WO2007138472A3 - Dérivés de la triazolopyridazine - Google Patents
Dérivés de la triazolopyridazine Download PDFInfo
- Publication number
- WO2007138472A3 WO2007138472A3 PCT/IB2007/001446 IB2007001446W WO2007138472A3 WO 2007138472 A3 WO2007138472 A3 WO 2007138472A3 IB 2007001446 W IB2007001446 W IB 2007001446W WO 2007138472 A3 WO2007138472 A3 WO 2007138472A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- formula
- triazolopyridazine derivatives
- relates
- triazolopyridazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La présente invention concerne des composés de formule (I) ou un de leurs sels pharmaceutiquement acceptable, dans laquelle R1, R2, R3 et R3' sont tels que définis ici. L'invention concerne également des compositions pharmaceutiques contenant les composés de formule (I) et des procédés de traitement des affections hyperprolifératives chez un mammifère par l'administration des composés de formule (I).
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009512702A JP2009538899A (ja) | 2006-05-30 | 2007-05-18 | トリアゾロピリダジン誘導体 |
CA002651979A CA2651979A1 (fr) | 2006-05-30 | 2007-05-18 | Derives de la triazolopyridazine |
EP07734734A EP2032578A2 (fr) | 2006-05-30 | 2007-05-18 | Dérivés de la triazolopyridazine |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80346906P | 2006-05-30 | 2006-05-30 | |
US60/803,469 | 2006-05-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007138472A2 WO2007138472A2 (fr) | 2007-12-06 |
WO2007138472A3 true WO2007138472A3 (fr) | 2008-02-07 |
Family
ID=38626862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2007/001446 WO2007138472A2 (fr) | 2006-05-30 | 2007-05-18 | Dérivés de la triazolopyridazine |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP2032578A2 (fr) |
JP (1) | JP2009538899A (fr) |
CA (1) | CA2651979A1 (fr) |
WO (1) | WO2007138472A2 (fr) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP3433A (en) | 2005-12-21 | 2015-10-31 | Janssen Pharmaceutica Nv | Triazolopyridazines as tyrosine kinase modultors |
US8217177B2 (en) * | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
US8198448B2 (en) | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
PE20080403A1 (es) * | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
PT2081937E (pt) * | 2006-10-23 | 2012-10-15 | Sgx Pharmaceuticals Inc | Moduladores de proteína-cinase de triazolo-piridazina |
WO2009005675A1 (fr) | 2007-06-28 | 2009-01-08 | Abbott Laboratories | Nouvelles triazolopyridazines |
PA8792501A1 (es) * | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
FR2919870B1 (fr) * | 2007-08-09 | 2014-05-16 | Sanofi Aventis | Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzothiazole et benzimidazole, procede, compositions pharmaceutiques et nouvelle utilisation comme inhibiteurs de cmet |
WO2009106577A1 (fr) | 2008-02-28 | 2009-09-03 | Novartis Ag | Dérivés d’imidazo[1,2-b]pyridazine pour le traitement de maladies médiées par la tyrosine kinase c-met |
US8324241B2 (en) | 2008-04-11 | 2012-12-04 | Bristol-Myers Squibb Company | Triazolo compounds useful as DGAT1 inhibitors |
WO2009126861A2 (fr) | 2008-04-11 | 2009-10-15 | Bristol-Myers Squibb Company | Composés de triazolopyridine utiles en tant qu'inhibiteurs de dgat1 |
DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
DE102008037790A1 (de) | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
DE102008038222A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | Indazol-5-carbonsäurehydrazid-derivate |
DE102008038221A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | 7-Azaindolderivate |
DE102008038220A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | Oxadiazolderivate |
NZ592825A (en) * | 2008-11-19 | 2013-01-25 | Vertex Pharma | A triazolothiadiazole inhibitor of c-met protein kinase |
US8592448B2 (en) | 2008-11-20 | 2013-11-26 | OSI Pharmaceuticals, LLC | Substituted pyrrolo[2,3-b]-pyridines and -pyrazines |
DE102008063667A1 (de) | 2008-12-18 | 2010-07-01 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-°[1,2,4]triazolo[4,3-b]pyrimidin-derivate |
DE102008062825A1 (de) | 2008-12-23 | 2010-06-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo [4,3-b]pyridazin-derivate |
FR2941950B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
FR2941951B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
FR2941949B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
FR2941952B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
EA019647B1 (ru) * | 2009-02-10 | 2014-05-30 | Астразенека Аб | ПРОИЗВОДНЫЕ ТРИАЗОЛО[4,3-b]ПИРИДАЗИНА И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ |
US8263776B2 (en) | 2009-05-28 | 2012-09-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-Met protein kinase |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
MX2012001838A (es) | 2009-08-12 | 2012-02-29 | Novartis Ag | Compuestos de hidrazona heterociclico y sus usos para tratar cancer e inflamacion. |
IN2012DN01453A (fr) | 2009-08-20 | 2015-06-05 | Novartis Ag | |
PT3795573T (pt) | 2009-12-31 | 2022-09-15 | Hutchison Medipharma Ltd | Certas triazolopirazinas, suas composições e seus métodos de utilização |
AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
EP2569315A1 (fr) | 2010-05-14 | 2013-03-20 | OSI Pharmaceuticals, LLC | Inhibiteurs de kinases bicycliques fusionnés |
US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
PE20130525A1 (es) * | 2010-07-02 | 2013-05-05 | Gilead Sciences Inc | Derivados de acido 2 quinolinil acetico como compuestos antivirales frente a vih |
ES2634490T3 (es) | 2010-07-02 | 2017-09-28 | Gilead Sciences, Inc. | Derivados de ácido napht-2-ylacetico para tratar el sida |
AU2012245187B2 (en) | 2011-04-21 | 2016-06-30 | Gilead Sciences, Inc. | Benzothiazole compounds and their pharmaceutical use |
US20140088114A1 (en) | 2011-05-16 | 2014-03-27 | OSI Pharmaceuticals ,LLC | Fused bicyclic kinase inhibitors |
EP2755976B1 (fr) | 2011-09-15 | 2018-07-18 | Novartis AG | 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines substituées en position 6 à activité tyrosine kinase |
WO2013103738A1 (fr) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Dérivés d'acide naphtalène acétique contre l'infection par le vih |
WO2013103724A1 (fr) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Dérivés d'acide 2-(tert-butoxy)-2-(7-méthylquinoléin-6-yl)acétique pour traiter le sida |
CA2850881C (fr) | 2012-04-20 | 2021-02-16 | Gilead Sciences, Inc. | Derives d'acide benzothiazol-6-yl acetique et leur utilisation dans le traitement d'une infection par le vih |
CN104447867B (zh) * | 2013-09-17 | 2017-12-26 | 江苏天士力帝益药业有限公司 | 一种噻吩并哌啶衍生物、制备方法及其应用 |
WO2015134854A2 (fr) * | 2014-03-06 | 2015-09-11 | Oyagen, Inc. | Antagonistes à petites molécules obtenus par dimérisation de vif à titre d'agents anti-vih et pouvant être utilisés à titre d'agents thérapeutiques |
PL224660B1 (pl) * | 2014-07-23 | 2017-01-31 | Inst Immunologii I Terapii Doświadczalnej | Nowe analogi 1,2,4-triazoli i sposób otrzymywania analogów 1,2,4-triazoli |
EP3229836B1 (fr) | 2014-12-09 | 2019-11-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Anticoprs monoclonaux contre 'axl' |
WO2016135041A1 (fr) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Protéines de fusion et anticorps les contenant pour favoriser l'apoptose |
CN108853108A (zh) * | 2015-12-31 | 2018-11-23 | 北京浦润奥生物科技有限责任公司 | 化合物在制备用于治疗脑胶质瘤的药物中的用途 |
CN116969955B (zh) * | 2023-09-25 | 2023-12-19 | 中国药科大学 | 一种[1,2,4]***[4,3-b]哒嗪类化合物及其制法与应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002012236A1 (fr) * | 2000-08-04 | 2002-02-14 | Bayer Cropscience Ag | Triazolopyrid(az)ines substituees en tant qu'agents de traitement des vegetaux (herbicides) |
WO2004058769A2 (fr) * | 2002-12-18 | 2004-07-15 | Vertex Pharmaceuticals Incorporated | Compositions utiles en tant qu'inhibiteurs des proteine kinases |
EP1481977A1 (fr) * | 2002-03-01 | 2004-12-01 | Yamanouchi Pharmaceutical Co. Ltd. | Compose heterocyclique azote |
WO2007064797A2 (fr) * | 2005-11-30 | 2007-06-07 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de c-met et leurs utilisations |
WO2007075567A1 (fr) * | 2005-12-21 | 2007-07-05 | Janssen Pharmaceutica, N.V. | Triazolopyridazines en tant que modulateurs de la tyrosine kinase |
-
2007
- 2007-05-18 WO PCT/IB2007/001446 patent/WO2007138472A2/fr active Application Filing
- 2007-05-18 CA CA002651979A patent/CA2651979A1/fr not_active Abandoned
- 2007-05-18 EP EP07734734A patent/EP2032578A2/fr not_active Withdrawn
- 2007-05-18 JP JP2009512702A patent/JP2009538899A/ja not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002012236A1 (fr) * | 2000-08-04 | 2002-02-14 | Bayer Cropscience Ag | Triazolopyrid(az)ines substituees en tant qu'agents de traitement des vegetaux (herbicides) |
EP1481977A1 (fr) * | 2002-03-01 | 2004-12-01 | Yamanouchi Pharmaceutical Co. Ltd. | Compose heterocyclique azote |
WO2004058769A2 (fr) * | 2002-12-18 | 2004-07-15 | Vertex Pharmaceuticals Incorporated | Compositions utiles en tant qu'inhibiteurs des proteine kinases |
WO2007064797A2 (fr) * | 2005-11-30 | 2007-06-07 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de c-met et leurs utilisations |
WO2007075567A1 (fr) * | 2005-12-21 | 2007-07-05 | Janssen Pharmaceutica, N.V. | Triazolopyridazines en tant que modulateurs de la tyrosine kinase |
Non-Patent Citations (2)
Title |
---|
CUCEK, KARMEN ET AL: "Synthesis of novel [1,2,4]triazolo[4,3-b]pyridazines", ARKIVOC (GAINESVILLE, FL, UNITED STATES) [ONLINE COMPUTER FILE] , (5), 79-86 CODEN: AGFUAR URL: HTTP://WWW.ARKAT-USA.ORG/ARK/JOURNAL/VOLUME2/PART3/TISLER/MT-161/MT- 161.PDF, 2001, XP002459200 * |
KOSARY ET AL.: "Preparation of New[1,2,4]Triazolo[4,3-b]pyridazines", PHARMAZIE, vol. 38, no. 6, 1983, pages 369 - 371, XP001536587 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007138472A2 (fr) | 2007-12-06 |
CA2651979A1 (fr) | 2007-12-06 |
JP2009538899A (ja) | 2009-11-12 |
EP2032578A2 (fr) | 2009-03-11 |
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