JP2006169180A - 銅含有経口投与組成物 - Google Patents
銅含有経口投与組成物 Download PDFInfo
- Publication number
- JP2006169180A JP2006169180A JP2004365548A JP2004365548A JP2006169180A JP 2006169180 A JP2006169180 A JP 2006169180A JP 2004365548 A JP2004365548 A JP 2004365548A JP 2004365548 A JP2004365548 A JP 2004365548A JP 2006169180 A JP2006169180 A JP 2006169180A
- Authority
- JP
- Japan
- Prior art keywords
- copper
- oral administration
- composition
- fatty acid
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 title abstract description 13
- 229910052802 copper Inorganic materials 0.000 title abstract description 13
- 239000010949 copper Substances 0.000 title abstract description 13
- -1 fatty acid ester Chemical class 0.000 claims abstract description 29
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 25
- 239000000194 fatty acid Substances 0.000 claims abstract description 25
- 229930195729 fatty acid Natural products 0.000 claims abstract description 25
- 229920000223 polyglycerol Polymers 0.000 claims abstract description 17
- 239000005749 Copper compound Substances 0.000 claims abstract description 13
- 150000001880 copper compounds Chemical class 0.000 claims abstract description 13
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims abstract description 9
- 229940108925 copper gluconate Drugs 0.000 claims abstract description 9
- RAOSIAYCXKBGFE-UHFFFAOYSA-K [Cu+3].[O-]P([O-])([O-])=O Chemical compound [Cu+3].[O-]P([O-])([O-])=O RAOSIAYCXKBGFE-UHFFFAOYSA-K 0.000 claims abstract description 3
- 229910000365 copper sulfate Inorganic materials 0.000 claims abstract description 3
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims abstract description 3
- XTVVROIMIGLXTD-UHFFFAOYSA-N copper(II) nitrate Chemical compound [Cu+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O XTVVROIMIGLXTD-UHFFFAOYSA-N 0.000 claims abstract description 3
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims abstract description 3
- FWBOFUGDKHMVPI-UHFFFAOYSA-K dicopper;2-oxidopropane-1,2,3-tricarboxylate Chemical compound [Cu+2].[Cu+2].[O-]C(=O)CC([O-])(C([O-])=O)CC([O-])=O FWBOFUGDKHMVPI-UHFFFAOYSA-K 0.000 claims abstract description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 235000019640 taste Nutrition 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 4
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 238000006116 polymerization reaction Methods 0.000 claims description 2
- 125000004185 ester group Chemical group 0.000 claims 1
- 229910001431 copper ion Inorganic materials 0.000 abstract description 24
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 abstract description 22
- 235000019606 astringent taste Nutrition 0.000 abstract description 11
- 235000011187 glycerol Nutrition 0.000 abstract description 7
- 238000002360 preparation method Methods 0.000 abstract description 5
- 206010013911 Dysgeusia Diseases 0.000 abstract description 3
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- 150000002314 glycerols Chemical class 0.000 abstract 1
- 230000000379 polymerizing effect Effects 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 239000008213 purified water Substances 0.000 description 17
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 150000002148 esters Chemical class 0.000 description 11
- 239000002253 acid Substances 0.000 description 10
- 235000015165 citric acid Nutrition 0.000 description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
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Images
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- General Preparation And Processing Of Foods (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
【解決手段】グルコン酸銅、硫酸銅、クエン酸銅、塩化銅、硝酸銅およびリン酸銅からなる群から選ばれた1種又は2種以上の銅化合物、および4〜20個のグリセリンが重合したポリグリセリンと炭素数8〜20個の脂肪酸を縮合したエステルであって、HLBが12以上のポリグリセリン脂肪酸エステルを含有し、pHが2.5〜7.0の内服液剤であることを特徴とする経口投与組成物。
【選択図】なし
Description
グルコン酸銅 0.004g
グルコン酸亜鉛 0.02g
ポリグリセリン脂肪酸エステル 0.12g
ポリオキシエチレン硬化ヒマシ油 0.10g
酢酸トコフェロール 0.10g
硝酸チアミン 0.01g
リン酸リボフラビンナトリウム 0.01g
塩酸ピリドキシン 0.01g
アスコルビン酸 1.00g
アミノエチルスルホン酸 2.00g
キシリトール 4.00g
トレハロース 5.00g
エリスリトール 5.00g
クエン酸 0.80g
クエン酸ナトリウム 適量
安息香酸ナトリウム 0.06g
グリセリン 0.10g
ミックスフルーツフレーバー 0.10g
上記成分を精製水に溶解した後、pHを3.0に調整し、精製水を加えて全量を100mLとした。この液をろ紙でろ過し、滅菌装置を用いて、ろ液を80℃で25分間加熱滅菌した後、ガラス瓶に充填しキャップを施して内服液剤を得た。
グルコン酸銅 0.007g
グルコン酸亜鉛 0.05g
ポリグリセリン脂肪酸エステル 0.10g
アルギン酸プロピレングリコール 0.05g
酢酸トコフェロール 0.05g
グルコン酸カルシウム 0.80g
硝酸チアミン 0.01g
リボフラビン 0.01g
塩酸ピリドキシン 0.10g
アスコルビン酸 1.00g
アミノエチルスルホン酸 1.00g
ソルビトール 4.00g
トレハロース 5.00g
キシリトール 4.00g
ステビア抽出物 0.03g
アセスルファムカリウム 0.03g
リンゴ酸 0.10g
クエン酸 0.40g
クエン酸ナトリウム 適量
安息香酸 0.06g
パラオキシ安息香酸ブチル 0.006g
パラオキシ安息香酸プロピル 0.006g
グリセリン 0.12g
アップルフレーバー 0.10g
上記成分を精製水に溶解した後、pHを4.0に調整し、精製水を加えて全量を100mLとした。この液をろ紙でろ過し、滅菌装置を用いて、ろ液を80℃で25分間加熱滅菌した後、ガラス瓶に充填しキャップを施して内服液剤を得た。
グルコン酸銅 0.03g
グルコン酸亜鉛 0.08g
ポリグリセリン脂肪酸エステル 0.20g
ショ糖脂肪酸エステル 0.10g
リボフラビン 0.01g
塩酸ピリドキシン 0.01g
アスコルビン酸 1.00g
シアノコバラミン 120μg
パンテノール 0.01g
ニコチン酸アミド 0.05g
アミノエチルスルホン酸 1.00g
ソルビトール 5.00g
トレハロース 2.00g
マルチトール 2.00g
クエン酸 0.40g
リンゴ酸ナトリウム 適量
安息香酸 0.06g
パラオキシ安息香酸ブチル 0.006g
パラオキシ安息香酸プロピル 0.006g
トリカプリリン 0.05g
グリセリン 0.20g
ミックスフルーツフレーバー 0.10g
上記成分を精製水に溶解した後、pHを4.5に調整し、精製水を加えて全量を100mLとした。この液をろ紙でろ過し、滅菌装置を用いて、ろ液を80℃で25分間加熱滅菌した後、ガラス瓶に充填しキャップを施して内服液剤を得た。
グルコン酸銅 0.007g
グルコン酸亜鉛 0.05g
ポリグリセリン脂肪酸エステル 0.10g
ポリオキシエチレン硬化ヒマシ油 0.07g
酢酸トコフェロール 0.02g
トリカプリリン 0.02g
グルコン酸カルシウム 0.80g
硝酸チアミン 0.01g
リン酸リボフラビンナトリウム 0.01g
塩酸ピリドキシン 0.01g
ニコチン酸アミド 0.10g
無水カフェイン 0.10g
アミノエチルスルホン酸 2.00g
ヨクイニン流エキス 2.00mL
ブドウ糖 5.00g
難消化性デキストリン 4.00g
エリスリトール 5.00g
キシリトール 2.00g
ステビア抽出物 0.02g
アセスルファムカリウム 0.03g
スクラロース 0.05g
クエン酸 0.80g
クエン酸ナトリウム 適量
安息香酸ナトリウム 0.06g
パラオキシ安息香酸ブチル 0.006g
パラオキシ安息香酸プロピル 0.006g
グリセリン 0.12g
ミックスフルーツフレーバー 0.10g
上記成分を精製水に溶解した後、pHを3.5に調整し、精製水を加え全量を100mLとした。この液をろ紙でろ過し、滅菌装置を用いて、ろ液を80℃で25分間加熱滅菌した後、ガラス瓶に充填しキャップを施して内服液剤を得た。
グルコン酸銅 0.03g
グルコン酸亜鉛 0.08g
ポリグリセリン脂肪酸エステル 0.20g
ポリオキシエチレン硬化ヒマシ油 0.10g
トリカプリリン 0.05g
グルコン酸カルシウム 0.40g
乳酸カルシウム 0.50g
硝酸チアミン 0.01g
リン酸リボフラビンナトリウム 0.02g
塩酸ピリドキシン 0.03g
ニコチン酸アミド 0.05g
無水カフェイン 0.10g
アミノエチルスルホン酸 2.00g
ヨクイニン流エキス 2.00mL
ローヤルゼリー 0.60g
ブドウ糖 5.00g
ソルビトール 5.00g
キシリトール 5.00g
ステビア抽出物 0.02g
アセスルファムカリウム 0.03g
クエン酸 0.80g
クエン酸ナトリウム 0.10g
リン酸 0.30g
塩酸 適量
安息香酸ナトリウム 0.06g
パラオキシ安息香酸ブチル 0.006g
パラオキシ安息香酸プロピル 0.006g
グリセリン 0.20g
ミックスフルーツフレーバー 0.10g
上記成分を精製水に溶解した後、pHを3.5に調整し、精製水を加え全量を100mLとした。この液をろ紙でろ過し、滅菌装置を用いて、ろ液を80℃で25分間加熱滅菌した後、ガラス瓶に充填しキャップを施して内服液剤を得た。
Hagermanらは、溶液中のタンパク(ウシ血清アルブミン:BSA)がタンニンにより凝集し、その沈澱量はタンニンの量に比例することを報告した(J.Agric.Food.Chem.,1978,Vol.26,809-812)。本発明者らは、銅イオン溶液にBSA溶液を加えると、この溶液が懸濁し、光の透過量が減少すること、この透過量の減少が、銅イオンの濃度に相関することを見出した。
(1)BSA溶液の調製:BSA(Sigma Chemical Co.;fraction V,fatty acid free)6gを適量の精製水に溶解し、クエン酸100mgを加え、NaOH溶液(1mol/L)でpHを4.8に調整し、精製水で100mLとした。
各銅イオン溶液2mLにBSA溶液6mLを加え、希釈液でそれぞれ全量を10mLとした。これを40℃で30分間振とうした。石英セル(L=1cm)を使用し、分光光度計(日立製作所製:U−3300)により、各透明溶液では吸収されない波長である500nmにおける吸光度を測定した。この結果(図1)は、銅イオン濃度と吸光度が相関することを示す。
上記(1)〜(4)に記載した方法により、表1に示す処方のタンパク凝集性を評価した。結果を併せて表1に示した。
Claims (5)
- 銅化合物およびポリグリセリン脂肪酸エステルを含有することを特徴とする経口投与組成物。
- 銅化合物が、グルコン酸銅、硫酸銅、クエン酸銅、塩化銅、硝酸銅およびリン酸銅からなる群から選ばれる1種又は2種以上の銅化合物である請求項1に記載の経口投与組成物。
- ポリグリセリン脂肪酸エステルが、4〜20個のグリセリンが重合したポリグリセリンと炭素数8〜20個の脂肪酸を縮合したエステルであって、HLBが12以上である請求項1又は2に記載の経口投与組成物。
- pHが2.5〜7.0の内服液剤である請求項1〜3のいずれかに記載の経口投与組成物。
- ポリグリセリン脂肪酸エステルを配合することを特徴とする銅化合物含有経口投与組成物の不快な味の低減方法。
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JP2002080347A (ja) * | 2000-09-04 | 2002-03-19 | Taisho Pharmaceut Co Ltd | 鉄化合物配合内服液剤 |
JP2002142720A (ja) * | 2000-11-08 | 2002-05-21 | Otsuka Pharmaceut Factory Inc | 栄養組成物 |
JP2003073284A (ja) * | 2001-06-22 | 2003-03-12 | Taisho Pharmaceut Co Ltd | 液体組成物 |
JP2003137755A (ja) * | 2001-11-02 | 2003-05-14 | Lion Corp | 口腔用組成物 |
JP2004224778A (ja) * | 2003-01-27 | 2004-08-12 | Kao Corp | 口腔用組成物 |
WO2005004640A1 (ja) * | 2003-07-10 | 2005-01-20 | Taiyo Kagaku Co., Ltd. | ミネラル組成物 |
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