JP2000507197A - R▲下1▼緩和性を増加した超常磁性体粒子、前記粒子の製造方法およびその使用 - Google Patents
R▲下1▼緩和性を増加した超常磁性体粒子、前記粒子の製造方法およびその使用Info
- Publication number
- JP2000507197A JP2000507197A JP9533047A JP53304797A JP2000507197A JP 2000507197 A JP2000507197 A JP 2000507197A JP 9533047 A JP9533047 A JP 9533047A JP 53304797 A JP53304797 A JP 53304797A JP 2000507197 A JP2000507197 A JP 2000507197A
- Authority
- JP
- Japan
- Prior art keywords
- particles
- group
- substances
- acid
- superparamagnetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
- A61K49/1836—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a carboxylic acid having less than 8 carbon atoms in the main chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
- A61K49/1857—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA
- A61K49/186—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA the organic macromolecular compound being polyethyleneglycol [PEG]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
- H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
- H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
- H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
- H01F1/12—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials
- H01F1/34—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites
- H01F1/36—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites in the form of particles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/44—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids
- H01F1/445—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids the magnetic component being a compound, e.g. Fe3O4
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
- G01N2446/84—Polymer coating, e.g. gelatin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Nanotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Power Engineering (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Iron (AREA)
- Silicon Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.平均粒子直径d50が2から4ナノメーターであり、1から10ナノメーター の範囲の粒子サイズをもつ水酸化鉄、酸化鉄水和物、酸化鉄、混合した酸化鉄あ るいは鉄からなり;2から50の増大したR1緩和性を有し;5以下のR2/R1 緩和性比を有し;そして、それらの表面にて脂肪族ジ−およびポリカルボン酸、 これらの置換生成物および誘導体から選択される安定化物質を有し;重力場ある いは磁場において凝集あるいは沈降を防ぎ;そして、付加的な安定化物質、組織 特異的結合物質、薬理的活性成分、薬理的活性細胞、薬理的活性キレート剤、細 胞融合媒介物質あるいは遺伝子導入媒介物質、ならびにそれらの混合物を任意に 含有する、増大したR1緩和性および表面安定化物質を有する超常磁性単一ドメ イン粒子。 2.微小の超常磁性単一ドメイン粒子の粒子サイズが1から5nmの範囲であり 、そして、微小の超常磁性単一ドメイン粒子が、水酸化鉄;酸化鉄水和物; γ−Fe2O3;Fe3O4;式中のMが二価の金属イオンFe、Co、Ni、Mn、Be 、Mg、Ca、Ba、Sr、Cu、Zn、Ptあるいはそれらの混合物である、一般式 mMO・nFe2O3の混合鉄酸化物;式中のMeが三価の金属イオンAl、Cr、Bi 、希土類金属あるいはそれらの混合物である、一般式mFe2O3・nMe2O3の混 合酸化物;あるいは鉄からなり、式中のmおよびnは1から6の整数である、請 求項1記載の超常磁性粒子。 3.微小の超常磁性単一ドメイン粒子がそれらの表面に、脂肪族ジ−およびポ リカルボン酸およびこれらの置換生成物および誘導体、たとえばマレイン酸、酒 石酸、クエン酸、アスパラギン酸、およびそれらの混合物、からなる群から選択 される表面安定化物質を有している、請求項1あるいは請求項2記載の超常磁性 粒子。 4.微小の超常磁性単一ドメイン粒子が、脂肪族ジ−およびポリカルボン酸お よびこれらの置換生成物および誘導体からなる群から選択される安定化物質をそ れらの表面にもつことに加え、さらにモノおよび/またはポリ水酸基を含む物質 、たとえばグリセロールおよびポリグリセロール基を含む物質、それらの置換生 成物および誘導体;モノ−および/またはポリヒドロキシル基を含む芳香族物 質、たとえば芳香族ベンゼノイド、クマリン、リグナン、テルフェニル、フラボ ノイド、タンニン、キサントン、ベンゾフェノン、ナフタレン、ナフトキノン、 アントラキノン、アントラサイクリン、ポリ環状縮合芳香族化合物、およびリン 酸基、ジリン酸基、ポリリン酸基、チオリン酸基、ホスフォン酸基、チオホスフ ォン酸基、カルボン酸基、硫酸基、メルカプト基あるいはシラントリオール基を 含むそれらの誘導体;アミノ酸を含む巨大分子、たとえばオリゴペプチド、ポリ ペプチド、たんぱく質、プロタイドおよびこれらの誘導体および変性生成物;ビ オチン、メルカプトプリン、メルカプトシトシン、メルカプトグアニン、メルカ プトウラシル、メルカプトチミン、メルカプトヒポキサンチン、同じくそれらの メルカプトヌクレオシドおよびメルカプトデオキシヌクレオシドから選択される 、チオ基を含む物質;珪酸基を含有するオルト珪酸物質、および二価および多価 の無機イオン、有機酸および塩基との縮合生成物;リン酸基を含むオルトまたは メタリン酸の物質、それらの縮合生成物およびヘテロ縮合生成物、および無機イ オンをもつ水不溶性塩化合物および塩基性基を有する有機化合物、たとえばスペ ルミン、スペルミジン、ポリエチレンイミン、プロタミン、オキシゼラチンおよ びそれらの誘導体;リン酸基、ジリン酸基、ポリリン酸基、チオリン酸基、ホス ホン酸基、チオホスホン酸基、カルボン酸基、硫酸基、スルホン酸基、メルカプ ト基、シラントリオール基あるいはトリアルコキシシラン基を有する炭水化物の 群からの物質、ポリエチレングリコール、ポリアルキレングリコール、アルキル ポリエチレングリコール、アリールポリエチレングリコール、アルキルアリール ポリエチレングリコール、ブロック共重合体(PEG)n−(PEG)m、(PEG)n− (PPG)m−(PEG)nあるいは(PPG)m−(PEG)n−(PPG)mといったポリエチレ ングリコール(PEG)およびポリプロピレングリコール(PPG)のブロック共重合 体;ムコ多糖、グリコプロタイド、キチン、およびそれらの誘導体および変性生 成物といった窒素含有多糖類;リン酸基を含有するヌクレオチドあるいはそれら のオリゴマーあるいはポリマー、およびそれらの混合物、から選択される安定化 物質をその表面に有する、請求項1から3のいずれか1項に記載の超常磁性粒子 。 5.粒子を鉄塩溶液から有機および無機塩基によって沈殿し、ここで沈殿は 50℃から120℃の範囲に温度を上げて実施され、そして脂肪族ジ−およびポ リカルボン酸およびそれらの置換生成物および誘導体、たとえばリンゴ酸、酒石 酸、クエン酸、アスパラギン酸、およびそれらの混合物からなる、溶解した安定 化物質を、鉄塩溶液に沈殿中あるいはその直後に、単一ドメイン粒子量に基づい て5から100重量%の量で添加し;そして1から無限大の範囲であるFe3+/ Fe2+濃度比が、還元剤あるいは酸化剤を沈殿物質に添加することで達成され; 次に、沈殿物質を精製して所望の粒子サイズを分離し;そして、安定化物質、組 織特異的結合物質、薬理的活性物質、薬理的活性細胞、薬理的活性キレート試薬 、細胞融合媒介物質および遺伝子導入媒介物質、それらの混合物からなる安定化 物質の群からの任意の付加的物質を、粒子に結合させるところの、R1緩和性が 際立って改変され、そして表面安定化物質をもつ、超常磁性単一ドメイン粒子の 製造方法。 6.薬理的に許容できる担体および1から10ナノメーターの範囲の粒子サイ ズである請求項1記載の超常磁性粒子、組織特異的結合物質、薬理的活性物質、 薬理的活性細胞、薬理的活性キレート試薬、細胞融合媒介物質および/または遺 伝子導入媒介物質;それらの混合物、との任意の組み合わせからなる、薬理的調 製品。 7.腫瘍破壊、免疫増強、磁気薬剤標的、細胞融合、遺伝子導入のために、NMR 診断における造影剤として、任意には磁場の影響下に、請求項6記載の薬理的調 製品を使用する方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19612001.2 | 1996-03-18 | ||
DE19612001A DE19612001A1 (de) | 1996-03-18 | 1996-03-18 | Superparamagnetische Teilchen mit vergrößerter R¶1¶-Relaxivität, Verfahren zur Herstellung und deren Verwendung |
PCT/DE1997/000578 WO1997035200A1 (de) | 1996-03-18 | 1997-03-13 | Superparamagnetische teilchen mit vergrösserter r1-relaxivität, verfahren zur herstellung und deren verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000507197A true JP2000507197A (ja) | 2000-06-13 |
JP4079996B2 JP4079996B2 (ja) | 2008-04-23 |
Family
ID=7789510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53304797A Expired - Fee Related JP4079996B2 (ja) | 1996-03-18 | 1997-03-13 | R▲下1▼緩和性を増加した超常磁性体粒子、前記粒子の製造方法およびその使用 |
Country Status (7)
Country | Link |
---|---|
US (1) | US6638494B1 (ja) |
EP (1) | EP0888545B1 (ja) |
JP (1) | JP4079996B2 (ja) |
AT (1) | ATE212442T1 (ja) |
DE (2) | DE19612001A1 (ja) |
ES (1) | ES2171930T3 (ja) |
WO (1) | WO1997035200A1 (ja) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003528911A (ja) * | 2000-04-03 | 2003-09-30 | ユクロ ヨーロピアン コントラクト リサーチ ゲーエムベーハー ウント コー.カーゲー | 生体系への活性物質輸送系 |
JP2005060221A (ja) * | 2003-07-31 | 2005-03-10 | Rikogaku Shinkokai | 有機物質とフェライトとの複合材料とその製造方法 |
JPWO2003066644A1 (ja) * | 2002-02-04 | 2005-05-26 | 財団法人理工学振興会 | フェライト結合有機物質及びその製造方法 |
JP2006502572A (ja) * | 2002-10-09 | 2006-01-19 | フェロファーマ ゲーエムベーハー フォルシュングスラボア | 安定化超常磁性粒子 |
WO2009014201A1 (ja) | 2007-07-26 | 2009-01-29 | Tokyo Institute Of Technology | 表面被覆無機物粒子の製造方法 |
JP2009536151A (ja) * | 2006-03-30 | 2009-10-08 | 富士フイルム株式会社 | ナノ粒子 |
JP2010514181A (ja) * | 2006-12-18 | 2010-04-30 | コロロッビア イタリア ソシエタ ペル アチオニ | 温熱療法に用いる磁気ナノ粒子、それの調製、及び構造体が有する薬理学的応用での使用 |
JP2013033943A (ja) * | 2011-07-29 | 2013-02-14 | Korea Institute Of Science And Technology | リサイクル可能な超常磁性ナノ粒子及びその製造方法 |
JP2013534893A (ja) * | 2010-08-05 | 2013-09-09 | ハンファ ケミカル コーポレーション | 極小かつ均一な大きさの酸化鉄系常磁性ナノ粒子の製造方法及びこれを用いるmrit1造影剤 |
JP2014528920A (ja) * | 2011-08-03 | 2014-10-30 | ハンワ ケミカル コーポレイション | 単糖類リン酸又はその誘導体で表面改質された親水性ナノ粒子、そのコロイド溶液及びその用途 |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9903183D0 (sv) * | 1999-09-08 | 1999-09-08 | Europ I Of Science Ab | Selektivt bindande och magnetiskt påverkbara nanopartiklar för medicinskt bruk |
WO2002083166A1 (fr) * | 2001-04-10 | 2002-10-24 | Santen Pharmaceutical Co., Ltd. | Complexes de polymeres d'interferons et leur utilisation medicinale |
US7731648B2 (en) * | 2001-07-25 | 2010-06-08 | Aduro Biotech | Magnetic nanoscale particle compositions, and therapeutic methods related thereto |
US6997863B2 (en) * | 2001-07-25 | 2006-02-14 | Triton Biosystems, Inc. | Thermotherapy via targeted delivery of nanoscale magnetic particles |
US7951061B2 (en) * | 2001-07-25 | 2011-05-31 | Allan Foreman | Devices for targeted delivery of thermotherapy, and methods related thereto |
EP1615551B1 (en) | 2003-04-15 | 2016-06-08 | Philips Intellectual Property & Standards GmbH | Device and method for examination and use of an electrical field in an object under examination containing magnetic particles |
FR2855315B1 (fr) * | 2003-05-23 | 2005-08-19 | Centre Nat Rech Scient | Ferrofluides stables en milieu neutre et ferrofluides modifies obtenus par modification de la surface des particules de ces ferrofluides |
US7846201B2 (en) * | 2004-02-20 | 2010-12-07 | The Children's Hospital Of Philadelphia | Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex |
US9028829B2 (en) * | 2004-02-20 | 2015-05-12 | The Children's Hospital Of Philadelphia | Uniform field magnetization and targeting of therapeutic formulations |
US8562505B2 (en) | 2004-02-20 | 2013-10-22 | The Children's Hospital Of Philadelphia | Uniform field magnetization and targeting of therapeutic formulations |
KR100604976B1 (ko) | 2004-09-03 | 2006-07-28 | 학교법인연세대학교 | 다작용기 리간드로 안정화된 수용성 나노입자 |
EP1791570A4 (en) * | 2004-09-14 | 2012-08-01 | Spago Imaging Ab | SUPERPARAMAGNETIC GADOLINIUM OXIDE NANOPARTICLES AND COMPOSITIONS COMPRISING SUCH PARTICULATES |
US20090220431A1 (en) * | 2005-12-02 | 2009-09-03 | Jin-Woo Cheon | Magnetic resonance imaging contrast agents containing water-soluble nanoparticles of manganese oxide or manganese metal oxide |
DE102005059751A1 (de) * | 2005-12-09 | 2007-06-14 | Ferropharm Gmbh Forschungslabor | Wässrige Dispersion von superparamagnetischen Eindomänenteilchen, deren Herstellung und Verwendung zur Diagnose und Therapie |
CZ301067B6 (cs) * | 2006-02-24 | 2009-10-29 | Ústav makromolekulární chemie AV CR | Superparamagnetické nanocástice na bázi oxidu železa s modifikovaným povrchem, zpusob jejich prípravy a použití |
KR100713745B1 (ko) * | 2006-02-27 | 2007-05-07 | 연세대학교 산학협력단 | 상전이 리간드로 코팅된 수용성 자성 또는 금속 산화물나노입자 및 이의 제조방법 |
FR2918868A1 (fr) * | 2006-06-06 | 2009-01-23 | Guerbet Sa | Methode d'imagerie de diagnostic utilisant en combinaison avec l'imagerie de diffusion de l'eau, des agents de contraste |
ZA200905420B (en) | 2007-02-07 | 2010-10-27 | Spago Imaging Ab | Visualization of biological material by the use of coated contrast agents |
FR2913886B1 (fr) * | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
FR2921660B1 (fr) | 2007-10-01 | 2015-09-25 | Centre Nat Rech Scient | Nanoparticules hybrides organiques inorganiques a base de carboxylates de fer. |
FR2921661B1 (fr) * | 2007-10-01 | 2013-05-31 | Centre Nat Rech Scient | Solide hybride organique inorganique a surface modifiee. |
FR2921837B1 (fr) * | 2007-10-05 | 2015-07-31 | Guerbet Sa | Nouveau procede de preparation de nanoparticules recouvertes d'une couche stabilisatrice organique couplee a des ligands de ciblage |
KR100957560B1 (ko) * | 2007-10-18 | 2010-05-11 | 한국생명공학연구원 | 양자점 나노입자를 함유한 퍼플루오르카본 나노에멀젼 및그 제조방법 |
US8323618B2 (en) | 2007-11-07 | 2012-12-04 | University Of Houston System | Ultrasmall superparamagnetic iron oxide nanoparticles and uses thereof |
US20100119608A1 (en) * | 2008-11-11 | 2010-05-13 | Jinhyuk Fred Chung | Synthesis of pH-sensitive, Acid-Stable Metal-Binding Nanoparticles |
US20100124571A1 (en) * | 2008-11-20 | 2010-05-20 | Nanomedicine Research Co., Ltd. | Use of pH-sensitive, Acid-Stable Metal-Binding Nanoparticles |
US8293213B2 (en) * | 2009-03-12 | 2012-10-23 | Palo Alto Research Center Incorporated | Method and apparatus for thrombus removal using magnetic particles |
GB2472446A (en) * | 2009-08-07 | 2011-02-09 | Ct Fuer Angewandte Nanotechnologie | Metal oxide particles coated with polyethylene glycol and their synthesis |
US20120251443A1 (en) * | 2009-10-02 | 2012-10-04 | The Brigham And Women's Hospital, Inc. | Implantable contrast agents and methods |
US9205155B2 (en) * | 2009-10-30 | 2015-12-08 | General Electric Company | Treating water insoluble nanoparticles with hydrophilic alpha-hydroxyphosphonic acid conjugates, the so modified nanoparticles and their use as contrast agents |
JP5865252B2 (ja) | 2009-11-02 | 2016-02-17 | パルス セラピューティクス インコーポレイテッド | 起磁性ステーターシステム及び磁性ローターの無線制御方法 |
US20120269896A1 (en) | 2009-11-20 | 2012-10-25 | Toshiyuki Hakata | Magnetic iron oxide fine particles, and magnetic particle-containing water dispersion and process for producing the same |
RU2471502C1 (ru) * | 2011-08-04 | 2013-01-10 | Федеральное государственное бюджетное учреждение науки Томский научный центр Сибирского отделения Российской академии наук (ТНЦ СО РАН) | Контрастное средство для t1 и/или t2 магнитно-резонансного сканирования и способ его получения |
WO2013023003A1 (en) * | 2011-08-08 | 2013-02-14 | Rutgers, The State University Of New Jersey | Bioactive amphiphilic polymer stabilized nanoparticles with enhanced stability and activity |
DK2742515T3 (en) | 2011-08-10 | 2016-06-13 | Magforce Ag | Medical device comprising agglomerated magnetic alkoxysilane coated nanoparticles |
DE102012201774A1 (de) * | 2012-02-07 | 2013-08-22 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Magnetisch abtrennbare Mikropartikel mit einer silikatischen Hülle, Verfahren zu ihrer Herstellung sowie ihre Verwendung |
EP2647389A1 (en) | 2012-04-04 | 2013-10-09 | Charité - Universitätsmedizin Berlin | Magnetic nanoparticle dispersion, its preparation and diagnostic and therapeutic use |
US9883878B2 (en) | 2012-05-15 | 2018-02-06 | Pulse Therapeutics, Inc. | Magnetic-based systems and methods for manipulation of magnetic particles |
DE102015215736A1 (de) * | 2015-08-18 | 2017-02-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung von stabil dispergierbaren magnetischen Eisenoxid-Einkern-Nanopartikeln, stabil dispergierbare magnetische Eisenoxid-Einkern-Nanopartikel und Verwendungen hiervon |
US10629339B2 (en) * | 2015-10-19 | 2020-04-21 | National Guard Health Affairs | Acid-stabilized iron-based metal oxide colloidal nanoparticles, and methods thereof |
CN106082522B (zh) * | 2016-08-04 | 2019-03-12 | 湖州慧能机电科技有限公司 | 一种节能高盐废水的正渗透处理方法 |
US11918315B2 (en) | 2018-05-03 | 2024-03-05 | Pulse Therapeutics, Inc. | Determination of structure and traversal of occlusions using magnetic particles |
KR102026100B1 (ko) * | 2019-03-25 | 2019-09-27 | 서울대학교산학협력단 | 극미세 산화철 나노입자 기반 자기공명영상 t1 조영제 |
CN110559453B (zh) * | 2019-10-15 | 2021-11-05 | 南京晓庄学院 | 一种用于显像指导的磁性纳米颗粒及其制备方法 |
DE102019134726A1 (de) * | 2019-12-17 | 2021-06-17 | Chiracon Gmbh | Verfahren zur Herstellung von superparamagnetischen Kleinstpartikeln aus Eisenoxid als Kontrastmittel für die MRT-Tomographie |
DE102021115439A1 (de) | 2021-06-15 | 2022-12-15 | Chiracon Gmbh | Verfahren zur Herstellung von superparamagnetischen Kleinstpartikeln aus Eisenoxid als Kontrastmittel für die MRT-Tomographie |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63255237A (ja) * | 1987-03-24 | 1988-10-21 | シリカ・ゲル・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・アドゾルプチオンス‐テヒニーク・アパラーテバウ | 生理学的に認容される超常磁性液体組成物,その製造方法並びにそれよりなる画像形成nmr,x線及び超音波診断剤 |
WO1990007380A2 (en) * | 1988-12-28 | 1990-07-12 | Stefan Miltenyi | Methods and materials for high gradient magnetic separation of biological materials |
JPH03504303A (ja) * | 1988-05-10 | 1991-09-19 | イーストマン コダック カンパニー | カプセル化された超常磁性粒子 |
JPH08508721A (ja) * | 1993-03-17 | 1996-09-17 | シリカゲル ゲス.エム.ビー.エイチ | 超常磁性粒子、その製法及びその用途 |
JPH10503281A (ja) * | 1994-07-27 | 1998-03-24 | シリカ ゲル ゲス.エム.ビー.エイチ | 超常磁性粒子、それらの製造法および使用法 |
JP2006502572A (ja) * | 2002-10-09 | 2006-01-19 | フェロファーマ ゲーエムベーハー フォルシュングスラボア | 安定化超常磁性粒子 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5055288A (en) * | 1987-06-26 | 1991-10-08 | Advanced Magnetics, Inc. | Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides |
ATE132758T1 (de) * | 1992-06-01 | 1996-01-15 | Basf Ag | Anwendung von dispersionen von magneto-ionischen partikeln in mri-kontrast-mitteln |
DE4309333A1 (de) * | 1993-03-17 | 1994-09-22 | Silica Gel Gmbh | Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben |
DE4416784A1 (de) * | 1994-05-09 | 1995-11-30 | Soft Gene Gmbh | Methode zur Anreicherung von Zellen, die durch ballistischen Transfer modifiziert wurden |
DK0783325T3 (da) * | 1994-09-27 | 2000-05-01 | Nycomed Imaging As | Kontrastmiddel |
-
1996
- 1996-03-18 DE DE19612001A patent/DE19612001A1/de not_active Withdrawn
-
1997
- 1997-03-13 EP EP97920534A patent/EP0888545B1/de not_active Expired - Lifetime
- 1997-03-13 WO PCT/DE1997/000578 patent/WO1997035200A1/de active IP Right Grant
- 1997-03-13 AT AT97920534T patent/ATE212442T1/de not_active IP Right Cessation
- 1997-03-13 ES ES97920534T patent/ES2171930T3/es not_active Expired - Lifetime
- 1997-03-13 JP JP53304797A patent/JP4079996B2/ja not_active Expired - Fee Related
- 1997-03-13 DE DE59706186T patent/DE59706186D1/de not_active Expired - Lifetime
-
2000
- 2000-11-20 US US09/716,709 patent/US6638494B1/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63255237A (ja) * | 1987-03-24 | 1988-10-21 | シリカ・ゲル・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・アドゾルプチオンス‐テヒニーク・アパラーテバウ | 生理学的に認容される超常磁性液体組成物,その製造方法並びにそれよりなる画像形成nmr,x線及び超音波診断剤 |
JPH03504303A (ja) * | 1988-05-10 | 1991-09-19 | イーストマン コダック カンパニー | カプセル化された超常磁性粒子 |
WO1990007380A2 (en) * | 1988-12-28 | 1990-07-12 | Stefan Miltenyi | Methods and materials for high gradient magnetic separation of biological materials |
JPH08508721A (ja) * | 1993-03-17 | 1996-09-17 | シリカゲル ゲス.エム.ビー.エイチ | 超常磁性粒子、その製法及びその用途 |
JPH10503281A (ja) * | 1994-07-27 | 1998-03-24 | シリカ ゲル ゲス.エム.ビー.エイチ | 超常磁性粒子、それらの製造法および使用法 |
JP2006502572A (ja) * | 2002-10-09 | 2006-01-19 | フェロファーマ ゲーエムベーハー フォルシュングスラボア | 安定化超常磁性粒子 |
Non-Patent Citations (2)
Title |
---|
D.POULIQUEN ET AL.: "Investigation of the magnetic properties of iron oxide nanoparticles used as contrast agent for MRI", MAGNETIC RESONANCE IN MEDICINE, vol. 24, no. 1, JPN7008000789, 1992, pages 75 - 84, ISSN: 0000972743 * |
D.POULIQUEN ET AL.: "Investigation of the magnetic properties of iron oxide nanoparticles used as contrast agent for MRI", MAGNETIC RESONANCE IN MEDICINE, vol. 24, no. 1, JPNX007046210, 1992, pages 75 - 84, ISSN: 0000888426 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003528911A (ja) * | 2000-04-03 | 2003-09-30 | ユクロ ヨーロピアン コントラクト リサーチ ゲーエムベーハー ウント コー.カーゲー | 生体系への活性物質輸送系 |
JPWO2003066644A1 (ja) * | 2002-02-04 | 2005-05-26 | 財団法人理工学振興会 | フェライト結合有機物質及びその製造方法 |
JP2006502572A (ja) * | 2002-10-09 | 2006-01-19 | フェロファーマ ゲーエムベーハー フォルシュングスラボア | 安定化超常磁性粒子 |
JP2005060221A (ja) * | 2003-07-31 | 2005-03-10 | Rikogaku Shinkokai | 有機物質とフェライトとの複合材料とその製造方法 |
JP2009536151A (ja) * | 2006-03-30 | 2009-10-08 | 富士フイルム株式会社 | ナノ粒子 |
JP2010514181A (ja) * | 2006-12-18 | 2010-04-30 | コロロッビア イタリア ソシエタ ペル アチオニ | 温熱療法に用いる磁気ナノ粒子、それの調製、及び構造体が有する薬理学的応用での使用 |
WO2009014201A1 (ja) | 2007-07-26 | 2009-01-29 | Tokyo Institute Of Technology | 表面被覆無機物粒子の製造方法 |
US8852555B2 (en) | 2007-07-26 | 2014-10-07 | Tokyo Institute Of Technology | Process for production of surface-coated inorganic particles |
JP2013534893A (ja) * | 2010-08-05 | 2013-09-09 | ハンファ ケミカル コーポレーション | 極小かつ均一な大きさの酸化鉄系常磁性ナノ粒子の製造方法及びこれを用いるmrit1造影剤 |
US9861712B2 (en) | 2010-08-05 | 2018-01-09 | Hanwha Chemical Corporation | Preparation of extremely small and uniform sized, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles and MRI T1 contrast agents using the same |
JP2013033943A (ja) * | 2011-07-29 | 2013-02-14 | Korea Institute Of Science And Technology | リサイクル可能な超常磁性ナノ粒子及びその製造方法 |
US8900474B2 (en) | 2011-07-29 | 2014-12-02 | Korea Institute Of Science And Technology | Recyclable superparamagnetic nanoparticles and method for producing the same |
JP2014528920A (ja) * | 2011-08-03 | 2014-10-30 | ハンワ ケミカル コーポレイション | 単糖類リン酸又はその誘導体で表面改質された親水性ナノ粒子、そのコロイド溶液及びその用途 |
Also Published As
Publication number | Publication date |
---|---|
US6638494B1 (en) | 2003-10-28 |
WO1997035200A1 (de) | 1997-09-25 |
DE59706186D1 (de) | 2002-03-14 |
ATE212442T1 (de) | 2002-02-15 |
ES2171930T3 (es) | 2002-09-16 |
EP0888545B1 (de) | 2002-01-23 |
EP0888545A1 (de) | 1999-01-07 |
JP4079996B2 (ja) | 2008-04-23 |
DE19612001A1 (de) | 1997-09-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2000507197A (ja) | R▲下1▼緩和性を増加した超常磁性体粒子、前記粒子の製造方法およびその使用 | |
US5928958A (en) | Superparamagnetic particles, process for their manufacture and usage | |
CA1301063C (en) | Biologically degradable superparamagnetic materials for use in clinicalapplications | |
US4951675A (en) | Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging | |
US5069216A (en) | Silanized biodegradable super paramagnetic metal oxides as contrast agents for imaging the gastrointestinal tract | |
DE4427821A1 (de) | Superparamagnetische Teilchen und deren Verwendung | |
US5219554A (en) | Hydrated biodegradable superparamagnetic metal oxides | |
US4770183A (en) | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents | |
US5160725A (en) | Magnetic liquid compositions | |
EP0525199B2 (en) | Composition containing ultrafine particles of magnetic metal oxide | |
US5389377A (en) | Solid care therapeutic compositions and methods for making same | |
JP2000504300A (ja) | 造影剤 | |
US5547682A (en) | Preparation and use of novel injectable RES avoiding inorganic particles for medical application | |
JPH07500823A (ja) | 医療診断イメージング用処理アパタイト粒子 | |
AU1694301A (en) | Magnetic nanoparticles having biochemical activity, method for the production thereof and their use | |
JPS5913521B2 (ja) | 磁性酸化鉄・デキストラン複合体の製造法 | |
JPH09511013A (ja) | 造影および治療剤としてのセグメント化キレート化重合体 | |
JPH08508721A (ja) | 超常磁性粒子、その製法及びその用途 | |
CA2159799A1 (en) | Treated calcium/oxyanion-containing particles for medical diagnostic imaging | |
US20210113717A1 (en) | Mri contrast agent including t1 contrast material coated on surface of nanoparticle support | |
EP1554734B1 (de) | Stabilisierte superparamagnetische teilchen | |
CN111388668B (zh) | 一种磁性复合纳米材料及其制备方法与应用 | |
JP4891763B2 (ja) | 「cest」用途のための、磁気共鳴シフト試薬と交換性プロトンを含有する基質との付加物 | |
RU2687748C1 (ru) | Способ получения нанодисперсного магнитоактивного рентгеноконтрастного средства | |
US5560902A (en) | Microfluidization of radioactive calcium/oxyanion-containing particles |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040302 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070828 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071122 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20080205 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20080206 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110215 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110215 Year of fee payment: 3 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120215 Year of fee payment: 4 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130215 Year of fee payment: 5 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140215 Year of fee payment: 6 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |