JP2014105167A - 化粧料 - Google Patents
化粧料 Download PDFInfo
- Publication number
- JP2014105167A JP2014105167A JP2012257782A JP2012257782A JP2014105167A JP 2014105167 A JP2014105167 A JP 2014105167A JP 2012257782 A JP2012257782 A JP 2012257782A JP 2012257782 A JP2012257782 A JP 2012257782A JP 2014105167 A JP2014105167 A JP 2014105167A
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- JP
- Japan
- Prior art keywords
- plant
- acid
- skin
- extract
- rice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Landscapes
- Cosmetics (AREA)
Abstract
【解決手段】米、アブラナ科ブラシカ属(Brassica)の植物、スイレン科(Nympaeaceae)ハス属(Nelumbo)の植物、及びハトムギのうちの3種以上の植物の成分を含む化粧料であって、上記植物の成分は当該植物の抽出物又は当該抽出物の加水分解物、或いは当該植物の発酵物であることから、これら植物成分が有する皮膚生理活性の相乗効果により、すぐれた美白及び美肌効果を発揮し、かつ、使用感にすぐれた化粧料。
【選択図】なし
Description
又、本発明は、さらに、美白剤、保湿剤、細胞賦活剤、抗炎症剤、抗酸化剤、及び血行促進剤のいずれか一種以上を含むことを特徴とする化粧料である。
なお、本発明に於いて、化粧料なる文言は、所謂化粧料のほかに医薬部外品をも含む広義の意味で用いる。
Gaertner)或いはアメリカキバス(Nelumbo Lutea Pers.)などが挙げられるが、それらのうちでも、ハス(Nelumbo nucifera Gaertner)の使用が好ましい。それらの植物の全草、葉、花、雄しべ、雌しべ、茎、根茎、種子(子実)、胚芽などのいずれの部分を使用してもよいが、種子の使用が好ましい。
ブレビス(L. brevis)、ラクトバシルス カゼイ(L. casei)等のラクトバシルス(Lactobacillus)属の乳酸菌;カルノバクテリウム ディバージェンス(Carnobacterium
divergens)、カルノバクテリウム ピシコーラ(Carnobacterium piscicola)等のカルノバクテリウム(Carnobacterium)属の乳酸菌;ロイコノストック メセンテロイズ(Leuconostoc
mesenteroides)、ロイコノストック シトレウム(Leuconostoc citreum)等のロイコノストック(Leuconostoc)属の乳酸菌; ストレプトコッカス フェーカリス(Streptococcus
faecalis)、ストレプトコッカス ピオジェネス(Streptococcus pyogenes)等のストレプトコッカス属の乳酸菌;エンテロコッカス
カゼリフラバス(Enterococcus caseliflavus)、エンテロコッカス サルフレウス(Enterococcus sulfreus)等のエンテロコッカス(
Enterococcus)属の乳酸菌;ラクトコッカス プランタラム(Lactococcus
plantarum) ラクトコッカス ラフィノラクティス(Lactococcus rafinolactis)等のラクトコッカス属の乳酸菌;ヴェイセラ
コンフューザ(Weissella confusa)、ヴェイセラ カンドウレリ(Weissella kandleri)等のヴェイセラ属の乳酸菌;アトポビウム ミニュタム(Atopobium minutum)、アトポビウム パービュラス(Atopobiumparvulus)等のアトポビウム(Atopobium)属の乳酸菌;バゴコッカス フルビアリス(Vagococcus
fluvialis)、バゴコッカス サーモニナラム(Vagococcus salmoninarum)等のバゴコッカス(Vagococcus)属の乳酸菌;ペディオコッカス ダムノサス(Pediococcus
damnosus)、ペディオコッカス ペントサセウス(Pediococcus pentosaceus)等のペディオコッカス(Pediococcus)属の乳酸菌等が挙げられる。それら乳酸菌のうちでも、得られる発酵物の皮膚生理活性の観点とさらに極端な嫌気性でなく取り扱い易いという点から、ラクトバシルス
プランタラム(Lactobacillus plantarum)の使用が最も好ましい。
フラバス(Aspergillus flavus)、アスペルギルス ポリオキソジェネス(Aspergillus polyoxogenes)、アスペルギルス ソーヤ(Aspergillus
sojae)等の黄麹菌、アスペルギルス アワモリ(Aspergillus awamori)、アスペルギルス
カワウチ(Aspergillus kawauchii)、アスペルギルス ウサミ(Aspergillus usami)、
アスペルギルス ニガー(Aspergillus niger)等の黒麹菌、モナスカス アンカ(Monascus anka)、モナスカス ピロサス(Monascus pilosus)等の紅麹菌などが挙げられる。それらのうちでも、得られる発酵物の皮膚生理活性の観点とさらに発酵液の着色や発酵臭が比較的少ないことから、アスペルギルス
オリゼー(Aspergillus oryzae)が最も好ましい。
circulans)等のバシルス属の細菌などが挙げられる。なかでも、食品に広く使用されており、安全性が高い点でバシルス ナットー(Bacillus natto)が最も好ましい。
ミクロスポラス チネンシス(Rhizopus microsporus chinensis)、リゾプス ミクロスポラス
オリゴスポラス(Rhizopus microsporus oligosporus)、リゾプス ニベウス(Rhizopus niveus)、リゾプス オリゼー(Rhizopus oryzae)等のリゾプス菌の真菌(カビ)が挙げられる。なかでも、インドネシアをはじめ東南アジア地域で発酵食品に広く使用されており、安全性が高い点で、リゾプス
ミクロスポラス オリゴスポラス(Rhizopus microsporus oligosporus)やリゾプス オリゼー(Rhizopus oryzae)が最も好ましい。
アワモリ(Saccharomyces awamori)、サッカロミセス チェバリエリ(Saccharomyces chevalieri)、サッカロミセス カールスバージェンシス(Saccharomyces carlsbergensis)、サッカロミセス バヨナス(Saccharomyces
bayon us)等のサッカロミセス属の酵母、トルラスポラ デルブルエキ(Torulaspora delbruekii)、トルラスポラ
ファーメンタチ(Torulaspora fermentati)、トルラスポラ ロゼイ(Torulaspora rosei)等のトルラスポラ属の酵母、ジゴサッカロミセス ローキシ(Zygosaccharomyces rouxii)、ジゴサッカロミセス ソーヤ(Zygosaccharomyces
soya)、ジゴサッカロミセス サケ(Zygosaccharomyces sake)、ジゴサッカロミセス
ミソ(Zygosaccharomyces miso)、ジゴサッカロミセス ラクティス(Zygosaccharomyces lactis)等のジゴサッカロミセス属の酵母、カンディダ ベルサチリス(Candida versatilis)、カンディダ エチェリシイ(Candida
etchellsii)、カンディダ ケフィール(Candida kefyr)、カンディダ サケ(Candida sake)、カンディダ スコッティ(Candida scottii)等のカンディダ属の酵母、オーレオバシディウム
プルランス(Aureobasidium Pullulans)、オーレオバシディウム マンソニー(Aureobasidium mansonii)、オーレオバシディウム マイクロスティクタム(Aureobasideium microstictum)等のオーレオバシディウム属の酵母などが挙げられる。それらのうちでも、食品に最も広く利用され、発酵力が強いという点からサッカロミセス
セレビシエ(Saccharomyces cerevisiae)が最も好ましい。
また、乳化剤乃至乳化助剤として、酵素処理ステビアなどのステビア誘導体、レシチン及びその誘導体、乳酸菌発酵米、乳酸菌発酵発芽米、乳酸菌発酵穀類(麦類、豆類、雑穀など)、ジュアゼイロ(Rhamnaceae zizyphus joazeiro)抽出物等を配合することもできる。
精白米1000gに0.025M水酸化ナトリウム溶液1250gを加え室温で、21時間攪拌した。ろ過によって固形物を除去し、抽出液をpH7.5に調製して、米抽出液750gを得た(固形分濃度2.1%)。
精白米1000gに0.025M水酸化ナトリウム溶液1250gを加え室温で、21時間攪拌した。ろ過によって固形物を除去し、抽出液をpH7.5に調製した。この抽出液にパパイン0.02%及びアクチナーゼ0.02%を加えて40℃2時間加水分解を行った。酵素を加熱失活した後、この液をろ過して米抽出物加水分解液600gを得た(固形分濃度1.8%)。
精白米100gを水洗し、精製水900gを加えて懸濁液を調製し、加熱殺菌した。この液にグルコアミラーゼ1.0g、パパイン1.0gを加えた後、乳酸菌(ラクトバシルス
プランタラム)を108個/mL接種し、37℃で3日間静置培養した。培養終了後、培養液を加熱殺菌し、室温まで冷却して米の発酵物を得た(固形分濃度2.5重量%)。
白芥子の種子の粉砕物100gと精製水1000gとを混合してpHを約5に調整し、室温下で24時間抽出したのち、これをろ過して抽出液(固形分濃度:約1.1重量%)を得た。
白芥の種子(白芥子)の粉砕物50gに精製水1000gを混合し、40℃で1時間抽出を行った後ろ過し、淡黄色透明の白芥子抽出物溶液805g(固形分濃度:1.2重量%)を得た。次に、ここに得られた抽出物溶液500gに、アクチナーゼAS(科研ファルマ株式会社製)を0.05g添加し、40℃で2時間加水分解した。その後、85℃で1時間加熱して酵素を失活させた後ろ過し、淡黄色透明の白芥子抽出物の加水分解物溶液460g(固形分濃度1.0重量%)を得た。
白芥の種子(白芥子)100gを粉砕し、これに精製水900gを加えて懸濁液を調製した。この懸濁液に蛋白分解酵素(アクチナーゼAS;科研ファルマ株式会社製)0.1gを加えて40℃で2時間加水分解した後、80℃で1時間抽出並びに酵素失活処理を行い、室温まで冷却後ろ過して白芥子の抽出物溶液を得た。次に、この液を加熱殺菌し、乳酸菌(ラクトバシルス
プランタラム)を108個/mL接種し、37℃で3日間静置培養した。培養終了後培養液を加熱殺菌し、室温まで冷却後ろ過して白芥子の乳酸菌発酵物溶液658g(固形分濃度2.2%)を得た。
ハスの種子(渋皮を除去したもの)100gを粉砕し、精製水1900gを加えて懸濁液を調製し、80℃で2時間加熱した。この液をろ過して、ハス種子抽出物溶液1360g(固形分濃度0.9%)を得た。
ハスの種子(渋皮を除去したもの)100gを粉砕し、精製水1900gを加えて懸濁液を調製し、加熱殺菌した。この液にグルコアミラーゼ1g、パパイン1g及びセルラーゼ0.5gを加えた後、を加えた後、pHを7.5に調整し、45℃に15時間保持した。この液をろ過して、ハス種子の加水分解溶液1400g(固形分濃度1.9%)を得た。
ハスの種子(渋皮を除去したもの)100gを粉砕し、精製水1900gを加えて懸濁液を調製し、加熱殺菌した。この懸濁液にグルコアミラーゼ1g、パパイン1g及びセルラーゼ0.5gを加えた後、乳酸菌(ラクトバチルス
プランタラム)を108個/mL接種し、窒素気流下に37℃で3日間静置培養した。培養終了後加熱殺菌し、培養液をろ過して、ハス種子の乳酸菌発酵物溶液1460g(固形分濃度3.0%)を得た。
殻を除いたハトムギ種子50gを粉砕し、精製水950gを加えて懸濁液を調製し、80℃で2時間加熱した。この液をろ過して、ハトムギ種子抽出物溶液770g(固形分濃度2.1%)を得た。
殻を除いたハトムギ種子50gを粉砕し、精製水950gを加えて懸濁液を調製し、80℃で2時間加熱した。この液にグルコアミラーゼ0.5g、パパイン0.5gを加えた得た後、37℃で酵素か分解処理を行った。冷却後、この液をろ過して、ハトムギ種子加水分解物溶液765g(固形分濃度2.2%)を得た。
殻を除いたハトムギ種子50gを粉砕し、精製水950gを加えて懸濁液を調製し、加熱殺菌をした。この懸濁液にグルコアミラーゼ0.5g、パパイン0.5gを加えた得た後、酵母(サッカロミセス セレビシエ)を107個/mL接種し、37℃で3日間静置培養した。培養数量後、加熱殺菌し、室温まで冷却後、ろ過してハトムギ種子発酵物溶液500gを得た(固形分濃度1.3%)。
処方例1.乳液
[A成分] 部
流動パラフィン 6.0
ヘキサラン 4.0
ホホバ油 1.0
ポリオキシエチレン(20)ソルビタンモノステアレート 2.0
大豆レシチン 1.5
メチルパラベン 0.15
エチルパラベン 0.03
[B成分]
実施例1の組成物 3.0(本処方例1の乳液100部に対する組成物の重量%)
L−アスコルビン酸−2−グルコシド 2.0
水酸化カリウム 0.5
豆乳乳酸菌発酵エキス 1.0
グリセリン 3.0
1、3−ブチレングリコール 2.0
カルボキシメチルセルロース 0.3
ヒアルロン酸ナトリウム 0.01
精製水 全量が100部となる量
[C成分]
香料 適量
上記のA成分とB成分をそれぞれ80℃以上に加熱した後、攪拌混合した。これを50℃まで冷却した後、C成分を加えてさらに攪拌混合して乳液を得た。
処方例1のB成分中、実施例1の組成物に代えて実施例2〜28のうちのいずれか1つの組成物3.0部を用いるほかは処方例1と同様にして乳液を得た。
処方例1のB成分中、実施例1の組成物に代えて実施例29〜37のうちのいずれか1つの組成物4.0部を用いるほかは処方例1と同様にして乳液を得た。
処方例1のB成分中、実施例1の組成物に代えて実施例38〜49のうちのいずれか1つの組成物5.0部を用いるほかは処方例1と同様にして乳液を得た。
[A成分] 部
実施例1の組成物 3.0(本処方例50のローション100部に対する組成物の重量%)
エタノール 10.0
グリセリン 3.0
1,3−ブチレングリコール 2.0
メチルパラベン 0.2
クエン酸 0.1
クエン酸ナトリウム 0.3
カルボキシビニルポリマー 0.1
香料 適量
水酸化カリウム 適量
精製水 全量が100部となる量
上記の成分を混合してローションを得た。
処方例50のA成分中、実施例1の組成物に代えて実施例2〜28のうちのいずれか1つの組成物3.0部を用いるほかは処方例50と同様にしてローションを得た。
処方例50のA成分中、実施例1の組成物に代えて実施例29〜37のうちのいずれか1つの組成物4.0部を用いるほかは処方例50と同様にしてローションを得た。
処方例50のB成分中、実施例1の組成物に代えて実施例38〜49のうちのいずれか1つの組成物5.0部を用いるほかは処方例50と同様にしてローションを得た。
[A成分] 部
オリーブ油 1.0
ポリオキシエチレン(5.5)セチルアルコール 5.0
ブチルパラベン 0.1
[B成分]
実施例1の組成物 3.0(本処方例100の化粧水100部に対する組成物の重量%)
エタノール 5.0
グリセリン 5.0
1,3−ブチレングリコール 5.0
メチルパラベン 0.1
水酸化カリウム 適量
精製水 全量が100部となる量
[C成分]
香料 適量
A成分及びB成分をそれぞれ80℃以上に加温後、A成分にB成分を加えて攪拌し、さらにヒスコトロン(5000rpm)で2分間ホモジナイズを行った。これを50℃まで冷却した後、C成分を加えて攪拌混合し、さらに30℃以下まで冷却して化粧水を得た。
処方例99のB成分中、実施例1の組成物に代えて実施例2〜28のいずれか1つの組成物3.0部を用いるほかは処方例99と同様にして化粧水を得た。
処方例99のB成分中、実施例1の組成物に代えて実施例29〜37のいずれか1つの組成物4.0部を用いるほかは処方例99と同様にして化粧水を得た。
処方例100のB成分中、実施例1の組成物に代えて実施例38〜49のいずれか1つの組成物5.0部を用いるほかは処方例100と同様にして化粧水を得た。
処方例1のB成分中、L−アスコルビン酸−2−グルコシド2.0部に代えてL−アスコルビン酸−2−グルコシド1.0部及びアルブチン1.0部を用いるほかは処方例1と同様にして乳液を得た。
処方例1のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてトラネキサム酸2.0部を用いるほかは処方例1と同様にして乳液を得た。
処方例1のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えて米糠抽出物加水分解物(固形分濃度3.5%)5.0部を用いるほかは処方例1と同様にして乳液を得た。
以下の実施例1〜49の組成物を試料として用いて各組成物のチロシナーゼ抑制効果及び線維芽細胞賦活効果について調べた。
[試験方法]
培養B16マウスメラノーマ細胞を、96穴マイクロプレートに8×103個/穴播種し、10%仔牛血清(FBS)含有イーグル最少必須培地(MEM)中、37℃、5%CO2の条件下に1日間プレ培養した後、10%FBS含有イーグルMEMに実施例1〜49の各組成物をそれぞれ試料溶液として添加し、同条件で2日間培養した。ここで、本試験で用いた各組成物の溶液としての終濃度は、実施例1〜28の各組成物であれば当該培地100部に対して3.0重量%となるように、又実施例29〜46の各組成物であれば、当該培地100部に対して4.0重量%となるように、又実施例47〜49の各組成物であれば5.0重量%となるように調製した。次に培養液を除去し、界面活性剤(Triton X-100)と5mMのL−ドーパ溶液を添加して37℃で反応を行った後、マイクロプレートリーダー(Model 450、バイオラッド社製)を用い、波長490nmでドーパ値を測定した。試料無添加の場合(対照)についても上記と同様の操作を行い、ここに得られたドーパ値に対する各試料添加時のドーパ値の相対値を求め、チロシナーゼ活性率(%)とした。なお、比較のため、試料溶液の代わりに、3mMのアルブチンを添加した場合(陽性対照)についても同様の試験を行った。なお、比較対照として、製造例1の米抽出物のみからなる比較試料1(培地100部に対して溶液としての終濃度が3.0重量%)についても、同様の試験を行った。
[試験方法]
ヒト真皮由来線維芽細胞を、0.5%FCS含有最少必須培地を入れた96穴マイクロプレートに1×104個/穴播種し、37℃で1日間プレ培養した後、実施例1〜49の各組成物をそれぞれ試料溶液として添加し、37℃でさらに6日間培養した。ここで、本試験で用いた各組成物の溶液としての終濃度は、実施例1〜28の各組成物であれば当該培地100部に対して3.0重量%となるように、又実施例29〜46の各組成物であれば、当該培地100部に対して4.0重量%となるように、又実施例47〜49の各組成物であれば5.0重量%となるように調製した。次に、培地を除去し界面活性剤(TRITON X-100)を添加した細胞処理液に、0.2%のMTTを添加して37℃に保持した後、マイクロプレートリーダー(Model1450、バイオラッド社製)を用い、波長370−530nmでMTT値を測定した。試料無添加の場合(対照)についても上記と同様の操作を行い、ここに得られたMTT値に対する各試料添加時のMTT値の相対値を求め、線維芽細胞MTT活性率(%)とした。なお比較のため、試料溶液の代わりにグルコースを50mM添加した場合(陽性対照)についても、同様の試験を行った。さらに、比較対照として、製造例1の米抽出物のみからなる比較試料1(培地100部に対して溶液としての終濃度が3.0重量%)についても、同様の試験を行った。
本発明の化粧料組成物を配合した化粧料(乳液)に関して、肌のハリ、ツヤ、くすみ、シミ、ソバカス、小ジワ及び使用感を、モニターによる実使用テストで評価した。
本試験例3においては、下記のエッセンスを試料とした。
(1)本発明試料1
[成分] 部
エタノール 2.0
グリセリン 5.0
1,3−ブチレングリコール 5.0
メチルパラベン 0.1
実施例3の組成物 3.0
クエン酸 0.3
クエン酸ナトリウム 0.6
精製水 全量が100部となる量
(2)本発明試料2.
上記本発明試料1に於いて実施例1の組成物に代えて、実施例6の組成物を配合したエッセンス。
(3)本発明試料3.
上記本発明試料1に於いて実施例1の組成物に代えて、実施例11の組成物を配合したエッセンス。
(4)本発明試料4.
上記本発明試料1に於いて実施例1の組成物に代えて、実施例20の組成物を配合したエッセンス。
(5)本発明試料5.
上記本発明試料1に於いて実施例1の組成物に代えて、実施例31の組成物を配合したエッセンス。
(6)本発明試料6.
上記本発明試料1に於いて実施例1の組成物に代えて、実施例49の組成物を配合したエッセンス。
(7)比較試料1.
上記本発明試料1に於いて実施例1の組成物に代えて、比較実施例1の組成物を配合したエッセンス。
[試験方法]
無作為に抽出した年齢18〜50歳の女性120名を被験者として、本発明試料1〜6のいずれか1つと、比較試料1とを、それぞれ左右の頬部に、本発明例又は比較例の乳液を1日2回(朝、晩)、1ヵ月間塗布してもらった時の使用感及び肌の状態を、下記の1〜4の項目毎に評価した。肌のハリ,ツヤ、くすみ、シミ,ソバカスについては、A:改善された、B:やや改善された、C:変わらない、D:やや悪くなった、E:悪くなった、という5段階評価によってそれぞれ行った。また、使用感は、手に取った感触、塗布時の伸び、塗布時のなめらかさ、及び塗布後の感触に基づいて、A:非常に良い、B:良い、C:普通、D:やや悪い、E:悪い、という5段階評価によって、それぞれ行った。
評価結果を表7に示す。
[表7]
以上のように、本発明試料1〜6は、いずれも比較試料1と比較して、肌のハリ,ツヤ、くすみ、シミ,ソバカス、小ジワの改善の実感効果が高かった。さらに、本発明試料1〜6は、使用感の実感効果も比較試料1と比較して高かった。
Claims (2)
- 米、アブラナ科ブラシカ属(Brassica)の植物、スイレン科(Nympaeaceae)ハス属(Nelumbo)の植物及びハトムギのうちの3種以上の植物の成分を含む化粧料であって、
上記植物の成分は当該植物の抽出物又は当該抽出物の加水分解物、或いは当該植物の発酵物であることを特徴とする化粧料。 - さらに、美白剤、保湿剤、細胞賦活剤、抗炎症剤、抗酸化剤及び血行促進剤のいずれか一種以上を含むことを特徴とする請求項1に記載の化粧料。
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JP2020186204A (ja) * | 2019-05-14 | 2020-11-19 | 共栄化学工業株式会社 | 皮膚外用剤 |
JP2021004214A (ja) * | 2019-06-27 | 2021-01-14 | 株式会社再春館製薬所 | 組み合わせ発酵物 |
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