JP2013523789A - ヘルペス感染症の予防措置及び治療措置のためのピロキシカム - Google Patents
ヘルペス感染症の予防措置及び治療措置のためのピロキシカム Download PDFInfo
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- JP2013523789A JP2013523789A JP2013503032A JP2013503032A JP2013523789A JP 2013523789 A JP2013523789 A JP 2013523789A JP 2013503032 A JP2013503032 A JP 2013503032A JP 2013503032 A JP2013503032 A JP 2013503032A JP 2013523789 A JP2013523789 A JP 2013523789A
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- drug
- piroxicam
- infection
- herpes
- preventive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
作用物質含分0.5質量%を有する市販のピロキシカムゲル剤を使用して、本発明による薬剤を42名の被検者に対して試験した。結果は以下の通りである:
スクリーニング試験において、作用物質含分0.4%を有するピロキシカム含有ゲル剤を、標準試験法を用いて、HSV1型のヘルペスウイルスに感染した培養物に対して試験した。最初にCD50値を求めたところ2.50であり、ウイルス力価は最初に7.00であった。1.5及び60分の滞留時間後にウイルス力価(log10 TCID50/ml)を求めたところ2.50未満であったが、これは99.99%を上回るウイルスカウントの低減に相当するものである。
Claims (8)
- ウイルス感染症の予防措置及び治療措置のための薬剤において、該薬剤がキャリア物質中にピロキシカムを含有していることを特徴とする薬剤。
- ピロキシカムの含分が0.1〜10質量%である、請求項1記載の薬剤。
- ピロキシカムの含分が1〜5質量%である、請求項2記載の薬剤。
- ウイルス感染症が、ヘルペスウイルス科のファミリーからのウイルスを伴う感染症である、請求項1から3までのいずれか1項記載の薬剤。
- ウイルス感染症が、単純ヘルペス、特に***ヘルペスを伴う感染症である、請求項1から4までのいずれか1項記載の薬剤。
- 局所投与のための、請求項1から5までのいずれか1項記載の薬剤。
- クリーム剤、軟膏剤、チンキ剤又はゲル剤の形の、請求項5記載の薬剤。
- 輸液又は注射のための、請求項1から3までのいずれか1項記載の薬剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102010014290A DE102010014290A1 (de) | 2010-04-08 | 2010-04-08 | Mittel zur prophylaktischen und therapeutischen Behandlung von Herpes-Infektionen |
DE102010014290.5 | 2010-04-08 | ||
PCT/EP2011/001704 WO2011124366A1 (de) | 2010-04-08 | 2011-04-06 | Piroxicam zur prophylaktischen und therapeutischen behandlung von herpes - infektionen |
Publications (4)
Publication Number | Publication Date |
---|---|
JP2013523789A true JP2013523789A (ja) | 2013-06-17 |
JP2013523789A5 JP2013523789A5 (ja) | 2013-12-26 |
JP6158077B2 JP6158077B2 (ja) | 2017-07-05 |
JP6158077B6 JP6158077B6 (ja) | 2018-08-29 |
Family
ID=43970974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013503032A Active JP6158077B6 (ja) | 2010-04-08 | 2011-04-06 | ヘルペス感染症の予防措置及び治療措置のためのピロキシカム |
Country Status (11)
Country | Link |
---|---|
US (2) | US20130190301A1 (ja) |
EP (1) | EP2374461B1 (ja) |
JP (1) | JP6158077B6 (ja) |
CN (1) | CN103153312B (ja) |
CA (1) | CA2795334C (ja) |
DE (1) | DE102010014290A1 (ja) |
DK (1) | DK2374461T3 (ja) |
ES (1) | ES2612584T3 (ja) |
PL (1) | PL2374461T3 (ja) |
RU (1) | RU2555765C2 (ja) |
WO (1) | WO2011124366A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102010014290A1 (de) * | 2010-04-08 | 2011-10-13 | Hans Otto Meyer zu Spelbrink | Mittel zur prophylaktischen und therapeutischen Behandlung von Herpes-Infektionen |
DE102013003756A1 (de) | 2013-03-06 | 2014-09-11 | DeaValorum UG (haftungsbeschränkt) | Piroxicam zur prophylaktischen und therapeutischen Behandlung von CMV-Infektionen |
DE102013014787A1 (de) | 2013-09-09 | 2015-03-12 | Dauphine UG (haftungsbeschränkt) | Mittel zur prophylaktischen und therapeutischen Behandlung von EHV-Infektionen |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004269528A (ja) * | 2003-03-10 | 2004-09-30 | Yongxin Pharmaceut Ind Co Ltd | ヘルペスウイルス感染により引き起こされる疼痛又は炎症の緩和に有効な局所皮膚適用製剤 |
JP2006517204A (ja) * | 2003-01-03 | 2006-07-20 | イネイムド ゲーエムベーハー インスティチュート フル アエロソルメディジン | ウイルス性疾患の予防及び/又は治療用活性成分の使用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3437232A1 (de) * | 1984-10-10 | 1986-04-17 | Mack Chem Pharm | Stabilisierte injektionsloesungen von piroxicam |
IT1216686B (it) * | 1988-04-01 | 1990-03-08 | Chiesi Farma Spa | Formulazioni farmaceutiche acquose di piroxicam e procedimento per laloro preparazione. |
IT1230922B (it) * | 1989-06-23 | 1991-11-08 | Giuseppe De Benedittis | Composizione per il trattamento della nevralgia erpetica acuta e della nevralgia post erpetica |
ES2059869T3 (es) * | 1990-04-26 | 1994-11-16 | Sagitta Arzneimittel Gmbh | Preparado farmaceutico que contiene piroxicam para uso topico. |
JP3031990B2 (ja) * | 1990-10-19 | 2000-04-10 | 同仁医薬化工株式会社 | 消炎鎮痛クリーム剤組成物 |
RU2182016C2 (ru) * | 1997-03-20 | 2002-05-10 | Панацея Биотек Лтд. | Спазмолитическая композиция, способ получения спазмолитической композиции |
DE102010014290A1 (de) * | 2010-04-08 | 2011-10-13 | Hans Otto Meyer zu Spelbrink | Mittel zur prophylaktischen und therapeutischen Behandlung von Herpes-Infektionen |
-
2010
- 2010-04-08 DE DE102010014290A patent/DE102010014290A1/de not_active Ceased
-
2011
- 2011-03-04 PL PL11001816T patent/PL2374461T3/pl unknown
- 2011-03-04 DK DK11001816.5T patent/DK2374461T3/en active
- 2011-03-04 ES ES11001816.5T patent/ES2612584T3/es active Active
- 2011-03-04 EP EP11001816.5A patent/EP2374461B1/de active Active
- 2011-04-06 WO PCT/EP2011/001704 patent/WO2011124366A1/de active Application Filing
- 2011-04-06 CA CA2795334A patent/CA2795334C/en active Active
- 2011-04-06 RU RU2012147474/15A patent/RU2555765C2/ru active
- 2011-04-06 US US13/639,357 patent/US20130190301A1/en not_active Abandoned
- 2011-04-06 JP JP2013503032A patent/JP6158077B6/ja active Active
- 2011-04-06 CN CN201180021384.XA patent/CN103153312B/zh active Active
-
2014
- 2014-01-29 US US14/167,676 patent/US20140148447A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006517204A (ja) * | 2003-01-03 | 2006-07-20 | イネイムド ゲーエムベーハー インスティチュート フル アエロソルメディジン | ウイルス性疾患の予防及び/又は治療用活性成分の使用 |
JP2004269528A (ja) * | 2003-03-10 | 2004-09-30 | Yongxin Pharmaceut Ind Co Ltd | ヘルペスウイルス感染により引き起こされる疼痛又は炎症の緩和に有効な局所皮膚適用製剤 |
Non-Patent Citations (1)
Title |
---|
JPN6014046023; 荻野篤彦ら: 'フェルデンの帯状疱疹に対する治験' 皮膚科紀要 79(4), 198411, 315-319 * |
Also Published As
Publication number | Publication date |
---|---|
JP6158077B2 (ja) | 2017-07-05 |
ES2612584T3 (es) | 2017-05-17 |
RU2012147474A (ru) | 2014-05-20 |
CA2795334A1 (en) | 2011-10-13 |
RU2555765C2 (ru) | 2015-07-10 |
WO2011124366A1 (de) | 2011-10-13 |
CA2795334C (en) | 2015-06-09 |
DK2374461T3 (en) | 2017-02-06 |
CN103153312A (zh) | 2013-06-12 |
US20140148447A1 (en) | 2014-05-29 |
EP2374461A1 (de) | 2011-10-12 |
DE102010014290A1 (de) | 2011-10-13 |
US20130190301A1 (en) | 2013-07-25 |
EP2374461B1 (de) | 2016-10-26 |
JP6158077B6 (ja) | 2018-08-29 |
PL2374461T3 (pl) | 2017-08-31 |
CN103153312B (zh) | 2015-07-22 |
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