JP2022550095A - オンボーディング及び1日総インスリンの適応性 - Google Patents
オンボーディング及び1日総インスリンの適応性 Download PDFInfo
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Abstract
Description
この出願は、2019年9月27日に出願された“オンボーディング及び1日総インスリンの適応性”と題された米国特許出願第16/586、499号明細書の優先権を主張する。前述の出願の内容はその全体が参照により本明細書に援用される。
式1 TDIオンボーディング=2Σb(t)*(tb、終了-tb、開始)
ここで、TDIはそれぞれのポッドの1日総インスリン、IAはA日目に送達されるインスリン、IBはB日目に送達されるインスリン、及びICはC日目に送達されるインスリンである。
ここで、TDIはそれぞれのポッドの1日総インスリン、IDはD日目に送達されるインスリン、IEはE日目に送達されるインスリン、IFはF日目に送達されるインスリンであり、除数3は日数である。
ここで、TDIはそれぞれのポッドに対する1日総インスリンであり、IGはG日目に送達されるインスリンの平均に等しい。
ここで、TDIはそれぞれのポッドの1日総インスリン、IHはH日目に送達されるインスリン、及びIIはI日目に送達されるインスリンである。
Claims (20)
- プロセッサによって実行可能なプログラミング・コードで具体化される非一時的なコンピュータ可読媒体であって、前記プログラミング・コードを実行するとき、前記プロセッサは機能を実行するよう作動して、
ユーザーに関連するインスリン送達履歴の部分を取得し、
前記インスリン送達履歴の前記部分が充分要件を満たすかどうかを判断し、
前記インスリン送達履歴が前記充分要件を満たすという決定に応じて、一定期間に亘って送達されるインスリンの量に対する制限として安全性上限を選択し、前記選択された安全性上限は、安全性下限に関連するインスリンの量を越えるインスリンの量であり、
前記安全性上限を下回る薬物送達デバイスによって送達されるインスリンの量を設定し、及び
前記設定されたインスリンの量によるインスリンの量の送達を開始する機能を含む、非一時的なコンピュータ可読媒体。 - 前記プロセッサによって実行可能なプログラミング・コードでさらに具体化され、前記プログラミング・コードを実行するとき、前記プロセッサは、前記インスリン送達履歴の前記部分が充分要件を満たすかどうかを判断するよう作動して、
所定の基準について前記インスリン送達履歴の前記取得された部分を分析し、
前記分析の結果に基づいて、前記インスリン送達履歴が、以前の日数内にある連続した期間内のデータの合計時間数を満足させる前記充分要件を満たすことを確認し、及び
前記インスリン送達履歴が前記充分要件を満たすことの確認を示す確認信号を生成するさらなる機能を実行する、請求項1に記載の非一時的なコンピュータ可読媒体。 - 前記プロセッサによって実行可能なプログラミング・コードでさらに具体化され、前記プログラミング・コードを実行するとき、前記プロセッサは、
更新されたインスリン送達履歴から、前記薬物送達デバイスによって送達されるインスリンの量に関連する新しい情報を取得し、
適応モードがアクティブであることを決定し、
前記適応モードがアクティブであるという前記決定に応じて、以前に設定された1日総インスリン投薬量と前記更新されたインスリン送達履歴に基づくインスリン投与量の1日平均の加重和で1日総インスリン投薬量を設定し、及び
ウェアラブル薬物送達デバイスで受信するために、前記設定された1日総インスリン投薬量を送信するさらなる機能を実行するよう作動する、請求項1に記載の非一時的なコンピュータ可読媒体。 - 前記プロセッサによって実行可能なプログラミング・コードでさらに具体化され、前記プログラミング・コードを実行するとき、前記プロセッサは、
インスリン送達が所定の最後のインスリン送達期間内に行われたかどうかを判断し、及び
前記インスリン送達が前記所定の最後のインスリン送達期間内に行われたという決定に応じて、前記選択された安全性限界の設定を前記薬物送達デバイスに送信するさらなる機能を実行するよう作動する、請求項3に記載の非一時的なコンピュータ可読媒体。 - 前記プロセッサによって実行可能なプログラミング・コードでさらに具体化され、前記プログラミング・コードを実行するとき、前記プロセッサは、
前記薬物送達デバイスが、所定の最後のインスリン送達期間内にインスリン送達を行ったかどうかを判断し、及び
前記薬物送達デバイスが前記所定の最後のインスリン送達期間内にインスリン送達を行わなかったという決定に応じて、前記設定された1日総インスリン投薬量の割合に等しい開始インスリン搭載設定を確立するさらなる機能を実行するよう作動する、請求項3に記載の非一時的なコンピュータ可読媒体。 - 前記プロセッサによって実行可能なさらなるプログラミング・コードでさらに具体化され、前記さらなるプログラミング・コードを実行するとき、前記プロセッサはさらなる機能を実行するよう作動して、
更新されたインスリン送達履歴から、前記薬物送達デバイスによって送達されるインスリンの量に関連する新しい情報を取得し、
適応モードが非アクティブであると決定し、
前記適応モードが非アクティブであるとの決定に応じて、前記取得された新しい情報に基づいて、1日総インスリン投薬量を1日平均に設定し、
前記適応モードをアクティブに設定し、及び
前記設定された総インスリン投薬量を前記薬物送達デバイスに提供する機能を含む、請求項1に記載の非一時的なコンピュータ可読媒体。 - 前記プロセッサによって実行可能なプログラミング・コードでさらに具体化され、前記プログラミング・コードを実行するとき、前記プロセッサは、
前記薬物送達デバイスが、所定の最後のインスリン送達期間内にインスリン送達を行ったかどうかを判断し、及び
前記薬物送達デバイスが前記所定の最後のインスリン送達期間内にインスリン送達を行ったという決定に応じて、前記選択された安全性限界の設定を前記薬物送達デバイスに送信するさらなる機能を実行するよう作動する、請求項6に記載の非一時的なコンピュータ可読媒体。 - 前記プロセッサによって実行可能なプログラミング・コードでさらに具体化され、前記プログラミング・コードを実行するとき、前記プロセッサは、
前記薬物送達デバイスが、所定の最後のインスリン送達期間内にインスリン送達を行ったかどうかを判断し、及び
前記薬物送達デバイスが前記所定の最後のインスリン送達期間内にインスリン送達を行わなかったという決定に応じて、前記設定された1日総インスリン投薬量の割合に等しい開始インスリン搭載設定を確立するさらなる機能を実行するよう作動する、請求項6に記載の非一時的なコンピュータ可読媒体。 - 前記プロセッサによって実行可能なプログラミング・コードでさらに具体化され、前記インスリン送達履歴の前記部分が充分要件を満たすかどうかを判断するための前記プログラミング・コードを実行するとき、前記プロセッサは、
前記インスリン送達履歴の前記部分が前記充分要件を満たしていないことを決定し、
前記インスリン送達履歴が前記充分要件を満たしていないという決定に応じて、一定期間の間送達されるインスリンの量に対して安全性下限を選択し、前記選択された安全性下限は前記選択された安全性上限よりも低く、前記薬物送達デバイスによって送達されるインスリンの最小量を越えている、及び
前記ウェアラブル薬物送達デバイスによって送達される前記インスリンの量を前記選択された安全性下限以下に制限するよう作動する、請求項1に記載の非一時的なコンピュータ可読媒体。 - 前記プロセッサによって実行可能なプログラミング・コードでさらに具体化され、前記プログラミング・コードを実行するとき、前記プロセッサは、
前記安全性下限を、基礎インスリン制限設定に適用される乗数に等しいインスリン・レベルに設定するようさらに作動して、前記期間は1日である、請求項9に記載の非一時的なコンピュータ可読媒体。 - 前記プロセッサによって実行可能なプログラミング・コードでさらに具体化され、前記プログラミング・コードを実行するとき、前記プロセッサは、
適応モードが非アクティブであるという表示を提供するようさらに作動する、請求項9に記載の非一時的なコンピュータ可読媒体。 - 前記プロセッサによって実行可能なプログラミング・コードでさらに具体化され、前記プログラミング・コードを実行するとき、前記プロセッサは機能を実行するよう作動し、前記インスリン送達履歴が充分であるかどうかを判断するとき、
前記インスリン送達履歴のデータが約54時間の連続した期間に亘って約6時間を越えるギャップなしに合計約48時間にわたり、及び
約30日間より古くないことを決定する機能を含む、請求項5に記載の非一時的なコンピュータ可読媒体。 - プロセッサと、
前記プロセッサに通信可能に結合され、プログラミング・コード、人工膵臓アプリケーション、オンボーディング・アプリケーション・コード、適応アプリケーション・コード、及び前記人工膵臓アプリケーション、前記オンボーディング・アプリケーション・コード、又は前記適応アプリケーション・コードに関連するデータを格納するよう作動するメモリと、
前記プログラミング・コード、前記人工膵臓アプリケーション、前記オンボーディング・アプリケーション・コード、及び前記適応アプリケーション・コードは、前記プロセッサによって実行可能であり、
前記プロセッサに通信可能に結合され、前記人工膵臓アプリケーション、前記オンボーディング・アプリケーション・コード、及び前記適応アプリケーション・コードによって使用可能な又は生成される情報を含む信号を送受信し、信号をウェアラブル薬物送達デバイスと交換するよう作動するトランシーバとを備え、
前記人工膵臓アプリケーション、前記オンボーディング・アプリケーション・コード、又は前記適応アプリケーション・コードを実行するとき、前記プロセッサはインスリンの送達を制御し、機能を実行するよう作動し、
ユーザーに関連するインスリン送達履歴の部分を取得し、前記インスリン送達履歴が前記ユーザーに投与されるいくらかのインスリン送達投薬量ごとに送達されるインスリンの量を含み、
前記インスリン送達履歴の前記部分がインスリン履歴の充分要件を満たすかどうかを判断し、
前記インスリン送達履歴が前記インスリン履歴の充分要件を満たすという決定に応じて、初期の1日総インスリン値を設定し、及び
前記ウェアラブル薬物送達デバイスで受信するために、前記初期の1日総インスリン値を送信する機能を含む、デバイス。 - 前記プロセッサは血糖センサーに通信可能に結合され、前記プロセッサは、
前記血糖センサーから複数の血糖測定値を受信し、それぞれの血糖測定値は、一定期間に亘って所定の時間間隔で受信され、
前記受信された複数の血糖測定値に基づいて前記初期の1日総インスリン値を変更し、適合された1日総インスリン値を生成し、及び
前記適合された1日総インスリン値を使用して、前記ウェアラブル薬物送達デバイスの動作を実行するようさらに作動する、請求項13に記載のデバイス。 - 前記プロセッサは、
前記ウェアラブル薬物送達デバイスが交換用ウェアラブル薬物送達デバイスと交換されているという表示を受信し、
前記交換されているウェアラブル薬物送達デバイスの動作の間に収集される更新されたインスリン送達履歴データを取得し、及び
前記取得されたインスリン送達履歴に基づいて、パラメーターの合計に基づいて前記交換用ウェアラブル薬物送達デバイスによって送達される1日総インスリンを設定するようさらに作動し、前記パラメーターは、前記ウェアラブル薬物送達デバイスに設定される1日総インスリン、及び前記交換されているウェアラブル薬物送達デバイスのライフサイクルの間に送達されるインスリンの量に対応し、重みは各パラメーターに適用される、請求項13に記載のデバイス。 - 前記プロセッサは、
パラメーターに適用される前記重みの値は、前記更新されたインスリン送達履歴の長さに基づくことを決定するようさらに作動し、各パラメーターに適用される前記重みの前記値は1未満である、請求項15に記載のデバイス。 - 前記プロセッサは、
前記ウェアラブル薬物送達デバイスから警報信号を受信するようさらに作動し、前記警報信号は前記ウェアラブル薬物送達デバイスの誤動作を示す、請求項13に記載のデバイス。 - 前記プロセッサに通信可能に結合されるタッチスクリーン・ディスプレイ・デバイスと、
前記プロセッサによって生成され、前記タッチスクリーン・ディスプレイ・デバイスに提示されるユーザー・インターフェースとをさらに備え、
前記プロセッサは、前記タッチスクリーン・ディスプレイ・デバイス及び前記ユーザー・インターフェースを介して、基礎インスリン投薬量を示す入力を受信するよう作動する、請求項13に記載のデバイス。 - 前記プロセッサは、
前記ウェアラブル薬物送達デバイスによって一定期間に亘って自動的に送達されるインスリン投与量の数の計算を維持し、
前記ウェアラブル薬物送達デバイスによって一定期間に亘って送達されるユーザー入力インスリン投与量の数の計算を維持し、
送達されるユーザー入力インスリン投与量の前記数に対する自動的に送達されたインスリン投与量の割合に基づいて、加重信頼度を生成し、及び
ユーザーが要求したインスリン送達と比較して、自動送達のより高い割合の日中の間により高い重みを前記インスリン送達に割り当てるようさらに作動する、請求項13に記載のデバイス。 - 前記プロセッサは、
前記ウェアラブル薬物送達デバイスによって投与される1日総インスリンの量をユーザーの基礎インスリン投薬量の倍数に制限するようさらに作動し、
1番目の乗数は、前記プロセッサが前記インスリン送達履歴は充分であると決定する場合に選択され、及び
2番目の乗数は、前記プロセッサが前記インスリン送達履歴は不充分であると決定する場合に選択される、請求項13に記載のデバイス。
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