JP2014020920A - 発光検出用流路デバイス - Google Patents
発光検出用流路デバイス Download PDFInfo
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- JP2014020920A JP2014020920A JP2012159793A JP2012159793A JP2014020920A JP 2014020920 A JP2014020920 A JP 2014020920A JP 2012159793 A JP2012159793 A JP 2012159793A JP 2012159793 A JP2012159793 A JP 2012159793A JP 2014020920 A JP2014020920 A JP 2014020920A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/168—Specific optical properties, e.g. reflective coatings
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
- G01N2021/056—Laminated construction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/064—Stray light conditioning
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
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- Clinical Laboratory Science (AREA)
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- Dispersion Chemistry (AREA)
- Plasma & Fusion (AREA)
- Engineering & Computer Science (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Measuring Cells (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
【解決手段】少なくとも2枚の基板を貼り合わせて構成される流路を有する流路デバイスであって、少なくともいずれか一方の基板には、流路を構成する第一の溝と、有機材料を含む接着材を配置するための第二の溝とを有し、第二の溝から発する光が第一の溝へ侵入するのを遮るように遮光層が第二の溝の内壁に配置されている流路デバイスを提供する。
【選択図】図3
Description
二枚の基板を貼り合わせて構成される流路を有する流路デバイスであって、少なくともいずれか一方の基板には、流路を構成する第一の溝と、有機材料を含む接着材を含む第二の溝とを有し、第二の溝は内壁に遮光膜を有することを特徴とする流路デバイスを提供する。
上記実施例で作成された流路デバイスを用いたDNA検査システムについて、以下に図7を参照して説明する。
流路デバイスの流路中の液体を移動させる手段として、正または負の圧力を発生させる圧力発生器22を有する。圧力発生器22は、シリンジポンプなどのポンプであり、流路デバイス23の排出孔に接続して流路中に圧力を発生させる。また、24はピペットなどの液体導入器である。
Claims (11)
- 少なくとも二枚の基板を貼り合わせて構成される流路を有する流路デバイスであって、第一の基板は、流路を構成する第一の溝と、有機材料を含む接着材を含む第二の溝を有し、第二の溝は内壁に遮光膜を有することを特徴とする流路デバイス。
- 第二の溝は、基板平面に対して垂直方向から見た際に、第一の溝を囲むよう配置されている請求項1に記載の流路デバイス。
- 第二の溝は、基板断面における形状が曲線からなることを特徴とする請求項1または2に記載の流路デバイス。
- 第二の溝に構成される遮光膜が金属膜である請求項1から3のいずれかに記載の流路デバイス。
- 請求項1に記載の流路デバイスの製造方法であって、
第一の基板に、第一の溝と第二の溝を形成する工程と、
第二の溝に遮光膜を形成する工程と、
第二の溝に接着材を配置する工程と、
第二の溝に配置した接着剤で、第一の基板と第二の基板を貼り合わせる工程とを有することを特徴とする流路デバイスの製造方法。 - 第二の溝をウェットエッチングにより形成する請求項5に記載の流路デバイスの製造方法。
- 第一および第二の溝をドライエッチングにより形成する請求項5に記載の製造方法。
- 第二の溝に遮光膜を形成した後に、第一の溝をさらにエッチングする請求項5に記載の流路デバイスの製造方法。
- DNA検査装置であって、
請求項1に記載の流路デバイスと
流路デバイスに光を照射するための光源と、
流路デバイスからの発光を検出する光検出器と、
発熱抵抗体に電流を供給するための回路と、
流路デバイスの流路中の液体を移動させる手段と、を具備するDNA検査装置。 - 請求項9に記載のDNA検査装置を用いるDNA検査システム。
- 請求項1に記載の流路デバイスを用いたDNAの検査方法であって、
流路内にDNAを含む液体を流す工程と、
流路内の液体からの発光を検出する工程と、を有するDNAの検査方法。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012159793A JP5995573B2 (ja) | 2012-07-18 | 2012-07-18 | 発光検出用流路デバイス |
US13/926,679 US9506870B2 (en) | 2012-07-18 | 2013-06-25 | Flow-channel device for detecting light emission |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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JP2012159793A JP5995573B2 (ja) | 2012-07-18 | 2012-07-18 | 発光検出用流路デバイス |
Publications (2)
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JP2014020920A true JP2014020920A (ja) | 2014-02-03 |
JP5995573B2 JP5995573B2 (ja) | 2016-09-21 |
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JP2012159793A Expired - Fee Related JP5995573B2 (ja) | 2012-07-18 | 2012-07-18 | 発光検出用流路デバイス |
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US (1) | US9506870B2 (ja) |
JP (1) | JP5995573B2 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9694339B2 (en) | 2014-06-27 | 2017-07-04 | Seiko Epson Corporation | Chemical synthesis device and method for manufacturing chemical synthesis device |
WO2018216673A1 (ja) * | 2017-05-23 | 2018-11-29 | ウシオ電機株式会社 | マイクロチップ |
KR102111024B1 (ko) * | 2018-11-19 | 2020-05-15 | 한국생명공학연구원 | 광-디지털 pcr 챔버 및 이를 이용하는 광-디지털 pcr 기기 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US20150334622A1 (en) * | 2014-05-19 | 2015-11-19 | Broadcom Corporation | Apparatus and Method to Perform LTE/WLAN Handoff by Keeping LTE Attached or in Suspended State |
EP3189004B1 (en) * | 2014-09-02 | 2021-08-11 | Bio-Rad Laboratories, Inc. | Microscale fluidic devices and components having a fluid retention groove |
EP3536774B1 (en) * | 2016-11-01 | 2021-06-16 | MGI Tech Co., Ltd. | Gene sequencing chip and combination with mounting frame |
CN110387321B (zh) * | 2018-04-23 | 2023-03-17 | 深圳华大智造科技股份有限公司 | 基因测序芯片及基因测序装置 |
CN113751789B (zh) * | 2021-09-29 | 2022-11-11 | 南通东海机床制造集团有限公司 | 一种剪板机剪切快速定位装置 |
Citations (6)
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JP2002286627A (ja) * | 2001-03-22 | 2002-10-03 | Olympus Optical Co Ltd | 蛍光検出容器 |
US20040241381A1 (en) * | 2002-01-31 | 2004-12-02 | Chen Yihfar | Microfluidic structures with circumferential grooves for bonding adhesives and related optical analysis discs |
JP2006053094A (ja) * | 2004-08-13 | 2006-02-23 | Alps Electric Co Ltd | 検査用プレート |
JP2006078414A (ja) * | 2004-09-13 | 2006-03-23 | Alps Electric Co Ltd | 検査用プレート |
WO2007099736A1 (ja) * | 2006-03-03 | 2007-09-07 | Konica Minolta Medical & Graphic, Inc. | マイクロ検査チップ、光学的検出装置およびマイクロ総合分析システム |
JP2010043928A (ja) * | 2008-08-12 | 2010-02-25 | Seiko Epson Corp | バイオチップの製造方法およびバイオチップ |
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JPWO2005024436A1 (ja) * | 2003-09-02 | 2007-11-08 | 日本電気株式会社 | カスタマイズ可能なチップおよびその製造方法 |
JP4850061B2 (ja) * | 2004-03-18 | 2012-01-11 | 日水製薬株式会社 | 抗原の分析装置の製造方法及び分析装置 |
JP5066085B2 (ja) * | 2006-07-05 | 2012-11-07 | アイダエンジニアリング株式会社 | マイクロ流路チップ及び流体移送方法 |
JP5004169B2 (ja) * | 2007-05-30 | 2012-08-22 | ローム株式会社 | マイクロチップの製造方法 |
WO2012037308A2 (en) * | 2010-09-16 | 2012-03-22 | Advanced Liquid Logic, Inc. | Droplet actuator systems, devices and methods |
-
2012
- 2012-07-18 JP JP2012159793A patent/JP5995573B2/ja not_active Expired - Fee Related
-
2013
- 2013-06-25 US US13/926,679 patent/US9506870B2/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2002286627A (ja) * | 2001-03-22 | 2002-10-03 | Olympus Optical Co Ltd | 蛍光検出容器 |
US20040241381A1 (en) * | 2002-01-31 | 2004-12-02 | Chen Yihfar | Microfluidic structures with circumferential grooves for bonding adhesives and related optical analysis discs |
JP2006053094A (ja) * | 2004-08-13 | 2006-02-23 | Alps Electric Co Ltd | 検査用プレート |
JP2006078414A (ja) * | 2004-09-13 | 2006-03-23 | Alps Electric Co Ltd | 検査用プレート |
WO2007099736A1 (ja) * | 2006-03-03 | 2007-09-07 | Konica Minolta Medical & Graphic, Inc. | マイクロ検査チップ、光学的検出装置およびマイクロ総合分析システム |
JP2010043928A (ja) * | 2008-08-12 | 2010-02-25 | Seiko Epson Corp | バイオチップの製造方法およびバイオチップ |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9694339B2 (en) | 2014-06-27 | 2017-07-04 | Seiko Epson Corporation | Chemical synthesis device and method for manufacturing chemical synthesis device |
WO2018216673A1 (ja) * | 2017-05-23 | 2018-11-29 | ウシオ電機株式会社 | マイクロチップ |
JP2018197663A (ja) * | 2017-05-23 | 2018-12-13 | ウシオ電機株式会社 | マイクロチップ |
KR102111024B1 (ko) * | 2018-11-19 | 2020-05-15 | 한국생명공학연구원 | 광-디지털 pcr 챔버 및 이를 이용하는 광-디지털 pcr 기기 |
WO2020106045A1 (ko) * | 2018-11-19 | 2020-05-28 | 한국생명공학연구원 | 광-디지털 pcr 챔버 및 이를 이용하는 광-디지털 pcr 기기 |
Also Published As
Publication number | Publication date |
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US9506870B2 (en) | 2016-11-29 |
JP5995573B2 (ja) | 2016-09-21 |
US20140024126A1 (en) | 2014-01-23 |
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