IT8220094A0 - Derivati della 3,4-diidro-5h-2,3benzodiazepina e procedimento per la loro preparazione - Google Patents

Derivati della 3,4-diidro-5h-2,3benzodiazepina e procedimento per la loro preparazione

Info

Publication number
IT8220094A0
IT8220094A0 IT8220094A IT2009482A IT8220094A0 IT 8220094 A0 IT8220094 A0 IT 8220094A0 IT 8220094 A IT8220094 A IT 8220094A IT 2009482 A IT2009482 A IT 2009482A IT 8220094 A0 IT8220094 A0 IT 8220094A0
Authority
IT
Italy
Prior art keywords
dihydro
derivatives
procedure
preparation
Prior art date
Application number
IT8220094A
Other languages
English (en)
Other versions
IT1190732B (it
Inventor
Jeno Korosi
Tibor Lang
Ferenc Andrasi
Jozsef Szekely
Tamas Hamori
Tibor Balogh
Lajos Ila
Katalin Goldschmidt
Eleonora Sinegere
Imre Moravcsik
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of IT8220094A0 publication Critical patent/IT8220094A0/it
Application granted granted Critical
Publication of IT1190732B publication Critical patent/IT1190732B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT20094/82A 1981-03-12 1982-03-11 Derivati della 3,4-diidro-5h-2,3-benzodiazepina e procedimento per la loro preparazione IT1190732B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU81620A HU186760B (en) 1981-03-12 1981-03-12 Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives

Publications (2)

Publication Number Publication Date
IT8220094A0 true IT8220094A0 (it) 1982-03-11
IT1190732B IT1190732B (it) 1988-02-24

Family

ID=10950496

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20094/82A IT1190732B (it) 1981-03-12 1982-03-11 Derivati della 3,4-diidro-5h-2,3-benzodiazepina e procedimento per la loro preparazione

Country Status (23)

Country Link
US (1) US4423044A (it)
JP (1) JPS57159772A (it)
AT (1) AT383120B (it)
AU (1) AU550388B2 (it)
BE (1) BE892395A (it)
CA (1) CA1178584A (it)
CH (1) CH648553A5 (it)
CS (1) CS224646B2 (it)
DD (1) DD204698A5 (it)
DE (1) DE3209100A1 (it)
DK (1) DK106882A (it)
ES (1) ES510348A0 (it)
FI (1) FI820839L (it)
FR (1) FR2501686A1 (it)
GB (1) GB2097387B (it)
GR (1) GR76111B (it)
HU (1) HU186760B (it)
IL (1) IL65076A (it)
IT (1) IT1190732B (it)
NL (1) NL8201005A (it)
NO (1) NO820798L (it)
SE (1) SE8201537L (it)
SU (1) SU1151206A3 (it)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971179A (en) * 1969-08-13 1976-07-27 Andrew Bodocsi Non-bonded framing system
DE3124013A1 (de) * 1981-06-19 1982-12-30 Kali-Chemie Pharma Gmbh, 3000 Hannover 2-acylaminomethyl-1,4-benzodiazepin-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
US5204339A (en) * 1986-01-31 1993-04-20 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
EP0322582A3 (en) * 1987-12-07 1989-09-13 Hoechst-Roussel Pharmaceuticals Incorporated 4-heteroaryl-1,3-benzodiazepines and 2-substituted-alpha-(heteroaryl)benzeneethanamines, a process for their preparation and their use us medicaments
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
EP0726256A1 (en) * 1995-02-09 1996-08-14 Egis Gyogyszergyar Rt. 1-Arylvinyl-3,4-dihydro-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders
HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
SK283859B6 (sk) * 1995-02-09 2004-03-02 EGIS Gyógyszergyár Rt. 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
ES2111493B1 (es) * 1996-02-08 1999-08-01 Egyt Gyogyszervegyeszeti Gyar Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes.
ZA972746B (en) * 1996-04-04 1998-10-09 Egyt Gyogyszervegyeszeti Gyar Novel 2,3-benzodiazepine derivatives
US6080736A (en) * 1999-10-27 2000-06-27 Janus Pharmaceuticals, Inc. Methods and compositions for treating and preventing anxiety and anxiety disorders using optically pure (R) tofisopam
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
EP1567161A4 (en) * 2002-12-03 2008-09-03 Vela Acquisition Corp PHARMACEUTICAL COMPOSITION OF 1- (3,4-DIMETHOXYPHENYL) -4-METHYL-5-ETHYL-7-METHOXY-8-HYDROXY-5H-2,3-BENZODIAZEPINE AND ITS USE
MXPA05005893A (es) * 2002-12-03 2006-02-08 Vela Pharmaceuticals Inc Composicion farmaceutica de 1-(3-hidroxi -4-metoxifenil) -4-metil-5 -etil-7, 8-dimetoxi- 5h-2, 3-benzodiazepina y usos de la misma.
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
JP4611308B2 (ja) * 2003-05-16 2011-01-12 ヴェラ アクイジション コーポレイション 鏡像的に純粋な（ｒ）２，３−ベンゾジアゼピンを使用する胃腸の機能不全及び関連するストレスの治療
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives

Also Published As

Publication number Publication date
IL65076A (en) 1984-12-31
NO820798L (no) 1982-09-13
US4423044A (en) 1983-12-27
AU550388B2 (en) 1986-03-20
FI820839L (fi) 1982-09-13
DD204698A5 (de) 1983-12-07
FR2501686B1 (it) 1985-03-01
GB2097387A (en) 1982-11-03
ATA96982A (de) 1986-10-15
HU186760B (en) 1985-09-30
GB2097387B (en) 1984-09-19
AU8130882A (en) 1982-09-16
AT383120B (de) 1987-05-25
BE892395A (fr) 1982-09-08
NL8201005A (nl) 1982-10-01
SU1151206A3 (ru) 1985-04-15
DK106882A (da) 1982-09-13
GR76111B (it) 1984-08-03
DE3209100A1 (de) 1982-10-28
ES8302671A1 (es) 1983-02-01
CA1178584A (en) 1984-11-27
SE8201537L (sv) 1982-09-13
IT1190732B (it) 1988-02-24
JPS57159772A (en) 1982-10-01
ES510348A0 (es) 1983-02-01
CS224646B2 (en) 1984-01-16
CH648553A5 (de) 1985-03-29
FR2501686A1 (fr) 1982-09-17

Similar Documents

Publication Publication Date Title
IT8220094A0 (it) Derivati della 3,4-diidro-5h-2,3benzodiazepina e procedimento per la loro preparazione
IT1157275B (it) Derivati della cefalosporina e procedimento per la loro preparazione
IT1213103B (it) Derivati della distamicina eprocedimento per la loro preparazione.!
IT1157104B (it) Procedimento per la preparazione di derivati della 3 alcossimetilcefalosporina
IT1196488B (it) Poli-4-aminopirrol-2-carbossamido derivati e procedimento per la loro preparazione
IT1170307B (it) Derivati cefalosporinici e procedimento per la loro preparazione
IT1188970B (it) Derivati della moranolina e procedimento per la loro preparazione
IT1178775B (it) Derivati della gonadoliberina e procedimento per la loro preparazione
IT1185828B (it) Derivati del calcone e procedimento per la loro preparazione
IT8348488A0 (it) Derivati della 1,4-diidropiridina, loro preparazione e loro impiego come medicamenti
IT8320278A0 (it) Derivati delle rifamicine eprocedimento per la loro preparazione.
IT1094864B (it) Derivati della bromexina e procedimento per la loro preparazione
IT1135629B (it) N-imidzolil derivati di 1-cromano e procedimento per la loro preparazione
IT8124030A0 (it) Derivati della 7-ossoprostaciclina e procedimento per la loro preparazione.
IT1157053B (it) Derivati della prolina e procedimento per la loro preparazione
IT1163943B (it) Derivati 15-cicloalifatici di 13,14-dideidro carboprostacicline e procedimento per la loro preparazione
IT1150799B (it) Cefem derivati e procedimento per la loro preparazione
IT8249765A0 (it) Derivati di amminopropilamminobleomicina e procedimento per la loro preparazione
IT1190711B (it) Derivati di alchilen-diammina e procedimento per la loro preparazione
IT8423507A0 (it) Derivati della 20-alchil-7-osso-prostaciclina eprocedimento per la loro preparazione.
IT8249400A0 (it) Derivati della 1,4-diidropiridazana loro preparazione e medicamenti con tenenti questi derivati
IT8547865A0 (it) Nuovi derivati della i,4-diidropiri dina,procedimento per la loro preparazione,e loro impiego come farmaci
IT1199830B (it) 10 b-alchinil-4,9(11)-estradiene derivati e procedimento per la loro preparazione
IT8120276A0 (it) Derivati steroidei della spiro-ossatiazolidina eprocedimento per la loro preparazione.
IT8122507A0 (it) Derivati della 16-ammino-prostaglandina e procedimento per la loro preparazione