JP2010518075A5 - - Google Patents
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- Publication number
- JP2010518075A5 JP2010518075A5 JP2009549052A JP2009549052A JP2010518075A5 JP 2010518075 A5 JP2010518075 A5 JP 2010518075A5 JP 2009549052 A JP2009549052 A JP 2009549052A JP 2009549052 A JP2009549052 A JP 2009549052A JP 2010518075 A5 JP2010518075 A5 JP 2010518075A5
- Authority
- JP
- Japan
- Prior art keywords
- phosphate
- composition
- sodium phosphate
- olopatadine
- adjusting agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JBIMVDZLSHOPLA-LSCVHKIXSA-N Olopatadine Chemical compound C1OC2=CC=C(CC(O)=O)C=C2C(=C/CCN(C)C)\C2=CC=CC=C21 JBIMVDZLSHOPLA-LSCVHKIXSA-N 0.000 claims 4
- 229960004114 olopatadine Drugs 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 229940061607 Dibasic Sodium Phosphate Drugs 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 3
- 239000003002 pH adjusting agent Substances 0.000 claims 3
- 239000010452 phosphate Substances 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 229960000686 Benzalkonium Chloride Drugs 0.000 claims 2
- 241000269435 Rana <genus> Species 0.000 claims 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 229940111685 Dibasic potassium phosphate Drugs 0.000 claims 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L Dipotassium phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 229940045641 Monobasic Sodium Phosphate Drugs 0.000 claims 1
- 229940111688 Monobasic potassium phosphate Drugs 0.000 claims 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M Monopotassium phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims 1
- 229940001496 Tribasic Sodium Phosphate Drugs 0.000 claims 1
- 229940062627 Tribasic potassium phosphate Drugs 0.000 claims 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims 1
- 235000019796 monopotassium phosphate Nutrition 0.000 claims 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims 1
- 235000019799 monosodium phosphate Nutrition 0.000 claims 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
Claims (2)
- ａ）オロパタジン遊離塩基０．５４〜０．６２％（ｗ／ｖ）または当量のオロパタジンの薬学的に許容できる塩；
ｂ）二塩基性リン酸ナトリウム０．２〜０．８％（ｗ／ｖ）と当量のリン酸塩であって、該リン酸塩は、一塩基性リン酸ナトリウム、二塩基性リン酸ナトリウム、三塩基性リン酸ナトリウム、一塩基性リン酸カリウム、二塩基性リン酸カリウム、および三塩基性リン酸カリウムからなる群から選択される、リン酸塩；
ｃ）ＮａＣｌ ０．３〜０．６％（ｗ／ｖ）；
ｄ）組成物がｐＨ３．６〜３．８を有するのに十分な量のｐＨ調節剤；
ｅ）塩化ベンザルコニウム０．００５〜０．０１５％（ｗ／ｖ）；
ｆ）エデト酸二ナトリウム０．００５〜０．０１５％（ｗ／ｖ）；ならびに
ｇ）水
からなる、組成物。 - ａ）オロパタジン遊離塩基０．６％（ｗ／ｖ）または当量のオロパタジンの薬学的に許容できる塩；
ｂ）二塩基性リン酸ナトリウム０．４〜０．６％（ｗ／ｖ）；
ｃ）ＮａＣｌ ０．３５〜０．４５％（ｗ／ｖ）；
ｄ）組成物がｐＨ３．６〜３．８を有するのに十分な量のｐＨ調節剤であって、該ｐＨ調節剤は、ＮａＯＨおよびＨＣｌからなる群から選択される、ｐＨ調節剤；
ｅ）塩化ベンザルコニウム０．０１％（ｗ／ｖ）；
ｆ）エデト酸二ナトリウム０．０１％（ｗ／ｖ）；ならびに
ｇ）水
からなる、組成物。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2007/003285 WO2008097220A1 (en) | 2007-02-07 | 2007-02-07 | Olopatadine formulations for topical nasal administration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518075A JP2010518075A (ja) | 2010-05-27 |
| JP2010518075A5 true JP2010518075A5 (ja) | 2011-03-10 |
| JP5149308B2 JP5149308B2 (ja) | 2013-02-20 |
Family
ID=38542957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549052A Active JP5149308B2 (ja) | 2007-02-07 | 2007-02-07 | 局所的鼻腔投与のためのオロパタジンの製剤 |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP2114367B1 (ja) |
| JP (1) | JP5149308B2 (ja) |
| KR (1) | KR20100014858A (ja) |
| CN (1) | CN101621989A (ja) |
| AU (1) | AU2007346121B2 (ja) |
| BR (1) | BRPI0721255B8 (ja) |
| CA (1) | CA2677631C (ja) |
| DK (1) | DK2114367T3 (ja) |
| ES (2) | ES2557939T3 (ja) |
| HK (1) | HK1217090A1 (ja) |
| HU (1) | HUE026162T2 (ja) |
| MX (1) | MX2009008548A (ja) |
| PL (1) | PL2114367T3 (ja) |
| PT (1) | PT2114367E (ja) |
| SI (1) | SI2114367T1 (ja) |
| WO (1) | WO2008097220A1 (ja) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011001317A (ja) * | 2009-06-19 | 2011-01-06 | Fumakilla Ltd | 鼻用洗浄剤 |
| EP2453872B1 (en) * | 2009-07-17 | 2013-08-21 | Alcon Research, Ltd. | Olopatadine nasal spray regimen for children |
| KR101271925B1 (ko) * | 2011-02-10 | 2013-06-05 | 비. 김 로버트 | 미네랄 알칼리수 |
| TW201336527A (zh) * | 2012-02-10 | 2013-09-16 | Alcon Res Ltd | 具增強的穩定性之水性藥學組成物 |
| CN103830219A (zh) * | 2012-11-20 | 2014-06-04 | 深圳大佛药业有限公司 | 一种稳定的奥洛他定组合物 |
| TW202133861A (zh) * | 2019-12-06 | 2021-09-16 | 日商東興藥品工業股份有限公司 | 含有歐羅派特錠的點鼻用組成物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4923892A (en) | 1985-08-17 | 1990-05-08 | Burroughs Wellcome Co. | Tricyclic aromatic compounds |
| GB8520662D0 (en) | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
| JPS6310784A (ja) | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
| JP3662944B2 (ja) * | 1993-08-24 | 2005-06-22 | 協和醗酵工業株式会社 | 点鼻剤 |
| US5641805A (en) | 1995-06-06 | 1997-06-24 | Alcon Laboratories, Inc. | Topical ophthalmic formulations for treating allergic eye diseases |
| ATE291913T1 (de) * | 2000-01-25 | 2005-04-15 | Alcon Inc | Antiallergische ophthalmische zubereitungen, geeignet zur anwendung mit kontaktlinsen |
| TWI231759B (en) * | 2001-06-27 | 2005-05-01 | Alcon Inc | Olopatadine formulations for topical administration |
| MXPA05005044A (es) * | 2002-11-12 | 2005-07-01 | Alcon Inc | El uso de un agente antialergico y un esteroide para tratar rinitis alergica. |
| ATE443516T1 (de) | 2004-11-24 | 2009-10-15 | Alcon Inc | Verfahren zur verabreichung eines nasensprays |
-
2007
- 2007-02-07 EP EP07750153.4A patent/EP2114367B1/en active Active
- 2007-02-07 AU AU2007346121A patent/AU2007346121B2/en active Active
- 2007-02-07 PT PT77501534T patent/PT2114367E/pt unknown
- 2007-02-07 ES ES07750153.4T patent/ES2557939T3/es active Active
- 2007-02-07 CN CN200780051017A patent/CN101621989A/zh active Pending
- 2007-02-07 HU HUE07750153A patent/HUE026162T2/en unknown
- 2007-02-07 SI SI200731711T patent/SI2114367T1/sl unknown
- 2007-02-07 EP EP15185071.6A patent/EP2977042B1/en active Active
- 2007-02-07 ES ES15185071T patent/ES2781090T3/es active Active
- 2007-02-07 PL PL07750153T patent/PL2114367T3/pl unknown
- 2007-02-07 BR BRPI0721255A patent/BRPI0721255B8/pt active IP Right Grant
- 2007-02-07 CA CA2677631A patent/CA2677631C/en active Active
- 2007-02-07 MX MX2009008548A patent/MX2009008548A/es active IP Right Grant
- 2007-02-07 JP JP2009549052A patent/JP5149308B2/ja active Active
- 2007-02-07 WO PCT/US2007/003285 patent/WO2008097220A1/en active Application Filing
- 2007-02-07 DK DK07750153.4T patent/DK2114367T3/en active
- 2007-02-07 KR KR1020097017832A patent/KR20100014858A/ko not_active Application Discontinuation
-
2016
- 2016-05-04 HK HK16105086.6A patent/HK1217090A1/zh unknown
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