JP4756868B2 - 検出方法 - Google Patents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/0656—Investigating concentration of particle suspensions using electric, e.g. electrostatic methods or magnetic methods
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
- G01R33/06—Measuring direction or magnitude of magnetic fields or magnetic flux using galvano-magnetic devices
- G01R33/09—Magnetoresistive devices
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- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
- G01R33/06—Measuring direction or magnitude of magnetic fields or magnetic flux using galvano-magnetic devices
- G01R33/09—Magnetoresistive devices
- G01R33/093—Magnetoresistive devices using multilayer structures, e.g. giant magnetoresistance sensors
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Description
D. L. Graham, et al. Biosensors & Bioelectronics 18, 483 (2003)
また、本発明にかかる検出方法は、膜面垂直方向に電流を流すことによって磁化方向が変化する磁性膜である検出層と、前記電流によって磁化方向が変化しない磁性膜である磁化固定層と、前記検出層と前記磁化固定層との間に形成される非磁性層とを含む磁気抵抗効果膜を有する磁性体センサを用いた検出方法であって、前記磁気抵抗効果膜に電流を流し、前記検出層の磁化状態を変化させることにより、前記磁気抵抗効果膜の抵抗値の変化を検出して、磁性体の有無あるいは磁性体の個数を検出することを特徴とする。
本発明の標的物質検出センサは、上記のいずれかに記載の磁性体センサの所望の領域に、検出対象である標的物質を介して磁性粒子が固定され、該標的物質を検出する。
102 磁化ベクトル
103 磁化ベクトル
104 検出層
105 スピンベクトル
106 電子
107 磁化固定層
108 電源
109 静磁結合
110 電圧検出器
401 センスアンプ
402 磁気抵抗効果膜
403 電源
501 下部電極
502 MnIr膜
503 積層膜
504 スピントンネル膜
505 FeCo膜
506 NiFe膜
507 保護膜
508 上部電極
509 保護膜
510 固定膜
511 上部電極
801 二次抗体
802 磁性粒子
803 抗原
804 一次抗体
805 Au膜
Claims (5)
- 膜面垂直方向に電流を流すことによって磁化方向が変化する磁性膜である検出層と、前記電流によって磁化方向が変化しない磁性膜である磁化固定層と、前記検出層と前記磁化固定層との間に形成される非磁性層とを含む磁気抵抗効果膜を有する磁性体センサを用いた検出方法であって、
前記磁気抵抗効果膜に電流を流し、前記検出層にスピンベクトルによる磁化反転を生じさせたときの前記磁気抵抗効果膜の抵抗値の変化を検出して、磁性体の有無あるいは磁性体の個数を検出することを特徴とする検出方法。 - 前記検出層と磁化固定層の磁化方向を平行な状態とし、電流を磁化固定層側から検出層側へ向けて、時間と共に電流値を大きくするようにして流し、前記磁気抵抗効果膜の抵抗の変化を検出することにより、検出する磁性体の有無あるいは磁性体の個数を検出することを特徴とする請求項1に記載の検出方法。
- 前記検出層と磁化固定層の磁化方向を反平行な状態とし、電流を検出層側から磁化固定層側へ向けて、時間と共に電流値を大きくするようにして流し、前記磁気抵抗効果膜の抵抗の変化を検出することにより、磁性体の有無あるいは磁性体の個数を検出することを特徴とする請求項1に記載の検出方法。
- 検出対象である磁性体と検出層の相互作用が無い場合には磁化状態が比較的大きく変化し、かつ相互作用が有る場合には磁化状態がほとんど変化しない、もしくは相互作用が無い場合と比較して小さい変化となるような大きさの電流を、前記磁化固定層側から検出層側へ向けて流し、前記磁気抵抗効果膜の抵抗の変化を検出することにより、磁性体の有無あるいは磁性体の個数を検出することを特徴とする請求項1に記載の検出方法。
- 検出対象である磁性体との間に相互作用が生じ無い磁気抵抗効果膜により得られる電圧を参照電圧とし、該参照電圧を用いて磁性体の有無あるいは磁性体の個数を検出することを特徴とする請求項1から請求項4のいずれか1項に記載の検出方法。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005023518A JP4756868B2 (ja) | 2005-01-31 | 2005-01-31 | 検出方法 |
US11/720,516 US8852957B2 (en) | 2005-01-31 | 2006-01-26 | Magnetic material sensor and detection method employing this sensor, and target material detection sensor and target material detection kit |
PCT/JP2006/301714 WO2006080558A1 (en) | 2005-01-31 | 2006-01-26 | Magnetic material sensor and detection method employing this sensor, and target material detection sensor and target material detection kit |
Applications Claiming Priority (1)
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JP2005023518A JP4756868B2 (ja) | 2005-01-31 | 2005-01-31 | 検出方法 |
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JP2006208295A JP2006208295A (ja) | 2006-08-10 |
JP4756868B2 true JP4756868B2 (ja) | 2011-08-24 |
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JP2005023518A Expired - Fee Related JP4756868B2 (ja) | 2005-01-31 | 2005-01-31 | 検出方法 |
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US (1) | US8852957B2 (ja) |
JP (1) | JP4756868B2 (ja) |
WO (1) | WO2006080558A1 (ja) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006016334B4 (de) * | 2006-04-06 | 2018-11-15 | Boehringer Ingelheim Vetmedica Gmbh | Verfahren und Vorrichtung zur Detektion magnetisierbarer Partikel |
JP5207668B2 (ja) * | 2007-06-22 | 2013-06-12 | キヤノン株式会社 | 検出装置及び検出方法 |
JP5159193B2 (ja) * | 2007-07-09 | 2013-03-06 | キヤノン株式会社 | 磁気検出素子及び検出方法 |
JP5408895B2 (ja) * | 2008-04-15 | 2014-02-05 | キヤノン株式会社 | 物質検出装置、及び、該物質検出装置を用いた物質検出方法 |
US9121887B2 (en) * | 2009-02-26 | 2015-09-01 | Regents Of The University Of Minnesota | High magnetic moment particle detection |
KR20100104396A (ko) * | 2009-03-17 | 2010-09-29 | 엘지이노텍 주식회사 | 자기저항센서를 이용한 검체의 신호검출 시스템 및 이를 이용한 검출방법 |
EP2461168A4 (en) * | 2009-07-27 | 2018-01-24 | III Holdings 3, LLC | Non-contact current sensor |
US9229071B2 (en) | 2011-06-01 | 2016-01-05 | International Business Machines Corporation | Identification of molecules based on frequency responses using electromagnetic write-heads and magneto-resistive sensors |
EP2756292A1 (en) | 2011-09-14 | 2014-07-23 | Regents of the University of Minnesota | External field-free magnetic biosensor |
JP2015503085A (ja) * | 2011-10-19 | 2015-01-29 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 高スループット生体分子試験用の磁気生体医学センサ及び感知システム |
EP2685273A1 (en) * | 2012-07-13 | 2014-01-15 | Université Montpellier 2, Sciences et Techniques | Micromagnetometry detection system and method for detecting magnetic signatures of magnetic materials |
US9097677B1 (en) | 2014-06-19 | 2015-08-04 | University Of South Florida | Magnetic gas sensors |
KR101890561B1 (ko) | 2016-02-03 | 2018-08-22 | 고려대학교 세종산학협력단 | 스핀홀 현상을 이용한 자기장 측정 장치 및 방법 |
CN107796865B (zh) | 2016-09-05 | 2021-05-25 | 财团法人工业技术研究院 | 生物分子磁传感器 |
AU2019310594A1 (en) * | 2018-07-27 | 2021-02-11 | Zepto Life Technology, Inc. | System and method for sample preparation in GMR-based detection of biomarkers |
KR101952543B1 (ko) * | 2018-08-29 | 2019-02-26 | 당현식 | 스핀밸브를 이용한 소형 전자 제품 탐지기 |
RU2704972C1 (ru) * | 2019-07-16 | 2019-11-01 | Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской Академии наук (ФГБУН ИПХФ РАН) | Способ изготовления дисковых секторов для захвата, удержания и анализа магнитных микрочастиц и меченных ими биологических объектов на поверхности спиновых вентилей с помощью фемтосекундного лазерного облучения |
JP7285745B2 (ja) * | 2019-09-18 | 2023-06-02 | 東京エレクトロン株式会社 | 成膜システム、磁化特性測定装置、および成膜方法 |
US20230243778A1 (en) * | 2022-01-28 | 2023-08-03 | Western Digital Technologies, Inc. | Self-aligned surface modification for magnetochemical sensors |
US20240125687A1 (en) * | 2022-10-13 | 2024-04-18 | Western Digital Technologies, Inc. | Sensitivity amplification techniques for magnetochemical sensors |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03223685A (ja) * | 1990-01-29 | 1991-10-02 | Fujitsu Ltd | 外部磁界検出センサ |
JP3679519B2 (ja) | 1995-09-14 | 2005-08-03 | キヤノン株式会社 | トンネル電流または微小力または磁気力検出用の微小ティップの製造方法、並びにその微小ティップを有するプローブの製造方法とそのプローブ、該プローブを有するプローブユニットと走査型プローブ顕微鏡及び情報記録再生装置 |
US5981297A (en) * | 1997-02-05 | 1999-11-09 | The United States Of America As Represented By The Secretary Of The Navy | Biosensor using magnetically-detected label |
US6468809B1 (en) * | 2000-02-04 | 2002-10-22 | The United States Of America As Represented By The Secretary Of The Navy | High efficiency magnetic sensor for magnetic particles |
JP3604617B2 (ja) | 2000-06-12 | 2004-12-22 | 富士通株式会社 | 磁気検出素子 |
JP2002299725A (ja) | 2001-03-30 | 2002-10-11 | Matsushita Electric Ind Co Ltd | 磁気抵抗デバイス |
US6781801B2 (en) * | 2001-08-10 | 2004-08-24 | Seagate Technology Llc | Tunneling magnetoresistive sensor with spin polarized current injection |
US7048890B2 (en) * | 2001-12-21 | 2006-05-23 | Koninklijke Philips Electronics N.V. | Sensor and method for measuring the areal density of magnetic nanoparticles on a micro-array |
JP4240303B2 (ja) * | 2002-01-29 | 2009-03-18 | 旭化成株式会社 | バイオセンサ、磁性分子測定方法、及び、測定対象物測定方法 |
JP4399211B2 (ja) * | 2002-12-21 | 2010-01-13 | 株式会社ハイニックスセミコンダクター | バイオセンサー |
JP2004289100A (ja) * | 2003-01-31 | 2004-10-14 | Japan Science & Technology Agency | Cpp型巨大磁気抵抗素子及びそれを用いた磁気部品並びに磁気装置 |
JP2005079508A (ja) | 2003-09-03 | 2005-03-24 | Canon Inc | 磁性膜及び多層磁性膜、磁性膜の磁化反転方法及び磁化反転機構、磁気ランダムアクセスメモリ |
JP2005315677A (ja) | 2004-04-28 | 2005-11-10 | Canon Inc | 検出装置および検出方法 |
JP4731927B2 (ja) | 2005-01-31 | 2011-07-27 | キヤノン株式会社 | 磁性体センサおよび検出キット |
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US20080284419A1 (en) | 2008-11-20 |
JP2006208295A (ja) | 2006-08-10 |
US8852957B2 (en) | 2014-10-07 |
WO2006080558A1 (en) | 2006-08-03 |
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