | 2005-05-26 |
NO20051654L (no) | 2005-05-24 |
CN1705483A (zh) | 2005-12-07 |
JP2006510607A (ja) | 2006-03-30 |
EP1558263A1 (en) | 2005-08-03 |
BRPI0315513B1 (pt) | 2017-11-28 |
CN1326526C (zh) | 2007-07-18 |
DE60305728D1 (de) | 2006-07-06 |
CO5700769A2 (es) | 2006-11-30 |
MXPA05004219A (es) | 2005-06-08 |
NO334158B1 (no) | 2013-12-23 |
PT1558263E (pt) | 2006-10-31 |
CA2501395A1 (en) | 2004-05-06 |
CA2501395C (en) | 2011-05-24 |
ATE327759T1 (de) | 2006-06-15 |
EP1558263B1 (en) | 2006-05-31 |
BR0315513A (pt) | 2005-08-23 |
ES2265590T3 (es) | 2007-02-16 |
PL376840A1 (pl) | 2006-01-09 |
WO2004037265A1 (en) | 2004-05-06 |
NZ539478A (en) | 2006-05-26 |
AU2003279302A1 (en) | 2004-05-13 |
DE60305728T2 (de) | 2006-10-12 |
ZA200502956B (en) | 2006-03-29 |
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