JOP20200157A1 - أجسام مضادة ذات سلسلة ثقيلة ترتبط بـ cd22 - Google Patents
أجسام مضادة ذات سلسلة ثقيلة ترتبط بـ cd22Info
- Publication number
- JOP20200157A1 JOP20200157A1 JOP/2020/0157A JOP20200157A JOP20200157A1 JO P20200157 A1 JOP20200157 A1 JO P20200157A1 JO P20200157 A JOP20200157 A JO P20200157A JO P20200157 A1 JOP20200157 A1 JO P20200157A1
- Authority
- JO
- Jordan
- Prior art keywords
- heavy chain
- chain antibodies
- antibodies binding
- antibodies
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
يتعلق الاختراع الحالي بالكشف عن الأجسام المضادة ذات السلسلة الثقيلة لـ CD22 (مثل، UniAbsTM)، بجانب الطرق الخاصة بتصنيع هذه الأجسام المضادة، التركيبات، المتضمنة تركيبات صيدلية، تشتمل على هذه الأجسام المضادة، واستخداماتها لمعالجة اضطرابات الخلية البائية التي يتم تحديد سماتها بواسطة التعبير الوراثي عن CD22.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762609759P | 2017-12-22 | 2017-12-22 | |
PCT/US2018/067299 WO2019126756A1 (en) | 2017-12-22 | 2018-12-21 | Heavy chain antibodies binding to cd22 |
Publications (1)
Publication Number | Publication Date |
---|---|
JOP20200157A1 true JOP20200157A1 (ar) | 2022-10-30 |
Family
ID=65041936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2020/0157A JOP20200157A1 (ar) | 2017-12-22 | 2018-12-21 | أجسام مضادة ذات سلسلة ثقيلة ترتبط بـ cd22 |
Country Status (21)
Country | Link |
---|---|
US (2) | US11873336B2 (ar) |
EP (1) | EP3728319A1 (ar) |
JP (2) | JP7486421B2 (ar) |
KR (1) | KR20200104342A (ar) |
CN (1) | CN111683966B (ar) |
AU (1) | AU2018392088A1 (ar) |
BR (1) | BR112020012554A2 (ar) |
CA (1) | CA3086665A1 (ar) |
CL (2) | CL2020001703A1 (ar) |
CO (1) | CO2020008925A2 (ar) |
CR (1) | CR20200322A (ar) |
EA (1) | EA202091557A1 (ar) |
EC (1) | ECSP20042489A (ar) |
IL (1) | IL275498A (ar) |
JO (1) | JOP20200157A1 (ar) |
MX (1) | MX2020006494A (ar) |
NI (1) | NI202000050A (ar) |
PE (1) | PE20201171A1 (ar) |
PH (1) | PH12020550964A1 (ar) |
SG (1) | SG11202005880XA (ar) |
WO (1) | WO2019126756A1 (ar) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3471773A4 (en) | 2016-06-21 | 2020-07-08 | Teneobio, Inc. | ANTIBODIES BINDING CD3 |
CR20190198A (es) | 2016-09-14 | 2019-10-11 | Teneobio Inc | Anticuerpos de unión a cd3 |
US11427642B2 (en) | 2017-06-20 | 2022-08-30 | Teneoone, Inc. | Anti-BCMA heavy chain-only antibodies |
KR20200104342A (ko) | 2017-12-22 | 2020-09-03 | 테네오바이오, 인코포레이티드 | Cd22에 결합하는 중쇄 항체 |
PE20220575A1 (es) * | 2019-06-14 | 2022-04-20 | Teneobio Inc | Anticuerpos multiespecificos de cadena pesada que se unen a cd22 y cd3 |
KR20210143097A (ko) * | 2020-05-19 | 2021-11-26 | (주)이노베이션바이오 | Cd22에 특이적인 항체 및 이의 용도 |
WO2022012682A1 (en) * | 2020-07-16 | 2022-01-20 | Nanjing Legend Biotech Co., Ltd. | Cd22 binding molecules and uses thereof |
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2018
- 2018-12-21 KR KR1020207021048A patent/KR20200104342A/ko active Search and Examination
- 2018-12-21 WO PCT/US2018/067299 patent/WO2019126756A1/en active Application Filing
- 2018-12-21 EA EA202091557A patent/EA202091557A1/ru unknown
- 2018-12-21 CA CA3086665A patent/CA3086665A1/en active Pending
- 2018-12-21 US US16/956,502 patent/US11873336B2/en active Active
- 2018-12-21 EP EP18836782.5A patent/EP3728319A1/en active Pending
- 2018-12-21 JP JP2020534858A patent/JP7486421B2/ja active Active
- 2018-12-21 BR BR112020012554-7A patent/BR112020012554A2/pt active Search and Examination
- 2018-12-21 CR CR20200322A patent/CR20200322A/es unknown
- 2018-12-21 MX MX2020006494A patent/MX2020006494A/es unknown
- 2018-12-21 CN CN201880083056.4A patent/CN111683966B/zh active Active
- 2018-12-21 JO JOP/2020/0157A patent/JOP20200157A1/ar unknown
- 2018-12-21 SG SG11202005880XA patent/SG11202005880XA/en unknown
- 2018-12-21 AU AU2018392088A patent/AU2018392088A1/en active Pending
- 2018-12-21 PE PE2020000809A patent/PE20201171A1/es unknown
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2020
- 2020-06-18 IL IL275498A patent/IL275498A/en unknown
- 2020-06-20 CL CL2020001703A patent/CL2020001703A1/es unknown
- 2020-06-22 PH PH12020550964A patent/PH12020550964A1/en unknown
- 2020-06-22 NI NI202000050A patent/NI202000050A/es unknown
- 2020-07-21 CO CONC2020/0008925A patent/CO2020008925A2/es unknown
- 2020-07-22 EC ECSENADI202042489A patent/ECSP20042489A/es unknown
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2022
- 2022-08-18 CL CL2022002247A patent/CL2022002247A1/es unknown
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2023
- 2023-12-07 US US18/532,880 patent/US20240117046A1/en active Pending
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2024
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US20210095022A1 (en) | 2021-04-01 |
CL2022002247A1 (es) | 2023-02-24 |
US20240117046A1 (en) | 2024-04-11 |
RU2020124188A (ru) | 2022-01-24 |
PE20201171A1 (es) | 2020-10-28 |
BR112020012554A2 (pt) | 2020-11-24 |
AU2018392088A2 (en) | 2020-08-27 |
SG11202005880XA (en) | 2020-07-29 |
JP2021506325A (ja) | 2021-02-22 |
CO2020008925A2 (es) | 2020-10-30 |
WO2019126756A1 (en) | 2019-06-27 |
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JP7486421B2 (ja) | 2024-05-17 |
CL2020001703A1 (es) | 2020-11-06 |
KR20200104342A (ko) | 2020-09-03 |
EP3728319A1 (en) | 2020-10-28 |
CN111683966B (zh) | 2023-07-11 |
MX2020006494A (es) | 2020-11-24 |
PH12020550964A1 (en) | 2021-03-22 |
AU2018392088A1 (en) | 2020-08-13 |
JP2024062992A (ja) | 2024-05-10 |
IL275498A (en) | 2020-08-31 |
NI202000050A (es) | 2020-12-04 |
CN111683966A (zh) | 2020-09-18 |
CA3086665A1 (en) | 2019-06-27 |
WO2019126756A9 (en) | 2019-10-17 |
ECSP20042489A (es) | 2020-11-30 |
US11873336B2 (en) | 2024-01-16 |
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