JP2020530551A - Gmrによるバイオマーカの検出におけるサンプル調整のためのシステムおよび方法 - Google Patents
Gmrによるバイオマーカの検出におけるサンプル調整のためのシステムおよび方法 Download PDFInfo
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Abstract
Description
本出願は、米国特許仮出願第62/711,396号(出願日:2018年7月27日)に基づく優先権を主張するものであり、この米国特許出願の開示は、参照により全体として本明細書に組み込まれる。
Claims (27)
- 検査サンプルを準備し当該検査サンプル中の被検物質をセンサを使用して検出するカートリッジアセンブリであって、
前記カートリッジアセンブリはサンプル処理カードを備え、
前記サンプル処理カードは、
前記カードの本体内に前記検査サンプルを受け取るための注入ポートと、
前記検査サンプルを受容するための少なくとも1つの計量チャンバと、
1つまたは複数の混合材料を前記少なくとも1つの計量チャンバに導入するための混合材料源と、
前記注入ポートおよび前記混合材料源を前記少なくとも1つの計量チャンバに流体接続する流体連通チャネルと、
前記検査サンプルおよび前記1つまたは複数の混合材料を前記センサに送達するべく、前記少なくとも1つの計量チャンバに流体接続された少なくとも1つの出力ポートと、
前記サンプル処理カードに取り付けられた基板と、を備え、
前記基板は、
前記検査サンプル中の被検物質を検出し、前記少なくとも1つの出力ポートを介して前記検査サンプルおよび前記1つまたは複数の混合材料を受け取るように構成されているセンサと、
読み取り機との電気接続を確立するように構成された電気接点部と、
前記サンプル処理カード内の前記検査サンプルの処理に関する情報を格納するためのメモリチップと、に関連付けられており、
前記カートリッジアセンブリは、空気圧インターフェースを更に備え、前記空気圧インターフェースは、少なくとも1つの空気圧制御ポートと、前記サンプル処理カードの前記少なくとも1つの計量チャンバに流体接続された対応する連通チャネルとを備え、前記空気圧インターフェースは、前記読み取り機のオフボード空気圧システムに接続するように構成されており、
前記空気圧インターフェースは、前記サンプル処理カードへ正圧および負圧の加圧流体を適用することにより、前記連通チャネル内および前記センサへと前記検査サンプルおよび前記1つまたは複数の混合材料を移動させるように構成されており、前記メモリチップは、少なくとも前記検査サンプルを前記サンプル処理カードから前記センサへと送達させるべく、前記空気圧インターフェースに選択的に圧力を印加するための工程および設定を含む空気圧系統プロトコルを格納する、カートリッジアセンブリ。 - 前記サンプル処理カードは更に、1つまたは複数の廃棄物チャンバを備え、
前記1つまたは複数の廃棄物チャンバは、1つまたは複数の連通チャネルを介して、前記少なくとも1つの計量チャンバもしくは前記センサからの入力ポートまたはその両方に流体接続されている、請求項1に記載のカートリッジアセンブリ。 - 前記サンプル処理カードは更に、前記少なくとも1つの計量チャンバに流体接続されたガス透過性膜を備え、
前記ガス透過性膜は、大気を受け取り、前記サンプル処理カードへと当該大気を送達するように構成されている、請求項1または請求項2に記載のカートリッジアセンブリ。 - 前記サンプル処理カードは、前記検査サンプルと前記1つまたは複数の混合材料とを実質的に均質な混合物へと混合するための少なくとも1つの混合チャネルを更に備え、
前記混合チャネルは、前記少なくとも1つの計量チャンバに選択的に接続され、前記少なくとも1つの出力ポートを介して前記実質的に均質な混合物を前記センサへと送達するように構成される、請求項1から請求項3の何れか一項に記載のカートリッジアセンブリ。 - 前記少なくとも1つの混合チャネルは、前記サンプル処理カードの縦軸に対して階段状の構成を含む、請求項4に記載のカートリッジアセンブリ。
- 前記サンプル処理カードは、ベントポートを更に備え、
前記ベントポートは大気に開放されて、前記サンプル処理カードから空気を排気するように構成されている、請求項1から請求項5の何れか一項に記載のカートリッジアセンブリ。 - 前記サンプル処理カードは、前記注入ポートに注入された前記検査サンプルをろ過するためのろ過膜を更に備える、請求項1から請求項6の何れか一項に記載のカートリッジアセンブリ。
- 前記混合材料源は、ブリスターパック、貯蔵チャンバ、カートリッジおよびウェルのうちの1つまたは複数である、請求項1から請求項7の何れか一項に記載のカートリッジアセンブリ。
- 前記1つまたは複数の混合材料は、試薬、緩衝液およびビーズ溶液のうちの1つまたは複数を含む、請求項1から請求項8の何れか一項に記載のカートリッジアセンブリ。
- 前記サンプル処理カードは、複数のバルブを更に備え、前記複数のバルブは前記サンプル処理カード内の前記連通チャネルに接続され、前記複数のバルブのそれぞれが開位置と閉位置との間で動くように構成されることにより、接続された連通チャネルへの流体連通が開閉される、請求項1から請求項9の何れか一項に記載のカートリッジアセンブリ。
- 前記複数のバルブのそれぞれは、前記開位置と前記閉位置との間で動くように構成されたエラストマー撓み部分を有する、請求項10に記載のカートリッジアセンブリ。
- 前記空気圧インターフェースは、前記複数のバルブのうちの1つまたは複数に加圧空気を送達し当該1つまたは複数のバルブを開位置と閉位置との間で動かすように構成される1つまたは複数のバルブ制御ポートを更に備える、請求項10に記載のカートリッジアセンブリ。
- 前記センサは、巨大磁気抵抗(GMR)センサを含む、請求項1から請求項12の何れか一項に記載のカートリッジアセンブリ。
- 前記基板は、前記読み取り機との電気接続が確立されると、前記センサ、前記電気接点パッドおよびメモリチップ間の通信を確立するように構成されたプリント回路基板を含む、請求項1から請求項13の何れか一項に記載のカートリッジアセンブリ。
- 前記基板は、前記サンプル処理カードに貼り付けられた積層体を含む、請求項1から請求項14の何れか一項に記載のカートリッジアセンブリ。
- 前記空気圧インターフェースは、前記サンプル処理カード上に設けられる、請求項1から請求項15の何れか一項に記載のカートリッジアセンブリ。
- 前記少なくとも1つの空気圧制御ポートは、前記サンプル処理カードの上面に設けられる、請求項15に記載のカートリッジアセンブリ。
- 前記カートリッジアセンブリと前記読み取り機との位置合わせのための位置合わせ装置を更に備える、請求項1から請求項17の何れか一項に記載のカートリッジアセンブリ。
- 前記混合チャネルに接続される蛇行チャネルを更に備える、請求項4に記載のカートリッジアセンブリ。
- 前記サンプル処理カードは複数の層を含み、前記少なくとも1つの計量チャンバおよび前記混合材料源は、同じ層上に設けられる、請求項1から請求項19の何れか一項に記載のカートリッジアセンブリ。
- 前記サンプル処理カードは複数の層を含み、前記少なくとも1つの計量チャンバは、前記混合材料源が設けられる層とは別個の層上に設けられる、請求項1から請求項20の何れか一項に記載のカートリッジアセンブリ。
- 前記サンプル処理カードは複数の層を含み、前記少なくとも1つの計量チャンバは、前記1つまたは複数の廃棄物チャンバが設けられる層とは別個の層上に設けられる、請求項2から請求項18の何れか一項に記載のカートリッジアセンブリ。
- 前記サンプル処理カードは複数の層を含み、前記少なくとも1つの計量チャンバおよび前記ろ過膜は、同じ層上に設けられる、請求項7から請求項18の何れか一項に記載のカートリッジアセンブリ。
- 前記サンプル処理カードは複数の層を含み、前記少なくとも1つの計量チャンバおよび前記複数のバルブは、同じ層上に設けられる、請求項10および請求項13から請求項18の何れか一項に記載のカートリッジアセンブリ。
- 前記サンプル処理カードは複数の層を含み、前記1つまたは複数の廃棄物チャンバおよび前記複数のバルブは、同じ層上に設けられる、請求項2から請求項23の何れか一項に記載のカートリッジアセンブリ。
- 前記基板上に設けられた加熱器を更に備える、請求項1から請求項25の何れか一項に記載のカートリッジアセンブリ。
- 請求項1に記載のカートリッジアセンブリを使用する方法であって、
前記方法は、
前記注入ポートに前記検査サンプルを注入する工程と、
前記読み取り機との前記電気的接続を確立する工程と、
前記オフボード空気圧系統を使用して前記空気圧インターフェースに加圧空気を選択的に印加し、前記検査サンプルおよび前記1つまたは複数の混合材料を前記連通チャネル内で移動させて前記センサへと供給する工程と、を備える方法。
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