JP2009538899A - トリアゾロピリダジン誘導体 - Google Patents
トリアゾロピリダジン誘導体 Download PDFInfo
- Publication number
- JP2009538899A JP2009538899A JP2009512702A JP2009512702A JP2009538899A JP 2009538899 A JP2009538899 A JP 2009538899A JP 2009512702 A JP2009512702 A JP 2009512702A JP 2009512702 A JP2009512702 A JP 2009512702A JP 2009538899 A JP2009538899 A JP 2009538899A
- Authority
- JP
- Japan
- Prior art keywords
- membered
- cancer
- aryl
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80346906P | 2006-05-30 | 2006-05-30 | |
PCT/IB2007/001446 WO2007138472A2 (fr) | 2006-05-30 | 2007-05-18 | Dérivés de la triazolopyridazine |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2009538899A true JP2009538899A (ja) | 2009-11-12 |
Family
ID=38626862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009512702A Withdrawn JP2009538899A (ja) | 2006-05-30 | 2007-05-18 | トリアゾロピリダジン誘導体 |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP2032578A2 (fr) |
JP (1) | JP2009538899A (fr) |
CA (1) | CA2651979A1 (fr) |
WO (1) | WO2007138472A2 (fr) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009543789A (ja) * | 2006-07-14 | 2009-12-10 | アムジエン・インコーポレーテツド | 縮合複素環誘導体およびそれの使用方法 |
JP2013533885A (ja) * | 2010-07-02 | 2013-08-29 | ギリアード サイエンシーズ, インコーポレイテッド | Hiv抗ウイルス化合物としての2−キノリニル−酢酸誘導体 |
JP2013209418A (ja) * | 2009-12-31 | 2013-10-10 | Hutchison Medipharma Ltd | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
JP2016530304A (ja) * | 2013-09-17 | 2016-09-29 | 江蘇天士力帝益薬業有限会社Jiangsu Tasly Diyi Pharmaceutical Co., Ltd. | チエノピペリジン誘導体およびその使用 |
JP2019505581A (ja) * | 2015-12-31 | 2019-02-28 | ベイジン・パール・バイオテクノロジー・リミテッド・ライアビリティ・カンパニー | 神経膠腫の治療用の薬剤の調製における化合物の使用 |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2634721C (fr) | 2005-12-21 | 2014-06-17 | Janssen Pharmaceutica N.V. | Triazolopyridazines en tant que modulateurs de la tyrosine kinase |
US8198448B2 (en) | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
US8217177B2 (en) * | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
KR101083177B1 (ko) * | 2006-10-23 | 2011-11-11 | 에스지엑스 파마슈티컬스, 인코포레이티드 | 트리아졸로-피리다진 단백질 키나제 조정제 |
WO2009005675A1 (fr) | 2007-06-28 | 2009-01-08 | Abbott Laboratories | Nouvelles triazolopyridazines |
FR2919870B1 (fr) * | 2007-08-09 | 2014-05-16 | Sanofi Aventis | Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzothiazole et benzimidazole, procede, compositions pharmaceutiques et nouvelle utilisation comme inhibiteurs de cmet |
PA8792501A1 (es) | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
UY31676A1 (es) | 2008-02-28 | 2009-09-30 | "derivados de 3-metil-imidiazo-[1,2-b]-piridazina" | |
US8324241B2 (en) | 2008-04-11 | 2012-12-04 | Bristol-Myers Squibb Company | Triazolo compounds useful as DGAT1 inhibitors |
WO2009126861A2 (fr) | 2008-04-11 | 2009-10-15 | Bristol-Myers Squibb Company | Composés de triazolopyridine utiles en tant qu'inhibiteurs de dgat1 |
DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
DE102008037790A1 (de) | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
DE102008038221A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | 7-Azaindolderivate |
DE102008038222A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | Indazol-5-carbonsäurehydrazid-derivate |
DE102008038220A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | Oxadiazolderivate |
US8217056B2 (en) * | 2008-11-19 | 2012-07-10 | Vertex Pharmaceuticals Incorporated | Triazolothiadiazole inhibitor of c-Met protein kinase |
JP2012509342A (ja) * | 2008-11-20 | 2012-04-19 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換ピロロ[2,3−b]−ピリジンおよび−ピラジン |
DE102008063667A1 (de) | 2008-12-18 | 2010-07-01 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-°[1,2,4]triazolo[4,3-b]pyrimidin-derivate |
DE102008062825A1 (de) | 2008-12-23 | 2010-06-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo [4,3-b]pyridazin-derivate |
FR2941951B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
FR2941952B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
FR2941949B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
FR2941950B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
KR20110113755A (ko) | 2009-02-10 | 2011-10-18 | 아스트라제네카 아베 | 트리아졸로 〔4,3-b〕 피리다진 유도체 및 전립샘암에 대한 이의 용도 |
AU2010254063A1 (en) * | 2009-05-28 | 2011-12-01 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-Met protein kinase |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
BR112012003262A8 (pt) | 2009-08-12 | 2016-05-17 | Novartis Ag | compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação |
KR20120089463A (ko) | 2009-08-20 | 2012-08-10 | 노파르티스 아게 | 헤테로시클릭 옥심 화합물 |
AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
WO2011143646A1 (fr) | 2010-05-14 | 2011-11-17 | OSI Pharmaceuticals, LLC | Inhibiteurs de kinases bicycliques fusionnés |
US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
PE20130385A1 (es) | 2010-07-02 | 2013-03-30 | Gilead Sciences Inc | Derivados del acido naft-2-ilacetico para tratar el sida |
WO2012145728A1 (fr) | 2011-04-21 | 2012-10-26 | Gilead Sciences, Inc. | Composés benzothiazoles et leur utilisation pharmaceutique |
US20140088114A1 (en) | 2011-05-16 | 2014-03-27 | OSI Pharmaceuticals ,LLC | Fused bicyclic kinase inhibitors |
WO2013038362A1 (fr) | 2011-09-15 | 2013-03-21 | Novartis Ag | 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines substituées en position 6 à activité tyrosine kinase |
WO2013103724A1 (fr) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Dérivés d'acide 2-(tert-butoxy)-2-(7-méthylquinoléin-6-yl)acétique pour traiter le sida |
US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
EP2788336B1 (fr) | 2012-04-20 | 2016-03-02 | Gilead Sciences, Inc. | Dérivés d'acide benzothiazole-6-yl acétique et leur utilisation pour le traitement d'une infection par le vih |
WO2015134854A2 (fr) * | 2014-03-06 | 2015-09-11 | Oyagen, Inc. | Antagonistes à petites molécules obtenus par dimérisation de vif à titre d'agents anti-vih et pouvant être utilisés à titre d'agents thérapeutiques |
PL224660B1 (pl) * | 2014-07-23 | 2017-01-31 | Inst Immunologii I Terapii Doświadczalnej | Nowe analogi 1,2,4-triazoli i sposób otrzymywania analogów 1,2,4-triazoli |
JP6864953B2 (ja) | 2014-12-09 | 2021-04-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Axlに対するヒトモノクローナル抗体 |
WO2016135041A1 (fr) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Protéines de fusion et anticorps les contenant pour favoriser l'apoptose |
CN116969955B (zh) * | 2023-09-25 | 2023-12-19 | 中国药科大学 | 一种[1,2,4]***[4,3-b]哒嗪类化合物及其制法与应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10038019A1 (de) * | 2000-08-04 | 2002-02-14 | Bayer Ag | Substituierte Triazolopyrid(az)ine |
KR20040087335A (ko) * | 2002-03-01 | 2004-10-13 | 야마노우치세이야쿠 가부시키가이샤 | 질소 함유 복소환 화합물 |
JP4817661B2 (ja) * | 2002-12-18 | 2011-11-16 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとしてのトリアゾロピリダジン |
EP1963329B1 (fr) * | 2005-11-30 | 2013-01-23 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de c-met et leurs utilisations |
CA2634721C (fr) * | 2005-12-21 | 2014-06-17 | Janssen Pharmaceutica N.V. | Triazolopyridazines en tant que modulateurs de la tyrosine kinase |
-
2007
- 2007-05-18 WO PCT/IB2007/001446 patent/WO2007138472A2/fr active Application Filing
- 2007-05-18 EP EP07734734A patent/EP2032578A2/fr not_active Withdrawn
- 2007-05-18 JP JP2009512702A patent/JP2009538899A/ja not_active Withdrawn
- 2007-05-18 CA CA002651979A patent/CA2651979A1/fr not_active Abandoned
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009543789A (ja) * | 2006-07-14 | 2009-12-10 | アムジエン・インコーポレーテツド | 縮合複素環誘導体およびそれの使用方法 |
JP2013209418A (ja) * | 2009-12-31 | 2013-10-10 | Hutchison Medipharma Ltd | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
JP2016155848A (ja) * | 2009-12-31 | 2016-09-01 | ハッチソン・メディファーマ・リミテッド | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
JP2018009004A (ja) * | 2009-12-31 | 2018-01-18 | ハッチソン・メディファーマ・リミテッド | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
JP2013533885A (ja) * | 2010-07-02 | 2013-08-29 | ギリアード サイエンシーズ, インコーポレイテッド | Hiv抗ウイルス化合物としての2−キノリニル−酢酸誘導体 |
JP2016530304A (ja) * | 2013-09-17 | 2016-09-29 | 江蘇天士力帝益薬業有限会社Jiangsu Tasly Diyi Pharmaceutical Co., Ltd. | チエノピペリジン誘導体およびその使用 |
JP2019505581A (ja) * | 2015-12-31 | 2019-02-28 | ベイジン・パール・バイオテクノロジー・リミテッド・ライアビリティ・カンパニー | 神経膠腫の治療用の薬剤の調製における化合物の使用 |
Also Published As
Publication number | Publication date |
---|---|
CA2651979A1 (fr) | 2007-12-06 |
EP2032578A2 (fr) | 2009-03-11 |
WO2007138472A2 (fr) | 2007-12-06 |
WO2007138472A3 (fr) | 2008-02-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A300 | Withdrawal of application because of no request for examination |
Free format text: JAPANESE INTERMEDIATE CODE: A300 Effective date: 20100803 |