JP2014177498A - 皮膚に影響を与える条件を制御し及び/又は安定化する方法 - Google Patents
皮膚に影響を与える条件を制御し及び/又は安定化する方法 Download PDFInfo
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- JP2014177498A JP2014177498A JP2014138221A JP2014138221A JP2014177498A JP 2014177498 A JP2014177498 A JP 2014177498A JP 2014138221 A JP2014138221 A JP 2014138221A JP 2014138221 A JP2014138221 A JP 2014138221A JP 2014177498 A JP2014177498 A JP 2014177498A
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Abstract
【解決手段】活性成分として、タマネギ(Allium species)の抽出物、シトリスレモン(Citrus species)の抽出物、パウリニア種(Paullinia species)の抽出物及びテオブロマ種(Theobroma species)の抽出物を含む組成物を皮膚に塗布する。
【選択図】なし
Description
これらの組成物のうち特に興味深いのは、前記組成物で、タマネギの水性アルコール抽出物、シトリスレモンの水性アルコール抽出物、及び
パウリニア種の水性アルコール抽出物(粉砕されていてもいなくても良い)及びテオブロマ種の水性アルコール抽出物(粉砕されていてもいなくても良い)を含む組成物ある。
タマネギの水性アルコール抽出物65%から93%、シトリスレモンの水性アルコール抽出物5%から33%、パウリニア種の水性抽出物0.25%から2.5%(粉砕されていてもいなくても良い)、及びテオブロマ種の水性抽出物0.25%から2.5%(粉砕されていてもいなくても良い)を含む組成物で、特にタマネギ(Allium cepa)の水性アルコール抽出物65%から93%、シトリスレモン(Citrus lemon)の水性アルコール抽出物5%から33%、パウリニア種の水性アルコール抽出物0.25%から2.5%(粉砕されていてもいなくても良い)、及びテオブロマ種の水性アルコール抽出物0.25%から2.5%(粉砕されていてもいなくても良い)を含む組成物である。
タマネギの水性アルコール抽出物65%から93%、シトリスレモンの水性アルコール抽出物5%から33%、サリックス種の水性抽出物0.25%から2.5%(粉砕されていてもいなくても良い)、及び硫酸亜鉛0.1%から1%を含む組成物で、特にタマネギの水性アルコール抽出物65%から93%、シトリスレモンの水性アルコール抽出物5%から33%、サリックス種の水性アルコール抽出物0.25%から2.5%(粉砕されていてもいなくても良い)、及び硫酸亜鉛六水和物0.1%から1%を含む組成物である。
[実施例1]
次の組成の組成物を調製した。
−タマネギの水性アルコール抽出物:87.04%
−シトリスレモンの水性アルコール抽出物:11.96%
−ガラナの粉砕した水性アルコール抽出物:0.50%
−テオブロマカカオの粉砕した水性アルコール抽出物:0.50%
次の組成の組成物を調製した。
−タマネギの水性アルコール抽出物:87.30%
−シトリスレモンの水性アルコール抽出物:12.00%
−ホワイトウィローの粉砕した水性抽出物:0.50%
−硫酸亜鉛6水和物:0.20%
次の組成の食品サプルメントを調製した。
−タマネギの乾燥抽出物:87.04%
−シトリスレモンの乾燥抽出物:11.96%
−ガラナの乾燥抽出物:0.50%
−テオブロマカカオの乾燥抽出物:0.50%
次の成分から頭皮処理用の化粧用ローションを調製した。
−実施例1で得た組成物:21ml
−賦形剤qsp(香水/アローマを含む):100ml
次の成分から頭皮処理用の医薬用ローションを調製した。
−実施例2で得た組成物:40ml
−賦形剤qsp(香水/アローマを含む):100ml
次の成分の錠剤を調製した。
−実施例3で得た組成物:100mg
−賦形剤qsp(香水/アローマを含む):300mg
(賦形剤の詳細:ラクトース、滑石、でんぷん、ステアリン酸マグネシウム)
次のように薬用軟膏を調製した。
−実施例3で得た組成物:5ml
−賦形剤qsp(香水/アローマを含む):100ml
ハミルトン・スケールのIIからIVの相当する禿の程度が僅かから中程度の35歳から55歳の20人の男性ボランティアを実施例4の組成物を使用して処置を施した(ハミルトン・スケール:タイプIは僅かに生え際が交代している。タイプIIは、生え際がこめかみまで後退し、頭頂領域が薄くなっている。タイプIIIは、こめかみの後退と頭頂の禿のスポットが一致している。タイプIVは、こめかみ以外が禿ている。タイプVは、頭頂の髪が喪失している。)
第1日:頭皮から髪が現れる点の髪の断面の一時的なサイトの位置の確認、及び研究する領域の接写写真の撮影。
第1〜2日:製品の塗布なし。シャンプーなし。
第3日:第1日と同じ領域の新規な接写写真の撮影、及び処置の開始。
第3〜42日:1日に2回、頭皮への製品の塗布(各回2〜3スプレイ)。
第42日:毛細管及び皮膚耐性の評価、頭皮から髪が現れる点の髪の断面の一時的なサイトの位置の確認、及び研究する領域の接写写真の撮影。
第42〜43日:製品の塗布なし。シャンプーなし。
第44日:第1日と同じ領域の新規な接写写真の撮影。
第44〜84日:1日に2回、頭皮へ、そして頭皮から髪が現れる点の髪の断面のサイトへの製品の塗布(各回2〜3スプレイ)。
第84日:毛細管及び皮膚耐性の評価、頭皮から髪が現れる点の髪の断面の研究している領域の一時的なサイトの位置の確認、及び研究する領域の接写写真の撮影。
第84〜85日:製品の塗布なし。シャンプーなし。
第86日:第1日と同じ領域の新規な接写写真の撮影。
−処置の6週間後の、大きな抗髪喪失効果:統計的なA/T(anagenic/telogenic)比は44.91%と大きく増加した。
−処置の12週間後の、大きな抗髪喪失効果:統計的なA/T比は46.78%と大きく増加した。
−良好な臨床的な耐性:皮膚科の試験の間、髪の反応は観察されなかった。
−良好な本来備わっている臨床的な耐性:それにもかかわらず1人のボランティアが皮膚の不快を経験した。
本発明の製品を、アンギオキット(Angiokit)プレート上でテストした。周知法を使用して、線維芽細胞との共培養の内皮細胞の成長をチェックし、毛細構造(細管)を観察した。異なった濃度でテストした製品は、ウェル中の各プレート上へ導入した。あるウェルはアクチベータ(VEGF)を追加受け入れし、他のウェルはインヒビタ(Suramine)を受け入れた。いくつかのウェルはコントロールとして機能した。
Claims (6)
- 活性成分として、タマネギ(Allium species)の抽出物、シトリスレモン(Citrus species)の抽出物、パウリニア種(Paullinia species)の抽出物及びテオブロマ種(Theobroma species)の抽出物を含む組成物を皮膚に塗布することを含む皮膚に影響を与える条件を制御し及び/又は安定化する方法。
- 前記組成物は、タマネギ(Allium species)の水性アルコール抽出物65%から93%、シトリスレモン(Citrus species)の水性アルコール抽出物5%から33%、パウリニア種(Paullinia species)の水性アルコール抽出物0.25%から2.5%、及びテオブロマ種(Theobroma species)の水性アルコール抽出物0.25%から2.5%を含む請求項1に記載の方法。
- 前記皮膚に影響を与える条件は、皮膚病、瘢痕形成疾患、角質化又は角化性病変の疾患である請求項1に記載した方法。
- 前記皮膚病は、種々の皮膚細菌及びウイルス性感染、皮膚の老化、皮膚の漂白及び美白化、白斑、肢端皮膚病、皮膚の光誘導性(光線)老化、及び太陽光(光線皮膚症)、任意の原因の座瘡(尋常性、炎症性又は膿疱性丘疹)、酒さ性座瘡(acne rosacea)、紅斑性狼瘡、敏感肌、昆虫刺傷アレルギー、油状又は乾燥肌、脂漏性疾患、任意の原因の脱毛症、脱毛、頭皮の乾癬及び類乾癬、発汗異常、いぼやうおのめ、疥癬、又は口角炎及び浮腫である請求項1に記載した方法。
- 前記瘢痕形成疾患は、傷の瘢痕形成、任意原因の疾患、火傷、シミ(blotchiness)、ベーチェット病、皮膚ポルフィリン症、又は肉腫性及び悪性ガンである請求項1に記載した方法。
- 前記角質化又は角化性病変は、角質化疾患、過角化、角皮症、異常角化症、ダリエ病、錯角化、魚鱗癬、湿疹、神経皮膚炎、紅皮症、苔蘚化、うろこ状皮膚病、痒疹,ケロイド又は膿疱症である請求項1に記載した方法。
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